@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KGP2_HUMAN: (2015-10-10 )
MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
Atome Classification :
(89 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.-......210.......220.......230.......240-.......250.......260.......---270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430....------...440.......450------.......460.......470.---.---.....480.......490..---......500...-...-.510.......520.......530.......540.......550.......560.......-570.......580......----.590.......600-....---....610.......620.....-..630.......640.......650--...-....660.......670.----......680........690.......-700.......710.......720.......730.......740.......750.......760
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGNGSVKPKHSKHPDGHSGNL
T
T
D
A
L
R
N
K
V
T
E
L
E
R
E
L
R
RKDA
E
I
Q
E
R
E
Y
H
L
K
E
L
R
E
Q
L
S
KQ
T
V
A
I
A
E
L
T
E
E
L
Q
N
K
C
I
Q
L
N
K
L
Q
D
V
V
HMQGGSPLQASPDKV
P
L
E
V
HRKTS
G
L
V
S
L
H
SRRGAKAGVSAEPTTRTYDLNKPPEFS
F
E
K
A
R
VRKDSSEK
K
L
I
T
D
AL
N
K
N
Q
F
L
K
RL
D
P
Q
Q
I
K
D
M
V
E
C
M
YGRNYQQG
S
Y
I
I
KQGEPG
N
-
H
I
F
V
L
AEG
R
L
E
V
FQ
G
E
K
L
L
S
SIPM
W
T
TFG
E
L
A
I
L
Y
NCTR-T
A
S
V
K
A
I
T
NV
K
T
W
AL
D
R
E
V
F
Q
N
I
M
R
R
T
---
A
Q
A
R
D
E
Q
Y
R
N
F
L
R
S
V
S
L
L
K
NL
P
E
D
K
L
T
K
I
I
D
C
L
E
V
E
Y
YDKG
D
Y
I
I
R
EGEEG
S
T
F
F
I
L
AK
G
K
V
K
V
T
QSTEGH
D
Q
P
Q
L
I
K
T
L
Q
KGEYFGEKALISDDVRSAN
I
I
AEEN
D
V
A
C
L
V
I
D
R
E
T
F
N
Q
T
VG
T
F
E
E
L
Q
K
Y
L
E
G
Y
V
A
NLN
R
D
D
E
K
R
H
A
K
RSMSNWKL
S
K
A
L
S
L
E
M
I
Q
------
L
K
E
K
V
A
R
FSSSSPFQ
N
------
L
E
I
I
A
T
LGVGGF
G
R
V
E
L
V
K
VK---N---E
N
V
A
F
A
M
K
C
I
R
K
K
HIVD-
T
K
---
Q
Q
E
H
V
Y
S
E
K
R
I
L
-
E
E
L
-
C
S
P
F
I
V
K
L
Y
R
T
FKDNK
Y
V
Y
M
L
L
E
A
CL
G
G
E
L
W
S
I
L
R
DRGSFDE
P
T
S
K
F
C
V
A
C
V
T
E
A
F
D
Y
L
H
R
-
L
G
I
I
Y
RDLKPE
N
L
I
LDAEG----
Y
L
K
L
V
D
F
G
F
A
K
K-I-GSGQ---
K
T
W
T
F
CGTPEYV
A
P
E
V
ILNKGH-DFS
V
D
F
W
S
L
G
I
L
V
Y
E
L
LTGNPPF
S
G
--
V
D
Q
-
M
M
T
Y
N
L
I
L
K
G
I
E
KMDF
P
R
----
K
I
TR
R
P
E
-
D
L
I
R
R
L
C
RQ
N
P
T
E
R
L
G
N
L
K
-
N
G
I
N
D
I
K
K
H
RWLNGFNWEGLKARSL
P
S
P
L
Q
R
E
LKGPID
H
S
Y
F
DKYPPEKGM
P
P
D
ELSGWDKDF
2
PsiBlast_PDB
81.73
30%
-104
- C3 -
4RZ7
1
?
A:
[277-816]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
M
T
E
A
L
Q
Q
S
E
I
F
R
Q
F
S
A
E
Q
L
N
D
L
A
D
T
A
I
V
R
D
Y
P
A
N
Y
H
I
L
H
K
D
K
V
K
S
V
K
Y
L
I
V
L
E
G
K
V
E
L
F
L
D
D
E
S
I
G
I
L
T
R
G
K
S
F
G
D
Q
Y
V
L
N
Q
K
Q
K
F
R
H
T
V
K
S
L
D
V
C
K
I
A
L
I
T
E
S
C
L
A
D
C
L
G
D
N
N
I
D
A
S
I
D
H
N
N
K
K
S
I
I
K
K
M
Y
I
F
R
Y
L
S
E
Q
Q
C
N
L
L
I
E
A
F
R
T
T
R
Y
E
E
G
D
Y
I
I
Q
E
G
E
V
G
S
R
F
Y
I
I
K
N
G
E
V
E
V
T
K
N
------
G
K
R
L
R
T
L
G
K
N
D
Y
F
G
E
R
A
L
L
Y
D
E
P
R
T
A
S
I
I
S
K
A
T
S
V
E
C
--------------------------------------------
W
F
V
D
K
S
V
F
L
Q
I
I
Q
G
P
M
L
T
H
L
E
E
R
I
K
M
Q
D
T
K
V
E
M
H
E
------
L
E
T
E
R
I
I
G
R
G
--
G
T
V
K
L
V
H
H
K
---
P
---
T
Q
I
R
Y
A
L
K
C
V
S
K
R
S
I
I
--------
Q
N
N
I
K
L
E
R
E
I
T
-
A
E
N
-
D
H
P
F
I
I
R
L
V
R
T
F
K
D
S
N
C
F
Y
F
L
T
E
L
V
T
G
G
E
L
Y
D
A
I
R
K
L
G
L
L
S
K
P
Q
A
Q
F
Y
L
G
S
I
I
L
A
I
E
Y
L
H
E
-
R
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
K
Q
G
----
Y
V
K
L
I
D
F
G
C
A
K
K
-
I
-
Q
G
-----
R
A
Y
T
L
V
G
T
P
H
Y
M
A
P
E
V
I
L
G
K
G
Y
-
G
C
T
V
D
I
W
A
L
G
V
C
L
Y
E
F
I
C
G
P
L
P
F
G
N
DQ
E
D
Q
-
L
E
I
F
R
D
I
L
T
G
--
Q
L
T
F
P
D
----
Y
V
S
D
Q
D
S
I
N
L
M
K
R
L
L
C
R
L
P
Q
G
R
I
G
C
S
I
-
N
G
F
K
D
I
K
E
H
A
F
F
G
N
F
N
W
D
K
L
A
G
R
L
L
E
P
P
L
V
S
--
K
G
E
T
Y
-------------------------
3
PsiBlast_PDB
81.54
30%
-109
- C3 -
4OXJ
1
?
A:
[277-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
M
T
E
A
L
Q
Q
S
E
I
F
R
Q
F
S
A
E
Q
L
N
D
L
A
D
T
A
I
V
R
D
Y
P
A
N
Y
H
I
L
H
K
---
K
S
V
K
Y
L
I
V
L
E
G
K
V
E
L
F
L
D
D
E
S
I
G
I
L
T
R
G
K
S
F
G
D
Q
Y
V
L
N
Q
K
Q
K
F
R
H
T
V
K
S
L
D
V
C
K
I
A
L
I
T
E
S
C
L
A
D
C
L
G
D
N
N
I
D
A
S
I
D
H
N
N
K
K
S
I
I
K
K
M
Y
I
F
R
Y
L
S
E
Q
Q
C
N
L
L
I
E
A
F
R
T
T
R
Y
E
E
G
D
Y
I
I
Q
E
G
E
V
G
S
R
F
Y
I
I
K
N
G
E
V
E
V
T
K
N
------
G
K
R
L
R
T
L
G
K
N
D
Y
F
G
E
R
A
L
L
Y
D
E
P
R
T
A
S
I
I
S
K
A
T
S
V
E
C
--------------------------------------------
W
F
V
D
K
S
V
F
L
Q
I
I
Q
G
P
M
L
T
H
L
E
E
R
I
K
M
Q
D
T
K
V
E
M
H
E
------
L
E
T
E
R
I
I
G
R
G
--
G
T
V
K
L
V
H
H
K
---
P
---
T
Q
I
R
Y
A
L
K
C
V
S
K
R
S
I
I
S
-
L
N
---
Q
Q
N
N
I
K
L
E
R
E
I
T
-
A
E
N
-
D
H
P
F
I
I
R
L
V
R
T
F
K
D
--
C
F
Y
F
L
T
E
L
V
T
G
G
E
L
Y
D
A
I
R
K
L
G
L
L
S
K
P
Q
A
Q
F
Y
L
G
S
I
I
L
A
I
E
Y
L
H
E
-
R
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
K
Q
G
----
Y
V
K
L
I
D
F
G
C
A
K
K
-
I
-
Q
G
-----
R
A
Y
T
L
V
G
T
P
H
Y
M
A
P
E
V
I
L
G
K
G
Y
-
G
C
T
V
D
I
W
A
L
G
V
C
L
Y
E
F
I
C
G
P
L
P
F
G
N
DQ
E
D
Q
-
L
E
I
F
R
D
I
L
T
G
--
Q
L
T
F
P
D
----
Y
V
S
D
Q
D
S
I
N
L
M
K
R
L
L
C
R
L
P
Q
G
R
I
G
C
S
I
-
N
G
F
K
D
I
K
E
H
A
F
F
G
N
F
N
W
D
K
L
A
G
R
L
L
E
P
P
L
V
S
--
K
G
E
T
Y
A
------------------------
84
PsiBlast_CBE
69.50
45%
-100
- C3 -
1SVG
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
59
PsiBlast_CBE
69.37
45%
-101
- C3 -
4NTT
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
98
PsiBlast_CBE
69.12
45%
-98
- C3 -
1XH5
3
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
31
PsiBlast_CBE
69.04
45%
-100
- C3 -
2UZT
1
KAPCA_BOVIN
A:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
36
PsiBlast_CBE
68.93
45%
-101
- C3 -
2ERZ
1
KAPCA_MOUSE
E:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
92
PsiBlast_CBE
68.88
45%
-102
- C3 -
2C1B
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
43
PsiBlast_CBE
68.84
45%
-97
- C3 -
3OW3
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
97
PsiBlast_CBE
68.80
45%
-100
- C3 -
1XH6
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
24
PsiBlast_CBE
68.77
45%
-103
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
22
PsiBlast_CBE
68.70
45%
-100
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
33
PsiBlast_CBE
68.68
46%
-96
- C3 -
3L9L
1
KAPCA_HUMAN
B:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
13
PsiBlast_PDB
68.64
46%
-98
- C3 -
3OVV
2
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
9
PsiBlast_PDB
68.56
45%
-96
- C3 -
1JBP
2
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
E
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
89
PsiBlast_CBE
68.54
45%
-99
- C3 -
4IE9
2
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
85
PsiBlast_CBE
68.53
45%
-95
- C3 -
1SVE
2
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
16
PsiBlast_PDB
68.48
46%
-97
- C3 -
3P0M
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
8
PsiBlast_PDB
68.41
46%
-97
- C3 -
3VQH
2
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
69
PsiBlast_CBE
68.35
45%
-96
- C3 -
1Q24
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
12
PsiBlast_PDB
68.35
46%
-100
- C3 -
3OOG
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
15
PsiBlast_PDB
68.25
46%
-97
- C3 -
3OXT
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
67
PsiBlast_CBE
68.24
45%
-96
- C3 -
2GNJ
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
K
V
A
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
50
PsiBlast_CBE
68.20
45%
-97
- C3 -
1RE8
2
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
117
HHSearch
68.16
46%
-97
* C3 *
1RDQ
3
KAPCA_MOUSE
E:
[37-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
--
G
---
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
27
PsiBlast_CBE
68.02
46%
-97
- C3 -
3L9M
1
KAPCA_HUMAN
B:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
25
PsiBlast_CBE
67.95
45%
-98
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
104
PsiBlast_CBE
67.94
45%
-99
- C3 -
2JDV
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
94
PsiBlast_CBE
67.91
45%
-98
- C3 -
4IJ9
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
90
PsiBlast_CBE
67.86
45%
-99
- C3 -
3ZO4
4
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
52
PsiBlast_CBE
67.84
45%
-98
- C3 -
1FMO
1
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
49
PsiBlast_CBE
67.82
45%
-97
- C3 -
1REJ
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
14
PsiBlast_PDB
67.81
46%
-96
- C3 -
3OWP
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
70
PsiBlast_CBE
67.72
45%
-98
- C3 -
3QAL
1
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
A
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
47
PsiBlast_CBE
67.71
45%
-100
- C3 -
3FJQ
1
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
53
PsiBlast_CBE
67.69
45%
-96
- C3 -
1ATP
1
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
17
PsiBlast_PDB
67.64
46%
-98
- C3 -
3POO
2
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
----
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
58
PsiBlast_CBE
67.60
45%
-106
- C3 -
4NTT
1
KAPCA_MOUSE
B:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
41
PsiBlast_CBE
67.52
45%
-97
- C3 -
4HPT
1
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
6
PsiBlast_PDB
67.48
46%
-100
- C3 -
3L9N
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
---
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
55
PsiBlast_CBE
67.40
45%
-97
- C3 -
1CDK
2
KAPCA_PIG
B:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
100
PsiBlast_CBE
67.34
45%
-98
- C3 -
4AXA
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
23
PsiBlast_CBE
67.30
45%
-99
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
11
PsiBlast_PDB
67.23
46%
-96
- C3 -
3L9L
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
99
PsiBlast_CBE
67.21
45%
-97
- C3 -
1SVH
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
88
PsiBlast_CBE
67.21
45%
-95
- C3 -
1Q8T
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
40
PsiBlast_CBE
67.08
45%
-98
- C3 -
1BKX
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
83
PsiBlast_CBE
67.07
45%
-98
- C3 -
1VEB
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
93
PsiBlast_CBE
67.05
45%
-100
- C3 -
2C1A
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
91
PsiBlast_CBE
67.05
45%
-103
- C3 -
2VO7
2
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
10
PsiBlast_PDB
67.04
46%
-96
- C3 -
3AGM
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
56
PsiBlast_CBE
67.01
45%
-98
- C3 -
1CDK
2
KAPCA_PIG
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
64
PsiBlast_CBE
66.99
45%
-96
- C3 -
2GU8
1
KAPCA_HUMAN
A:
[23-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
5
PsiBlast_PDB
66.95
46%
-98
- C3 -
3L9M
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
26
PsiBlast_CBE
66.94
45%
-99
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
46
PsiBlast_CBE
66.88
45%
-99
- C3 -
3IDB
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
102
PsiBlast_CBE
66.71
45%
-97
- C3 -
2UW4
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
28
PsiBlast_CBE
66.71
45%
-95
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
87
PsiBlast_CBE
66.64
45%
-96
- C3 -
1Q8U
3
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
38
PsiBlast_CBE
66.61
46%
-93
- C3 -
3MVJ
1
KAPCA_HUMAN
A:
[53-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
66
PsiBlast_CBE
66.54
45%
-96
- C3 -
2GNL
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
K
V
A
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
37
PsiBlast_CBE
66.53
46%
-98
- C3 -
3MVJ
1
KAPCA_HUMAN
E:
[53-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
101
PsiBlast_CBE
66.50
45%
-94
- C3 -
2UW7
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
35
PsiBlast_CBE
66.49
46%
-95
- C3 -
3AMA
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
K
V
A
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
65
PsiBlast_CBE
66.48
45%
-95
- C3 -
3QAM
1
KAPCA_MOUSE
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
32
PsiBlast_CBE
66.38
46%
-97
- C3 -
3AGL
1
KAPCA_HUMAN
B:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
30
PsiBlast_CBE
66.20
45%
-93
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
42
PsiBlast_CBE
65.92
45%
-94
- C3 -
4DIN
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
7
PsiBlast_PDB
65.88
46%
-94
- C3 -
3AGL
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
LDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
103
PsiBlast_CBE
65.81
45%
-95
- C3 -
2UVX
1
KAPCA_BOVIN
A:
[37-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
----
Y
I
K
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
96
PsiBlast_CBE
65.79
45%
-97
- C3 -
1XH8
1
KAPCA_BOVIN
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
86
PsiBlast_CBE
65.66
45%
-99
- C3 -
1STC
1
KAPCA_BOVIN
E:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
20
PsiBlast_PDB
65.34
45%
-98
- C3 -
3O7L
2
KAPCA_MOUSE
B:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
---
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
C
G
K
E
F
T
E
F
--
121
HHSearch
65.32
37%
-106
- C3 -
2R5T
1
SGK1_HUMAN
A:
[35-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
S
D
------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-----------------
V
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
---
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
-
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
--
R
N
T
-
A
E
M
Y
D
N
I
L
N
K
--
P
L
Q
L
K
P
----
N
I
T
N
S
A
R
-
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
----------------------------
34
PsiBlast_CBE
65.26
46%
-95
- C3 -
3AMB
1
KAPCA_HUMAN
A:
[33-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
K
V
A
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
45
PsiBlast_CBE
65.04
45%
-98
- C3 -
3IDC
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
48
PsiBlast_CBE
64.93
45%
-98
- C3 -
1REK
2
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
39
PsiBlast_CBE
64.52
45%
-93
- C3 -
1BX6
1
KAPCA_MOUSE
A:
[36-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
------
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
29
PsiBlast_CBE
63.98
45%
-96
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
116
HHSearch
63.04
35%
-102
- C3 -
4GV1
5
AKT1_HUMAN
A:
[3-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
------
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
-
G
I
K
D
G
A
---
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
--
Q
D
H
-
E
K
L
F
E
L
I
L
M
E
--
E
I
R
F
P
R
----
T
L
G
P
E
A
K
-
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
S
M
E
C
V
D
S
E
131
HHSearch
61.37
41%
-85
- C3 -
3WF7
2
KS6B1_HUMAN
A:
[13-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
-
S
I
H
D
------
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
-
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
--
E
N
R
-
K
K
T
I
D
K
I
L
K
C
--
K
L
N
L
P
P
----
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-----------------------------
143
HHSearch
59.42
31%
-109
- C3 -
4BKY
1
MELK_HUMAN
A:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
Y
------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
---
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--------
D
L
P
R
I
K
T
E
I
E
A
L
-
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
--
K
Y
D
V
P
K
----
W
L
S
P
S
S
I
-
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
------
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
141
HHSearch
58.59
40%
-93
- C3 -
3UBD
1
KS6A3_MOUSE
A:
[20-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
-
V
R
---
D
R
V
------
D
I
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------
K
---
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
-
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
--
K
D
R
-
K
E
T
M
T
M
I
L
K
A
--
K
L
G
M
P
Q
----
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------
124
HHSearch
58.56
35%
-95
- C3 -
3TXO
1
A:
[23-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
------
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
---
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
D
---
D
V
E
C
T
M
T
E
K
R
I
L
-
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
----
H
C
K
L
A
D
F
G
M
C
K
E
-
G
I
C
------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
-
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
--
E
N
E
-
D
D
L
F
E
A
I
L
N
D
--
E
V
V
Y
P
T
----
W
L
H
E
D
A
T
-
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
137
HHSearch
54.60
30%
-95
- C3 -
2Y0A
1
DAPK1_HUMAN
A:
[12-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
---
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-
S
R
RGV
S
R
E
D
I
E
R
E
V
S
I
L
-
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
-
D
F
G
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
E
F
E
D
EYFS
N
T
S
A
L
A
K
-
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
------
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------
147
HHSearch
49.40
32%
-90
- C3 -
2YEX
8
CHK1_HUMAN
A:
[7-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
---
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
------
C
P
E
N
I
K
K
E
I
C
I
N
-
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
-
F
-
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
--
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
----
K
I
D
S
A
P
L
-
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
------
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
----------------------------------------------
61
PsiBlast_CBE
40.30
46%
-43
- C3 -
4WB6
1
KAPCA_HUMAN
B:
[32-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
19
PsiBlast_PDB
35.36
46%
-30
- C3 -
4WB5
1
KAPCA_HUMAN
A:
[32-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
18
PsiBlast_PDB
34.96
46%
-29
- C3 -
4WB7
1
DNJB1_HUMAN (first)
A:
[87-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
TAHLDQ
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
--
K
V
R
F
P
S
----
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S