@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HIPK4_HUMAN: (2015-10-08 )
MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH
Atome Classification :
(10 SA)
.........10........20........30.........40....-..---.-.50........60.......-.70.......---..80.------.......90........100.......110.......120......--.130.......140.......-----------150.......160.......170.......180.......190........200.......210.......220.......230.......240....-...250.......260.-......270.......280.......290.......300....-...310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTIQSET
D
C
Y
D
I
I
E
V
LGKGT
F
G
E
V
A
K
G
W
R
-RSTG
E
M
V
A
I
K
I
LKN
D
-
A
Y
---
R
-
N
R
I
I
K
N
E
L
K
L
L
H
C
MRGL
D
P
E
-
E
A
-
H
V
I
R
F
L
E
---
F
F
H
D
A
------
L
K
F
Y
L
V
F
E
L
L
E
Q
N
L
F
E
F
Q
KENNFAPL
P
A
R
H
I
R
T
V
T
L
Q
V
L
T
A
L
A
R
L
K
--
E
L
A
I
I
HADLKPE
N
I
M
L
V
DQTR-----------C
P
F
R
V
K
V
I
DFG
S
A
S
I
F
S
E
V
R
Y
V
KE
P
Y
I
Q
S
R
FYRA
P
E
I
LLGLP-FCEKV
D
V
W
S
L
G
C
V
M
A
E
L
HLGWPLYPGNNE
Y
D
Q
V
R
Y
I
CETQGLPK
P
H
L
L
H
A
A
C
K
A
H
-
H
F
FKRNPHPDAANPWQL-KSSA
D
Y
L
A
ETKVR
P
L
E
R
R
K
Y
M
L
K
S
L
D
Q
IETVNGGSVASRLTFP-
D
R
E
A
L
A
E
H
A
D
L
K
S
M
V
E
L
I
K
R
M
LTWESHERIS
P
S
A
A
LRHP
F
V
S
M
Q
Q
L
R
S
A
HET
T
H
Y
Y
Q
L
S
L
R
S
Y
R
L
S
L
Q
V
EGKPPT
P
V
V
AAEDGT
P
Y
Y
C
L
AEEKEAAGMGSVAGSSPFFREEKAP
G
M
Q
R
A
I
D
Q
L
DD
L
S
L
Q
E
AGHGL
W
G
E
T
C
T
N
A
V
S
D
M
M
V
P
L
K
A
A
ITGHHVPDSGP
E
P
I
L
A
F
Y
S
S
R
LAGRHKARKPPAGSKSDS
N
F
S
N
L
I
R
LSQVSPEDDRPCRGSSWEEGEHLGASAE
P
L
A
I
L
QRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDC
T
L
E
SVRGPRAQGLPPRRSHQHGPPR
G
A
T
S
F
L
Q
H
V
TGHH
13
PsiBlast_PDB
87.81
38%
-102
- C1 -
4AZE
1
DYR1A_HUMAN
A:
[54-375]
--------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
---
L
-
N
Q
A
-
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
------
L
--
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
-----------
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
---
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
-
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
F
E
K
L
P
D
----
G
T
W
N
L
-
K
K
T
K
D
--
G
K
R
E
Y
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
-
S
G
H
T
V
A
D
Y
L
K
F
K
---
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.17
38%
-102
- C1 -
2WO6
1
DYR1A_HUMAN
A:
[54-375]
--------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
---
L
-
N
Q
A
-
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
------
L
--
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
-----------
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
---
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
-
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
F
E
K
L
P
D
----
G
T
W
N
L
-
K
K
T
------
R
E
Y
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
-
S
G
H
T
V
A
D
Y
L
K
F
K
---
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
83.19
33%
-102
- C1 -
4AZF
2
DYRK2_HUMAN
A:
[99-412]
----------
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
-
K
R
---
F
-
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
-
N
T
M
N
V
I
H
M
L
E
---
N
F
T
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-----------
S
G
--
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
-
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
---------------
G
P
P
E
S
R
-----
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
81.71
36%
-99
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[97-413]
--------
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
-
K
R
---
F
-
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
-
N
V
I
H
M
L
E
---
N
F
T
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-------------
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
---
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
--
S
D
--
V
V
L
N
G
G
-
R
S
-
R
R
G
K
L
R
-----------
G
P
P
-----
E
S
R
-
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
80.63
31%
-100
- C1 -
1Z57
1
CLK1_HUMAN
A:
[13-333]
-------
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
-
D
R
---
Y
-
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
-
R
C
V
Q
M
L
E
---
W
F
E
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
NR
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
---
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
-
Y
F
H
H
D
------
R
L
D
W
D
E
-
H
S
S
A
G
-------------
R
Y
V
S
R
A
C
K
P
L
K
E
F
--------
M
L
S
Q
-
D
V
-------
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.78
33%
-99
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[99-412]
----------
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
-
K
R
---
F
-
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
-
N
T
M
N
V
I
H
M
L
E
---
N
F
T
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-----------
S
G
--
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
-
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
---------------
G
P
P
E
S
R
-----
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
71.19
31%
-111
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-299]
-------
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
---------V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
------
Q
E
-
N
I
V
E
L
K
E
---
A
F
R
R
R
------
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
--
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
---------------
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
-
R
F
-
H
G
L
R
F
------------
P
A
V
----
N
H
P
Q
S
L
E
R
R
Y
----------
L
G
---------
I
L
--
N
----------
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
70.93
30%
-107
- C1 -
3TTJ
1
MK10_HUMAN
A:
[61-360]
-------
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
D
-
A
V
L
D
R
N
V
A
I
K
K
L
S
R
P
-
F
Q
N
Q
T
H
-
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
------
H
K
-
N
I
I
S
L
L
N
---
V
F
T
P
Q
KTLEEF
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
----
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
--
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
---------------
C
T
L
K
I
L
D
F
G
L
A
-----
S
-
F
M
M
----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
G
-
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
Q
W
N
K
V
I
E
Q
L
G
T
P
C
P
E
F
M
K
K
L
Q
P
T
V
R
N
Y
V
E
N
R
P
K
Y
A
G
L
-
T
F
P
--------------------
K
-
L
F
P
D
---------------
S
L
F
P
A
D
S
E
H
--
N
K
L
K
A
S
Q
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
A
P
P
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.49
38%
-59
- C1 -
4YLK
13
DYR1A_HUMAN
A:
[33-354]
--------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
---
L
-
N
Q
A
-
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
------
L
--
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
-----------
S
A
--
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
---
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
-
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
F
E
K
L
P
D
----
G
T
W
N
L
-
K
K
--------
E
Y
K
P
P
G
T
R
K
-----
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
-
S
G
H
T
V
A
D
Y
L
K
F
K
---
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
59.43
32%
-91
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-296]
-----------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
I
-----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
------
H
P
-
N
I
I
G
L
L
D
---
A
F
G
H
K
------
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
S
-
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
--
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
---------------
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
-----------------------
W
P
D
M
C
S
L
P
D
Y
V
T
---
F
K
S
F
P
G
-----
I
P
L
H
H
I
F
-------------
S
-
A
--------
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------