@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HIPK2_HUMAN: (2015-10-08 )
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.....-..180.......190.......200.......210......-.220........230.......240.......250....-.-..260.......270.......280.......290........300.......310.....--..320.......330....-...340----------........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.........460.--------......470.......480.......490..----....--.500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
P
V
Y
E
G
M
A
S
H
V
Q
VFSPHTLQSSA
F
C
S
V
K
K
L
K
IEPSSNWDMTGYGSH
S
K
V
YSQSKNIPLSQPAT
T
T
VSTSLPVPNPSLPY
E
Q
T
I
V
FPGSTG
H
I
V
V
TSASST
S
V
T
G
Q
VLGG
P
H
N
L
M
R
R
S
T
V
S
L
L
D
T
Y
Q
K
CGLKR
K
S
E
EIENTSS
V
Q
I
IEEHPPMIQNNASG
A
T
V
A
T
A
T
TSTATSKNSG-SNSEG
D
Y
Q
L
V
Q
H
E
V
L
C
SMT
N
T
Y
E
V
L
E
F
LGRG
T
F
G
Q
V
V
K
C
W
K-RG-TN
E
I
V
A
I
K
I
LKNHPSYARQG
Q
I
E
V
S
I
L
A
RLSTESAD-D-
Y
N
F
V
R
A
Y
E
C
F
Q
HKNH
T
C
L
V
F
E
M
L
E
Q
N
L
Y
D
F
L
K
Q-NKFSPL
P
L
K
Y
I
R
P
V
L
Q
Q
V
A
T
A
L
M
K
L
K
S--LG
L
I
H
ADLKPE
N
I
M
L
VDPS-RQ
P
Y
R
-----------
V
K
V
I
DFG
S
A
S
H
V
S
K
A
V
C
S
T
Y
L
Q
S
R
YYRAPE
I
I
L
GL
P
F
C
E
A
I
D
M
W
S
L
G
C
V
I
A
E
L
F
LGWPLYPGASE
Y
D
Q
I
R
Y
I
S
QTQGL
P
A
E
Y
L
L
SAGTK
T
T
R
F
FNRDTDSPY
P
L
W
R
LKT--PDDH
E
A
ETGI
K
S
K
--------
E
A
R
K
Y
I
F
N
C
L
D
D
M
A
QVNMTTDLEGS
D
M
L
V
E
K
----
A
D
R
R
--
E
F
I
D
L
L
K
K
M
L
TIDADKRIT
P
I
ETLNH
P
F
V
T
M
T
H
L
LDFPH
S
T
H
V
K
S
C
F
Q
N
M
E
I
C
K
R
R
V
N
M
Y
DTVNQSKT
P
F
I
T
H
VAPSTST
N
L
T
M
T
FNN
Q
L
T
T
V
HNQAPSST
S
A
T
I
S
LANP
E
V
S
I
LNY
P
S
TLYQP
S
A
A
S
M
A
A
V
A
Q
RSMPLQTGTAQICARPD
P
F
Q
Q
A
L
I
VCPPGFQGLQASPSKHA
G
Y
S
V
R
MENAV
P
I
V
TQAPGAQ
P
L
QIQP
G
L
L
A
Q
QAWPSGT
Q
Q
I
LLP
P
A
W
Q
Q
L
TGVATHTSV
Q
H
A
TVI
P
E
T
MA
G
T
Q
Q
L
A
D
W
RNTHAHGSHY
N
P
I
MQQP
A
L
L
TG
H
V
TLPAAQPL
N
V
G
V
A
H
V
M
RQQPTSTTS
S
R
K
S
K
Q
H
Q
S
SVRN
V
S
T
C
EVSSSQAISS
P
Q
R
SKRVKENTPP
R
C
A
M
VHSSPACS
T
S
V
T
CGWGDVAS
S
T
T
R
ERQR
Q
T
I
V
IPDTPSP
T
V
S
V
I
T
ISSDT
D
E
E
E
E
Q
KHAPT
S
T
V
S
K
Q
RKN
V
I
S
C
V
T
VHDSPYSDSSSNTSPY
S
V
Q
Q
RAGHNNANAFDTKGSLENHCTGNP
R
T
I
I
VPPLKT
Q
A
S
E
V
L
V
ECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSS
G
A
I
T
Y
RQQRPGPHFQQQQPL
N
L
S
Q
A
Q
Q
H
ITTDRTGSHR
R
Q
Q
A
Y
ITPTMAQAPYSFPHNSPSHGTV
H
P
H
L
A
A
A
A
A
A
AHLPTQP
H
L
Y
T
Y
TAPAALGSTGT
V
A
H
L
VASQGSAR
H
T
V
QHTAY
P
A
S
I
V
H
QVPVSMGPRVLPSPTIHPSQY
P
A
Q
F
A
H
QTYISASPAS
T
V
Y
TGYPLS
P
A
KVNQYPYI
13
PsiBlast_PDB
90.40
39%
-92
- C1 -
4AZE
1
DYR1A_HUMAN
A:
[54-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-
R
S
A
-------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
---
W
N
L
K
K
--
T
K
D
G
K
R
E
--
Y
K
P
P
--------
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
90.14
39%
-94
* C1 *
2WO6
1
DYR1A_HUMAN
B:
[54-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-
R
S
A
-------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
---
W
N
L
K
K
-------
R
E
--
Y
K
P
P
--------
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.47
34%
-86
- C1 -
4AZF
2
DYRK2_HUMAN
A:
[62-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
---
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
-
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-
R
S
G
-------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
-
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
---
S
S
K
G
Y
P
R
Y
C
T
V
T
TL
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
PP
E
S
R
E
W
-------------
G
N
A
L
K
G
C
D
D
P
L
-------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.20
39%
-91
- C1 -
2WO6
1
DYR1A_HUMAN
A:
[54-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-
R
S
A
-------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
---
W
N
L
K
K
--
T
----
R
E
--
Y
K
P
P
--------
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.90
34%
-81
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[62-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
---
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
-
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-
R
S
G
-------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
-
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
---
S
S
K
G
Y
P
R
Y
C
T
V
T
TL
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
PP
E
S
R
E
W
-------------
G
N
A
L
K
G
C
D
D
P
L
-------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.67
30%
-96
- C1 -
2VAG
1
CLK1_HUMAN
A:
[12-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
-
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
--
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
K
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
R
K
Y
F
H
H
D
--------
R
L
D
W
---
D
E
H
S
S
----------------
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
--------------
H
E
--
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.50
30%
-96
- C1 -
1Z57
1
CLK1_HUMAN
A:
[12-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
-
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
--
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
R
D
E
R
T
L
INP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
R
K
Y
F
H
H
D
--------
R
L
D
W
---
D
E
H
S
S
----------------
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
--------------
H
E
--
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.36
32%
-81
- C1 -
4IFC
1
PRP4B_HUMAN
A:
[13-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
---
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
-
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
--
C
N
I
L
H
A
D
I
K
P
D
N
I
-
L
V
N
E
S
-
K
T
I
-------------
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
Y
--
I
E
--------
R
E
K
V
T
V
M
S
T
I
--------
N
P
T
K
------------
D
L
L
A
D
L
I
----
L
P
E
D
----
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.61
39%
-52
- C1 -
4YLK
13
DYR1A_HUMAN
A:
[33-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-
R
S
A
-------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
---
W
N
L
K
K
--------
E
--
Y
K
P
P
--------
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------