@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HIPK3_HUMAN: (2015-10-08 )
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210......-.220.......230.......240.......250..-.-....260.......270.......280......-.290.......300.......310...--....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430--------.......440.......450.......460.......470.......480.......490----....--...500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAS
Q
V
L
VYPP
Y
V
Y
QTQSS
A
F
C
S
V
K
K
L
KVEPS
S
C
V
F
QERNYPRTYVNGRNFGNSHPPTKGS
A
F
Q
TKIPFNRPRGHN
F
S
L
Q
T
S
A
V
V
L
KNTAGA
T
K
V
I
A
AQAQQAHVQAPQI
G
A
W
R
N
RLHFLEG
P
Q
RCGLK
R
K
S
E
E
LDN
H
S
S
A
M
Q
I
V
D
E
L
S
I
L
P
A
M
L
Q
TNMGN
P
V
T
V
V
T
ATTGSKQNCTTGEG
D
Y
Q
L
V
Q
H
E
V
L
C
SMK
N
T
Y
E
V
L
D
F
LGRG
T
F
G
Q
V
V
K
C
W
KRG-TN
E
I
V
A
I
K
I
LKNHPSYARQG
Q
I
E
V
S
I
L
A
R
LSTENAD-E-Y
N
F
V
R
A
Y
E
C
F
Q
HRNH
T
C
L
V
F
E
M
L
E
Q
N
L
Y
D
F
L
K
Q-NKFSPL
P
L
K
V
I
R
P
I
L
Q
Q
V
A
T
A
L
K
K
L
K
S--LG
L
I
HADLKPE
N
I
M
L
VDPVRQ
P
Y
R
V
K
V
I
DFGS
A
S
H
V
S
K
T
V
C
S
T
Y
L
Q
S
R
YYRAPE
I
I
L
GL
P
F
C
E
A
I
D
M
W
S
L
G
C
V
I
A
E
L
F
LGWPLYPGALE
Y
D
Q
I
R
Y
I
S
QTQGL
P
G
E
Q
L
L
NVGTKS
T
R
F
--------
F
C
KETDMSHSG
W
R
L
K
T
L
E
E
H
E
A
ETGM
K
S
K
E
A
R
K
Y
I
F
NS
L
D
D
V
AHV
N
T
V
MDLEG
S
D
L
L
A
E
K
----
A
D
R
R
--
E
F
V
S
L
L
K
K
M
L
LIDADLRI
T
P
A
E
TLNHPFV
N
M
K
H
L
LDFPHSN
H
V
K
S
C
F
H
I
M
D
I
C
K
S
H
L
N
SCDTNNHNK
T
S
LLRPVASSS
T
A
T
L
T
AN
F
T
K
I
G
T
L
R
S
Q
A
L
T
T
S
A
H
S
V
V
HHGIPLQAGTAQFG
C
G
D
A
F
Q
Q
T
L
I
ICPPAIQGIPATHGKP
T
S
Y
S
I
R
VDNTV
P
L
V
TQAPAVQ
P
L
Q
IRPGVLSQTWSGRTQ
Q
M
L
V
P
A
W
Q
QVTPLAPA
T
T
T
LTSESVAGSHRLGDWG
K
M
I
S
CSNHYNSVMPQPLLTN
Q
I
TLSAPQPVSVG
I
A
H
V
VWPQPATTKK
N
K
QCQNR
G
I
L
V
K
L
MEWEP
G
R
E
E
I
N
A
FSWSNSLQNTNIPHSAFISPKIINGKDV
E
E
V
S
C
I
ETQDNQNSEG
E
A
R
N
C
C
E
T
S
IRQDSDSSVSDKQR
Q
T
I
I
I
ADSPSP
A
V
S
V
I
T
ISSDT
D
E
E
E
T
S
Q
R
H
S
L
R
E
C
KGSL
D
C
E
A
C
Q
S
TL
N
I
D
R
MCSLSSPDSTLSTSSSGQSSPSPCKRPNSMS
D
E
E
Q
ESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKP
A
V
C
S
V
VVP
P
V
E
LENGLNA
D
E
HMA
N
T
D
S
I
C
Q
P
L
I
KGRSAPGRLNQPSAV
G
T
R
Q
Q
K
L
T
S
A
F
Q
Q
QHL
N
F
S
Q
V
Q
H
FGSGHQEWNGNFGH
R
R
Q
Q
A
YIPTSVTSN
P
F
TLSHGSPN
H
T
A
V
H
A
H
LAGNTHLGGQPTLLPYPSSATLSSA
A
P
V
A
H
L
L
ASPCTSRPMLQHPTYNISHPSG
I
V
H
QVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPL
S
P
T
KLSQYPYM
7
PsiBlast_PDB
89.10
39%
-86
- C2 -
4AZE
1
DYR1A_HUMAN
A:
[54-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------
F
E
K
L
P
D
G
T
---
W
N
L
K
K
T
K
D
G
K
R
E
Y
--
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
--
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
87.10
39%
-88
- C2 -
2WO6
1
DYR1A_HUMAN
B:
[54-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------
F
E
K
L
P
D
G
T
---
W
N
L
K
K
-----
R
E
--
Y
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
--
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.45
39%
-86
- C2 -
2WO6
1
DYR1A_HUMAN
A:
[54-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------
F
E
K
L
P
D
G
T
---
W
N
L
K
K
T
----
R
E
--
Y
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
--
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.43
34%
-82
- C2 -
4AZF
2
DYRK2_HUMAN
A:
[84-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
S
Y
V
Q
V
P
H
D
---
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
-
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
--
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
-
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSKGYP
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
-
R
G
P
P
E
S
R
E
W
------------------
G
N
A
L
--
K
G
----
C
D
D
P
--
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
82.09
31%
-86
- C2 -
4IIR
1
PRP4B_HUMAN
A:
[13-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
---
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
-
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
--
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
---
S
K
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
--------
F
--
D
Q
N
L
N
F
M
Y
I
E
------
R
E
K
V
T
V
M
S
T
I
N
P
T
K
------------
D
L
L
A
D
L
I
----
L
P
E
D
----
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.44
34%
-79
- C2 -
3KVW
1
DYRK2_HUMAN
A:
[84-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
S
Y
V
Q
V
P
H
D
---
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
-
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
--
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
-
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSKGYP
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
-
R
G
P
P
E
S
R
E
W
------------------
G
N
A
L
--
K
G
----
C
D
D
P
--
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.73
31%
-82
- C2 -
4IJP
1
PRP4B_HUMAN
A:
[15-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
---
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
-
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
--
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
---
S
K
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
--------
F
--
D
Q
N
L
N
F
M
Y
I
E
V
D
---
E
R
E
K
V
T
V
M
S
T
I
N
P
T
K
------------
D
L
L
A
D
L
I
--
Q
R
L
P
E
D
----
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.81
31%
-81
- C2 -
4IFC
1
PRP4B_HUMAN
A:
[13-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
---
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
-
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
--
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
---
S
K
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
--------
F
--
D
Q
N
L
N
F
M
Y
I
E
------
R
E
K
V
T
V
M
S
T
I
N
P
T
K
------------
D
L
L
A
D
L
I
----
L
P
E
D
----
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.76
39%
-53
- C2 -
4YLK
13
DYR1A_HUMAN
A:
[33-354]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------
F
E
K
L
P
D
G
T
---
W
N
L
K
K
------
E
--
Y
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
--
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
--
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------