@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : HUNK_HUMAN: (2015-10-08 )
MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC

Atome Classification :

(38 SA) .........10........20........30........40........50........60........70........80........90........-100.........110.....-..120.......130.........140.......150...---------------.-----------------------...---160.......170.......180.......190.---.---.---...----.200.......210-........---220.......230.....---.--.240..-......250.......260..-.....270......--.280-.---..---..---.--..290.......300.......310-.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710..
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAK-K--DTYVTKNLRREGQIQQM-IRHPNITQLLDIL--ETENSYYLVMELCPGGNLMHKIYEK---------------K-----------------------RLE---ESEARRYIRQLISAVEHLHRAGVVHRDLKIENLL---L---D---EDN----NIKLIDFGLSNCA--GILGYSDP---FSTQCGSPAYAAPELLAR---K--KY-GPK-IDVWSIGVNMYAMLTGTLPFT-VEPFSLRALYQKMV--DKE--M---NP---LP---T--QLSTGAISFLRSLLEPDPVKRPNIQ-QALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
118 HHSearch 83.1337% -87 - C1 -4BKY MELK_HUMAN A:[9-328] ---------------------------------------------------------LKYYELH-ETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL-----D---LPRIKTEIEALKN-LRHQHICQLYHVL--ETANKIFMVLEYCPGGELFDYIISQ---------------D-----------------------RLS---EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLL---F---D---EYH----KLKLIDFGLCA---------------------SLAYAAPELIQG---K-----GSE-ADVWSMGILLYVLMCGFLPFD-DD--NVMALYKKIM--RGK--Y---D----VP---K--WLSPSSILLLQQMLQVDPKKRISMK-NLLNHPWIMQDYNYP----VEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 77.1239% -78 - C1 -4CZU CIPKN_ARATH D:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHDTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSNLVVERRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 76.4640% -79 - C1 -4CZT CIPKN_ARATH D:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHTTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSNLVVERRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 PsiBlast_CBE 75.3040% -83 - C1 -4CQG MELK_MOUSE A:[17-291] -------------------------------------------------------------------IGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-S--DL---PRVKTEIDALKS-LRHQHICQLYHVL--ETKNKIFMVLEYCPGGELFDYIISQ---------------D-----------------------RLS---EEETRVVFRQILSAVAYVHSQGYAHRDLKPENLL---F---D---ENH----KLKLIDFGL--CA--K--------------CGSLAYAAPELIQG----------SE-ADVWSMGILLYVLMCGFLPFD-DD--NVMALYKKIM---RG--K---YE---VP---K--WLSPSSILLLQQMLQVDPKKRISMR-NLLNHPWVMQDYS----CPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLISSWQYDHLTATYLLLLAKKARLEHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 PsiBlast_PDB 74.3440% -72 - C1 -4CZT CIPKN_ARATH A:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHTTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFENVSLDDVDAIFDDSGES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26 PsiBlast_CBE 72.8840% -74 - C1 -4CZT CIPKN_ARATH B:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHTTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFEDDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25 PsiBlast_CBE 72.5240% -79 - C1 -4CZT CIPKN_ARATH C:[10-272] ---------------------------------------------------------VGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHTTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 72.3439% -72 - C1 -4CZU CIPKN_ARATH B:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHDTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFEDDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30 PsiBlast_CBE 72.2939% -78 - C1 -3AQV AAPK2_HUMAN A:[9-268] --------------------------------------------------------KIGHYVLGD-TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-S--LDVVGK-IKREIQNLKL-FRHPHIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKH---------------G-----------------------RVE---EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVL---L---D---AHM----NAKIADFGLSN-----MMSDGEF---L------PNYAAPEVISG---R--LYAGPE-VDIWSCGVILYALLCGTLPFD-DE--HVPTLFKK-I--RGG--V---FY---IP---E--YLNRSVATLLMHMLQVDPLKRATIK-DIREHEWFKQDLPSYLFPE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12 PsiBlast_PDB 71.9839% -76 - C1 -4CZU CIPKN_ARATH A:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHDTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFENDDVDAIFDDSGESKNLVV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 71.8439% -79 - C1 -4CZU CIPKN_ARATH C:[9-272] --------------------------------------------------------RVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-K--NKMIAQ-IKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G-----------------------RLK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL---L---D---ANG----ALKVSDFGLSALP--QQVREDGL---LHDTCGTPNYVAPEVINN---K--GYDGAK-ADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF--KAE--F----T---CP---P--WFSASAKKLIKRILDPNPATRITFA-EVIENEWFKKGYKAPKFENADVDAIFDDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53 PsiBlast_CBE 71.6538% -95 - C1 -4FG7 KCC1A_HUMAN A:[9-276] --------------------------------------RWKQA---EDIRDIYDFRDV---------LGTGAFSEVILAEDKRTQKLVAIKCIA---------------SMENEIAVLHK-IKHPNIVALDDIY--ESGGHLYLIMQLVSGGELFDRIVEK---------------G-----------------------FYT---ERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL---D---EDS----KIMISDFGLSKM--------EDPG--------TPGYVAPEVLAQ---K-----SKA-VDCWSIGVIAYILLCGYPPFY-DENDA--KLFEQIL--KAE--YEFDSP---YW---D--DISDSAKDFIRHLMEKDPEKRFTCE-QALQHPWIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56 PsiBlast_CBE 70.5538% -99 - C1 -4FG9 KCC1A_HUMAN B:[14-276] ----------------------------------------------EDIRDIYDFRDV---------LGTGAFSEVILAEDKRTQKLVAIKCIAK------------------EIAVLHK-IKHPNIVALDDIY--ESGGHLYLIMQLVSGGELFDRIVEK---------------G-----------------------FYT---ERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL---D---EDS----KIMISDF----------------V--LSTACGTPGYVAPEVLAQ---K--PY-SKA-VDCWSIGVIAYILLCGYPPFY-DENDA--KLFEQIL--KAE--YEFDSP---YW---D--DISDSAKDFIRHLMEKDPEKRFTCE-QALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55 PsiBlast_CBE 69.3038%-100 - C1 -4FG8 KCC1A_HUMAN A:[10-276] ---------------------------------------WKQA---EDIRDIYDFRDV---------LGTGAFSEVILAEDKRTQKLVAIKCIAKE----------------NEIAVLHK-IKHPNIVALDDIY--ESGGHLYLIMQLVSGGELFDRIVEK---------------G-----------------------FYT---ERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL---D---EDS----KIMISDF-------------------------TPGYVAPEVLAQ---K--PY-SKA-VDCWSIGVIAYILLCGYPPFY-DENDA--KLFEQIL--KAE--YEFDSP---YW---D--DISDSAKDFIRHLMEKDPEKRFTCE-QALQHPWIAGDTALDKNIHQSVSEQIKKNFA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134 HHSearch 69.2332% -74 - C1 -3HKO ? A:[26-337] ----------------------------------------------------------KKYHLK-GAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR-Q----KDVERIKTEVRLMKK-LHHPNIARLYEVY--EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIFRESLDFVQR---EKLISNIMRQIFSALHYLHNQGICHRDIKPENFL---F---S---TNKSF--EIKLVDFGLSKEF--YKLNNG---------AGTPYFVAPEVLNT---TNESY-GPK-CDAWSAGVLLHLLLMGAVPFP-GV--NDADTISQVL--NKK--L---CFENPNY---N--VLSPLARDLLSNLLNRNVDERFDAM-RALQHPWISQFSDKIYKMS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54 PsiBlast_CBE 69.0538% -95 - C1 -4FG8 KCC1A_HUMAN B:[14-276] ----------------------------------------------EDIRDIYDFRDV---------LGTGAFSEVILAEDKRTQKLVAIKCIAK-----------------NEIAVLHK-IKHPNIVALDDIY--ESGGHLYLIMQLVSGGELFDRIVEK---------------G-----------------------FYT---ERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL---D---EDS----KIMISDFG---------------GSVLSTACGTPGYVAPEVLAQ---K--PY-SKA-VDCWSIGVIAYILLCGYPPFY-DENDA--KLFEQIL--KAE--YEFDSP---YW---D--DISDSAKDFIRHLMEKDPEKRFTCE-QALQHPWIAGDTALDKNIHQSVSEQIKKNFA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57 PsiBlast_CBE 68.3138% -99 - C1 -4FG9 KCC1A_HUMAN A:[10-276] ---------------------------------------WKQA---EDIRDIYDFRDV---------LGTGAFSEVILAEDKRTQKLVAIKCIAKE---------------ENEIAVLHK-IKHPNIVALDDIY--ESGGHLYLIMQLVSGGELFDRIVEK---------------G-----------------------FYT---ERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSL---D---EDS----KIMISDF--------------------------PGYVAPEVLAQ---K--PY-SKA-VDCWSIGVIAYILLCGYPPFY-DENDA--KLFEQIL--KAE--YEFDSP---YW---D--DISDSAKDFIRHLMEKDPEKRFTCE-QALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 67.1839% -88 - C1 -2JAM KCC1G_HUMAN B:[11-268] -------------------------------------------------------------FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK---------S----SLENEIAVLKK-IKHENIVTLEDIY--ESTTHYYLVMQLVSGGELFDRILER---------------G-----------------------VYT---EKDASLVIQQVLSAVKYLHENGIVHRDLKPENLL---YLTPE---ENS----KIMITDFGLSKMEQNGIM---------STACGTPGYVAPEVLAQ---K--PY-SKA-VDCWSIGVITYILLCGYPPFY-EETES--KLFEKIK--EGY--YEFESP---FW---D--DISESAKDFICHLLEKDPNERYTCE-KALSHPWIDGNTALHRDIYPSVSLQIQKNFAK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 67.0936% -74 - C1 -3MA6 ? A:[36-295] ---------------------------------------------------------------GQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVK-Q--KT-DKESLLREVQLLKQ-LDHPNIMKLYEFF--EDKGYFYLVGEVYTGGELFDEIISR---------------K-----------------------RFS---EVDAARIIRQVLSGITYMHKNKIVHRDLKPENLL---L---ESKSKDA----NIRIIDFGLSTH-----FE-SKK---MKDKIGTAYYIAPEVL-H---G--TY-DEK-CDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGK--YTF--E---LP---QW---K--KVSESAKDLIRKMLTYVPSMRISAR-DALDHEWI-QTYTK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52 PsiBlast_CBE 66.7639% -90 - C1 -2JAM KCC1G_HUMAN A:[11-268] -------------------------------------------------------------FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK---------S----SLENEIAVLKK-IKHENIVTLEDIY--ESTTHYYLVMQLVSGGELFDRILER---------------G-----------------------VYT---EKDASLVIQQVLSAVKYLHENGIVHRDLKPENLL---YLTPE---ENS----KIMITDFGLSKMEQNGIM---------STACGTPGYVAPEVLAQ---K--PY-SKA-VDCWSIGVITYILLCGYPPFY-EETES--KLFEKIK--EGY--YEFESP---FW---D--DISESAKDFICHLLEKDPNERYTCE-KALSHPWIDGNTALHRDIYPSVSLQIQKNFAKS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69 PsiBlast_CBE 66.7134% -73 - C1 -4B6L PLK3_HUMAN A:[6-268] --------------------------------------------------------RSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVA-K--PHQREKILN-EIELHRD-LQHRHIVRFSHHF--EDADNIYIFLELCSRKSLAHIWKAR---------------H-----------------------TLL---EPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFF---I---T---ENM----ELKVGDFGLA--A--RLEPPEQR---KKTICGTPNYVAPEVLLR---Q--GH-GPE-ADVWSLGCVMYTLLCGSPPF---ETADLKETY-RCI--KQV--H---YT---LP---A--SLSLPARQLLAAILRASPRDRPSID-QILRHDFFTKGYTPDRLPISSCVTVP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135 HHSearch 66.3334% -85 - C1 -2Y0A DAPK1_HUMAN A:[11-276] ----------------------------------------------------------DYYDTG-EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTK-SSRRGVSREDIEREVSILKE-IQHPNVITLHEVY--ENKTDVILILELVAGGELFDFLAEK---------------E-----------------------SLT---EEEATEFLKQILNGVYYLHSLQIAHFDLKPENIM---L---L---DRNVPKPRIKIIDFGLAHKI--DFG---NE---FKNIFGTPEFVAPEIVNY---E--PL-GLE-ADMWSIGVITYILLSGASPFL-GD--TKQETLANVS--AVN--Y---EFEDEYF---S--NTSALAKDFIRRLLVKDPKKRMTIQ-DSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAAR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95 PsiBlast_CBE 64.5936% -68 - C1 -3MA6 ? B:[36-295] ---------------------------------------------------------------GQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVK-Q---T-DKESLLREVQLLKQ-LDHPNIMKLYEFF--EDKGYFYLVGEVYTGGELFDEIISR---------------K-----------------------RFS---EVDAARIIRQVLSGITYMHKNKIVHRDLKPENLL---L---ESKSKDA----NIRIIDFGLSTH-----FEASKK---MKDKIGTAYYIAPEVL-H---G--TY-DEK-CDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGK--YTF--E---LP---QW---K--KVSESAKDLIRKMLTYVPSMRISAR-DALDHEWI-QTYT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97 PsiBlast_CBE 64.2937% -73 - C1 -2WEI ? A:[30-282] -------------------------------------------------------------------LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNK--DT---STILREVELLKK-LDHPNIMKLFEIL--EDSSSFYIVGELYTGGELFDEIIKR---------------K-----------------------RFS---EHDAARIIKQVFSGITYMHKHNIVHRDLKPENIL---LESKE---KDC----DIKIIDFGLSTC-----FQQNTK---MKDRIGTAYYIAPEVL-R---G--TY-DEK-CDVWSAGVILYILLSGTPPFY-GKN-EYDILKRVET--GKY--A---FD---LP---QWRTISDDAKDLIRKMLTFHPSLRITAT-QCLEHPWIQKYSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139 HHSearch 63.6931% -73 - C1 -1XJD A:[16-275] ---------------------------------------------------------IEDFILH-KMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVL-M--DDD-VECTMVEKRVLSLAWEHPFLTHMFCTF--QTKENLFFVMEYLNGGDLMYHIQSC---------------H-----------------------KFD---LSRATFYAAEIILGLQFLHSKGIVYRDLKLDNIL---L---D---KDG----HIKIADFGMCKEN--MLG--DAK---TNTFCGTPDYIAPEILLG---Q--KY-NHS-VDWWSFGVLLYEMLIGQSPFH-GQ--DEEELFHSIR--MDN--P---F----YP---R--WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPQNMFRNFSF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129 HHSearch 63.3633% -79 - C1 -3TKI CHK1_HUMAN A:[6-271] ---------------------------------------------------------VEDWDLV-QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-------------NIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EFHAEP-VDVWSCGIVLTAMLAGELPWD-QPSDSC-QEYSDWK--EKK--T---YLN--PW---K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101 PsiBlast_CBE 63.1233% -76 - C1 -2R0U CHK1_HUMAN A:[13-267] -----------------------------------------------------------------QTLGE---GEVQLAVNRVTEEAVAVKIVDMK-------------NIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EF-HAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK--EKKTYL---NP---W----K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100 PsiBlast_CBE 62.1933% -81 - C1 -3TKH CHK1_HUMAN A:[13-267] -----------------------------------------------------------------QTLGEGAYGEVQLAVNRVTEEAVAVKIV----------------NIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EF-HAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK--EKKTYL---NP---W----K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102 PsiBlast_CBE 62.0133% -77 - C1 -2HY0 CHK1_HUMAN A:[12-266] -----------------------------------------------------------------QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-------------NIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EF-HAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK--EKKTYL---NP---W----K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105 PsiBlast_CBE 61.6733% -77 - C1 -2HOG CHK1_HUMAN A:[12-266] -----------------------------------------------------------------QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-------------NIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EF-HAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK--EKKTYL---NP---W----K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122 HHSearch 61.4233% -70 - C1 -2YEX CHK1_HUMAN A:[6-270] ---------------------------------------------------------VEDWDLV-QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAV-D-----CPENIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EFHAEP-VDVWSCGIVLTAMLAGELPWD-QPSDSC-QEYSDWK--EKK--T---YLN--PW---K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107 PsiBlast_CBE 61.3434% -77 - C1 -4BDI CHK2_HUMAN A:[19-287] --------------------------------------------------------------IMSKTLG----GEVKLAFERKTCKKVAIKIISK------------ALNVETEIEILKK-LNHPCIIKIKNFF--DAED-YYIVLELMEGGELFDKVVGN---------------K-----------------------RLK---EATCKLYFYQMLLAVQYLHENGIIHRDLKPENVL---LSSQE---EDC----LIKITDFGHSK-----ILGETSL---MRTLCGTPTYLAPEVLVSVGTA--GY-NRA-VDCWSLGVILFICLSGYPPFS--EHRTQVSLKDQIT--SGK--Y---NF---IPEVWA--EVSEKALDLVKKLLVVDPKARFTTE-EALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103 PsiBlast_CBE 61.2933% -73 - C1 -2HXQ CHK1_HUMAN A:[12-266] -----------------------------------------------------------------QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR---------CPENIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EF-HAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK--EKKTYL---NP---W----K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104 PsiBlast_CBE 60.8933% -77 - C1 -2HXL CHK1_HUMAN A:[12-266] -----------------------------------------------------------------QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR---------CPENIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I-----------------------GMP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL---L---D---ERD----NLKISDFGLATVF--RYNNRERL---LNKMCGTLPYVAPELLKR---R--EF-HAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWK--EKKTYL---NP---W----K--KIDSAPLALLHKILVENPSARITIP-DIKKDRWYNKPLKKGAKRP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93 PsiBlast_CBE 60.5835% -80 - C1 -4YUR PLK4_HUMAN A:[10-269] ----------------------------------------------EKIEDF----KVGNLL------GKGSFAGVYRAESIHTGLEVAIKMIDKKAMY-K--AGMVQR-VQNEVKIHCQ-LKHPSILELYNYF--EDSNYVYLVLEMCHNGEM--NRYLK---------------N-----------------------RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLL---L---T---RNM----NIKIADF----------------------------------------------GLE-SDVWSLGCMFYTLLIGRPPF------TVKNTLNKVVLADYE--M---------P---S--FLSIEAKDLIHQLLRRNPADRLSLS-SVLDHPFMS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98 PsiBlast_CBE 59.0535% -86 - C1 -4JXF PLK4_HUMAN A:[4-264] ----------------------------------------------EKIEDF----KVGNLL------GKGSFAGVYRAESIHTGLEVAIKMIDKKAMY-K--AGMVQR-VQNEVKIHCQ-LKHPSILELYNYF--EDSNYVYLVLEMCHNGEM--NRYLK---------------N-----------------------RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLL---L---T---RNM----NIKIADFGLATQL--KMP--HE-----------------------------------SDVWSLGCMFYTLLIGRPPF-------VKNTLNKVVLADYE--M---------P---S--FLSIEAKDLIHQLLRRNPADRLSLS-SVLDHPFMSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94 PsiBlast_CBE 58.8035% -84 - C1 -3COK PLK4_HUMAN A:[8-267] ----------------------------------------------EKIEDF----KVGNLL------GKGSFAGVYRAESIHTGLEVAIKMIDKKAMY-K--AGMVQR-VQNEVKIHCQ-LKHPSILELYNYF--EDSNYVYLVLEMCHNGEM--NRYLK---------------N-----------------------RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLL---L---T---RNM----NIKIADFGLATQL--K---------------------------------------E-SDVWSLGCMFYTLLIGRPPFD-TD--TVK-----VVLADYE--M---------P---S--FLSIEAKDLIHQLLRRNPADRLSLS-SVLDHPFMS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130 HHSearch 58.5030% -75 - C1 -2W5A NEK2_HUMAN A:[4-274] --------------------------------------------------------RAEDYEVL-YTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMT-E--A--EKQMLVSEVNLLRE-LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKER-----------Q-----------------------YLD---EEFVLRVMTQLTLALKECHRRS-LHRDLKPANVF---L---D---GKQ----NVKLGDFGLARIL-------TSF---AKTFVGTPYYMSPEQMNR---M---Y-NEK-SDIWSLGCLLYELCALMPPFT-AF--SQKELAGKIR--EGK--F---RR---IP---Y--RYSDELNEIITRMLNLKDYHRPSVE-EILENPLILEHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------