@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : JAK3_HUMAN: (2015-10-09 )
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Atome Classification :
(91 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530......-.540...-....550--.......560.......570.......580.......590..-.-....600.......610..-.....620.......630.......640.......650.......--660.......670.......680.......690....-...700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850......-.860........870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040.....-.1050......1060......1070......1080......1090......1100......1110......1120.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPPSEETPLIPQRSCSLLSTEA
G
A
L
H
V
L
LPARGPGPPQ
R
L
S
F
S
F
G
D
H
L
A
E
D
L
C
V
Q
A
A
KASG
I
L
P
V
Y
H
S
L
F
A
L
A
TEDL
S
C
WFPPS
H
I
F
SVEDAS
T
Q
V
L
L
Y
R
I
R
F
YFPNWF
G
L
E
K
C
H
R
FG
L
R
K
D
L
A
S
A
I
L
D
L
P
V
L
E
H
L
F
A
Q
H
R
S
D
L
VSGRLPVGLSLKEQGE
C
L
S
L
A
V
L
D
L
A
R
M
A
R
E
Q
A
QR
P
G
E
L
L
K
T
VSYKACL
P
P
S
L
R
D
L
I
Q
G
L
S
F
V
T
R
R
R
I
R
R
T
V
R
R
A
L
R
R
V
A
A
C
Q
A
D
R
H
S
L
M
A
K
Y
I
M
D
L
E
RLDPAGAA
E
T
F
H
VGLPGALGGHDG
L
G
L
L
R
V
AGDG
G
I
AWTQG
E
Q
E
V
L
Q
P
FCDFP
E
I
V
D
I
S
IKQAPRVGPAGE
H
R
L
V
T
V
TRTDN
Q
I
L
EAEFPG
L
P
E
A
L
S
F
V
A
L
VD
G
Y
F
R
L
TTDSQ
H
F
F
C
K
EVA
P
P
R
L
L
E
E
V
A
E
QCHG
P
I
T
L
D
F
A
I
N
K
L
KTGGSRPG
S
Y
V
L
RRSP
Q
D
F
D
S
F
L
L
T
V
C
VQNPLGPDYK
G
C
L
I
RRSPT
G
T
F
L
L
V
GLSR
P
H
S
S
L
R
E
L
L
A
T
CWDG
G
L
H
VD
G
V
A
V
T
L
T
S
CCIPRPKEKS
N
L
I
V
V
QRGHSPPTSSLVQPQSQY
Q
L
S
Q
M
T
F
HKIPAD
S
L
E
W
H
ENLGH
G
S
F
T
K
I
Y
R
G
-CRHEVVD-GE
A
R
K
T
E
--
V
L
L
K
V
M
D
A
K
H
K
N
C
M
E
S
F
L
E
A
A
S
L
M
S
Q
V
S
Y
R
H
L
V
L
L
HGVCMAG-
D
-
S
T
M
V
Q
E
F
V
H
L
G
A
I
D
M
Y
L
R
K-RGHLVP
A
S
W
K
L
Q
V
V
K
Q
L
A
Y
A
L
N
Y
L
E
DKGLPHGNVS
A
R
K
V
L
L
A
REG--ADGSP
P
F
I
K
LSDPGVS
P
A
V
L
S
L
E
M
L
T
DRIPWV
A
P
E
C
L
-
R
E
A
Q
T
L
SLEADKWGF
G
A
T
V
W
E
V
FSGVTMPISAL
D
P
A
K
K
L
Q
F
Y
E
D
R
Q
QLPA
P
K
W
T
E
L
A
L
L
I
Q
Q
C
MAYEPVQR
P
S
F
R
A
V
I
R
D
L
N
S
L
I
S
S
D
Y
E
LLSDPTPGALAPRDGLWNG
A
Q
L
Y
ACQDP
T
I
F
E
E
R
H
L
K
Y
I
S
Q
LGKGNFGS
V
E
L
C
R
YDPLGDNT
G
A
L
V
A
V
K
Q
L
Q-HS-GP
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
YRGVSYGP
G
R
Q
S
L
R
L
V
M
E
YLP
S
G
C
L
R
D
F
L
Q
R
H
R
A
RL
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
GS
R
R
C
V
H
R
D
L
A
AR
N
I
L
VESEA
H
V
K
I
A
D
FG
L
A
K
LLPLDK
D
Y
Y
V
V
REPGQS
P
I
F
W
YA
P
E
SLS
D
N
I
F
SRQS
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
CDKSCS
P
S
A
E
F
L
R
M
MGCER
D
V
P
A
L
C
-
R
L
L
E
L
L
EEGQRLPAPPA
C
P
A
E
V
H
E
L
M
K
L
CWAPSPQDRPSFSALGPQ
L
D
MLWSGSRGCET
H
A
F
TAHPEGKHHSLSFS
14
PsiBlast_PDB
89.44
45%
-104
- C2 -
4OLI
2
TYK2_HUMAN
A:
[37-635]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
V
-----------
E
L
R
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
-
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
-
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L-
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P
G
----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
S
C
P
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
P
-------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
--------
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
--
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
-----
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
---------------------
10
PsiBlast_PDB
76.85
98%
-113
- C2 -
4QPS
1
A:
[4-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
-
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
-------
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
-----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
A
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
------
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
E
R
D
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
------------------------
25
PsiBlast_CBE
76.73
98%
-111
- C2 -
3ZC6
1
D:
[2-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
-----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
-----
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
--------
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
------------------------
24
PsiBlast_CBE
76.34
98%
-115
- C2 -
3ZEP
3
JAK3_HUMAN
B:
[2-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
---
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
-----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
----
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
-----
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
------------------------
12
PsiBlast_PDB
75.55
98%
-112
- C2 -
3ZC6
2
JAK3_HUMAN
A:
[2-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
----
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
E
R
D
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
------------------------
21
PsiBlast_CBE
74.65
98%
-104
- C2 -
4QPS
1
?
C:
[4-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
---
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
A
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
-----
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
------
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
----------------------
26
PsiBlast_CBE
74.49
98%
-111
- C2 -
3ZC6
2
JAK3_HUMAN
C:
[2-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
----
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
E
R
D
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
------------------------
7
PsiBlast_PDB
74.08
99%
-107
- C2 -
4HVI
1
A:
[5-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
----
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
-----------------------
8
PsiBlast_PDB
73.85
99%
-105
- C2 -
4I6Q
2
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
----------------------
2
PsiBlast_PDB
73.66
99%
-104
- C2 -
3LXL
1
A:
[17-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
--------------------------
4
PsiBlast_PDB
73.29
99%
-105
- C2 -
4HVD
2
?
A:
[5-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
-----------------------
6
PsiBlast_PDB
73.28
99%
-107
- C2 -
4HVH
1
A:
[4-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
----------------------
5
PsiBlast_PDB
73.21
99%
-103
- C2 -
4HVG
1
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
----
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
R
---------------------
22
PsiBlast_CBE
72.62
98%
-106
- C2 -
4RIO
1
A:
[8-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
E
R
D
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
-------------------------
11
PsiBlast_PDB
72.58
98%
-98
- C2 -
1YVJ
3
A:
[1-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
P
E
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
C
E
R
D
V
P
A
L
C
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
R
---------------------
23
PsiBlast_CBE
72.24
98%
-102
- C2 -
3ZEP
1
D:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
---
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
-----
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
-------------------------
9
PsiBlast_PDB
71.83
99%
-104
- C2 -
4QT1
1
JAK3_HUMAN
A:
[4-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
------
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
----------------------
13
PsiBlast_PDB
71.67
98%
-102
- C2 -
3ZEP
1
JAK3_HUMAN
A:
[2-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
-----
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
S
----
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
--------------------------
1
PsiBlast_PDB
71.60
99%
-103
- C2 -
3LXK
1
A:
[18-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
--------------------------
16
PsiBlast_PDB
67.05
61%
-103
- C2 -
4BBF
2
JAK2_HUMAN
A:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
55
PsiBlast_CBE
66.97
60%
-111
- C2 -
4C62
1
B:
[9-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
---
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
--------
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
-------
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
---------------------
20
PsiBlast_PDB
66.88
61%
-101
- C2 -
4D0W
2
A:
[5-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
-
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
----------------------
27
PsiBlast_CBE
66.62
61%
-102
- C2 -
4BBF
1
D:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
54
PsiBlast_CBE
65.96
59%
-104
- C2 -
2XA4
1
B:
[9-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
------
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
------
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
-
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
---------------------
56
PsiBlast_CBE
65.60
60%
-105
- C2 -
4C61
1
B:
[9-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
--------
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
-------
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
---------------------
57
PsiBlast_CBE
64.73
60%
-104
- C2 -
3ZMM
2
B:
[9-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
--------
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
-------
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
A
H
A
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
---------------------
37
PsiBlast_CBE
64.44
59%
-96
- C2 -
4JI9
1
B:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
15
PsiBlast_PDB
64.20
61%
-102
- C2 -
4BBE
2
JAK2_HUMAN
A:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
39
PsiBlast_CBE
64.03
59%
-99
- C2 -
4IVA
1
A:
[9-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
48
PsiBlast_CBE
63.89
59%
-99
- C2 -
4E4M
1
JAK2_HUMAN
D:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
50
PsiBlast_CBE
63.54
59%
-99
- C2 -
4E4M
1
JAK2_HUMAN
A:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
49
PsiBlast_CBE
63.54
59%
-96
- C2 -
4E4M
1
JAK2_HUMAN
B:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
42
PsiBlast_CBE
63.48
59%
-102
- C2 -
4GMY
1
A:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
18
PsiBlast_PDB
63.46
61%
-98
- C2 -
3Q32
1
JAK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
29
PsiBlast_CBE
63.33
61%
-101
- C2 -
4BBF
2
JAK2_HUMAN
B:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
17
PsiBlast_PDB
63.23
61%
-99
- C2 -
3UGC
1
A:
[6-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
-------------
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
-----------------------
47
PsiBlast_CBE
63.06
59%
-98
- C2 -
4E4M
1
E:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
40
PsiBlast_CBE
62.98
59%
-96
- C2 -
4HGE
1
B:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
30
PsiBlast_CBE
62.61
61%
-101
- C2 -
4BBE
1
D:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
43
PsiBlast_CBE
62.59
59%
-102
- C2 -
4GFM
1
A:
[10-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
----------------------
38
PsiBlast_CBE
62.58
59%
-99
- C2 -
4JI9
1
JAK2_HUMAN
A:
[11-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
34
PsiBlast_CBE
62.27
59%
-95
- C2 -
4AQC
1
JAK2_HUMAN
A:
[11-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
72
PsiBlast_CBE
62.18
52%
-102
- C2 -
4FK6
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
--
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
E
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
D
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
36
PsiBlast_CBE
61.78
59%
-98
- C2 -
4JIA
2
A:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
35
PsiBlast_CBE
61.77
60%
-100
- C2 -
2W1I
1
JAK2_HUMAN
A:
[37-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
--------------------
78
PsiBlast_CBE
61.69
52%
-101
- C2 -
4EHZ
6
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
D
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
41
PsiBlast_CBE
61.50
59%
-98
- C2 -
4HGE
1
JAK2_HUMAN
A:
[11-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
28
PsiBlast_CBE
61.50
61%
-99
- C2 -
4BBF
1
JAK2_HUMAN
C:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
46
PsiBlast_CBE
61.43
59%
-95
- C2 -
4F08
1
JAK2_HUMAN
A:
[13-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
65
PsiBlast_CBE
61.23
52%
-102
- C2 -
4IVD
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
32
PsiBlast_CBE
61.23
61%
-97
- C2 -
4BBE
2
JAK2_HUMAN
B:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
71
PsiBlast_CBE
60.98
52%
-99
- C2 -
4FK6
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
E
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
--
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
64
PsiBlast_CBE
60.87
52%
-101
- C2 -
4IVD
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
44
PsiBlast_CBE
60.86
59%
-94
- C2 -
4F09
1
A:
[13-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
31
PsiBlast_CBE
60.86
61%
-96
- C2 -
4BBE
1
JAK2_HUMAN
C:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
------------------------
77
PsiBlast_CBE
60.85
52%
-97
- C2 -
4EHZ
2
JAK1_HUMAN
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
81
PsiBlast_CBE
60.83
52%
-102
- C2 -
4E4L
1
E:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
67
PsiBlast_CBE
60.76
52%
-99
- C2 -
4IVC
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
84
PsiBlast_CBE
60.74
52%
-102
- C2 -
4E4L
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
-------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
80
PsiBlast_CBE
60.71
52%
-104
- C2 -
4E4N
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
75
PsiBlast_CBE
60.65
52%
-100
- C2 -
4EHZ
5
D:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
33
PsiBlast_CBE
60.53
59%
-95
- C2 -
4AQC
1
B:
[5-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
79
PsiBlast_CBE
60.44
52%
-101
- C2 -
4E4N
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
74
PsiBlast_CBE
60.42
52%
-102
- C2 -
4EI4
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
-------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
70
PsiBlast_CBE
60.40
52%
-101
- C2 -
4I5C
5
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
45
PsiBlast_CBE
60.27
59%
-94
- C2 -
4F08
1
B:
[13-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
--------------------
66
PsiBlast_CBE
60.25
52%
-100
- C2 -
4IVC
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
69
PsiBlast_CBE
60.06
52%
-99
- C2 -
4IVB
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
76
PsiBlast_CBE
59.91
52%
-101
- C2 -
4EHZ
5
JAK1_HUMAN
C:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
83
PsiBlast_CBE
59.68
52%
-101
- C2 -
4E4L
1
JAK1_HUMAN
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
------
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
68
PsiBlast_CBE
59.46
52%
-99
- C2 -
4IVB
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
63
PsiBlast_CBE
59.04
52%
-104
- C2 -
4K6Z
1
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
82
PsiBlast_CBE
59.02
52%
-97
- C2 -
4E4L
1
JAK1_HUMAN
D:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
-------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
--
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
73
PsiBlast_CBE
58.95
52%
-100
- C2 -
4EI4
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
92
PsiBlast_CBE
58.60
50%
-105
- C2 -
3NYX
3
A:
[8-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
--
G
E
M
V
A
V
K
A
L
K
A
D
C
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
-
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
--------------------
96
PsiBlast_CBE
58.55
51%
-102
* C2 *
4E20
1
A:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
-
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
----
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
C
V
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
----
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
---------------------
61
PsiBlast_CBE
58.40
52%
-98
- C2 -
4K77
1
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
62
PsiBlast_CBE
58.07
52%
-100
- C2 -
4K77
1
JAK1_HUMAN
A:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P----
G
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
85
PsiBlast_CBE
57.79
52%
-95
- C2 -
3EYH
1
A:
[2-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
E
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
D
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
K
N
K
N
K
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
T
H
G
Q
M
T
V
T
-
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
------------------------
91
PsiBlast_CBE
57.58
50%
-104
- C2 -
4GFO
4
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
------------
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
------
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
--------------------
93
PsiBlast_CBE
57.37
50%
-99
- C2 -
3NZ0
1
A:
[7-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
C
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
------
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
--------------------
89
PsiBlast_CBE
57.02
50%
-91
- C2 -
4GII
1
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
--------------------
87
PsiBlast_CBE
56.99
50%
-92
- C2 -
4GJ3
1
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
88
PsiBlast_CBE
56.41
50%
-91
- C2 -
4GJ2
1
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
95
PsiBlast_CBE
56.19
50%
-97
- C2 -
4PY1
1
A:
[25-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
--------------------
86
PsiBlast_CBE
56.13
50%
-95
- C2 -
4GVJ
1
A:
[8-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
--------------------
90
PsiBlast_CBE
55.80
50%
-90
- C2 -
4GIH
1
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
60
PsiBlast_CBE
54.97
56%
-89
- C2 -
4FVP
2
A:
[1-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
H
K
I
R
N
E
D
L
I
F
N
E
S
L
G
Q
G
T
F
T
K
I
F
K
G
-
V
R
R
E
V
G
D
Y
G
Q
L
H
E
T
E
--
V
L
L
K
V
L
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
S
M
M
S
K
L
S
H
K
H
L
V
L
N
Y
G
V
C
V
C
G
-
D
E
N
I
L
V
Q
E
F
V
K
F
G
S
L
D
T
Y
L
K
K
-
N
K
N
C
I
N
I
L
W
K
L
E
V
A
K
Q
L
A
A
A
M
H
F
L
E
E
N
T
L
I
H
G
N
V
C
A
K
N
I
L
L
I
R
E
E
DR
K
T
G
N
P
P
F
I
K
L
S
D
P
G
I
S
I
T
V
L
P
K
D
I
L
Q
E
R
I
P
W
V
P
P
E
C
I
-
E
N
P
K
N
L
N
L
A
T
D
K
W
S
F
G
T
T
L
W
E
I
C
S
G
G
D
K
P
L
S
A
L
D
S
Q
R
K
L
Q
F
Y
E
D
R
H
Q
L
P
A
P
K
A
A
E
L
A
N
L
I
N
N
C
M
D
Y
E
P
D
H
R
P
S
F
R
A
I
I
R
D
L
N
S
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
54.79
51%
-96
- C2 -
4E1Z
1
A:
[2-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
-
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
---
K
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
C
V
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
H
T
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
---------------------
97
PsiBlast_CBE
49.09
44%
-87
- C2 -
3ZON
1
A:
[39-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
L
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
V
-----------
E
LR
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
-
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
-
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L-
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P-----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
---
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
31.19
61%
-50
- C2 -
5CF8
1
?
A:
[5-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
-------------------