@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HUNK_HUMAN: (2015-10-08 )
MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........-100.........110.....-..120.......130.........140.......150...---------------.-----------------------...---160.......170.......180.......190.---.---.---...----.200.......210-........---220.......230.....---.--.240..-......250.......260..-.....270......--.280-.---..---..---.--..290.......300.......310-.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSF
L
P
A
W
V
SGV
P
R
E
R
L
R
D
F
Q
H
H
K
R
VG
N
Y
L
IGSRKLGE
G
S
F
A
K
V
R
EG
L
H
VLTG
E
K
V
A
I
K
V
I
D
K
KRAK-K--D
T
Y
V
T
K
N
L
RR
E
G
Q
I
Q
Q
M
-
I
RHP
N
I
T
Q
L
L
D
I
L--ETEN
S
Y
Y
L
V
M
E
LCPG
G
N
L
M
H
K
I
Y
E
K
---------------K-----------------------RL
E
---
E
S
E
A
R
R
Y
I
R
Q
L
I
S
A
V
E
H
L
H
RAGVVHRD
L
K
I
E
N
L
L
---L---D---EDN----
N
I
K
L
I
DFGLSN
C
A
--
G
ILGYSDP---FSTQCGSPAY
A
A
P
E
L
L
A
R---K--KY-GPK-
I
D
V
W
S
IG
V
N
M
Y
A
M
L
TGTLP
F
T
-VE
P
F
S
L
R
A
L
Y
Q
K
M
V
--
D
KE--M---NP---LP---T--QL
S
T
G
A
I
S
F
L
R
S
LLEPDPVKRP
N
I
Q
-
Q
A
L
A
N
R
WLNENYTGK
V
P
C
NVTYP
N
R
I
S
L
E
DLS
P
S
V
V
L
H
M
T
E
K
LGYK
N
S
D
V
I
N
T
V
L
SNRA
C
H
I
L
A
I
Y
F
L
L
N
K
K
L
E
R
Y
LSGK
S
D
I
Q
D
S
L
C
Y
K
T
R
L
Y
Q
I
EKYRAP
K
E
S
Y
E
A
S
L
D
T
W
TRD
L
E
F
H
AVQDKKP
K
E
Q
E
K
R
G
D
F
LHR
P
F
S
K
K
L
D
KNLPSHKQPS
G
S
L
M
T
Q
I
Q
N
T
K
A
L
L
K
DRKASKSSFPDKDSF
G
C
R
N
I
F
R
KTSDSNCVASSSM
E
F
I
PVPPPRTPRIVKKPEPHQPGPGSTGIPHKED
P
L
M
L
D
M
V
R
S
F
E
SVDRDD
H
V
E
VLSPSH
H
Y
R
ILNS
P
V
S
L
A
RRNSSERTLSPGLPSGSMSPLHTPL
H
P
T
L
V
S
F
A
HEDKNSPPKEEGLCCPPPVPSNGPMQPLGS
P
N
C
V
KSRGRFPMM
G
I
G
Q
M
L
R
K
R
H
QSLQPSADRPLEASLPPLQPLAPV
N
L
A
F
DMADGVKTQC
118
HHSearch
83.13
37%
-87
- C1 -
4BKY
1
MELK_HUMAN
A:
[9-328]
---------------------------------------------------------
L
K
Y
Y
E
L
H
-
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-----
D
---
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
-----------------------
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
---
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
---------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
---
K
-----
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
-
D
D
--
N
V
M
A
L
Y
K
K
I
M
--
R
G
K
--
Y
---
D
----
V
P
---
K
--
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
-
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.12
39%
-78
- C1 -
4CZU
3
CIPKN_ARATH
D:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.46
40%
-79
- C1 -
4CZT
4
CIPKN_ARATH
D:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
75.30
40%
-83
- C1 -
4CQG
1
MELK_MOUSE
A:
[17-291]
-------------------------------------------------------------------
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
L
G
-
S
--
D
L
---
P
R
V
K
T
E
I
D
A
L
K
S
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
-----------------------
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
---
E
N
H
----
K
L
K
L
I
D
F
G
L
--
C
A
--
K
--------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
----------
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
-
D
D
--
N
V
M
A
L
Y
K
K
I
M
---
R
G
--
K
---
Y
E
---
V
P
---
K
--
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
-
N
L
L
N
H
P
W
V
M
Q
D
Y
S
----
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
L
E
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.34
40%
-72
- C1 -
4CZT
3
CIPKN_ARATH
A:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.88
40%
-74
- C1 -
4CZT
2
CIPKN_ARATH
B:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.52
40%
-79
- C1 -
4CZT
3
CIPKN_ARATH
C:
[10-272]
---------------------------------------------------------
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.34
39%
-72
- C1 -
4CZU
3
CIPKN_ARATH
B:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.29
39%
-78
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[9-268]
--------------------------------------------------------
K
I
G
H
Y
V
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-
S
--
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
L
-
F
R
H
P
H
I
I
K
L
Y
Q
V
I
--
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
---------------
G
-----------------------
R
V
E
---
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
---
A
H
M
----
N
A
K
I
A
D
F
G
L
S
N
-----
M
M
S
D
G
E
F
---
L
------
P
N
Y
A
A
P
E
V
I
S
G
---
R
--
L
Y
A
G
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
E
--
H
V
P
T
L
F
K
K
-
I
--
R
G
G
--
V
---
F
Y
---
I
P
---
E
--
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
-
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.98
39%
-76
- C1 -
4CZU
3
CIPKN_ARATH
A:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.84
39%
-79
- C1 -
4CZU
3
CIPKN_ARATH
C:
[9-272]
--------------------------------------------------------
R
V
G
K
Y
E
L
G
-
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
--
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
---
K
--
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
L
Y
K
K
I
F
--
K
A
E
--
F
----
T
---
C
P
---
P
--
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
71.65
38%
-95
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
--------------------------------------
R
W
K
Q
A
---
E
D
I
R
D
I
Y
D
F
R
D
V
---------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------
S
M
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---------------
G
-----------------------
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
----
K
I
M
I
S
D
F
G
L
S
K
M
--------
E
D
P
G--------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
-----
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
-
D
E
N
D
A
--
K
L
F
E
Q
I
L
--
K
A
E
--
Y
EFD
S
P
---
Y
W
---
D
--
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
70.55
38%
-99
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-276]
----------------------------------------------
E
D
I
R
D
I
Y
D
F
R
D
V
---------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---------------
G
-----------------------
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
----
K
I
M
I
S
D
F
----------------V--
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
-
D
E
N
D
A
--
K
L
F
E
Q
I
L
--
K
A
E
--
Y
EFD
S
P
---
Y
W
---
D
--
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.30
38%
-100
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
---------------------------------------
W
K
Q
A
---
E
D
I
R
D
I
Y
D
F
R
D
V
---------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
----------------
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---------------
G
-----------------------
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
----
K
I
M
I
S
D
F
-------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
-
D
E
N
D
A
--
K
L
F
E
Q
I
L
--
K
A
E
--
Y
EFD
S
P
---
Y
W
---
D
--
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
69.23
32%
-74
- C1 -
3HKO
2
?
A:
[26-337]
----------------------------------------------------------
K
K
Y
H
L
K
-
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
-
Q
----
K
D
V
E
R
I
K
T
E
V
R
L
M
K
K
-
L
H
H
P
N
I
A
R
L
Y
E
V
Y
--
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KT
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
---
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
---
F
---
S
---
T
N
K
SF--
E
I
K
L
V
D
F
G
L
S
K
E
F
--
Y
K
L
N
N
G
---------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
---
T
NE
S
Y
-
G
P
K
-
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
-
G
V
--
N
D
A
D
T
I
S
Q
V
L
--
N
K
K
--
L
---
C
F
ENP
N
Y
---
N
--
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
-
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.05
38%
-95
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
----------------------------------------------
E
D
I
R
D
I
Y
D
F
R
D
V
---------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---------------
G
-----------------------
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
----
K
I
M
I
S
D
F
G
---------------G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
-
D
E
N
D
A
--
K
L
F
E
Q
I
L
--
K
A
E
--
Y
EFD
S
P
---
Y
W
---
D
--
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
68.31
38%
-99
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-276]
---------------------------------------
W
K
Q
A
---
E
D
I
R
D
I
Y
D
F
R
D
V
---------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
---------------
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---------------
G
-----------------------
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
----
K
I
M
I
S
D
F
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
-
D
E
N
D
A
--
K
L
F
E
Q
I
L
--
K
A
E
--
Y
EFD
S
P
---
Y
W
---
D
--
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.18
39%
-88
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[11-268]
-------------------------------------------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
---------
S
----
S
L
E
N
E
I
A
V
L
K
K
-
I
K
H
E
N
I
V
T
L
E
D
I
Y
--
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
---------------
G
-----------------------
V
Y
T
---
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
---
E
N
S
----
K
I
M
I
T
D
F
G
L
S
K
M
E
QN
G
I
M
---------
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
-
E
E
T
E
S
--
K
L
F
E
K
I
K
--
E
G
Y
--
Y
EFE
S
P
---
F
W
---
D
--
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
-
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
67.09
36%
-74
- C1 -
3MA6
1
?
A:
[36-295]
---------------------------------------------------------------
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
--
K
T
-
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
--
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---------------
K
-----------------------
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
----
N
I
R
I
I
D
F
G
L
S
T
H
-----
F
E
-
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
---
G
--
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
T
F
--
E
---
L
P
---
Q
W
---
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
66.76
39%
-90
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[11-268]
-------------------------------------------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
---------
S
----
S
L
E
N
E
I
A
V
L
K
K
-
I
K
H
E
N
I
V
T
L
E
D
I
Y
--
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
---------------
G
-----------------------
V
Y
T
---
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
---
E
N
S
----
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
I
M
---------
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
-
E
E
T
E
S
--
K
L
F
E
K
I
K
--
E
G
Y
--
Y
EFE
S
P
---
F
W
---
D
--
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
-
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
66.71
34%
-73
- C1 -
4B6L
1
PLK3_HUMAN
A:
[6-268]
--------------------------------------------------------
R
S
G
R
T
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
-
K
--
P
H
Q
R
E
K
I
L
N
-
E
I
E
L
H
R
D
-
L
Q
H
R
H
I
V
R
F
S
H
H
F
--
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
R
---------------
H
-----------------------
T
L
L
---
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
---
I
---
T
---
E
N
M
----
E
L
K
V
G
D
F
G
L
A
--
A
--
R
L
E
P
P
E
Q
R
---
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
---
Q
--
G
H
-
G
P
E
-
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
---
E
T
A
D
L
K
E
T
Y
-
R
C
I
--
K
Q
V
--
H
---
Y
T
---
L
P
---
A
--
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
-
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
66.33
34%
-85
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[11-276]
----------------------------------------------------------
D
Y
Y
D
T
G
-
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
SR
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---------------
E
-----------------------
S
L
T
---
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
---
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
--
D
F
G
---
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
--
T
K
Q
E
T
L
A
N
V
S
--
A
V
N
--
Y
---
E
F
EDE
Y
F
---
S
--
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
-
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
64.59
36%
-68
- C1 -
3MA6
1
?
B:
[36-295]
---------------------------------------------------------------
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
---
T
-
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
--
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---------------
K
-----------------------
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
----
N
I
R
I
I
D
F
G
L
S
T
H
-----
F
E
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
---
G
--
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
T
F
--
E
---
L
P
---
Q
W
---
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
-
Q
T
Y
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
64.29
37%
-73
- C1 -
2WEI
1
?
A:
[30-282]
-------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
--
D
T
---
S
T
I
L
R
E
V
E
L
L
K
K
-
L
D
H
P
N
I
M
K
L
F
E
I
L
--
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
---------------
K
-----------------------
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
---
K
D
C
----
D
I
K
I
I
D
F
G
L
S
T
C
-----
F
Q
Q
N
T
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-
R
---
G
--
T
Y
-
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-
G
K
N
-
E
Y
D
I
L
K
R
V
E
T
--
G
K
Y
--
A
---
F
D
---
L
P
---
Q
WR
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
63.69
31%
-73
- C1 -
1XJD
1
A:
[16-275]
---------------------------------------------------------
I
E
D
F
I
L
H
-
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
--
D
D
D
-
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
--
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
---------------
H
-----------------------
K
F
D
---
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
---
L
---
D
---
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
N
--
M
L
G
--
D
A
K
---
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
---
Q
--
K
Y
-
N
H
S
-
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
-
G
Q
--
D
E
E
E
L
F
H
S
I
R
--
M
D
N
--
P
---
F
----
Y
P
---
R
--
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
63.36
33%
-79
- C1 -
3TKI
1
CHK1_HUMAN
A:
[6-271]
---------------------------------------------------------
V
E
D
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
-
Q
P
S
D
S
C
-
Q
E
Y
S
D
W
K
--
E
K
K
--
T
---
Y
L
N--
P
W
---
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
63.12
33%
-76
- C1 -
2R0U
1
CHK1_HUMAN
A:
[13-267]
-----------------------------------------------------------------
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
-
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
--
E
K
K
TY
L
---
N
P
---
W
----
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
62.19
33%
-81
- C1 -
3TKH
1
CHK1_HUMAN
A:
[13-267]
-----------------------------------------------------------------
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
-
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
--
E
K
K
TY
L
---
N
P
---
W
----
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
62.01
33%
-77
- C1 -
2HY0
1
CHK1_HUMAN
A:
[12-266]
-----------------------------------------------------------------
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
-
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
--
E
K
K
TY
L
---
N
P
---
W
----
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
61.67
33%
-77
- C1 -
2HOG
1
CHK1_HUMAN
A:
[12-266]
-----------------------------------------------------------------
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
-
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
--
E
K
K
TY
L
---
N
P
---
W
----
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
61.42
33%
-70
- C1 -
2YEX
8
CHK1_HUMAN
A:
[6-270]
---------------------------------------------------------
V
E
D
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-
D
-----
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
-
Q
P
S
D
S
C
-
Q
E
Y
S
D
W
K
--
E
K
K
--
T
---
Y
L
N--
P
W
---
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
61.34
34%
-77
- C1 -
4BDI
6
CHK2_HUMAN
A:
[19-287]
--------------------------------------------------------------
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---------------
K
-----------------------
R
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
----
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
G
E
T
S
L
---
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
K
--
Y
---
N
F
---
I
P
EVW
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
61.29
33%
-73
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[12-266]
-----------------------------------------------------------------
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
-
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
--
E
K
K
TY
L
---
N
P
---
W
----
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
60.89
33%
-77
- C1 -
2HXL
1
CHK1_HUMAN
A:
[12-266]
-----------------------------------------------------------------
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
--
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
---
R
--
E
F
-
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
--
E
K
K
TY
L
---
N
P
---
W
----
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.58
35%
-80
- C1 -
4YUR
1
PLK4_HUMAN
A:
[10-269]
----------------------------------------------
E
K
I
E
D
F
----
K
V
G
N
L
L
------
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-
K
--
A
G
M
V
Q
R
-
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
--
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
--
N
R
Y
L
K
---------------
N
-----------------------
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
---
R
N
M
----
N
I
K
I
A
D
F
----------------------------------------------
G
L
E
-
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------
T
V
K
N
T
L
N
K
V
V
L
A
D
Y
E
--
M
---------
P
---
S
--
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.05
35%
-86
- C1 -
4JXF
2
PLK4_HUMAN
A:
[4-264]
----------------------------------------------
E
K
I
E
D
F
----
K
V
G
N
L
L
------
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-
K
--
A
G
M
V
Q
R
-
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
--
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
--
N
R
Y
L
K
---------------
N
-----------------------
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
---
R
N
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
--
K
M
P
--
H
E
-----------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-------
V
K
N
T
L
N
K
V
V
L
A
D
Y
E
--
M
---------
P
---
S
--
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
58.80
35%
-84
- C1 -
3COK
1
PLK4_HUMAN
A:
[8-267]
----------------------------------------------
E
K
I
E
D
F
----
K
V
G
N
L
L
------
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-
K
--
A
G
M
V
Q
R
-
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
--
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
--
N
R
Y
L
K
---------------
N
-----------------------
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
---
R
N
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
--
K
---------------------------------------
E
-
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
-
T
D
--
T
V
K
-----
V
V
LA
D
Y
E
--
M
---------
P
---
S
--
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
58.50
30%
-75
- C1 -
2W5A
5
NEK2_HUMAN
A:
[4-274]
--------------------------------------------------------
R
A
E
D
Y
E
V
L
-
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
--
A
--
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R-----------
Q
-----------------------
Y
L
D
---
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
---
L
---
D
---
G
K
Q
----
N
V
K
L
G
D
F
G
L
A
R
I
L
-------
T
S
F
---
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
M
---
Y
-
N
E
K
-
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
-
A
F
--
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
--
F
---
R
R
---
I
P
---
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
-
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------