@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC2A_HUMAN: (2015-10-10 )
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Atome Classification :
(45 SA)
.........10........20........30........40..--....---..--50.----..----....----.60.......-.70........80........90........100.--------------------------------------..----....110.......120.......130.......140....-.-..150.......160..----.....170..-.....180....------.--..-190.......200.......210....--...220........230.......240.......250.......260.......270.......280...---....--290..---.....300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
T
I
T
C
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
LAG
Q
E
Y
A
A
K
I
--
I
NTK---KL--S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
LK-HP
N
I
V
R
LHDSISEEG
H
H
Y
L
I
F
D
LVT
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
YSEA
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
QM
G
V
V
HRDLKPENL
L
L
A
S
K-L-KG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E----GEQ
Q
A
W
F
GFA-GTPGYL
S
P
E
V
LR------K--DP-YGK
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
VGYPPFWD
E
--
D
Q
H
R
-
L
Y
Q
Q
I
K
AGAYDFPSPEWDTVTP
E
A
K
D
L
I
N
K
M
LTINPSKR
I
T
A
A
E
A
LKHP
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
---
T
V
D
C
--
L
K
K
F
N
---
A
R
R
K
L
K
G
A
I
L
T
T
M
L
ATRNFSGGKSGGNKKSDGVKESSESTNTTIEDED
T
K
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
SNG
D
F
E
S
Y
T
KMCDPGMTAF
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
WSRNSK
P
V
H
T
T
I
LN
P
H
I
H
L
MGDE
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
DAGGIPRTAQSEE
T
R
V
W
HRRDG
K
W
Q
I
V
H
F
HRSGAPSVLPH
139
HHSearch
86.09
99%
-102
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-444]
------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
----
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
-
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
---
T
V
D
C
--
L
K
K
F
N
---
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
------------------------------
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
----
1
PsiBlast_PDB
84.79
93%
-102
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-444]
------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
----
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
-
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
---
T
V
D
C
--
L
K
K
F
N
---
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
------------------------------
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
----
5
PsiBlast_PDB
77.53
92%
-116
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-301]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
----
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
---
T
V
D
C
--
L
K
K
F
N
---
A
R
R
K
L
K
G
A
I
L
T
T
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.80
90%
-118
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-293]
--------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
----
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
E
A
-
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
---
T
V
E
C
--
L
K
K
F
N
---
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.73
90%
-118
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-293]
--------
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
----
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
E
A
-
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
---
T
V
E
C
--
L
K
K
F
N
---
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.34
89%
-112
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[25-321]
----
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
----
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
-
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
---
T
V
E
C
--
L
R
K
F
N
---
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.15
90%
-125
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-308]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
----
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
---
T
V
D
C
--
L
K
K
F
N
---
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.11
92%
-115
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-301]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
--
S
A
R
----
D
H
----
Q
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
----
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
---
T
V
D
C
--
L
K
K
F
N
---
A
R
R
K
L
K
G
A
I
L
T
T
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.91
46%
-107
- C1 -
3C0H
1
CSKP_HUMAN
A:
[22-318]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.84
47%
-106
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-320]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.40
47%
-104
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-320]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.33
47%
-103
- C1 -
3MFR
1
CSKP_HUMAN
A:
[22-320]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.96
46%
-106
- C1 -
3C0I
1
CSKP_HUMAN
A:
[22-317]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
63.79
47%
-104
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
--
K
-
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.41
46%
-107
- C1 -
3C0H
1
CSKP_HUMAN
B:
[22-318]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
DAGF
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
PsiBlast_CBE
62.95
40%
-115
- C1 -
1QL6
1
PHKG1_RABIT
A:
[15-289]
--------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
--
S
A
E
----
E
V
----
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
-
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P---
G
E
K
L
R
--
S
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
-
N
--
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
L
-
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
62.29
40%
-116
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[92-363]
--------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
---
R
L
--
S
P
E
----
Q
L
----
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
-
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
---
G
E
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
ET
H
--
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
L
-
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
62.15
40%
-114
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-289]
--------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
--
S
A
E
----
E
V
----
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
-
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P---
G
E
K
L
R
--
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D-
N
--
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
L
-
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
61.94
43%
-121
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
----------------------
S
-
M
E
----
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
----
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
61.65
40%
-114
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[92-363]
--------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
L
--
S
P
E
----
Q
L
----
E
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
-
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P---
G
E
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
--
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
L
-
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.16
46%
-103
- C1 -
3C0G
1
CSKP_HUMAN
A:
[22-326]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
K
--
V
L
A
A
V
S
F
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
HHSearch
61.06
34%
-112
- C1 -
3HKO
2
?
A:
[23-337]
-------
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
--
M
N
K
N
---
K
I
R
Q--
K
----
D
V
----
E
R
I
K
----
T
E
V
R
L
M
K
K
L
H
-
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
----
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
-
K
--
S
F
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
KLNN
G
--------
A
-
G
T
P
Y
F
V
A
P
E
V
L
N
------
T
TN
E
S
-
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
--
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
61.01
40%
-116
- C1 -
2PHK
2
PHKG1_RABIT
A:
[2-276]
--------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
--
S
A
E
----
E
V
----
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
-
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P---
G
E
K
L
R
--
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D-
N
--
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
L
-
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
60.21
42%
-111
- C1 -
3MA6
1
?
A:
[30-291]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
--
K
Q
K
T---
D
K
----
E
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-----
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
---------
G
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
60.13
40%
-116
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[92-363]
--------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
------
R
L
--
S
P
E
----
Q
L
----
E
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
-
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P---
G
E
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
--
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
L
-
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.99
42%
-116
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[20-299]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
----------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
K
I
M
I
S
D
F
-----------------------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
-
Q
S
---
V
S
E
Q
--
I
K
K
N
F
---
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
HHSearch
59.81
34%
-107
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[8-302]
-------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
--
K
S
S
RRGV
S
R
----
E
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----
F
G
N
-
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
-
Q
A
L
S
R
K
A
SAV
N
M
E
K
--
F
K
K
F
A
---
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
PsiBlast_CBE
59.73
37%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
--
R
A
S
R
R
G
V
S
R
----
E
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
--------------------------------------
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-----
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
-
Q
Q
A
M
V
R
R
E
---
S
V
V
N
--
L
E
N
F
R
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
59.51
46%
-103
- C1 -
3C0G
1
CSKP_HUMAN
B:
[22-326]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
--
T
S
S
PGL-
S
T
----
E
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
----
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
---
T
V
E
Q
--
L
R
K
F
N
---
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
G
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------
126
PsiBlast_CBE
58.08
37%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
--
R
A
S
R
R
G
V
S
R
----
E
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
--------------------------------------
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-----
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
-
Q
Q
A
M
V
R
R
E
---
S
V
V
N
--
L
E
N
F
R
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
PsiBlast_CBE
57.04
37%
-105
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
--
R
A
S
RRGV
S
R
----
E
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
--------------------------------------
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-----
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
-
Q
Q
A
M
V
R
R
E
---
S
V
V
N
--
L
E
N
F
R
KQY
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
56.80
42%
-106
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[24-314]
------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
---
A
----------------
S
S
I
E
----
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
-
D
-
E
E
S
K
I
M
I
S
--------------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
I
H
E
S
V
---
S
A
Q
I
--
R
K
N
F
----
A
K
S
K
W
R
Q
A
F
N
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
56.58
37%
-105
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
--
R
A
S
RRGV
S
R
----
E
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
--------------------------------------
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-----
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
-
Q
Q
A
M
V
R
R
E
---
S
V
V
N
--
L
E
N
F
R
KQY
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
56.56
37%
-106
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
--
R
A
S
----
R
R
GVC
R
E
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
--------------------------------------
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
----
D
G
V
E
-
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
---
V
V
N
L
E
N
F
K
K
Q
Y
---
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
56.53
37%
-107
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[3-302]
-
E
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
--
R
A
S
----
R
R
GVC
R
E
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
--------------------------------------
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
----
D
G
V
E
-
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
---
V
V
N
L
E
N
F
K
K
Q
Y
---
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
56.28
42%
-113
- C1 -
3MA6
1
?
B:
[30-291]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
--
K
Q
-T---
D
K
----
E
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
----
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
---------
G
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
56.17
42%
-112
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-299]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
-----------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
K
I
M
I
S
D
F
G
------------
G
S
V
L
S
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
-
Q
S
---
V
S
E
Q
--
I
K
K
N
F
---
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
55.97
42%
-106
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[24-314]
------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
---
A
-----------------
S
I
E
----
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
-
D
-
E
E
S
K
I
M
I
S
--------------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
I
H
E
S
V
---
S
A
Q
I
--
R
K
N
F
----
A
K
S
K
W
R
Q
A
F
N
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
HHSearch
55.43
42%
-107
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-346]
-------
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
K
-------------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
-
P
D
A
P
L
K
I
A
D
F
----------------------
G
T
P
G
Y
C
A
P
E
I
L
R
------
G
--
C
A
-
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
--
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
--
A
N
F
V
H
M
D
T
---
A
Q
K
K
--
L
Q
E
F
N
---
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
55.23
42%
-106
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-346]
--------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
---------
K
----------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
-
P
D
A
P
L
K
I
A
D
F
----------------------
G
T
P
G
Y
C
A
P
E
I
L
R
------
G
--
C
A
-
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
RG
D
Q
F
--
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
--
A
N
F
V
H
M
D
T
---
A
Q
K
K
--
L
Q
E
F
N
---
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
54.11
42%
-107
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[20-313]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
-----------------------
E
----
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
K
I
M
I
S
D
F
------------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
-
Q
S
---
V
S
E
Q
--
I
K
K
N
F
---
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
52.81
41%
-100
- C1 -
2WEI
1
?
A:
[20-285]
--------
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
--
K
N
K
----
D
T
----
S
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
--------------------------------------
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-----
Q
N
T
K
M
K
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
---------
G
T
-
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
--
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
52.65
42%
-96
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
S
----------------
S
L
E
----
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
--------------------------------------
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
---
K
----
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
--
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
---
S
L
Q
I
--
Q
K
N
F
----
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
52.15
42%
-97
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
-----
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
S
----------------
S
L
E
----
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
--------------------------------------
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
---
K
----
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
--
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
---
S
L
Q
I
--
Q
K
N
F
----
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
51.97
42%
-107
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[20-313]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
K
I
M
I
S
D
F
---------------
V
L
S
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
-
Q
S
---
V
S
E
Q
--
I
K
K
N
F
---
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------