@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IKKE_HUMAN: (2015-10-09 )
MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
Atome Classification :
(16 SA)
-.........10........20........30........40....--....------50........60.-.......70........80........90........100.......110.......120.......130.......140.......150.......160......---.170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470-..--------.....480-.......490.......500.......510.......520--........530...-....540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MQSTA
N
Y
L
WHTDDLLGQGAT
A
S
V
Y
K
ARNKKSG
E
L
V
A
V
K
V
FNTTSY--LRPR------EV
Q
V
R
E
F
E
V
L
R
K
L-NHQ
N
I
V
K
L
F
A
V
EETGGS
R
Q
K
V
L
V
M
E
YCSSG
S
L
L
S
V
L
ESPENAFGL
P
E
D
E
F
L
V
V
L
R
C
V
V
A
G
M
N
H
L
R
ENG
I
V
HRDIKPG
N
I
M
R
L
VGEEG
Q
S
I
Y
K
LTDFGAARELDDD
E
---
K
F
V
S
V
YG
T
E
EYL
H
P
D
M
Y
E
R
A
V
LRKPQQKA
F
G
V
T
V
D
L
W
SI
G
V
T
L
Y
HAATGSLPFIPFGGPRRN
K
E
I
M
Y
R
I
TTEKPAGAIAGAQRRENGP
L
E
W
S
Y
T
L
P
I
T
C
Q
L
SLG
L
Q
S
Q
L
V
P
I
L
A
N
I
L
E
V
E
Q
A
KCW
G
F
D
Q
F
F
A
E
T
S
D
I
L
Q
R
V
V
V
H
V
F
S
L
S
Q
A
V
L
H
H
I
Y
I
HAH
N
T
I
A
I
F
Q
E
A
V
H
K
QTSVA
P
R
H
Q
E
Y
L
FEG
H
L
C
V
LEPSVS
A
Q
H
I
AHTTASSP
L
T
L
F
S
TAIPKGLAFRDPALDVPKFVP
K
V
D
L
QADYNTAK
G
V
L
G
A
G
Y
Q
A
L
R
L
A
R
A
L
LD
G
Q
E
L
M
F
R
G
L
H
W
V
M
E
V
L
Q
A
T
C
R
R
T
L
E
V
A
R
T
S
L
L
Y
L
SSSL-G
T
--------
E
R
F
S
SVAG-T
P
E
I
Q
E
L
K
A
A
A
E
L
R
S
R
L
R
T
L
A
E
V
L
S
R
C
S
Q
N
I
T
E
T
Q
E
S
L
S
---
S
L
N
R
E
L
V
K
S
R
D
Q
V
H-ED
R
S
I
Q
Q
I
Q
C
C
L
D
K
M
N
F
I
Y
K
Q
F
K
K
SRMRPGLGY
N
E
E
Q
I
H
K
LDKV
N
F
S
H
L
A
K
R
L
L
Q
V
F
Q
E
E
C
V
Q
K
Y
Q
A
S
L
V
THG
K
R
M
R
V
V
H
ETRN
H
L
R
L
V
G
C
S
V
A
ACN
T
E
A
Q
G
V
Q
E
S
L
S
K
L
L
E
E
L
S
H
Q
L
L
Q
D
R
AKGAQASPPPIAPYPSP
T
R
K
D
L
L
L
H
M
Q
E
L
C
E
G
M
K
L
L
A
S
D
LLDN
N
R
I
I
E
R
L
NRVPAPPDV
5
PsiBlast_PDB
94.94
50%
-98
- C2 -
4IW0
1
TBK1_HUMAN
A:
[3-657]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
--------
E
K
T
V
K
V
Y
E
K------
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
PGG
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
-
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
--------------------------------------------------------------------
4
PsiBlast_PDB
92.67
50%
-100
- C2 -
4IWO
1
TBK1_HUMAN
A:
[5-659]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
-------------
G
T
E
E
Y
L
H
P
D
M
Y
E
------------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
--------
E
K
T
V
K
V
Y
-----
A
A
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
PGG
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
-
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
--------------------------------------------------------------------
1
PsiBlast_PDB
92.58
50%
-103
- C2 -
4IM3
1
TBK1_HUMAN
A:
[7-662]
-
M
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
------
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
-------------------------------------------
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
--------
E
K
T
V
K
V
------
A
A
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
PGG
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
-
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
--------------------------------------------------------------------
3
PsiBlast_PDB
90.67
50%
-98
- C2 -
4IWQ
1
TBK1_HUMAN
A:
[4-658]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
-------------
G
T
E
E
Y
L
H
P
D
M
Y
E
------------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
--------
E
K
T
V
K
V
Y
E
-------
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
PGG
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
-
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
--------------------------------------------------------------------
2
PsiBlast_PDB
89.74
50%
-94
- C2 -
4IWP
1
TBK1_HUMAN
A:
[4-658]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
-------------
G
T
E
E
Y
L
H
P
D
M
Y
E
------------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
--------
E
K
T
V
K
V
Y
-----
A
A
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
PGG
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
-
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
--------------------------------------------------------------------
6
PsiBlast_PDB
89.04
52%
-99
- C2 -
4JL9
1
TBK1_MOUSE
A:
[3-612]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
Y
A
V
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
----------
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
V
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
L
S
C
S
L
S
Q
G
L
Q
A
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
V
L
H
R
M
V
I
H
V
F
S
L
Q
H
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
A
V
F
H
E
L
V
Y
K
Q
T
K
I
V
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
L
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
T
S
R
E
Q
L
N
T
V
G
L
R
Y
E
K
I
S
L
P
K
I
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
V
T
G
V
V
C
Y
A
C
R
T
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
V
R
W
L
V
E
L
V
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
-
R
N
I
E
K
T
V
K
V
Y
E
K
L
M
K
V
---
N
----
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
S
S
L
Q
D
I
S
S
R
L
S
PG-
G
L
L
A
D
T
W
A
H
Q
E
G
T
H
P
R
D
R
N
V
E
K
L
Q
V
L
L
N
C
I
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
S
H
F
S
E
E
C
V
R
K
Y
E
A
F
K
D
K
S
E
E
W
M
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
D
Y
T
N
E
L
Q
E
---------------------------------------------------------------------
7
PsiBlast_PDB
87.40
52%
-101
- C2 -
4JLC
1
TBK1_MOUSE
A:
[3-612]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
Y
A
V
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
----------
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
V
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
L
S
C
S
L
S
Q
G
L
Q
A
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
V
L
H
R
M
V
I
H
V
F
S
L
Q
H
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
A
V
F
H
E
L
V
Y
K
Q
T
K
I
V
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
L
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
T
S
R
E
Q
L
N
T
V
G
L
R
Y
E
K
I
S
L
P
K
I
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
V
T
G
V
V
C
Y
A
C
R
T
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
V
R
W
L
V
E
L
V
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
-
R
N
I
E
K
T
V
K
V
Y
E
K
L
M
K
V
---
N
----
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
S
S
L
Q
D
I
S
S
R
L
S
PG-
G
L
L
A
D
T
W
A
H
Q
E
G
T
H
P
R
D
R
N
V
E
K
L
Q
V
L
L
N
C
I
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
S
H
F
S
E
E
C
V
R
K
Y
E
A
F
K
D
K
S
E
E
W
M
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
D
Y
T
N
E
L
Q
E
---------------------------------------------------------------------
21
PsiBlast_CBE
72.62
67%
-108
- C2 -
4EUT
1
TBK1_HUMAN
B:
[4-385]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
-------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.63
67%
-102
- C2 -
4EUT
1
TBK1_HUMAN
A:
[4-385]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
--
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
70.59
67%
-102
- C2 -
4EUT
1
TBK1_HUMAN
A:
[2-387]
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
D
--
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
70.05
72%
-93
- C2 -
4EUU
6
TBK1_HUMAN
A:
[3-309]
-
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.35
72%
-92
- C2 -
4EUU
6
TBK1_HUMAN
A:
[4-309]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
67.48
72%
-90
- C2 -
4EUU
6
TBK1_HUMAN
B:
[4-309]
--
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
--
L
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
---
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
43.65
30%
-91
- C2 -
1PHK
1
PHKG1_RABIT
A:
[19-281]
---------
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
GS
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
--
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
---
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
D
D
D
M
--
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
---
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
--
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
----
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
----------
G
S
P
E
W
-----------
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
39.92
30%
-77
- C2 -
3TKI
1
CHK1_HUMAN
A:
[9-258]
---------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
--
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
---
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
--
L
D
E
R
D
N
--
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
-------
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
-----------
L
N
P
W
-----------
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
38.03
30%
-71
- C2 -
2YEX
8
CHK1_HUMAN
A:
[9-258]
---------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--
V
D
C
P
------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
--
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
---
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
--
L
D
E
R
D
--
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
-------
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
-----------
L
N
P
W
-----------
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------