@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KKCC2_HUMAN: (2015-10-10 )
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160-.......170---.........180.......190.......200.......210.......220.......230.......-240-.......250.......260.......270....-.-----..---------------------------------280.--------.--.....290.......300.......310.......---320--..---.--.....330...--...----.--340.......350.......360.......370.......380.......390...-.-...400.......--410-.--.......420.......430...-----...----.440....-----...450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSCVSSQPSSNRAAP
Q
D
ELGGRGSSSSESQ
K
P
C
E
A
L
R
G
L
S
S
L
S
I
H
LG
M
E
S
F
I
V
V
TECEPG
C
A
V
DLGLARDRPLEADGQEVPLDTSGSQARPHLSG
R
K
L
S
L
Q
ERSQGGLAAGGSLDMNG
R
C
ICPSLPYSPVSSPQSSPRLPRRPTVESH
H
V
S
IT
G
M
Q
D
C
V
Q
L
-NQY
T
L
K
DE-----IGKGS
Y
G
V
V
K
L
A
YNEND
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
QAGFPRRPPPRGTRPAPGGCIQPRG
P
I
E
Q
V
Y
Q
E
I
A
I
-
L
K
K-LDH
P
N
V
V
K
L
V
E
V
LDDPNEDH
L
Y
M
V
F
E
L
VNQGPVM-E-----VP---------------------------------TLKP--------L--
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
RDIKPS
N
L
L
---VG---ED---G--
H
I
K
I
A
D
FGVSN--EFK----G--S
D
A
L
L
SNTVGTPAFMA
P
E
S
L
S
E
T
R
K
I
FSGKA
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
FGQCPFM
D
E
R
I
-
M
-
C
L
H
S
K
I
K
S
Q
A
LEF--PD--Q--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
LDKNPES
R
I
-----
V
V
P
----E
I
K
LH
P
W
V-----TRHGAEPLPSEDEN
C
T
L
V
E
V
T
E
E
E
V
E
N
S
V
K
H
I
P
S
L
A
T
V
I
L
V
K
T
M
I
R
KRSFGNPFEGSRREERSLSAPGNLLTKK
P
T
R
E
C
E
S
L
S
E
L
K
E
A
R
Q
RRQPPGHRPAPRGGGGS
A
L
VRGS
P
C
V
E
SCWAPAPGSPARMHPLR
P
E
EAMEPE
85
HHSearch
87.78
100%
-116
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
-
N
Q
Y
T
L
K
D
E
-----
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-------------------------------
E
Q
V
Y
Q
E
I
A
I
-
L
K
K
-
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
-
E
-----
V
P
---------------------------------
T
L
K
P
--------
L
--
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
G
---
E
D
---
G
--
H
I
K
I
A
D
F
G
V
S
N
--
E
F
K
----
G
--
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
-
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
D
--
Q
--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
----
E
I
K
L
H
P
W
V
-----
T
R
--------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.78
100%
-116
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
-
N
Q
Y
T
L
K
D
E
-----
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-------------------------------
E
Q
V
Y
Q
E
I
A
I
-
L
K
K
-
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
-
E
-----
V
P
---------------------------------
T
L
K
P
--------
L
--
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
G
---
E
D
---
G
--
H
I
K
I
A
D
F
G
V
S
N
--
E
F
K
----
G
--
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
-
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
D
--
Q
--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
----
E
I
K
L
H
P
W
V
-----
T
R
--------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.25
32%
-100
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
-----
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
------------------------
Q
K
L
E
R
E
A
R
I
-
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
---------------------------------
A
R
E
Y
--------
Y
--
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
SKS
K
G
---
A
--
A
V
K
L
A
D
F
G
L
A
I
--
E
V
Q
----
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
E
--
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
----
E
A
L
K
H
P
W
I
-----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
---------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.59
31%
-99
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[23-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
-----
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
------------------------
Q
K
L
E
R
E
A
R
I
-
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
---------------------------------
A
R
E
Y
--------
Y
--
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
SKC
K
G
---
A
--
A
V
K
L
A
D
F
G
L
A
I
--
E
V
Q
----
G
--
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
--
W
--
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
D
----
Q
A
L
K
H
P
W
V
-----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
----------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
61.20
32%
-99
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
-----
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
------------------------
Q
K
L
E
R
E
A
R
I
-
C
R
L
-
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D----
I
V
---------------------------------
A
R
E
Y
--------
Y
--
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
SKS
K
G
---
A
--
A
V
K
L
A
D
F
G
L
A
I
--
E
V
Q
----
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
E
--
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
----
E
A
L
K
H
P
W
I
-----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
---------------------------------------------------------------------------------------------------------
101
HHSearch
60.54
36%
-102
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[38-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
-
D
Q
F
D
R
I
K
T
-----
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-----------------------
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
--
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
-
S
-----
H
L
R--------------------------------
R
I
G
R
--------
F
--
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
Q
---
G
--
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
K
----
G
--
R
T
---
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
--
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
--
P
S
------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
----
D
I
K
N
H
K
W
F
-----
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
-----------------------------------------------------------------------------------------
3
PsiBlast_PDB
58.82
31%
-87
- C1 -
4CZT
3
CIPKN_ARATH
A:
[8-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
-
G
K
Y
E
L
G
R
T
-----
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----------------------
M
I
A
Q
I
K
R
E
I
S
T
-
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
-
D
K
----
I
S
---------------------------------
S
N
G
R
--------
L
--
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
---
A
N
---
G
--
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
----
R
--
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
--
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
-
S
L
Y
K
K
I
F
K
A
--
E
F
--
T
C
--
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
----
E
V
I
E
N
E
W
F
------
K
K
G
Y
K
A
P
K
F
E
N
--
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
----------------------------------------------------------------------------------------------------------------
87
HHSearch
58.58
32%
-105
- C1 -
3HKO
2
?
A:
[26-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
H
L
K
G
A
-----
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
------------------------
K
D
V
E
R
I
K
T
E
V
R
L
-
M
K
K
-
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
-
D
-----
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
S
I
--F
R
E
S
L
D
F
V
Q
--
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
---
F
S
---
T
N
---
K
SF
E
I
K
L
V
D
F
G
L
S
K
--
E
F
Y
KLNN
G
----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
N
E
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
-
A
-
D
T
I
S
Q
V
L
N
K
K
L
C
F
--
E
N
PN
Y
--
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
-----
D
A
M
----
R
A
L
Q
H
P
W
I
-----
S
Q
F
S
D
K
I
Y
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
57.67
32%
-104
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
-
D
V
Y
E
L
C
E
V
-----
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
---------------------
L
S
T
E
D
L
K
R
E
A
S
I
-
C
H
M
-
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
-
F
E
I
V
K
R
A
D
---------------------------------
A
G
F
V
--------
Y
--
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
---
L
A
---
S
K
ENS
A
--
P
V
K
L
G
G
F
G
V
A
I
--
Q
L
G
----
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
--
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
---
R
L
F
E
G
I
I
K
G
K
Y
K
M
--
N
P
--
R
QW
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
----
E
A
L
N
H
P
W
L
-----
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
57.26
31%
-84
- C1 -
4CZU
3
CIPKN_ARATH
D:
[8-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
-
G
K
Y
E
L
G
R
T
-----
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----------------------
M
I
A
Q
I
K
R
E
I
S
T
-
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
-
D
K----
I
S
---------------------------------
S
N
G
R
--------
L
--
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
---
A
N
---
G
--
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
----
R
--
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
--
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
-
S
L
Y
K
K
I
F
K
A
--
E
F
--
T
C
--
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
----
E
V
I
E
N
E
W
F
------
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
-----------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
56.93
31%
-110
- C1 -
4PRJ
1
AURKA_HUMAN
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
EIGRP
L
G
K
G
---
N
V
Y
L
A
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
-----------------------
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
--
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
-----
L
Q
---------------------------------
K
L
S
K
--------
F
--
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
A
---
G
--
E
L
K
I
A
D
F
G
W
S
V
--------------------
C
G
T
L
D
Y
L
P
P
E
M
I
-
E
G
R
--
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
-
Q
-
D
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
----
E
V
L
E
H
P
W
I
-----
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
56.76
31%
-90
- C1 -
4CZT
3
CIPKN_ARATH
C:
[10-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
G
K
Y
E
L
G
R
T
-----
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----------------------
M
I
A
Q
I
K
R
E
I
S
T
-
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
-
D
K
----
I
S
---------------------------------
S
N
G
R
--------
L
--
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
---
A
N
---
G
--
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
----
R
--
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
--
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
-
S
L
Y
K
K
I
F
K
A
--
E
F
--
T
C
--
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
----
E
V
I
E
N
E
W
F
------
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
56.44
31%
-87
- C1 -
4CZT
4
CIPKN_ARATH
D:
[8-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
-
G
K
Y
E
L
G
R
T
-----
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----------------------
M
I
A
Q
I
K
R
E
I
S
T
-
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
-
D
K
----
I
S
---------------------------------
S
N
G
R
--------
L
--
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
---
A
N
---
G
--
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
----
R
--
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
--
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
-
S
L
Y
K
K
I
F
K
A
--
E
F
--
T
C
--
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
----
E
V
I
E
N
E
W
F
------
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
-----------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.73
31%
-97
- C1 -
4A9S
1
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
55.19
32%
-115
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
-----
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----------------------------------
S
M
E
N
E
I
A
V
-
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
--
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
-
D
-----
R
I
---------------------------------
V
E
K
G
--------
F
YT
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
---
E
D
---
S
--
K
I
M
I
S
D
F
G
L
S
---
K
M
E
----
D
--
P
G
--------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
-
A
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
DS
P
Y
--
W
--
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
----
Q
A
L
Q
H
P
W
I
-----
A
---------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.90
31%
-98
- C1 -
2WTD
4
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
54.47
31%
-93
- C1 -
2YCF
1
CHK2_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
54.38
31%
-97
- C1 -
2YCS
1
CHK2_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------
92
HHSearch
54.26
31%
-94
- C1 -
1XJD
1
A:
[16-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
E
D
F
I
L
H
K
M
-----
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-----------------------
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
--
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
-
Y
-----
H
I
Q
--------------------------------
S
C
H
K
--------
F
--
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
---
L
D
---
K
D
---
G
--
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
----
L
--
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
--
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
-
E
-
E
L
F
H
S
I
R
M
D
N
P
F
Y
--
P
R
------
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
R
G---
D
I
R
Q
H
P
L
F
-----
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
----------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
54.19
31%
-92
- C1 -
4A9T
4
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.16
31%
-96
- C1 -
2CN5
1
CHK2_HUMAN
A:
[16-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
--------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
53.97
31%
-112
- C1 -
3COH
1
AURKA_HUMAN
B:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
EIGRP
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
-----------------------
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
--
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
-----
L
Q
---------------------------------
K
L
S
K
--------
F
--
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
A
---
G
--
E
L
K
I
A
D
------------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
-
E
G
R
--
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
-
Q
-
D
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
----
E
V
L
E
H
P
W
I
-----
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
53.81
31%
-100
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[4-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
Y
E
D
-----
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
------
S
A
R
D
H
Q
K
L
E
R
E
A
R
------------------
I
-
C
R
L
-
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D----
I
V
---------------------------------
A
R
E
Y
--------
Y
--
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
SKC
K
G
---
A
--
A
V
K
L
A
D
F
G
L
A
I
--
E
V
Q
----
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
E
--
W
--
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
----
E
A
L
K
H
P
W
V
-----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-----------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
53.80
31%
-97
- C1 -
2CN8
1
CHK2_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
53.68
31%
-97
- C1 -
2W0J
1
CHK2_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
53.65
31%
-113
- C1 -
3COH
1
AURKA_HUMAN
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
EIGRP
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
-----------------------
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
--
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
-----
L
Q
---------------------------------
K
L
S
K
--------
F
--
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
A
---
G
--
E
L
K
I
A
D
------------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
-
E
G
R
--
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
-
Q
-
D
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
----
E
V
L
E
H
P
W
I
-----
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
53.57
31%
-98
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[4-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
Y
E
D
-----
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
------
S
A
R
D
H
Q
K
L
E
R
E
A
R
------------------
I
-
C
R
L
-
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
----
I
V
---------------------------------
A
R
E
Y
--------
Y
--
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
SKC
K
G
---
A
--
A
V
K
L
A
D
F
G
L
A
I
--
E
V
Q
----
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
E
--
W
--
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
----
E
A
L
K
H
P
W
V
-----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-----------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
53.51
31%
-99
- C1 -
4BDD
3
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
103
HHSearch
53.33
30%
-106
- C1 -
2R5T
1
SGK1_HUMAN
A:
[35-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
-
S
D
F
H
F
L
K
V
-----
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
------------------------------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
--
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
-
Y
-----
H
L
Q
--------------------------------
R
E
R
C
--------
F
--
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
---
S
Q
---
G
--
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
----
E
--
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
--
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
-
A
-
E
M
Y
D
N
I
L
N
K
P
L
Q
L
--
K
P
------
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
-----
G
A
K
DD
F
M
E
I
K
S
H
V
F
F
-----
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-----------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
53.15
31%
-92
- C1 -
2YCR
1
CHK2_HUMAN
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
-------------
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
--------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.07
31%
-95
- C1 -
2WTI
3
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
52.75
31%
-103
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.73
31%
-98
- C1 -
4A9U
10
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------
D
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
52.63
31%
-97
- C1 -
4BDF
3
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
52.37
31%
-94
- C1 -
4BDI
6
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
----------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
52.21
31%
-97
- C1 -
2YIR
1
CHK2_HUMAN
A:
[10-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
52.13
31%
-91
- C1 -
2YIT
1
CHK2_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
51.94
31%
-92
- C1 -
2XM9
1
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
51.75
31%
-94
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
51.73
31%
-95
- C1 -
4BDG
2
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
51.72
31%
-96
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
51.72
31%
-99
- C1 -
4BDC
2
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
51.72
31%
-95
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
51.60
31%
-96
- C1 -
4BDK
4
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
51.47
31%
-100
- C1 -
4BDB
10
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
51.41
32%
-119
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
-----
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------------------------
N
E
I
A
V
-
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
--
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
-
D
-----
R
I
---------------------------------
V
E
K
G
--------
F
YT
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
---
E
D
---
S
--
K
I
M
I
S
D
F
G
----------------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
-
A
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
DS
P
Y
--
W
--
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
----
Q
A
L
Q
H
P
W
I
-----
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.08
31%
-95
- C1 -
4A9R
2
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
93
HHSearch
50.06
31%
-83
- C1 -
2YEX
8
CHK1_HUMAN
A:
[6-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
E
D
W
D
L
V
Q
T
-----
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-------------------------
D
C
P
E
N
I
K
K
E
I
C
I
-
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
-
D
-----
R
I
E--------------------------------
P
D
I
G
--------
M
--
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
---
E
R
---
D
--
N
L
K
I
S
D
F
G
L
A
T
--
V
F
R
----
Y
NN
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
-
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
P
--
W
--
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
----
D
I
K
K
D
R
W
Y
-----
N
K
P
L
K
-----------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
49.98
31%
-98
- C1 -
4BDA
8
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.70
31%
-95
- C1 -
2WTC
1
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
49.45
31%
-96
- C1 -
4BDE
5
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------
A
L
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
48.41
31%
-99
- C1 -
4BDH
4
CHK2_HUMAN
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
-----
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
-
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
----
V
V
---------------------------------
G
N
K
R
--------
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
S
SQE
E
D
---
C
--
L
I
K
I
T
D
F
G
H
S
---
K
I
L
----
G
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
--
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
----
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------