@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ITK_HUMAN: (2015-10-09 )
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
Atome Classification :
(111 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-..-.....210-.-.-.....220.......230.......240.......250..-..-.-..-260.....-.-.270........280.......290.......300.......310.......320.......330.......340.......--------------350-.--.......360.....-..370.......380..--------.-.-----...390.....--.-.---400.........410.-......420......-.430.......440.......-450---------------.------...-.-...460.......470.......480.......490---.......500.......--510--......-..520.......530.......540.......550.......560.-.-.....570.......580.......590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNN
F
I
L
L
E
E
Q
L
I
K
K
S
Q
Q
KRRTSPSN
F
K
V
R
F
F
V
L
T
KA
S
L
A
Y
F
EDRHGKKRTLKGS
I
E
L
S
R
I
K
C
V
E
I
V
K
SDISI
P
C
H
YKY
P
F
Q
V
V
HD
N
Y
L
L
Y
V
FAPDRES
R
Q
R
W
V
L
A
L
K
E
ETRNNNSLVPKYHPNFWMD
G
K
W
R
C
C
S
Q
L
E
K
L
A
T
G
CAQYDPTKNASKKPLPPTPEDNRRPLWEPE
E
T
V
V
I
A
L
Y
DYQTN
D
P
Q
E
L
A
L
RRNE
E
Y
C
L
LD-SS-E
I
H
W
W
R
V
Q-D-R-NGHEGYVPSS
Y
L
VEKSPNNL
E
T
Y
E
W
Y
N
KSI
S
R
D
K
A
E
K
L
L
L
-DT-G-KE-
G
A
F
M
V
RDS-R-TA-
G
T
Y
T
V
S
V
F
T
K
A
V
VSENNPC
I
K
H
Y
H
IKETNDNP
K
R
Y
Y
V
A
E
K
Y
VFDSI
P
L
L
I
N
Y
HQHNGG
G
L
V
T
R
LRY
P
V
CFGRQKAPVTA--------------GL--R--YG
K
W
VI
D
P
S
E
L
T
F
V
Q
-
E
IGSGQ
F
G
L
V
H
L
G
Y
W
LN--------K-
D
-----
K
V
A
I
K
T
I
R
EGA--M-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
KL-SH
P
K
L
V
Q
L
Y
G
V
C
L
EQ-A
P
I
C
L
V
F
E
F
M
EH
G
C
L
S
D
Y
L
R
T
-Q-R---------------G------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
ARNCLVGE---N
Q
V
I
K
V
SDFG
M
T
R
F
V
LD--D-Q--YTSSTG-
T
K
F
P
V
KWASP
E
V
F
S
F
SRYSSKS
D
V
W
S
F
G
V
L
M
W
E
V
F
SEGKIPYENRS-
N
-
S
E
V
V
E
D
I
S
TG
F
R
LYKPRLA
S
T
H
V
Y
Q
I
M
N
H
C
W
KERPED
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
ESGL
3
PsiBlast_PDB
86.40
99%
-131
- C4 -
4HCV
1
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
118
HHSearch
86.29
99%
-129
- C4 -
4HCU
1
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
2
PsiBlast_PDB
86.29
99%
-129
- C4 -
4HCU
1
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
1
PsiBlast_PDB
86.10
99%
-129
- C4 -
4HCT
1
A:
[3-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
4
PsiBlast_PDB
85.15
99%
-129
- C4 -
4M0Y
2
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
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H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
7
PsiBlast_PDB
84.66
99%
-129
- C4 -
4M13
1
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
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G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
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S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
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F
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R
Y
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K
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F
G
V
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M
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V
F
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K
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-
N
-
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E
V
V
E
D
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F
R
L
Y
K
P
R
L
A
S
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V
Y
Q
I
M
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H
C
W
R
E
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E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
20
PsiBlast_PDB
84.31
99%
-130
- C4 -
4L7S
1
ITK_HUMAN
A:
[3-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
9
PsiBlast_PDB
83.85
99%
-127
- C4 -
4M15
2
A:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
6
PsiBlast_PDB
83.78
99%
-124
- C4 -
4M12
1
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
39
PsiBlast_CBE
83.69
99%
-133
- C4 -
4KIO
3
ITK_HUMAN
C:
[3-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
23
PsiBlast_CBE
83.69
100%
-135
- C4 -
3V5L
1
D:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
--
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
38
PsiBlast_CBE
83.66
99%
-130
- C4 -
4L7S
1
B:
[3-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
8
PsiBlast_PDB
83.66
99%
-127
- C4 -
4M14
2
A:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
5
PsiBlast_PDB
83.56
99%
-127
- C4 -
4M0Z
2
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
25
PsiBlast_CBE
83.43
100%
-140
- C4 -
3V5J
1
B:
[3-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
21
PsiBlast_CBE
83.08
100%
-136
- C4 -
3V8W
1
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
-----
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
40
PsiBlast_CBE
82.89
99%
-136
- C4 -
4KIO
2
ITK_HUMAN
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
49
PsiBlast_CBE
82.84
98%
-123
- C4 -
3MJ2
1
A:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
42
PsiBlast_CBE
82.68
98%
-128
- C4 -
3QGY
1
ITK_HUMAN
A:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
-
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
35
PsiBlast_CBE
82.51
99%
-132
- C4 -
4PP9
1
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
36
PsiBlast_CBE
82.39
99%
-129
- C4 -
4PP9
1
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
10
PsiBlast_PDB
82.19
99%
-129
- C4 -
3T9T
3
A:
[3-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
-
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
16
PsiBlast_PDB
82.12
100%
-127
- C4 -
1SNU
1
ITK_HUMAN
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
44
PsiBlast_CBE
81.93
98%
-132
- C4 -
3QGW
1
ITK_HUMAN
A:
[24-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
-
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
18
PsiBlast_PDB
81.93
99%
-131
- C4 -
4KIO
2
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------------
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
14
PsiBlast_PDB
81.83
100%
-136
- C4 -
3V8W
1
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
-
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
112
HHSearch
81.67
38%
-107
- C4 -
1OPK
3
ABL1_MOUSE
A:
[44-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
H
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
P
V
--
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
-
S
--
G
-
I
N
-
G
S
F
L
V
R
E
S
-
E
S
S
P
-
G
Q
R
S
I
S
L
R
Y
E
-------
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
--
N
K
P
T
I
Y
--------------
G
V
--
S
PN
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y-------
S
-
L
-----
T
V
A
V
K
T
L
K
E
D
T
--
M
-
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
---------------
Q
------
E
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
-
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
11
PsiBlast_PDB
81.46
100%
-134
- C4 -
3V5J
1
ITK_HUMAN
A:
[3-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
-----
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
15
PsiBlast_PDB
81.40
100%
-131
- C4 -
1SM2
1
ITK_HUMAN
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
24
PsiBlast_CBE
81.01
100%
-134
- C4 -
3V5L
1
ITK_HUMAN
C:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
78
PsiBlast_CBE
80.84
37%
-110
- C4 -
1OPK
3
ABL1_MOUSE
A:
[44-469]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
S
-
G
-
I
N
-
G
S
F
L
V
R
E
S
-
E
-
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
-------
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
I
Y
--------------
G
V
SP
N
--
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------
Y
-
S
L
----
T
V
A
V
K
T
L
K
E
D
T
--
M
-
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---------------
Q
------
E
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
-
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
26
PsiBlast_CBE
80.77
100%
-134
- C4 -
1SNU
1
B:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
22
PsiBlast_CBE
80.69
100%
-132
- C4 -
3V8T
1
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
13
PsiBlast_PDB
80.66
100%
-136
- C4 -
3V8T
1
ITK_HUMAN
A:
[3-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
--------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
81
PsiBlast_CBE
80.29
37%
-110
- C4 -
1OPL
2
ABL1_HUMAN
A:
[81-508]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
S
-
G
-
I
N
-
G
S
F
L
V
R
E
S
-
E
-
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
-------
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
V
Y
--------------
G
V
SP
N
--
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------
Y
-
S
L
----
T
V
A
V
K
T
L
K
E
D
T
--
M
-
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---------------
Q
------
E
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
-
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
113
HHSearch
79.82
37%
-108
- C4 -
2H8H
1
SRC_HUMAN
A:
[87-523]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
-
S
-
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
--
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
-
N
-
P
R
-
G
T
F
L
V
R
E
S
-
E
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
--
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
---
S
K
P
Q
T
Q
--------------
G
L
--
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--------
T
-
T
-----
R
V
A
I
K
T
L
K
P
G
T
--
M
-
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
G--------------
K
------
Y
L
R
-
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
-
E
--
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
45
PsiBlast_CBE
79.81
98%
-132
- C4 -
4RFM
1
A:
[3-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
--
47
PsiBlast_CBE
79.65
98%
-128
- C4 -
4MF1
1
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-
111
HHSearch
79.41
37%
-112
- C4 -
1QCF
1
HCK_HUMAN
A:
[8-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
-
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
G
N
-
M
L
-
G
S
F
M
I
R
D
S
E
T
-
T
K
-
G
S
Y
S
L
S
V
R
D
Y
D
P
--
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
---
K
P
Q
K
P
---------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
G
---------------
S
------
K
Q
P
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
--
N
-
E
--
Y
T
A
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
27
PsiBlast_CBE
78.67
100%
-135
- C4 -
1SM2
1
B:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
12
PsiBlast_PDB
78.62
100%
-131
- C4 -
3V5L
1
ITK_HUMAN
A:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
50
PsiBlast_CBE
78.35
98%
-132
- C4 -
3MJ1
1
A:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
-------------------
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
48
PsiBlast_CBE
78.26
98%
-128
- C4 -
4MF1
1
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-
41
PsiBlast_CBE
78.01
98%
-120
- C4 -
3QGY
1
B:
[23-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
-
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
46
PsiBlast_CBE
77.50
98%
-125
- C4 -
4PQN
2
A:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
43
PsiBlast_CBE
77.31
98%
-128
- C4 -
3QGW
1
B:
[24-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
-
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
85
PsiBlast_CBE
76.81
37%
-100
- C4 -
4K11
1
SRC_HUMAN
A:
[1-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
-
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
-
N
A
E
N
-
P
R
-
G
T
F
L
V
R
E
S
-
E
-
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
T
Q
--------------
G
L
--
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--------
T
-
T
-----
R
V
A
I
K
T
L
K
P
G
T
--
M
-
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---------------
G
------
K
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
-
E
--
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
79
PsiBlast_CBE
76.27
37%
-107
- C4 -
2FO0
4
ABL1_HUMAN
A:
[37-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
S
-
G
-
I
N
-
G
S
F
L
V
R
E
S
-
E
-
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
Y
-------
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
V
Y
--------------
G
V
SP
N
--
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------
Y
-
S
L
----
T
V
A
V
K
T
L
K
E
D
T
--
M
-
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---------------
Q
------
E
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
-
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
83
PsiBlast_CBE
75.73
37%
-102
- C4 -
2SRC
1
SRC_HUMAN
A:
[3-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
-
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
-
N
A
E
N
-
P
R
-
G
T
F
L
V
R
E
S
-
E
-
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
T
Q
--------------
G
L
--
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--------
T
-
T
-----
R
V
A
I
K
T
L
K
P
G
T
--
M
-
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---------------
G
------
K
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
-
E
--
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
86
PsiBlast_CBE
75.67
37%
-103
- C4 -
1KSW
1
SRC_HUMAN
A:
[3-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
-
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
-
N
A
E
N
-
P
R
-
G
T
F
L
V
R
E
S
-
E
-
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
T
Q
--------------
G
L
--
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--------
T
-
T
-----
R
V
A
I
K
T
L
K
P
G
T
--
M
-
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---------------
G
------
K
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
-
E
--
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
30
PsiBlast_CBE
75.50
99%
-134
- C4 -
4PPC
2
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------------------
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
92
PsiBlast_CBE
75.43
37%
-107
- C4 -
3VS6
1
HCK_HUMAN
A:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
80
PsiBlast_CBE
75.33
37%
-113
- C4 -
1OPL
1
ABL1_HUMAN
B:
[140-508]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
S
-
G
-
I
N
-
G
S
F
L
V
R
E
S
-
E
-
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
-------
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------
Y
-
S
L
----
T
V
A
V
K
T
L
K
E
D
T
--
M
-
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---------------
Q
------
E
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
-
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
117
HHSearch
75.16
33%
-121
- C4 -
2OZO
1
ZAP70_HUMAN
A:
[155-597]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
-
S
G
-
A
Q
T
D
-
G
K
F
L
L
R
P
R
-
K
-
E
Q
-
G
T
Y
A
L
S
L
I
Y
G
-------
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
--
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------MDTSVFESPFSDPE
E
L
--
K
--
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
RK
K
-----
Q
-
I
-----
D
V
A
I
K
V
L
K
Q
G
T
EK
A
-
D
---
T
--
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
---------------
E
------
E
I
P
-
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
---
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
84
PsiBlast_CBE
75.09
37%
-104
- C4 -
1Y57
1
SRC_HUMAN
A:
[3-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
-
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
-
N
A
E
N
-
P
R
-
G
T
F
L
V
R
E
S
-
E
-
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
T
Q
--------------
G
L
--
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--------
T
-
T
-----
R
V
A
I
K
T
L
K
P
G
T
--
M
-
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---------------
G
------
K
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
-
E
--
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
99
PsiBlast_CBE
75.02
37%
-107
- C4 -
3VS2
1
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
93
PsiBlast_CBE
75.02
37%
-109
- C4 -
3VS5
1
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
64
PsiBlast_CBE
74.91
58%
-137
- C4 -
3PJ1
2
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
--------
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-----------------------
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
34
PsiBlast_CBE
74.87
99%
-132
- C4 -
4PPA
2
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
97
PsiBlast_CBE
74.82
37%
-107
- C4 -
3VS3
1
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
----------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
67
PsiBlast_CBE
74.80
58%
-128
- C4 -
3PIX
1
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
19
PsiBlast_PDB
74.79
99%
-128
- C4 -
4MF0
2
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
96
PsiBlast_CBE
74.55
37%
-105
- C4 -
3VS4
1
HCK_HUMAN
A:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
63
PsiBlast_CBE
74.40
58%
-137
- C4 -
3PJ2
1
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
89
PsiBlast_CBE
74.21
37%
-112
- C4 -
4LUD
2
HCK_HUMAN
A:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
-----
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
------
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
33
PsiBlast_CBE
74.06
99%
-130
- C4 -
4PPA
2
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
32
PsiBlast_CBE
73.99
99%
-128
- C4 -
4PPB
2
ITK_HUMAN
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
100
PsiBlast_CBE
73.88
37%
-108
- C4 -
3VS2
1
HCK_HUMAN
A:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
95
PsiBlast_CBE
73.86
37%
-105
- C4 -
3VS4
1
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
94
PsiBlast_CBE
73.62
37%
-107
- C4 -
3VS5
1
HCK_HUMAN
A:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
74
PsiBlast_CBE
73.58
57%
-134
- C4 -
3OCT
1
A:
[3-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
-----
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
--------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
59
PsiBlast_CBE
73.54
58%
-124
- C4 -
4YHF
2
B:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
87
PsiBlast_CBE
73.49
37%
-109
- C4 -
4LUE
4
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
----------------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
---
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
52
PsiBlast_CBE
73.39
58%
-128
- C4 -
4RG0
1
A:
[20-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
37
PsiBlast_CBE
73.38
99%
-128
- C4 -
4MF0
2
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------
M
-
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
65
PsiBlast_CBE
73.18
58%
-135
- C4 -
3PIZ
1
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
--------
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
31
PsiBlast_CBE
73.13
99%
-126
- C4 -
4PPB
2
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
---------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
119
HHSearch
72.92
57%
-126
- C4 -
4OT5
3
A:
[20-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
62
PsiBlast_CBE
72.88
58%
-135
- C4 -
3PJ3
1
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
---------------
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
-------------------------
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
29
PsiBlast_CBE
72.78
99%
-131
- C4 -
4PPC
2
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------------------
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
---
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
58
PsiBlast_CBE
72.75
58%
-127
- C4 -
4OT5
3
A:
[20-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
54
PsiBlast_CBE
72.70
58%
-129
- C4 -
4RFY
3
A:
[20-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
53
PsiBlast_CBE
72.54
58%
-128
- C4 -
4RFZ
3
A:
[20-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
88
PsiBlast_CBE
72.51
37%
-105
- C4 -
4LUD
3
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
---
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
-------------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
-----
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
56
PsiBlast_CBE
72.43
58%
-128
- C4 -
4OTQ
3
A:
[20-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
28
PsiBlast_CBE
72.39
99%
-128
- C4 -
4QD6
2
B:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--------
K
-
D
-----
K
V
A
I
K
T
I
------------
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
---------------
G
------
L
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
91
PsiBlast_CBE
72.38
37%
-104
- C4 -
3VS6
1
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
69
PsiBlast_CBE
72.35
58%
-122
- C4 -
4ZLY
5
A:
[1-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
57
PsiBlast_CBE
72.23
58%
-127
- C4 -
4OT6
1
A:
[18-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
55
PsiBlast_CBE
71.88
58%
-128
- C4 -
4OTR
3
A:
[20-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
---------------
H
------
A
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
90
PsiBlast_CBE
71.63
37%
-103
- C4 -
3VS7
1
HCK_HUMAN
B:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
98
PsiBlast_CBE
71.62
37%
-102
- C4 -
3VS3
1
HCK_HUMAN
A:
[10-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
-
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
------------------
W
--
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--------
H
-
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
-
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
---------------
G
------
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
66
PsiBlast_CBE
71.57
58%
-124
- C4 -
3PIY
1
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
------------
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
76
PsiBlast_CBE
71.45
59%
-118
- C4 -
3SXR
1
B:
[9-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
L
L
K
-
E
L
------
V
V
K
L
G
K
W
K
G
--------
Q
-
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
---------------
K
------
G
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
-
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
51
PsiBlast_CBE
71.24
57%
-128
- C4 -
3GEN
1
A:
[16-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
120
HHSearch
71.22
58%
-122
- C4 -
3SXS
1
A:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
G
--------
Q
-
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
---------------
K
------
G
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
-
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
60
PsiBlast_CBE
71.02
58%
-122
- C4 -
4Z3V
5
A:
[13-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
73
PsiBlast_CBE
70.99
57%
-122
- C4 -
3OCS
2
A:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
N
-
61
PsiBlast_CBE
70.60
57%
-131
- C4 -
3K54
1
A:
[16-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
---------------
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
75
PsiBlast_CBE
70.12
59%
-119
- C4 -
3SXS
1
A:
[9-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
G
--------
Q
-
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
---------------
K
------
G
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
-
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
68
PsiBlast_CBE
69.66
58%
-124
- C4 -
4ZLZ
5
A:
[1-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
--------
Q
-
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
---------------
H
------
R
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
-
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
77
PsiBlast_CBE
69.54
59%
-118
- C4 -
3SXR
1
BMX_HUMAN
A:
[9-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
L
L
K
-
E
L
G
S
----
V
V
K
L
G
K
W
K
G
--------
Q
-
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
-
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
---------------
K
------
G
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
-
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
126
HHSearch
68.35
38%
-116
* C4 *
4AOJ
1
NTRK1_HUMAN
A:
[35-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LLP-----
K
-
M
-----
L
V
A
V
K
A
L
K
E
A
S
--
E
S
A
---
R
--
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
-
H
-
G
PDP------------
G
------
P
L
G
-
L
-
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
---------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
102
Fugue
64.75
44%
-127
- C4 -
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
-----------
N
----
K
V
A
V
K
C
I
K
-----
N
-
D
---
A
--
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
-
G
----------------RS----
V
L
G
-
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
---
D
N
V
A
K
V
S
D
F
G
----------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L--
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
127
HHSearch
63.95
34%
-110
- C4 -
1T46
1
?
A:
[15-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
LIKSD
A
--
A
-
M
-----
T
V
A
V
K
M
L
K
P
S
A
--
H
-
L
T
E
-
R
--
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
-
R
---------------
D
SFL---
A
L
D
-
L
-
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
--
D
-
S
N-
Y
V
V
K
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
-
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
125
HHSearch
63.66
38%
-114
- C4 -
4FYO
1
A:
[11-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
KK
V
-----
V
-
K
-----
T
V
A
V
K
I
L
---------P
A
L
K
--
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
---
N
---------------
R
------
H
V
K
-
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
---
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--
D
-
E
NY
Y
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
131
HHSearch
63.48
38%
-102
- C4 -
4CLJ
1
A:
[12-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
--------------
S
I
--
S
---
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
----------P
L
-----
Q
V
A
V
K
T
L
P
E
V
C
--
S
-
E
Q
D
-
E
--
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
-
R
---------------
P
RPSQPS
S
L
A
-
M
-
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
128
HHSearch
63.16
40%
-112
- C4 -
3KUL
2
EPHA8_HUMAN
A:
[43-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
PGQ
R
----
D
-
V
-----
P
V
A
I
K
A
L
K
A
G
Y
--
T
-
E
R
Q
-
R
--
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
-
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
-
H
-
D
---------------
G
------
Q
F
T
-
I
-
M
Q
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
---
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
------A-
A
Y
T
T
T
----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
-
N
-
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
122
HHSearch
61.06
36%
-116
- C4 -
1U59
1
A:
[2-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
-K-------
Q
-
I
-----
D
V
A
I
K
V
L
K
Q
G
T
--
E
-
K
A
D
-
T
--
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
E
--
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
---------------
E
------
E
I
P
-
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
---
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
DD
S
-
Y
--
Y
T
A
R
S
A
-
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
130
HHSearch
57.97
35%
-109
- C4 -
3TT0
1
FGFR1_HUMAN
A:
[61-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDKDKPN
R
V
-
T
-----
K
V
A
V
K
M
L
K
S
D
A
--
T
-
E
---
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
-
R
PPGLEYSYNPSHNP
E
E
------
Q
L
S
-
S
-
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
--
I
D
Y
--
Y
K
K
T
T
N
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
129
HHSearch
56.95
33%
-110
- C4 -
4OTW
1
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
I
F
K
E
T
E
L
R
K
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
--------
E
-
G
ES
I
K
I
P
V
C
I
K
V
I
E
D
K
S
GR
Q
-
S
---
F
--
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
C
P
G
--
S
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
-
R
---------------
G
------
A
L
G
-
P
-
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
---
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
--
D
------------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
-
L
-
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
D
P
P