@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC1B_HUMAN: (2015-10-10 )
MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
Atome Classification :
(59 SA)
.........10........20........30........40........50..-----..-----...-----.60........70........80........90........100..---------------..----------------..--------.110.......120.......130.......140...---....-.150.......160-...----.--...---.170.......180....--...190.......200.......210...-....-220.......230.......240.......250.......260.......270--.-..--..---...-280........290.......300.......310.......320.......330.......340.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLL
L
K
K
H
T
E
D
I
S
S
V
Y
E
I
R
E
R
LGSG
A
F
S
E
V
V
L
A
QERGS
A
H
L
V
A
L
KCI
P
K
K
ALRG-----
K
E
-----
A
L
V
-----
E
N
E
I
A
V
L
R
RISHP
N
I
V
A
L
E
D
VHESP
S
H
L
Y
L
A
M
ELVTG
G
E
L
F
D
R
I
M
E---------------RG----------------SY--------T
E
K
D
A
S
H
L
V
G
Q
V
L
G
A
V
S
Y
L
H
S
L
G
I
V
HRDLKPEN-
L
L
Y
---ATPF-ED
S
K
I
M
V
SDFGL-S-KIQ----A--GNM---LGTACGTPGYV
A
P
E
L
L
EQ--KPYGK
A
V
D
V
W
A
L
G
V
I
S
Y
I
L
LCGYPPFYDE-S
D
P
E
-
L
F
S
Q
I
L
R
A
SYEFDSP
F
W
D
D
I
S
E
S
A
K
D
F
I
R
H
L
L
ERD
P
Q
KR
F
T
C
Q
Q
A
L
R
H
LWIS---G-DT--AF---
D
R
D
-
I
L
-
G
S
V
S
E
Q
I
R
K
N
F
A
R
T
H
W
K
R
AF
N
A
T
S
F
L
R
H
I
R
K
LGQIPEGEGASEQG
M
A
RHSHSGLRAGQPPKW
21
PsiBlast_CBE
90.83
69%
-128
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[14-314]
----
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
----------------
S
I
-----
E
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
Q
D
-
E
E
S
K
I
M
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
---
G
-
D
T
--
A
L
---
N
K
N
-
I
H
-
E
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
---------------------------------------
1
PsiBlast_PDB
90.17
69%
-129
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[14-314]
----
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
---------------
S
S
I
-----
E
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
Q
D
-
E
E
S
K
I
M
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
---
G
-
D
T
--
A
L
---
N
K
N
-
I
H
-
E
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
---------------------------------------
5
PsiBlast_PDB
89.00
69%
-134
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[11-299]
-----
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---
G
-
D
T
--
A
L
---
D
K
N
-
I
H
-
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------
124
HHSearch
87.08
70%
-134
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[12-277]
------
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------------
S
M
-----
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
-
S
-
K
M
E
D
---
P
--
G
-----------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------
23
PsiBlast_CBE
86.30
69%
-132
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
--------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
--------------
G
S
V
---
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---
G
-
D
T
--
A
L
---
D
K
N
-
I
H
-
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------
6
PsiBlast_PDB
85.37
69%
-132
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[11-277]
-----
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------------
S
M
-----
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
-
S
-
K
M
E
D
---
P
--
G
-----------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
84.80
69%
-122
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[11-314]
-----
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---
G
-
D
T
--
A
L
---
D
K
N
-
I
H
-
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-----------------------------------
22
PsiBlast_CBE
80.81
69%
-125
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
--------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
-----------------
V
---
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---
G
-
D
T
--
A
L
---
D
K
N
-
I
H
-
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-----------------------------------
24
PsiBlast_CBE
79.89
63%
-119
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
-------
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-
K
K
S
----------------
S
L
-----
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
G
----------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
-
S
-
K
M
E
----
Q
--
N
G
I
---
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
---
G
-
N
T
--
A
L
---
H
R
D
-
I
Y
-
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-------------------------------------------------
122
HHSearch
79.14
63%
-120
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
---------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-----------------
S
L
-----
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
G
----------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
-
S
-
K
M
E
----
Q
--
N
G
I
---
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
---
G
-
N
T
--
A
L
---
H
R
D
-
I
Y
-
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
------------------------------------------------
7
PsiBlast_PDB
78.64
63%
-119
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
---------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-
K
K
S
----------------
S
L
-----
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
G
----------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
-
S
-
K
M
E
----
Q
--
N
G
I
---
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
---
G
-
N
T
--
A
L
---
H
R
D
-
I
Y
-
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
------------------------------------------------
138
HHSearch
71.56
35%
-117
- C1 -
3HKO
2
?
A:
[21-336]
-------
L
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
K----
D
V
-----
E
R
I
-----
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SI-
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
-
F
L
F
---
S
T
-
N
-
K
S
F
E
I
K
L
V
D
F
G
L
-
S
-
K
E
F
YKLN
N
--
G
---------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
-
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
---
Q
-
F
S
--
D
K
---
I
Y
K
-
M
S
---------------------------------------------------------------
18
PsiBlast_PDB
70.94
45%
-122
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-265]
----------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H
----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
---
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
Q
--
G
D
Q
QAW
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
---
Q
-
R
S
--
T
V
---
A
S
M
-
M
H
-
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------------
17
PsiBlast_PDB
70.47
44%
-114
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[23-292]
M
A
T
C
T
R
F
T
D
D
----
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H
----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
-
L
L
L
---
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
Q
--
G
E
Q
QAW
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
---
Q
-
R
S
--
T
V
---
A
S
M
-
M
H
-
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------
95
PsiBlast_CBE
70.21
40%
-130
- C1 -
3F3Z
5
?
A:
[6-265]
---------
D
I
N
Q
Y
Y
T
L
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
F
V
E
D
-----
V
D
-----
R
F
------
K
Q
E
I
E
I
M
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
---------------
K
R
----------------
V
F
--------
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
-
F
L
F
---
L
T
D
S
-
P
D
S
P
L
K
L
I
D
F
G
L
A
A
-
R
F
K
----
P
--
G
K
M
---
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
--
L
-
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
-
T
D
S
E
-
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
---
K
-
Q
L
--
S
S
---
S
P
R
-
N
L
-
L
-------------------------------------------------------------
126
HHSearch
69.50
35%
-112
- C1 -
3C0I
1
CSKP_HUMAN
A:
[22-317]
----------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SPGL-
S
T
-----
E
D
L
-----
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
---------------
R
A
D
A
G
F
------------
V
Y
--------
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
L
---
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
-
A
-
I
Q
L
G
E--
S
--
G
L
V
---
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
--
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
---
E
-
R
D
--
R
Y
---
A
Y
K
I
H
L
-
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------------
129
HHSearch
69.21
40%
-118
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[6-279]
-------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
SRRGV
S
R
-----
E
D
I
-----
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
L
---
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
-
A
-
H
K
I
D---
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
K
D
--
T
Q
---
Q
A
L
-
S
R
-
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------
28
PsiBlast_CBE
69.12
45%
-120
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-265]
----------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
---
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
Q
--
G
D
Q
QAW
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
---
Q
-
R
S
--
T
V
---
A
S
M
-
M
H
-
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------------
16
PsiBlast_PDB
68.58
45%
-123
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-264]
----------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H
----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
---
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
Q
--
G
D
Q
QAW
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
---
Q
-
R
S
--
M
M
---
H
R
Q
-
E
T
-
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------------------
70
PsiBlast_CBE
67.57
40%
-114
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------
19
PsiBlast_PDB
67.16
43%
-125
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-265]
----------
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H
----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
---
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
Q
--
G
D
Q
QAW
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
---
Q
-
R
S
--
T
V
---
A
S
M
-
M
H
-
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
--------------------------------------------
76
PsiBlast_CBE
66.28
40%
-113
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[26-294]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-------------------------------------------------------------------------------
45
PsiBlast_CBE
66.18
39%
-104
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[7-302]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P--
K
-
D
T
Q
Q
A
L
---
S
R
K
-
A
S
-
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------
69
PsiBlast_CBE
66.06
40%
-119
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
K
-----------------------------------------------------------------------------
8
PsiBlast_PDB
65.66
50%
-129
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-314]
----------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
Y
Y
--------
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
--------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
---
G
-
K
A
--
A
N
---
F
V
H
-
M
D
-
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
------------------------------------
72
PsiBlast_CBE
65.46
40%
-115
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
SREDI
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
47
PsiBlast_CBE
64.85
38%
-103
- C1 -
4UV0
1
?
A:
[9-304]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P--
K
-
D
T
Q
Q
A
L
---
S
R
K
-
A
C
-
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------
130
HHSearch
64.53
40%
-117
- C1 -
3LIJ
1
?
A:
[31-332]
------
K
K
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
----
S
-----
S
N
-----
S
K
L
-----
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
---------------
R
M
----------------
K
F
--------
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
L
---
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
-
S
-
A
V
F
E
---
N
--
Q
K
K
---
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
---
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
-
T
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
---
E
-
M
C
--
S
K
K
E
S-
L
P
-
S
L
-
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
S
Q
E
E
T
K
E
L
T
D
I
F
R
H
I
D
K
N
G
D
G
Q
L
D
R
Q
E
L
I
D
G
Y
S
46
PsiBlast_CBE
64.30
40%
-115
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[9-277]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
K
D
--
T
Q
---
Q
A
L
-
S
R
-
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
---------------------------------------------
29
PsiBlast_CBE
64.25
43%
-125
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-265]
----------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H
----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
---
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
Q
--
G
D
Q
QAW
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
---
Q
-
R
S
--
T
V
---
A
S
M
-
M
H
-
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
--------------------------------------------
61
PsiBlast_CBE
63.99
40%
-112
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
135
HHSearch
63.98
48%
-117
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-342]
----------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
Y
Y
--------
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
---
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
--------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
-
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
---
G
-
K
A
--
A
N
---
F
V
H
--
M
-
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
-----------------------------------
84
PsiBlast_CBE
63.84
40%
-113
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
39
PsiBlast_CBE
63.63
37%
-110
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[8-302]
--------
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-----
S
R
R
G
V
S
R
E
E
I
-----
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
LDK
N
I
P
I
-
P
H
I
K
L
I
--
D
F
G
L
-
A
H
E
I
E
----
D
--
G
V
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
PVD
N
-
Q
Q
--
A
M
---
V
R
R
-
E
S
-
V
V
N
L
E
N
F
R
K
Q
Y
V
--------------------------------------------------
86
PsiBlast_CBE
63.46
40%
-113
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
Q
F
----------------------------------------------------------------------------
77
PsiBlast_CBE
63.38
40%
-113
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
---
K
--------------------------------------------------------------------
80
PsiBlast_CBE
63.35
40%
-115
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
78
PsiBlast_CBE
63.31
40%
-114
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
Q
F
--
E
K
------------------------------------------------------------------------
65
PsiBlast_CBE
63.31
40%
-131
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---------------------
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
-------------------
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------
64
PsiBlast_CBE
63.27
40%
-112
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
62
PsiBlast_CBE
62.96
40%
-114
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
82
PsiBlast_CBE
62.76
40%
-113
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
83
PsiBlast_CBE
62.65
40%
-112
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
F
-----------------------------------------------------------------------------
63
PsiBlast_CBE
62.61
40%
-112
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
81
PsiBlast_CBE
62.24
40%
-113
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
------
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
74
PsiBlast_CBE
62.20
40%
-110
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
P
Q
--
F
E
------------------------------------------------------------------------
31
PsiBlast_CBE
62.15
38%
-106
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[8-302]
--------
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-----
S
R
RGVC
R
E
E
I
-----
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
LDK
N
I
P
I
-
P
H
I
K
L
I
--
D
F
G
L
-
A
H
E
I
E
----
D
--
G
V
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
---
P
V
D
T
Q
Q
A
M
---
V
R
R
-
E
S
-
V
V
N
L
E
N
F
K
K
Q
Y
V
--------------------------------------------------
85
PsiBlast_CBE
61.89
40%
-114
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
Q
F
----------------------------------------------------------------------------
66
PsiBlast_CBE
61.82
40%
-123
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
--------------------
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------
75
PsiBlast_CBE
61.54
40%
-112
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-------------------------------------------------------------------------------
44
PsiBlast_CBE
60.96
40%
-118
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
K
D
--
T
Q
---
Q
A
L
-
S
R
-
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------
68
PsiBlast_CBE
60.41
40%
-120
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------------R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
-
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
---------------------
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------
37
PsiBlast_CBE
60.21
37%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[8-302]
--------
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-----
S
R
RGVSR
E
E
I
-----
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
LDK
N
I
P
I
-
P
H
I
K
L
I
--
D
F
G
L
-
A
H
E
I
E
----
D
--
G
V
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
PVD
N
-
Q
Q
--
A
M
---
V
R
R
-
E
S
-
V
V
N
L
E
N
F
R
K
Q
Y
V
--------------------------------------------------
36
PsiBlast_CBE
59.45
37%
-110
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[8-302]
--------
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-----
S
R
RGVSR
E
E
I
-----
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
LDK
N
I
P
I
-
P
H
I
K
L
I
--
D
F
G
L
-
A
H
E
I
E
----
D
--
G
V
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
PVD
N
-
Q
Q
--
A
M
---
V
R
R
-
E
S
-
V
V
N
L
E
N
F
R
K
Q
Y
V
--------------------------------------------------
38
PsiBlast_CBE
58.54
37%
-110
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[8-302]
--------
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-----
S
R
R
G
V
S
R
E
E
I
-----
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
LDK
N
I
P
I
-
P
H
I
K
L
I
--
D
F
G
L
-
A
H
E
I
E
----
D
--
G
V
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
PVD
N
-
Q
Q
--
A
M
---
V
R
R
-
E
S
-
V
V
N
L
E
N
F
R
K
Q
Y
V
--------------------------------------------------
32
PsiBlast_CBE
57.96
38%
-109
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[8-302]
--------
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-----
S
R
RGVC
R
E
E
I
-----
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
LDK
N
I
P
I
-
P
H
I
K
L
I
--
D
F
G
L
-
A
H
E
I
E
----
D
--
G
V
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
---
P
V
D
T
Q
Q
A
M
---
V
R
R
-
E
S
-
V
V
N
L
E
N
F
K
K
Q
Y
V
--------------------------------------------------
73
PsiBlast_CBE
57.89
40%
-110
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[6-274]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
S
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
--
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
----
F
--
G
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---
P
-
Q
F
----------------------------------------------------------------------------
67
PsiBlast_CBE
56.90
40%
-114
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-275]
--------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
------
R
-----
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
------------------
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
-------------------
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------
127
HHSearch
56.62
41%
-102
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-304]
--------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
A
R
----
D
H
-----
Q
K
L
-----
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
-
L
L
L
---
A
S
K
L
-
K
G
A
A
V
K
L
A
D
F
G
L
-
A
-
I
E
V
----
E
GE
Q
Q
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
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Y
P
P
F
W
D
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-
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
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S
P
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W
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V
T
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A
K
D
L
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M
L
T
I
N
P
S
K
R
I
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A
A
E
A
L
K
H
P
W
I
S
---
H
-
R
S
--
T
V
---
A
S
C
-
M
H
R
Q
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T
V
D
C
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K
K
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N
A
R
R
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