@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC1G_HUMAN: (2015-10-10 )
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCSSCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
Atome Classification :
(56 SA)
.........10........20..-.....---.30........40........50...--..--...60----.------.----.---......70........80........90........100.......110.----......120.......130.......140.......150...-..---..160......---.-170-.-.-.-....180.......190.---..--....200.......210.......220....-.-...230.......240..-.....250.......260.......270.....---..280--....-...290..-.....-300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGRKE
E
D
D
C
S
S
W
K
K
Q
TTN
I
R
K
T
F
-
I
F
M
E
V
---LGSG
A
F
S
E
V
F
L
V
K
Q
R
LTG
K
L
F
A
L
K
C
I
--KK--SPAF-----R------D----S---
S
L
E
N
E
I
A
V
L
K
K
IKHEN
I
V
T
L
E
D
I
Y
ESTT
H
Y
Y
L
V
M
Q
L
VSG
G
E
L
F
D
R
I
L
ERG----VYTE
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
ENG
I
V
HRDLKPE
N
L
L
Y
LTPE-EN---
S
K
I
M
I
T
DFGL
S
---
K
-
M
E
Q-N-G-
I
-
M
STACGTPGYV
A
P
E
V
L
AQ---KP--YSKA
V
D
C
W
S
I
G
V
I
T
Y
I
L
LCGYPP
F
Y
E
-
E
T
E
S
-
K
-
L
F
E
K
I
K
E
G
Y
Y
EFESP
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
EKDPNER
Y
T
C
E
K
A
LSHPWI---DGNTA--LHRD-IYPS
V
S
L
Q
-
I
Q
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
A
A
V
V
H
H
M
R
K
L
H
M
NLHSPGVRPEVENRPPETQASETSRPSSP
E
I
T
I
TEAPVLDHSVA
L
P
A
L
T
QL
P
C
QHGRRPTAPGG
R
S
L
N
C
L
V
NG
S
L
H
I
SS
S
L
VPMHQGSLAAG
P
C
G
C
C
S
S
C
L
NIGSKGKSSYCSE
P
T
L
L
K
KANKKQNFKSE
V
M
V
P
V
KASGSSHCRAGQ
T
G
V
C
L
IM
21
PsiBlast_CBE
84.11
100%
-123
- C3 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
---------------
T
T
N
I
R
K
T
F
-
I
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
--
S
------------------------
S
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
---
S
K
I
M
I
T
D
F
G
L
S
---
K
-
M
E
Q
-
N
-
G
-
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
S
-
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---
D
G
N
T
A
--
L
H
R
D
-
I
Y
P
S
V
S
L
Q
-
I
Q
K
N
F
-
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
83.69
100%
-121
* C3 *
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-----------------
N
I
R
K
T
F
-
I
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
--
S
------------------------
S
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
---
S
K
I
M
I
T
D
F
G
L
S
---
K
-
M
E
Q
-
N
-
G
-
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
S
-
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---
D
G
N
T
A
--
L
H
R
D
-
I
Y
P
S
V
S
L
Q
-
I
Q
K
N
F
-
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.69
100%
-121
- C3 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-----------------
N
I
R
K
T
F
-
I
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
--
S
------------------------
S
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
---
S
K
I
M
I
T
D
F
G
L
S
---
K
-
M
E
Q
-
N
-
G
-
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
S
-
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---
D
G
N
T
A
--
L
H
R
D
-
I
Y
P
S
V
S
L
Q
-
I
Q
K
N
F
-
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.00
70%
-133
- C3 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
----------------
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-
K
-------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
G
-------------
G
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
-
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
-
I
H
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
78.08
69%
-132
- C3 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
----------
R
W
-
K
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
----------------------------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
G
L
S
---
K
-
M
E
D
-
P
-
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
-
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.03
70%
-129
- C3 -
4FG8
1
KCC1A_HUMAN
A:
[11-299]
-------------
K
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-
K
E
------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
-
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
-
I
H
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.22
70%
-119
- C3 -
4FG9
1
KCC1A_HUMAN
A:
[11-314]
-------------
K
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-
K
E
-----------------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
-
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
-
I
H
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.71
69%
-133
- C3 -
4FG7
1
KCC1A_HUMAN
A:
[11-277]
-------------
K
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A------------------------------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
G
L
S
---
K
-
M
E
D
-
P
-
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
-
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.85
70%
-123
- C3 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
----------------
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-
K
--------------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
----------------
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
-
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
-
I
H
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
67.54
35%
-109
- C3 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
----------------
V
L
F
E
D
V
Y
-
E
L
C
E
V
---
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--
D
V
--
A
K
F
T
S
SPGL
S
------
T
----
E
---
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
---
A
P
V
K
L
G
G
F
G
V
A
---
I
-
Q
L
G
E
S
-
G
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
--
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
K
-
E
-
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
---
K
E
R
D
R
--
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
-
L
R
K
F
N
-
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
65.77
38%
-108
- C3 -
2CKE
1
DAPK2_HUMAN
A:
[18-302]
---------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--
K
K
R
Q
S
R
A
S
-----
R
------
R
G
V
S
R
E
---
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
---
H
-
E
I
E
-
D
-
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
64.33
38%
-110
- C3 -
2CKE
1
DAPK2_HUMAN
B:
[18-302]
---------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--
K
K
R
Q
S
R
A
S
-----
R
------
R
G
V
S
R
E
---
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
---
H
-
E
I
E
-
D
-
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.61
43%
-120
- C3 -
2V7O
3
KCC2G_HUMAN
A:
[27-291]
----------------
T
R
F
T
D
D
Y
-
Q
L
F
E
E
---
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
NT
K
K
--
L
S
A
R
-----
D
------
H
----
Q
---
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
E
Q
-
Q
-
A
-
W
-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
--
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
-
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
---
C
Q
R
S
T
--
V
A
S
M
-
M
H
R
Q
E
T
V
E
-
C
L
R
K
F
-
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
63.60
38%
-110
- C3 -
2CKE
1
DAPK2_HUMAN
D:
[18-302]
---------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--
K
K
RQ
S
R
A
S
-----
R
------
R
GVSR
E
---
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
N
IPI
P
H
I
K
L
I
D
F
G
L
A
---
H
-
E
I
E
-
D
-
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
63.15
40%
-112
- C3 -
2Y0A
1
DAPK1_HUMAN
A:
[5-279]
--------------
R
Q
E
N
V
D
D
Y
Y
-
D
T
G
E
E
---
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--
K
K
--
R
R
T
K
-----
S
SRRGVS
R
----
E
---
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
---
P
R
I
K
I
I
D
F
G
L
A
---
H
-
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---
K
P
K
D
T
--
Q
Q
A
L
-
S
R
K
A
S
A
V
N
-
M
E
K
F
K
-
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
62.97
38%
-107
- C3 -
2YAA
1
DAPK2_MOUSE
A:
[18-302]
---------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--
K
K
R
Q
S
R
A
S
-----
R
------
R
GVC
R
E
---
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
---
H
-
E
I
E
-
D
-
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPV
D
T
Q
Q
A
--
M
V
R
R
--
E
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
62.82
38%
-107
- C3 -
2CKE
1
DAPK2_HUMAN
C:
[18-302]
---------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--
K
K
RQ
S
R
A
S
-----
R
------
R
GVSR
E
---
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
N
IPI
P
H
I
K
L
I
D
F
G
L
A
---
H
-
E
I
E
-
D
-
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.67
46%
-123
- C3 -
2VN9
2
KCC2D_HUMAN
A:
[6-264]
----------------------
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT
K
K
--
L
S
A
R
-----
D
------
H
----
Q
---
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
-
A
-
W
-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
--
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
-
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
---
C
Q
R
S
T
--
V
A
S
M
-
M
H
R
Q
E
T
V
D
-
C
L
K
K
F
-
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
62.51
38%
-106
- C3 -
2YAA
1
DAPK2_MOUSE
B:
[18-302]
---------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--
K
K
RQ
S
R
A
S
-----
R
------
R
GVC
R
E
---
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
---
H
-
E
I
E
-
D
-
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
-
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPV
D
T
Q
Q
A
--
M
V
R
R
--
E
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
62.31
46%
-112
- C3 -
2W4O
1
KCC4_HUMAN
A:
[49-344]
----------------
D
A
L
S
D
F
F
-
E
V
E
S
E
---
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
--
K
K
--------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
---
A
P
L
K
I
A
D
F
-----------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
---
C
A
--
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
D
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
-
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
---
T
G
K
A
A
--
N
F
V
H
--
M
D
T
A
Q
K
K
-
L
Q
E
F
N
-
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
61.84
41%
-110
- C3 -
3BHH
1
KCC2B_HUMAN
B:
[6-293]
----------------------
Y
-
Q
L
Y
E
D
---
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
NT
K
K
--
L
S
A
R
-----
D
------
H
----
Q
---
K
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
D
Q
-
Q
-
A
-
W
-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
E
A
--
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
-
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
---
C
Q
R
S
T
--
V
A
S
M
-
M
H
R
Q
E
T
V
E
-
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.61
46%
-122
- C3 -
2WEL
7
KCC2D_HUMAN
A:
[6-264]
----------------------
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT
K
K
--
L
S
A
R
-----
D
------
H
----
Q
---
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
-
A
-
W
-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
--
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
-
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
---
C
Q
R
S
M
--
M
H
R
Q
-
E
T
V
D
C
L
K
K
-
F
N
A
R
R
-
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
61.17
46%
-122
- C3 -
2VN9
1
KCC2D_HUMAN
B:
[6-264]
----------------------
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT
K
K
--
L
S
A
R
-----
D
------
H
----
Q
---
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
D
Q
-
Q
-
A
-
W
-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
--
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
-
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
---
C
Q
R
S
T
--
V
A
S
M
-
M
H
R
Q
E
T
V
D
-
C
L
K
K
F
-
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.34
41%
-109
- C3 -
3BHH
1
KCC2B_HUMAN
A:
[6-293]
----------------------
Y
-
Q
L
Y
E
D
---
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
--
L
S
A
R
-----
D
------
H
----
Q
---
K
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
-
A
-
W
-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
E
A
--
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
-
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
---
C
Q
R
S
T
--
V
A
S
M
-
M
H
R
Q
E
T
V
E
-
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
60.23
44%
-129
- C3 -
2YIT
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
-----
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.79
44%
-130
- C3 -
2W0J
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
T
A
L
P
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.70
44%
-126
- C3 -
2YIR
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
-----
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.65
44%
-129
- C3 -
2YCR
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
K
-
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
59.39
44%
-126
- C3 -
4BDF
3
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
59.15
44%
-126
- C3 -
2YCQ
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.33
44%
-110
- C3 -
2WEI
1
?
A:
[29-280]
----------------------------
M
---
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--
N
K
--
A
S
A
K
-----
N
------
K
D
T
--
S
---
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
---
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
-
T
-
K
-
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-
R
---
G
T
--
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
-
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
---
Q
K
Y
S
S
--
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.05
44%
-128
- C3 -
2WTD
4
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
57.99
44%
-128
- C3 -
4BDG
2
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
57.88
44%
-119
- C3 -
4A9T
4
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.87
48%
-112
- C3 -
2W4O
1
KCC4_HUMAN
A:
[54-341]
-------------------------
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
--
K
K
--------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
---
A
P
L
K
I
A
D
F
-----------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
---
C
A
--
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
D
-
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
-
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
---
T
G
K
A
A
NF
V
H
M
D
----
T
A
Q
K
K
-
L
Q
E
F
N
-
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
57.86
44%
-126
- C3 -
4A9R
2
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
57.84
44%
-109
- C3 -
3MA6
1
?
A:
[39-295]
----------------------------
V
---
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--
S
K
--
R
Q
V
K
-----
Q
------
K
----
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
---
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
--
S
-
K
-
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
---
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
Y
-
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
---
Q
T
Y
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
57.76
42%
-129
- C3 -
4PDS
1
RAD53_YEAST
B:
[26-301]
----------------
T
G
I
F
K
D
F
S
I
I
------------
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
--------------------------------
V
T
R
E
L
E
V
L
Q
K
L
N
H
P
R
I
V
R
L
K
G
F
Y
-----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
----
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
-
I
E
Q
D
-
D
P
---
V
L
V
K
I
T
A
F
G
L
A
---
K
-
V
---------------
T
L
A
Y
V
A
P
E
V
I
-------NE
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
-
S
T
Q
D
-
Q
-
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
---
K
M
S
P
L
--
Y
G
D
F
-
S
Q
I
S
L
S
Q
S
-
L
S
Q
Q
K
-
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
57.76
44%
-133
- C3 -
4BDH
4
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
57.75
44%
-125
- C3 -
2CN5
1
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
R--------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.73
44%
-119
- C3 -
2YCF
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.72
44%
-127
- C3 -
4A9S
1
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
57.36
44%
-134
- C3 -
4BDD
3
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.15
44%
-127
- C3 -
2YIQ
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
----------------------------
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
56.83
44%
-131
- C3 -
2CN8
1
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H---
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
56.75
44%
-127
- C3 -
2YCS
1
CHK2_HUMAN
A:
[8-278]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
56.66
44%
-132
- C3 -
4BDB
10
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
-----
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
56.50
44%
-121
- C3 -
2XM9
1
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
56.22
44%
-130
- C3 -
4BDE
5
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
----
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
56.20
44%
-126
- C3 -
4A9U
10
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
--
D
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
56.08
44%
-132
- C3 -
4BDA
8
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
55.76
44%
-130
- C3 -
4BDJ
1
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---------------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
55.49
44%
-128
- C3 -
2WTJ
5
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.43
44%
-127
- C3 -
2WTC
1
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
---
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
54.94
44%
-125
- C3 -
2WTI
3
CHK2_HUMAN
A:
[14-284]
------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--
S
K
---
P
A
L
---------------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
-
T
-
S
-
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
---
Q
D
E
D
M
--
K
R
K
F
-
Q
D
L
L
S
E
E
N
-
E
S
T
A
L
-
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
54.01
44%
-111
- C3 -
3MA6
1
?
B:
[39-295]
----------------------------
V
---
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--
S
K
--
R
Q
V
K
-----
Q
-----------
T
DK
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
---
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
-
K
-
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
---
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
Y
-
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
---
Q
T
Y
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------