@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : JAK2_HUMAN: (2015-10-09 )
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
Atome Classification :
(95 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830...-----------....840.......850.......860.......870.......880...-....890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
M
A
C
L
T
M
T
EMEGTSTS
S
I
YQNGDISGNAN
S
M
K
Q
I
D
P
V
L
Q
V
Y
L
Y
H
SLGKSEA
D
Y
L
TFPS
G
E
Y
V
A
E
E
I
C
I
A
ASKACGI
T
P
V
Y
H
N
M
F
A
L
M
SET
E
R
I
WYPPN
H
V
F
HIDESTRH
N
V
L
Y
R
I
R
F
Y
F
P
R
W
Y
CSGS
N
R
A
Y
R
HGISRGAEAP
L
L
D
D
F
V
M
S
Y
L
F
A
Q
W
R
H
D
F
VH
G
W
I
KVPVTHE
T
Q
E
E
C
L
G
M
A
V
L
D
M
M
R
I
A
KENDQT
P
L
A
I
Y
NSI
S
Y
K
T
F
L
P
K
C
I
R
A
K
I
Q
D
Y
H
I
L
T
R
K
R
I
R
Y
R
F
R
R
F
I
Q
Q
F
S
Q
C
K
A
T
ARN
L
K
L
K
Y
L
I
N
L
E
T
L
Q
S
A
FYT
E
K
F
E
VKEPGSGPSG
E
E
I
F
A
T
I
I
I
TGNGGIQWSRGKHKESETL
T
E
Q
D
L
Q
L
Y
CDFP
N
I
I
D
V
S
I
K
QANQEGSNE
S
R
V
V
T
I
HKQDGK
N
L
E
I
E
L
S
S
L
R
E
A
L
S
F
V
S
L
I
D
G
Y
Y
R
LTA
D
A
H
H
Y
L
C
K
EVA
P
P
A
V
L
E
N
I
Q
S
NCHGP
I
S
M
D
F
A
I
S
K
L
K
KAGNQT
G
L
Y
V
L
RCSPKDF
N
K
Y
F
L
T
F
A
V
ER
E
N
V
I
E
Y
K
H
C
L
I
TKNENEEYNLSGTKK
N
F
S
S
L
K
D
L
L
N
C
Y
Q
M
E
TVRSD
N
I
I
F
Q
FTKCCPPKPKDKS
N
L
L
V
F
RTNGVSDVPTSPTLQRPT
H
M
N
Q
M
V
F
H
K
IRNE
D
L
I
FNESLGQ
G
T
F
T
K
I
F
K
G
V
R
R
E
VGDYGQ
L
H
E
T
E
V
L
L
K
V
L
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
S
M
M
S
K
LSH
K
H
L
V
L
N
Y
G
V
C
V
CGDE
N
I
L
V
Q
E
F
V
K
FGS
L
D
T
Y
L
K
KNK
N
C
I
N
I
L
W
K
L
E
V
A
K
Q
L
A
W
A
M
H
F
L
EEN
T
L
I
HGNVCA
K
N
I
L
L
I
R
EEDRKTGNP
P
F
I
K
LSDPG
I
S
I
T
VL
P
K
D
I
L
Q
ERIPWV
P
P
E
CIENPKNLNLATDKWSF
G
T
T
L
W
E
I
CSGGDK
P
L
S
A
L
D
S
Q
R
K
L
Q
F
Y
E
D
R
HQLPA
P
K
W
A
E
L
A
N
L
I
N
N
CMDYEPDF
R
P
S
F
R
A
I
I
R
D
L
N
S
LFTPD
Y
E
LLTENDMLPN
M
R
I
G
A
LGFSGA-----------FEDRDP
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
LGKGNFGS
V
E
M
C
RYDPLQDNTG
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
LQHDN
I
V
K
Y
K
G
V
C
YSAGR
R
N
L
K
L
I
M
E
YLPY
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
LG
T
K
R
Y
I
H
R
DLAT
R
N
I
L
VENEN
R
V
K
IGDF
G
L
T
KVLPQDK
E
Y
Y
KVKEPGES
P
I
F
W
YAPESL
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
KSKS
P
P
A
E
F
M
R
M
IGNDKQGQ
M
I
V
F
H
L
I
E
L
L
KNNGRLPRPDG
C
P
D
E
I
Y
M
I
M
T
E
C
WNNNVNQRP
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
NMAG
82
PsiBlast_CBE
84.53
44%
-90
- C1 -
4OLI
2
TYK2_HUMAN
A:
[37-635]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
V
--------
E
L
R
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
-
G
L
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P
G
---
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
S
C
P
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
P
-----------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-------
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
--
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
------
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
-
43
PsiBlast_CBE
80.00
98%
-99
- C1 -
4C62
1
B:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
---
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-------
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
-------
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
-
75
PsiBlast_CBE
79.16
99%
-93
- C1 -
3JY9
1
A:
[23-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
--
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
44
PsiBlast_CBE
79.14
98%
-93
- C1 -
4C61
1
B:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-------
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
-------
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
-
22
PsiBlast_CBE
78.51
99%
-88
- C1 -
4E4M
1
E:
[5-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
9
PsiBlast_PDB
78.47
99%
-87
- C1 -
4JIA
2
A:
[1-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
35
PsiBlast_CBE
77.90
98%
-90
- C1 -
2XA4
1
B:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
-----
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
------
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
-
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
65
PsiBlast_CBE
77.38
98%
-90
- C1 -
3FUP
1
B:
[1-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
27
PsiBlast_CBE
77.21
99%
-85
- C1 -
4AQC
1
B:
[5-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
2
PsiBlast_PDB
77.09
99%
-86
- C1 -
4F08
1
JAK2_HUMAN
A:
[13-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
5
PsiBlast_PDB
77.06
99%
-88
- C1 -
4GMY
1
A:
[3-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
60
PsiBlast_CBE
77.02
99%
-89
- C1 -
3E64
1
A:
[1-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
31
PsiBlast_CBE
76.89
99%
-88
- C1 -
4BBF
2
JAK2_HUMAN
A:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
45
PsiBlast_CBE
76.87
98%
-92
- C1 -
3ZMM
2
B:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-------
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
-------
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
-
36
PsiBlast_CBE
76.82
99%
-88
- C1 -
3UGC
1
A:
[6-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
-------------
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
---
17
PsiBlast_PDB
76.64
98%
-92
- C1 -
2XA4
1
JAK2_HUMAN
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
--
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
----
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
11
PsiBlast_PDB
76.63
99%
-89
- C1 -
4D0W
2
A:
[5-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
-
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
38
PsiBlast_CBE
76.41
99%
-89
- C1 -
3TJC
1
B:
[6-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
12
PsiBlast_PDB
76.38
99%
-88
- C1 -
4D0X
2
A:
[5-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
19
PsiBlast_PDB
76.36
99%
-89
- C1 -
3TJD
1
JAK2_HUMAN
A:
[9-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
67
PsiBlast_CBE
76.35
98%
-91
- C1 -
2B7A
1
B:
[1-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
28
PsiBlast_CBE
76.35
99%
-88
- C1 -
4BBF
1
D:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
25
PsiBlast_CBE
76.32
99%
-89
- C1 -
4JI9
1
B:
[7-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
18
PsiBlast_PDB
76.32
99%
-88
- C1 -
3TJC
1
JAK2_HUMAN
A:
[9-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
8
PsiBlast_PDB
76.22
99%
-88
- C1 -
4JI9
1
JAK2_HUMAN
A:
[11-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
42
PsiBlast_CBE
76.21
98%
-87
- C1 -
4E6D
1
JAK2_HUMAN
A:
[6-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
R
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
F
L
P
Y
G
S
L
R
E
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
37
PsiBlast_CBE
76.16
99%
-89
- C1 -
3TJD
1
B:
[6-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
72
PsiBlast_CBE
76.08
99%
-88
- C1 -
3KCK
1
A:
[23-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
--
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
1
PsiBlast_PDB
76.06
99%
-87
- C1 -
4E4M
1
JAK2_HUMAN
A:
[5-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
23
PsiBlast_CBE
75.89
99%
-86
- C1 -
4E4M
1
JAK2_HUMAN
D:
[5-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
49
PsiBlast_CBE
75.87
99%
-89
- C1 -
3Q32
1
JAK2_HUMAN
A:
[3-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
26
PsiBlast_CBE
75.86
99%
-89
- C1 -
4HGE
1
B:
[7-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
24
PsiBlast_CBE
75.84
99%
-85
- C1 -
4E4M
1
JAK2_HUMAN
B:
[5-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
7
PsiBlast_PDB
75.73
99%
-89
- C1 -
4IVA
1
A:
[9-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
6
PsiBlast_PDB
75.57
99%
-86
- C1 -
4HGE
1
JAK2_HUMAN
A:
[11-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
41
PsiBlast_CBE
75.53
98%
-87
- C1 -
4E6D
2
B:
[6-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
R
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
F
L
P
Y
G
S
L
R
E
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
21
PsiBlast_CBE
75.23
99%
-86
- C1 -
4F08
1
B:
[13-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
74
PsiBlast_CBE
75.17
99%
-91
- C1 -
3IO7
1
A:
[23-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
--
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
61
PsiBlast_CBE
75.05
99%
-86
- C1 -
3E63
1
A:
[2-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
62
PsiBlast_CBE
75.03
99%
-86
- C1 -
3E62
1
A:
[1-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
39
PsiBlast_CBE
74.91
98%
-86
- C1 -
4E6Q
1
B:
[1-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
R
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
F
L
P
Y
G
S
L
R
E
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
4
PsiBlast_PDB
74.77
99%
-92
- C1 -
4GFM
1
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
68
PsiBlast_CBE
74.61
98%
-90
- C1 -
2B7A
1
JAK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
13
PsiBlast_PDB
74.58
99%
-93
- C1 -
4D1S
1
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
-
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
-----
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
-
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
58
PsiBlast_CBE
74.54
99%
-89
- C1 -
3LPB
1
JAK2_HUMAN
A:
[5-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
-----
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
48
PsiBlast_CBE
74.34
99%
-88
- C1 -
3Q32
1
B:
[2-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
59
PsiBlast_CBE
74.22
99%
-87
- C1 -
3KRR
1
A:
[3-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
40
PsiBlast_CBE
74.01
98%
-87
- C1 -
4E6Q
1
JAK2_HUMAN
A:
[1-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
R
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
F
L
P
Y
G
S
L
R
E
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
3
PsiBlast_PDB
74.01
99%
-87
- C1 -
4F09
1
A:
[13-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
66
PsiBlast_CBE
73.98
98%
-87
- C1 -
3FUP
1
JAK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
73
PsiBlast_CBE
73.88
99%
-88
- C1 -
3IOK
1
A:
[23-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
--
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
30
PsiBlast_CBE
73.54
99%
-86
- C1 -
4BBF
2
JAK2_HUMAN
B:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
10
PsiBlast_PDB
73.49
97%
-90
- C1 -
2W1I
1
JAK2_HUMAN
A:
[37-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
15
PsiBlast_PDB
73.36
99%
-88
- C1 -
4AQC
1
JAK2_HUMAN
A:
[11-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
16
PsiBlast_PDB
72.93
99%
-85
- C1 -
3RVG
1
A:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
-----
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
20
PsiBlast_PDB
72.14
99%
-89
- C1 -
4BBE
2
JAK2_HUMAN
A:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
29
PsiBlast_CBE
71.97
99%
-88
- C1 -
4BBF
1
JAK2_HUMAN
C:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
32
PsiBlast_CBE
71.94
99%
-89
- C1 -
4BBE
1
D:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
33
PsiBlast_CBE
71.52
99%
-84
- C1 -
4BBE
1
JAK2_HUMAN
C:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
34
PsiBlast_CBE
71.37
99%
-84
- C1 -
4BBE
2
JAK2_HUMAN
B:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
----
83
PsiBlast_CBE
64.49
62%
-86
- C1 -
4RIO
1
A:
[8-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
E
R
D
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
-----
88
PsiBlast_CBE
64.06
61%
-85
- C1 -
4QT1
1
JAK3_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
------
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
--
89
PsiBlast_CBE
64.03
61%
-82
- C1 -
4I6Q
2
A:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
--
84
PsiBlast_CBE
63.29
62%
-83
- C1 -
3LXL
1
A:
[17-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
------
91
PsiBlast_CBE
62.96
61%
-85
- C1 -
4HVH
1
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
--
92
PsiBlast_CBE
62.77
61%
-81
- C1 -
4HVG
1
A:
[4-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
----
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
R
-
93
PsiBlast_CBE
62.26
61%
-82
- C1 -
4HVD
2
?
A:
[5-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
---
98
PsiBlast_CBE
62.15
56%
-83
- C1 -
4IVD
1
B:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
90
PsiBlast_CBE
61.81
61%
-82
* C1 *
4HVI
1
A:
[5-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
---
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
---
86
PsiBlast_CBE
61.59
61%
-85
- C1 -
4QPS
1
?
C:
[4-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
---
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
A
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
-----
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
------
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
--
87
PsiBlast_CBE
61.26
61%
-84
- C1 -
4QPS
1
A:
[4-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
-
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
------
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
-----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
A
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
------
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
E
R
D
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
----
100
PsiBlast_CBE
60.94
56%
-81
- C1 -
4IVC
1
B:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
96
PsiBlast_CBE
60.57
56%
-83
- C1 -
4K77
1
JAK1_HUMAN
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P---
G
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
99
PsiBlast_CBE
60.46
56%
-84
- C1 -
4IVD
1
JAK1_HUMAN
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
85
PsiBlast_CBE
59.96
62%
-83
- C1 -
3LXK
1
A:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
------
95
PsiBlast_CBE
59.67
56%
-81
- C1 -
4K77
1
B:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
97
PsiBlast_CBE
59.33
56%
-85
- C1 -
4K6Z
1
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
101
PsiBlast_CBE
58.10
56%
-81
- C1 -
4IVC
1
JAK1_HUMAN
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
-
P
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
----
54
PsiBlast_CBE
46.13
99%
-30
- C1 -
5CF4
1
?
B:
[22-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
-
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
46
PsiBlast_CBE
44.82
99%
-27
- C1 -
5CF8
1
?
B:
[2-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
50
PsiBlast_CBE
44.78
99%
-27
- C1 -
5CF6
1
?
B:
[22-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
----
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
53
PsiBlast_CBE
44.77
99%
-31
- C1 -
5CF5
1
?
A:
[25-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
64
PsiBlast_CBE
44.23
98%
-30
- C1 -
4P7E
1
JAK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
---
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
63
PsiBlast_CBE
43.43
98%
-28
- C1 -
4P7E
1
B:
[1-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
--
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
57
PsiBlast_CBE
43.24
99%
-30
- C1 -
4ZIM
1
JAK2_HUMAN
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
51
PsiBlast_CBE
43.05
99%
-29
- C1 -
5CF6
1
?
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
47
PsiBlast_CBE
42.99
99%
-31
- C1 -
5CF8
1
?
A:
[5-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
55
PsiBlast_CBE
42.49
99%
-29
- C1 -
5CF4
1
?
A:
[26-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
----
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
52
PsiBlast_CBE
42.33
99%
-27
- C1 -
5CF5
1
?
B:
[22-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
14
PsiBlast_PDB
42.32
99%
-27
- C1 -
5AEP
1
A:
[6-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
-
56
PsiBlast_CBE
41.53
99%
-30
- C1 -
4ZIM
1
B:
[22-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
71
PsiBlast_CBE
40.98
99%
-27
- C1 -
4YTF
1
?
A:
[6-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
--
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
--
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
104
Fugue
40.27
30%
-54
- C1 -
3CD3
3
A:
[1-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
--------
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
QQPLSG
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
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E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
----
D
N
T
L
V
A
V
K
S
C
R
-
P
D
L
K
A
K
---
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
--
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
-
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
---------------
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--
69
PsiBlast_CBE
39.47
99%
-26
- C1 -
4YTI
1
?
A:
[6-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--
70
PsiBlast_CBE
38.74
99%
-25
- C1 -
4YTH
1
?
A:
[6-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
--