@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KKCC1_HUMAN: (2015-10-10 )
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLVKEGFGEGGKSPELPGVQEDEAAS
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...-....210.......220.......230.......-240---..----------------.-----------------....--------..250.......260.......270.......280.---.---.---.---..---.290.......300----.--......310.......320.......330.......340.......350......-.360.......370--.--..--....380.......390.......400........410.......420.......430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEGGP
A
V
CCQD
P
R
A
E
L
V
E
R
V
A
A
I
D
V
T
H
LEEADGGPEPTRNGVDPPPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIES
H
H
V
AISD
A
E
D
C
V
Q
L
N
Q
Y
K
L
Q
S
E
IGKGA
Y
G
V
V
R
L
A
YNESE
D
R
H
Y
A
M
K
V
L
S
K
K
K
L
L
K
QYGFPRRPPPRGSQAAQGG
P
A
KQLL
P
L
E
R
V
Y
Q
E
I
A
I
L
K
K
-LD
H
V
N
V
V
K
L
I
E
V
LDDPAEDN
L
Y
L
V
F
D
L
L
RKG
P
V
M
-E-----VP----------------C-----------------DKPF--------
S
E
E
Q
A
R
L
Y
L
R
D
V
I
L
G
L
E
Y
L
H
C
Q
K
I
V
H
RDIKPS
N
L
L
L---G---D---D---G
H
---
V
K
I
A
DFGVSNQFEG----N--DAQLSSTAGTPAFMA
P
E
AISDSGQSFSG
K
A
L
D
V
W
AT
G
V
T
L
Y
C
F
V
YGKCP
F
I
D
D
F
I
-
L
A
L
H
R
K
IKNEPVVF--P--EE--P
E
I
S
E
E
L
K
D
L
I
L
K
M
LDKNPETRIGVP-DIKLHPWVTKNGEEPLPS
E
E
EHCS
V
V
EV
T
E
E
E
V
K
N
S
V
R
LIP
S
W
T
T
V
I
L
V
K
S
M
L
R
KRSFGNPFE
P
Q
A
R
R
E
ERSMSAPG
N
L
L
V
KEGFGEGGKSPELPGVQEDEAAS
82
HHSearch
92.63
70%
-111
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
--------------------------------------------------------------------------------------------------------------------------
V
Q
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-------------------------------
E
Q
V
Y
Q
E
I
A
I
L
K
K
-
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
-
E
-----
V
P
----------------
T
-----------------
L
K
P
L
--------
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
---
E
---
D
---
G
H
---
I
K
I
A
D
F
G
V
S
N
E
F
K
G
----
S
--
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
--
D
Q
--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
-
E
I
K
L
H
P
W
V
T
R
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.63
70%
-111
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
--------------------------------------------------------------------------------------------------------------------------
V
Q
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-------------------------------
E
Q
V
Y
Q
E
I
A
I
L
K
K
-
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
-
E
-----
V
P
----------------
T
-----------------
L
K
P
L
--------
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
---
E
---
D
---
G
H
---
I
K
I
A
D
F
G
V
S
N
E
F
K
G
----
S
--
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
--
D
Q
--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
-
E
I
K
L
H
P
W
V
T
R
----------------------------------------------------------------------------------------------
85
HHSearch
68.61
32%
-103
- C1 -
3HKO
2
?
A:
[26-338]
-----------------------------------------------------------------------------------------------------------------------------
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
------------------------
K
D
V
E
R
I
K
T
E
V
R
L
M
K
K
-
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
-
D
-----
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
TQICPC
P
E
C
N
E
E
A
I
N
G
S
I
--
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
---
S
---
T
---
N
KS-
F
E
---
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
LNNG----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
N
E
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
-
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
--
E
NP
N
Y
--
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
-
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
-------------------------------------------------------------------------------------
26
PsiBlast_CBE
68.20
32%
-100
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
---------------------
S
A
R
D
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
-
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
----------------
A
-----------------
R
E
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
---
K
CKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
----
D
--
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
---
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
--
E
W
--
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
-
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-------------------------------------------------------------------
25
PsiBlast_CBE
66.19
32%
-101
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
---------------------
S
A
R
D
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
-
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D----
I
V
----------------
A
-----------------
R
E
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
---
K
CKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
----
D
--
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
---
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
--
E
W
--
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
-
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-------------------------------------------------------------------
23
PsiBlast_CBE
63.68
33%
-98
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---------------------
S
A
R
D
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D----
I
V
----------------
A
-----------------
R
E
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
---
K
---
S
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
----
D
--
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
---
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
--
P
SP
E
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
-
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
-----------------------------------------------------------
24
PsiBlast_CBE
63.55
33%
-98
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---------------------
S
A
R
D
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
----------------
A
-----------------
R
E
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
---
K
---
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
----
D
--
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
---
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
--
P
SP
E
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
-
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
-----------------------------------------------------------
28
PsiBlast_CBE
62.35
33%
-96
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[31-293]
-----------------------------------------------------------------------------------------------------------------------------
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---------------------
S
A
R
D
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
----------------
A
-----------------
R
E
Y
Y
--------
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
---
K
CKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
----
E
--
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
---
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
--
E
W
--
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
-
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
------------------------------------------------------------------
92
HHSearch
61.06
32%
-97
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-293]
--------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
---------------------
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
-
F
E
I
V
K
R
A
D
----------------
A
-----------------
G
F
V
Y
--------
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
---
S
---
K
ENS
A
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
----
S
--
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
--
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
--
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
--
N
--
P
R
QW
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
-
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
---------------------------------------------------------------------
89
HHSearch
60.04
32%
-96
- C1 -
1XJD
1
A:
[16-275]
----------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-----------------------
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
--
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
-
Y
-----
H
I
Q
---------------
S
-----------------
C
H
K
F
--------
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
---
D
---
K
---
D
---
G
H
---
I
K
I
A
D
F
G
M
C
K
E
N
M
L
----
G
--
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
--
K
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
-
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
--
P
--
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
------------------------------------------------------------------------
22
PsiBlast_CBE
60.04
33%
-100
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---------------------
S
A
R
D
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
----------------
A
-----------------
R
E
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
---
K
---
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
----
D
--
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
---
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
--
P
SP
E
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
-
E
A
L
K
H
P
W
I
C
Q
R
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
--------------------------------------------------------
66
PsiBlast_CBE
58.91
31%
-97
- C1 -
2WEI
1
?
A:
[23-286]
------------------------------------------------------------------------------------------------------------------------------
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
------------------
A
S
A
K
N
K
D
T
S
T
I
L
------
R
E
V
E
L
L
K
K
-
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
--
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
-----
I
I
----------------
K
-----------------
R
K
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
E
---
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
----
N
---
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
-
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
DL
P
--
Q
W
--
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
------------------------------------------------------------------------------------------
55
PsiBlast_CBE
55.99
31%
-108
- C1 -
2YIR
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
-------------------------------------------------------------------------
48
PsiBlast_CBE
55.72
31%
-106
- C1 -
2WTI
3
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
----------------------------------------------------------------------
58
PsiBlast_CBE
55.07
31%
-106
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
------------------------------------------------------------------------
46
PsiBlast_CBE
54.91
31%
-105
- C1 -
2XM9
1
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
----------------------------------------------------------------------
49
PsiBlast_CBE
54.84
31%
-109
- C1 -
2WTD
4
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
----------------------------------------------------------------------
21
PsiBlast_CBE
54.76
33%
-94
- C1 -
3MA6
1
?
B:
[32-295]
-----------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-----------------------
K
Q
-
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
--
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
-----
I
I
----------------
S
-----------------
R
K
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
---
K
---
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
----
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
--
Q
W
--
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
Q
T
Y
T
--------------------------------------------------------------------------------------------
53
PsiBlast_CBE
54.64
31%
-109
- C1 -
2YCR
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
------------------------------------------------------------------------
40
PsiBlast_CBE
54.38
31%
-112
- C1 -
4BDB
10
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
---------------------------------------------------------------------
20
PsiBlast_PDB
54.33
33%
-96
- C1 -
3MA6
1
?
A:
[32-296]
-----------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-----------------------
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
--
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
-----
I
I
----------------
S
-----------------
R
K
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
---
K
---
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
-----
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
--
Q
W
--
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
Q
T
Y
T
K
-------------------------------------------------------------------------------------------
52
PsiBlast_CBE
53.99
31%
-108
- C1 -
2CN5
1
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
--------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
------------------------------------------------------------------------------
38
PsiBlast_CBE
53.87
31%
-112
- C1 -
4BDD
3
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
----------------------------------------------------------------------
31
PsiBlast_CBE
53.83
31%
-108
- C1 -
4BDK
4
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
---------------------------------------------------------------------
56
PsiBlast_CBE
53.57
31%
-108
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
------------------------------------------------------------------------
59
PsiBlast_CBE
53.54
31%
-108
- C1 -
2W0J
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
T
A
L
P
Q
-------------------------------------------------------------------------
57
PsiBlast_CBE
53.51
31%
-110
- C1 -
2YCS
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
------------------------------------------------------------------------
37
PsiBlast_CBE
53.50
31%
-111
- C1 -
4BDE
5
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
---------------------------------------------------------------------
41
PsiBlast_CBE
52.79
31%
-111
- C1 -
4BDA
8
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
----------------------------------------------------------------------
50
PsiBlast_CBE
52.49
31%
-108
- C1 -
2WTC
1
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
----------------------------------------------------------------------
34
PsiBlast_CBE
52.22
31%
-111
- C1 -
4BDH
4
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
G
----
E
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
---------------------------------------------------------------------
87
HHSearch
49.83
31%
-86
- C1 -
2YEX
8
CHK1_HUMAN
A:
[6-268]
----------------------------------------------------------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-------------------------
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
-
D
-----
R
I
----------------
E
P----------------
D
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
---
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
--
P
W
--
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------
51
PsiBlast_CBE
48.42
31%
-101
- C1 -
2CN8
1
CHK2_HUMAN
A:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
----------------
G
-----------------
N
K
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
---
D
---
C
L
---
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
--
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
-
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
-------------------------------------------------------------------------------