@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC4_HUMAN: (2015-10-10 )
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
Atome Classification :
(78 SA)
.........10........20........30........40.-.......50........60........70......-----.----.----80-------.-------.--------...-....90........100.......110.......120.......130.---.----.-....140.......150.......160.......-170....-...180.......-190.-..-....200.......210...---....220.......230.......240----......--..-250.......260.......270.......280.......290.......300-------...--.--...-----.--310---........320.......330-........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
K
V
TVPSCSASSCSSVTASAAPGTASLVP
D
Y
W
IDGSN
R
D
A
L
-
S
D
F
F
E
V
E
S
E
LGR
G
A
T
S
I
V
Y
R
C
K
QKGTQK
P
Y
A
L
K
V
L
-----
K
----
K
----
T
--------
V
-------
D
--------
K
K
I
-
V
R
T
E
I
G
V
L
L
RLSHP
N
I
I
K
L
K
E
I
FETP
T
E
I
S
L
V
L
E
LVT
G
G
E
L
F
D
R
I
V
E
K---G----Y-YSER
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
ENG
I
V
HRDLKPEN-
L
L
Y
ATPA-PDAPL
K
I
A
D
F
G
L
S
-
K
I
V
E
-
H
Q
-
V
L
M
K
T
VCGTPGY
C
A
P
E
I
L
R
G---CAYGPEV
D
M
W
S
V
G
I
I
T
Y
I
L
L
CGFE
P
F
-----
Y
DERG
D
--
Q
F
-
M
F
R
R
I
LNC
E
Y
Y
F
ISP
W
W
D
EVSL
N
A
K
D
L
V
R
K
L
I
VLDP
K
K
R
L
T
T
F
Q
A
L
QHPWVT--------GKA--A--
N
F
V
-----H--M-
D
---
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
--
A
V
V
A
SSRLGSASSSHGS
I
Q
E
S
HKASRDPSPIQDGN
E
D
M
K
AIPEGEKIQGDG
A
Q
A
A
VKG
A
Q
A
E
L
M
K
V
Q
A
L
E
K
VKGADI
N
A
E
E
A
P
K
M
V
P
K
A
V
EDG
I
K
V
AD
L
E
L
E
E
G
L
A
E
E
K
L
K
T
V
E
E
AAAPREGQGSSAVGFEVPQQDVILPEY
121
HHSearch
85.79
100%
-108
* C2 *
2W4O
1
KCC4_HUMAN
A:
[43-346]
---------------------------------
I
D
G
S
N
R
D
A
L
-
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
-----
K
----
K
--------------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
---
G
----
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
-----
Y
D
E
R
G
D
--
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
--------
G
K
A
--
A
--
N
F
V
-----
H
--
M
-
D
---
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
--
A
V
V
A
S
S
----------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.56
99%
-108
- C2 -
2W4O
1
KCC4_HUMAN
A:
[43-346]
---------------------------------
I
D
G
S
N
R
D
A
L
-
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
-----
K
----
K
--------------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
---
G
----
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
-----
Y
D
E
R
G
D
--
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
--------
G
K
A
--
A
--
N
F
V
-----
H
--
M
-
D
---
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
--
A
V
V
A
S
S
----------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.03
47%
-110
- C2 -
4FG8
1
KCC1A_HUMAN
B:
[16-299]
-----------------------------------------
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-----
A
----
K
------------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
---------
G
-
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------
G
D
T
--
A
LD
K
N
I
-----
H
--
Q
-
S
---
V
S
E
Q
I
K
K
N
F
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.65
42%
-106
- C2 -
2V7O
3
KCC2G_HUMAN
A:
[29-321]
-----------------------------------------
F
-
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
-----
N
TKKL
S
----
A
--------
R
-------
D
--------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
Q
G
E
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
--
D
--
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
--------
Q
R
S
TV
A
--
S
M
M
-----
H
--
R
-
Q
---
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
69.40
35%
-108
- C2 -
3MFS
1
CSKP_HUMAN
A:
[18-320]
--------------------------------------
D
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-----
D
----
V
----
A
K
F
T
S
SPG-
L
-------
S
--------
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
----
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
-
S
G
-
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-----
Y
G
T
K
----
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R------
D
R
Y
--
A
--
Y
K
I
-----
H
--
L
-
P
---
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
68.77
35%
-108
- C2 -
3MFU
1
CSKP_HUMAN
A:
[19-320]
---------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-----
D
----
V
----
A
K
F
T
SSPG-
L
-------
S
--------
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
----
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
-
S
G
-
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-----
Y
G
T
K
----
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R------
D
R
Y
--
A
--
Y
K
I
-----
H
--
L
-
P
---
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
67.19
35%
-107
- C2 -
3MFR
1
CSKP_HUMAN
A:
[19-320]
---------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-----
D
----
V
----
A
K
F
T
S
SPG-
L
-------
S
--------
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
----
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
-
S
G
-
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-----
Y
G
T
K
----
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
ER------
D
R
Y
--
A
--
Y
K
I
-----
H
--
L
-
P
---
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
66.89
35%
-103
- C2 -
3C0I
1
CSKP_HUMAN
A:
[21-317]
----------------------------------------
L
F
-
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-----
D
----
V
----
A
--------
K
F
T
S
SPGL
S
--------
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
---
A
D
A
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-----
Y
G
T
--
K
--
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
--------
E
R
D
--
R
YA
Y
K
I
-----
H
--
L
-
P
---
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
66.62
44%
-101
- C2 -
2VN9
1
KCC2D_HUMAN
B:
[1-296]
----------------------------------------
S
M
-
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
-----
N
TKKL
S
----
A
--------
R
-------
D
--------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
--
D
--
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
--------
Q
R
S
TV
A
--
S
M
M
-----
H
--
R
-
Q
---
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
--
T
T
M
L
------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.22
44%
-102
- C2 -
2VN9
2
KCC2D_HUMAN
A:
[1-296]
----------------------------------------
S
M
-
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
-----
N
TKKL
S
----
A
--------
R
-------
D
--------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
--
D
--
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
--------
Q
R
S
TV
A
--
S
M
M
-----
H
--
R
-
Q
---
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
--
T
T
M
L
------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
66.16
39%
-107
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[5-302]
-------------------------------------
R
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
--------
R
-------
T
KSSRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
G
D
-
T
K
--
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
K
D
--
T
--
Q
Q
A
L
S
---
R
K
A
S
-
A
---
V
N
M
E
K
F
K
K
F
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.63
47%
-112
- C2 -
4FG8
1
KCC1A_HUMAN
A:
[16-299]
-----------------------------------------
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-----
A
----
K
----
E
-------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------
G
D
T
--
A
LD
K
N
I
-----
H
--
Q
-
S
---
V
S
E
Q
I
K
K
N
F
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.59
43%
-110
- C2 -
2WEL
7
KCC2D_HUMAN
A:
[1-308]
----------------------------------------
S
M
-
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
-----
N
TKKL
S
----
A
--------
R
-------
D
--------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
--
D
--
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
--------
Q
R
------
S
M
M
-----
H
--
R
-
Q
---
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
--
T
T
M
L
A
T
R
N
F
S
A
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.08
50%
-123
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[16-277]
-----------------------------------------
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-----
A
-------------------------------------
S
-
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
D
-
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
N
-
D
--
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
63.85
42%
-108
- C2 -
3BHH
1
KCC2B_HUMAN
B:
[2-293]
-----------------------------------------
M
-
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
-----
N
TK
K
L
S
----
A
--------
R
-------
D
--------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
--
D
--
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
--------
Q
R
S
TV
A
--
S
M
M
-----
H
--
R
-
Q
---
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.65
47%
-103
- C2 -
4FG9
1
KCC1A_HUMAN
A:
[16-310]
-----------------------------------------
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-----
A
----
K
----
E
------------------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------
G
D
T
--
A
LD
K
N
I
-----
H
--
Q
-
S
---
V
S
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
--
A
T
A
V
V
R
----------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
62.81
47%
-105
- C2 -
4FG9
1
KCC1A_HUMAN
B:
[16-310]
-----------------------------------------
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-----
A
----
K
-------------------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
-------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------
G
D
T
--
A
LD
K
N
I
-----
H
--
Q
-
S
---
V
S
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
--
A
T
A
V
V
R
----------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
62.67
48%
-122
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
-------------------------------
R
W
K
---
Q
A
E
D
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-----
A
-------------------------------------
S
-
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
D
-
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.65
42%
-107
- C2 -
3BHH
1
KCC2B_HUMAN
A:
[1-293]
----------------------------------------
S
M
-
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
-----
N
TKKL
S
----
A
--------
R
-------
D
--------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
--
D
--
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
--------
Q
R
S
TV
A
--
S
M
M
-----
H
--
R
-
Q
---
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
62.49
40%
-110
- C2 -
4TXC
7
DAPK1_HUMAN
A:
[25-296]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.46
42%
-113
- C2 -
2YAA
1
DAPK2_MOUSE
B:
[10-277]
-----------------------------------------
V
-
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
-----
K
----
K
----
R
QSRASRRG
V
-------
C
--------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
---
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
-
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--------
P
V
D
--
T
--
Q
Q
A
-----
M
--
V
-
R
---
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
62.42
38%
-104
- C2 -
2W4K
1
DAPK1_HUMAN
A:
[6-302]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
PKD
T
Q
Q
A
L
S
R
K
--
A
--
S
A
V
-----
N
--
M
-
E
-------
K
F
K
K
F
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
61.77
40%
-109
- C2 -
1WVY
1
DAPK1_HUMAN
A:
[6-276]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
61.43
40%
-110
- C2 -
2YAK
1
DAPK1_HUMAN
A:
[6-278]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
60.64
36%
-86
- C2 -
4TZR
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
79
PsiBlast_CBE
60.51
43%
-122
- C2 -
2YIT
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
--------------------------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
60.49
36%
-83
- C2 -
4WG3
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
57
PsiBlast_CBE
60.46
42%
-115
- C2 -
2YAA
1
DAPK2_MOUSE
A:
[10-277]
-----------------------------------------
V
-
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
-----
K
----
K
----
R
QSRASRRG
V
-------
C
--------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
---
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
-
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--------
P
V
D
--
T
--
Q
Q
A
-----
M
--
V
-
R
---
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.10
47%
-107
- C2 -
2JC6
1
KCC1D_HUMAN
A:
[24-314]
----------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
-----
P
----
K
----
K
--------
A
-----------------
S
S
-
I
E
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
Q
D
-
E
E
S
K
I
M
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
--------
G
D
T
--
A
LN
K
N
I
-----
H
--
E
-
S
---
V
S
A
Q
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
AT----------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
59.84
36%
-80
- C2 -
4ONA
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
--
E
Q
I
SV
D
V
P
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
49
PsiBlast_CBE
59.50
36%
-86
- C2 -
3V51
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
41
PsiBlast_CBE
59.50
36%
-85
- C2 -
4WG4
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
46
PsiBlast_CBE
59.49
36%
-85
- C2 -
4JBV
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
108
PsiBlast_CBE
59.44
40%
-112
- C2 -
4UV0
1
?
A:
[8-280]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
K
D
--
T
--
Q
Q
A
-----
L
--
S
-
R
---
K
A
C
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.02
40%
-109
- C2 -
4B4L
3
DAPK1_HUMAN
A:
[8-280]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
K
D
--
T
--
Q
Q
A
-----
L
--
S
-
R
---
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.71
36%
-86
- C2 -
3SX9
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
----
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
54
PsiBlast_CBE
58.60
40%
-109
- C2 -
2XUU
1
DAPK1_HUMAN
A:
[6-278]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
K
D
--
T
--
Q
Q
A
-----
L
--
S
-
R
---
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
58.57
36%
-84
- C2 -
3V5T
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
-----DVP--
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
129
HHSearch
58.47
46%
-104
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
----------------------------------------
N
I
-
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-----
K
----
K
-------------------------------
S
S
-
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
---
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
Q
-
N
G
--
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-----
Y
E
E
-
T
E
--
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
--------
G
N
T
--
A
--
L
H
R
-----
D
--
I
Y
P
---
S
V
S
L
Q
I
Q
K
N
F
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
57.97
43%
-122
- C2 -
2W0J
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
T
A
L
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
57.95
43%
-121
- C2 -
2WTI
3
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
57.82
47%
-107
- C2 -
2JC6
1
KCC1D_HUMAN
C:
[24-314]
----------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
-----
P
----
K
----
K
--------
A
------------------
S
-
I
E
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
Q
D
-
E
E
S
K
I
M
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-----
Y
D
E
-
N
D
--
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
--------
G
D
T
--
A
LN
K
N
I
-----
H
--
E
-
S
---
V
S
A
Q
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
AT----------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
57.78
43%
-119
- C2 -
4A9S
1
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
57.75
43%
-120
- C2 -
4BDI
6
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.56
48%
-107
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[13-290]
---------------------------------------------
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-----
K
----
K
----
S
---------------------------
S
-
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
---
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
-
Q
N
-
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-----
Y
E
E
T
E
S
--
K
--
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
--------
G
N
T
--
A
----
L
-----
H
--
R
-
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
57.46
43%
-130
- C2 -
4BDD
3
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
57.45
43%
-125
- C2 -
2YIR
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
--------------------------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
57.22
43%
-121
- C2 -
2CN5
1
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
----
R
----------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.19
43%
-115
- C2 -
2YCF
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
57.06
43%
-121
- C2 -
2WTD
4
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
57.01
36%
-82
- C2 -
4WG5
1
?
A:
[24-381]
-----------------------------------------
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KRQV
K
----
Q
----
K
--------
T
-------
D
--------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-
A
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGAN
E
Y
D
---------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
--------
T
Y
T
--
K
--
E
Q
I
SVDVP
S
--
L
-
D
---
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
-
A
Q
A
A
--
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
----
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
-----
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
90
PsiBlast_CBE
56.98
43%
-124
- C2 -
4BDG
2
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
56.83
43%
-128
- C2 -
4BDA
8
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
56.65
43%
-124
- C2 -
4BDC
2
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
56.62
40%
-110
- C2 -
2W4J
1
DAPK1_HUMAN
A:
[6-275]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
56.12
43%
-118
- C2 -
4A9R
2
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
56.00
43%
-122
- C2 -
4BDF
3
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
55.88
43%
-122
- C2 -
2YCS
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
55.84
43%
-130
- C2 -
4BDB
10
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
--------------------------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
55.82
43%
-124
- C2 -
2CN8
1
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
-----
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
55.58
40%
-116
- C2 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
---------------------------------------
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
------------------------
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
55.57
43%
-114
- C2 -
4A9T
4
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
55.53
43%
-120
- C2 -
2YCQ
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
55.48
43%
-127
- C2 -
4BDE
5
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
55.06
43%
-117
- C2 -
2XM9
1
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
54.88
43%
-119
- C2 -
4A9U
10
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------
D
--------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
54.82
43%
-126
- C2 -
4BDH
4
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
54.80
41%
-108
- C2 -
2WEI
1
?
A:
[19-280]
----------------------------------------
T
F
-
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
-----
N
----
K
ASAK
N
--------
K
-------
D
--------
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
---
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
-
Q
N
-
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
----
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-----
Y
G
-
K
N
E
--
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
--------
K
Y
S
--
S
--
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
54.60
43%
-120
- C2 -
2YCR
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
K
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
54.54
43%
-124
- C2 -
4BDJ
1
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
---------------------------------N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
54.25
43%
-119
- C2 -
2WTC
1
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
54.13
43%
-121
- C2 -
2YIQ
1
CHK2_HUMAN
A:
[7-278]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
----------------------------------
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
53.70
43%
-119
- C2 -
4BDK
4
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
-
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
53.59
48%
-105
- C2 -
2JAM
3
KCC1G_HUMAN
B:
[13-289]
---------------------------------------------
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-----
K
----
K
----
S
---------------------------
S
-
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
---
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
-
Q
N
-
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-----
Y
E
E
T
E
S
--
K
--
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
--------
G
N
T
--
A
----
L
-----
H
--
R
-
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
53.22
43%
-121
- C2 -
2WTJ
5
CHK2_HUMAN
A:
[13-284]
----------------------------------------
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-----
S
----
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
---
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
E
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-----
S
E
H
R
T
Q
--
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
--------
D
E
D
--
M
--
K
R
K
-----
F
--
Q
-
D
---
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
51.63
40%
-100
- C2 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
---------------------------------------
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSRRG-
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
50.80
40%
-112
- C2 -
3ZXT
1
DAPK1_HUMAN
C:
[6-276]
--------------------------------------
Q
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RTKSSRRG
V
-------
S
--------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-------------
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
48.10
40%
-106
- C2 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
---------------------------------------
E
N
V
-
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----
K
----
K
----
R
RT-----------------------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
-
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
--------------
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-----
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------