@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCD2_HUMAN: (2015-10-10 )
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDVRWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
Atome Classification :
(64 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......-----520.......530.......540.......550.......560.......570.......580.....---.-.590-..----..----.....600....-.-..610.......620.......630.-...--....640-..------------------------..--.--------.-...650.......660.......670.......680....-...690.......-700..----...-..-710........720...---....730.......740.......750--..--.--.---.--..--.760...-------------------....770---------.......780.......790.......800.......810---........820.......830.......840.......850.......860.......870......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGS
G
V
S
F
H
I
Q
IGL
T
R
E
F
V
LLP
A
A
S
E
L
A
H
V
K
Q
L
A
C
S
I
V
D
QKFPECG
F
Y
G
L
Y
D
K
I
L
L
F
KHDPT
S
A
N
L
L
Q
L
V
R
SSGDIQEG
D
L
V
E
V
V
L
SASATFE
D
F
Q
IRP
H
A
L
T
V
HSYRA
P
A
F
C
D
H
C
G
E
M
L
F
G
L
V
RQGLKCDGCGLNYH
K
R
C
A
FSIPNNCS
G
A
R
K
RRLSSTSLASG
H
S
V
RLGTSESLPC
T
A
E
E
L
S
R
S
T
T
E
LLPRRPPSSSSSSSASSYTGRP
I
E
L
D
K
M
L
L
S
KVKV
P
H
T
F
L
I
HSYTR
P
T
V
C
Q
A
C
K
K
L
L
K
G
L
F
RQGLQCKDCKF
N
C
H
K
R
C
A
TRV
P
N
D
C
L
G
E
A
LINGDVP
M
E
EATDF
S
E
A
D
K
S
ALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSL
G
Y
I
P
L
M
R
V
V
Q
S
V
R
H
T
TRKSSTTLRE
G
W
V
V
H
YSN
K
D
T
L
RKR
H
Y
W
R
L
D
C
K
C
I
T
L
F
QNNTTN
R
Y
Y
K
EI
P
L
S
E
I
L
T
VESAQ
N
F
S
LVPPGTNP
H
C
F
E
I
V
TAN
A
T
Y
F
V
GEMPGGTPGGPSGQGA
E
A
A
R
G
W
E
T
A
I
R
Q
A
L
M
P
V
I
L
QDAPSA-----PGHAPH
R
Q
A
S
L
S
I
S
VSN
S
Q
I
QENVD
I
A
T
V
Y
QI
F
P
D
E
VLGSGQ
F
G
V
V
YGGKHRKT
G
R
D
V
A
V
K
V
I
D
K
LRF---P-
T
K
---
Q
E
----
S
Q
----
L
R
N
E
V
A
I
L
Q
SLR-H-PG
I
V
N
L
E
C
M
FET
P
E
K
V
F
V
V
M
E
K
L
H
-
G
-
D
M
L
--
E
M
I
L
S
---SE------------------------KG--R--------
L
-
P
E
R
L
T
K
F
L
I
T
Q
I
L
V
A
L
R
H
L
H
F
K
N
I
V
HCDLKPE
N
V
L
L
ASAD-PFPQ
V
K
LCD
F
G
F
A
-
R
I
I
G
E
----
K
S
F
-
R
R
-
S
-VVGT
P
A
Y
L
A
P
E
V
L
L
N---QGYNRSL
D
M
W
S
V
G
V
I
M
Y
V
S
LSGTFPF---NE--D--E---
D
--
I
N
--
D
Q
I
QN
A
A
-------------------
F
MYPASP---------WSHISAG
A
I
D
L
I
N
N
L
L
Q
V
K
M
R
K
R
YSVDKSLS
H
P
W
L
Q
E
Y
Q
----
T
W
L
D
L
R
E
L
E
G
KMGE
R
Y
ITHESDD
V
R
W
E
Q
F
AAEHPLPGSGLPTDRDLGGACPPQDH
D
M
Q
G
L
A
E
R
ISVL
18
PsiBlast_PDB
67.68
35%
-118
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------------
S
----
M
E
N
E
I
A
V
L
H
K
I
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
-
G
G
E
L
F
--
D
R
I
V
-----
E
------------------------
K
G
--
F
--------
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
D
P
----
G
-----------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
--
E
--
N
---
D
A
K
L
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------------------------------------------------------------------------
29
PsiBlast_CBE
66.66
36%
-116
- C1 -
3MFR
1
CSKP_HUMAN
A:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
C
F
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
G
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------------
28
PsiBlast_CBE
65.81
36%
-116
- C1 -
3MFS
1
CSKP_HUMAN
A:
[18-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
C
F
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
G
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------------
27
PsiBlast_CBE
65.64
36%
-112
- C1 -
3MFU
1
CSKP_HUMAN
A:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
SS
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
C
F
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
G
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------------
121
HHSearch
65.22
36%
-109
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
---
T
-
S
S
PGL
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
A
D
L
C
--
F
E
I
V
K
---
R
A
D
A
----------------------
G
F
--
V
--------
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
-
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
---
Y
G
--
T
K
-
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
--------------------------------------------
45
PsiBlast_CBE
65.19
35%
-114
- C1 -
3C0H
1
CSKP_HUMAN
B:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
TSS
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
CF
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
-------------------------------------------
34
PsiBlast_CBE
64.74
34%
-99
- C1 -
3NCG
1
?
A:
[29-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
---
K
-
N
K
---
D
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
G
E
L
F
--
D
E
I
I
-----
K
------------------------
R
K
--
R
--------
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
----
N
T
--------
I
G
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
N
--
E
--
Y
---
D
--
I
L
--
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
Q
---------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
---------
N
I
R
--
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
68
PsiBlast_CBE
64.56
34%
-102
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
-GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
-------------------------
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
-----------------------------------------------------------------
60
PsiBlast_CBE
64.08
34%
-98
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[25-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------------------------------------------------------------------
81
PsiBlast_CBE
64.02
34%
-102
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
------------------------------------------------------------------------
49
PsiBlast_CBE
63.97
35%
-100
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
----
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------------------------------------------
127
HHSearch
63.88
30%
-105
- C1 -
3HKO
2
?
A:
[23-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
K
K
Y
H
L
--
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
---
R
Q-
K
---
D
V
----
E
R
----
I
K
T
E
V
R
L
M
K
K
L
H
-
H
-
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
-
G
G
H
L
L
--
D
K
L
N
V
F
I
D
D
S
TG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SI-F
R
E
S
L
D
F
V
Q
-
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
--
S
F
E
I
K
L
V
D
F
G
L
S
-
K
E
F
Y
K
LNNG----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN-
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
---
P
G
VN
D
--
A
---
D
--
T
I
--
S
Q
V
L
N
K
K
-------------------
L
C
F
E
N
P
N
---------
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
----
D
K
I
Y
K
M
S
------------------------------------------------------------
73
PsiBlast_CBE
63.74
34%
-100
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
----
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------------------------------------------
74
PsiBlast_CBE
63.71
34%
-98
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------------------------------------------------------------------
47
PsiBlast_CBE
63.49
35%
-116
- C1 -
3C0G
1
CSKP_HUMAN
B:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
C
F
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
G
D
P
-----------------------
57
PsiBlast_CBE
63.45
34%
-100
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[8-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
----
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
-------------------------------------------
48
PsiBlast_CBE
63.25
35%
-112
- C1 -
3C0G
1
CSKP_HUMAN
A:
[20-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
C
F
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
V
L
A
A
V
S
F
Y
G
---------------------------------
88
PsiBlast_CBE
63.16
34%
-112
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
---
R
-
A
S
---
R
R
G
V
S
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
-
G
-
G
E
L
--
F
D
F
L
A
---
Q
K
------------------------
E
S
--
L
--------
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
I
T
S
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
----
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
---------------------------------------------
24
PsiBlast_CBE
63.10
35%
-118
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
-
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------
N
E
I
A
V
L
H
K
I
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
-
G
G
E
L
F
--
D
R
I
V
-----
E
------------------------
K
G
--
F
--------
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
------------
G
S
V
-
L
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
--
E
--
N
---
D
A
K
L
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
----
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
------------------------------------------------
32
PsiBlast_CBE
62.96
36%
-107
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---
S
-
A
R
---
D
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
-
G
G
E
L
F
--
E
D
I
V
A
---
R
E
----------------------------
Y
--------
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
----
Q
Q
A
-
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W--
D
E
--
D
--
Q
---
H
R
-
L
Y
--
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
E
---------
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
----
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------
25
PsiBlast_CBE
62.89
35%
-121
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
--------------------------
N
E
I
A
V
L
H
K
I
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
-
G
G
E
L
F
--
D
R
I
V
-----
E
------------------------
K
G
--
F
--------
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
-------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
--
E
--
N
---
D
A
K
L
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
----
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
------------------------------------------------
35
PsiBlast_CBE
62.76
34%
-102
- C1 -
3MWU
1
?
A:
[29-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
---
K
-
N
K
---
D
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
G
E
L
F
--
D
E
I
I
-----
K
------------------------
R
K
--
R
--------
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
----
N
------
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
N
--
E
--
Y
---
D
--
I
L
--
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
Q
---------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
---------
N
I
R
--
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
52
PsiBlast_CBE
62.58
35%
-111
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
---
R
-
A
S
---
R
R
GVC
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
-
G
-
G
E
L
--
F
D
F
L
A
---
Q
K
------------------------
E
S
--
L
--------
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
I
T
A
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
----
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------
36
PsiBlast_CBE
62.56
34%
-100
- C1 -
3IGO
8
?
A:
[29-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
---
K
-
N
K
----
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
G
E
L
F
--
D
E
I
I
-----
K
------------------------
R
K
--
R
--------
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
----
N
T
----------
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
N
--
E
--
Y
---
D
--
I
L
--
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
Q
---------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
---------
N
I
R
--
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
53
PsiBlast_CBE
62.53
35%
-110
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
---
R
-
A
S
---
R
R
GVC
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
-
G
-
G
E
L
--
F
D
F
L
A
---
Q
K
------------------------
E
S
--
L
--------
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
I
T
A
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
----
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------
62
PsiBlast_CBE
62.49
34%
-97
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
--
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
-----------------------------------------------------------------
105
PsiBlast_CBE
62.29
34%
-99
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVSR
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
TK
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
-----------------------------------------------------------------
46
PsiBlast_CBE
62.29
35%
-112
- C1 -
3C0H
1
CSKP_HUMAN
A:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
---
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
-
G
-
A
D
L
C
F
E
I
V
K
R
---
A
D
------------------------
A
G
--
F
--------
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
-
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
T
--
K
--
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
-------------------------------------------
71
PsiBlast_CBE
62.23
34%
-100
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
-----------------------------------------------------------------
65
PsiBlast_CBE
62.16
34%
-99
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----
E
K
-----------------------------------------------------------------
10
PsiBlast_PDB
62.14
37%
-112
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------------------------------------------
67
PsiBlast_CBE
62.09
34%
-101
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
-------------------------
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
-----------------------------------------------------------------
122
HHSearch
61.99
32%
-96
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIPAP
P
A
P
F
D
H
R
I
V
T
A
K
----------
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
------
K
---
D
K
----
E
E
----
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
-
G
G
E
L
F
--
D
R
I
I
----
D
E
------------------------
S
Y
--
N
--------
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
----
R
E
K
-
L
K
-
V
-
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
---
L
G
--
D
--
N
D
A
-
E
--
T
L
--
N
N
I
L
A
C
R
-------------------
W
D
L
E
D
E
E
---------
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
----
L
H
S
R
L
S
A
Q
-----------------------------------------------------------
64
PsiBlast_CBE
61.99
34%
-100
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
K
----------------------------------------------------------------
83
PsiBlast_CBE
61.83
34%
-100
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
50
PsiBlast_CBE
61.66
35%
-106
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[33-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---
S
-
A
R
---
D
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
-
G
G
E
L
F
--
E
D
I
V
A
---
R
E
----------------------------
Y
--------
Y
-
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
E
----
Q
Q
A
-
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W--
D
E
--
D
--
Q
H
--
K
--
L
Y
--
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
E
---------
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
----
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------------
77
PsiBlast_CBE
61.48
34%
-113
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----------------VS
R
-
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
--------------------------------------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-----------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
2
PsiBlast_PDB
61.46
37%
-112
- C1 -
2CN5
1
CHK2_HUMAN
A:
[22-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
--------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-----------------------------------------------------
87
PsiBlast_CBE
61.20
34%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
---
R
-
A
S
---
R
R
GVSR
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
-
G
-
G
E
L
--
F
D
F
L
A
---
Q
K
------------------------
E
S
--
L
--------
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
TK
Q
---
E
--
T
L
--
A
N
I
T
S
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
----
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
---------------------------------------------
70
PsiBlast_CBE
61.11
34%
-97
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
F
------------------------------------------------------------------------
6
PsiBlast_PDB
60.94
37%
-114
- C1 -
2YCR
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
-----------------------------------------------
8
PsiBlast_PDB
60.80
37%
-114
- C1 -
2YIR
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------LN--
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
------------------------------------------------
89
PsiBlast_CBE
60.78
34%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
---
R
-
A
S
---
R
R
G
V
S
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
-
G
-
G
E
L
--
F
D
F
L
A
---
Q
K
------------------------
E
S
--
L
--------
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
I
T
S
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
----
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
---------------------------------------------
86
PsiBlast_CBE
60.70
34%
-109
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
---
R
-
A
S
---
R
R
GVSR
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
-
G
-
G
E
L
--
F
D
F
L
A
---
Q
K
------------------------
E
S
--
L
--------
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
TK
Q
---
E
--
T
L
--
A
N
I
T
S
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
----
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
---------------------------------------------
33
PsiBlast_CBE
60.65
34%
-99
- C1 -
4Y5Q
1
?
A:
[29-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
---
K
-
N
K
---
D
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
G
E
L
F
--
D
E
I
I
-----
K
------------------------
R
K
--
R
--------
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
----
N
T
-----
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
N
--
E
--
Y
---
D
--
I
L
--
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
Q
---------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
---------
N
I
R
--
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
69
PsiBlast_CBE
60.62
34%
-99
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
----
F
E
-----------------------------------------------------------------
11
PsiBlast_PDB
60.54
37%
-112
- C1 -
2YCS
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------------------------------------------
133
HHSearch
60.16
33%
-106
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[14-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
L
--
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
--------------
V
K
----
E
T
----
T
L
R
E
L
K
M
L
R
T
L
K
-
Q
-
E
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
E
-
K
-
N
M
L
--
E
L
L
E
E
---
M
-------------------------
P
N
--
G
--------
V
-
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
----
D
V
L
K
L
C
D
F
G
F
A
-
R
N
L
S
E
----------------
T
R
W
Y
R
S
P
E
L
L
L
G
---
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
---
P
G
--
E
--
S
---
E
--
I
D
Q
L
F
T
I
Q
K
V
L
GPLP
S
E
Q
M
K
L
F
Y
S
NPRFHG
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
----
L
------------------------------------------------------------------
78
PsiBlast_CBE
59.88
34%
-100
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
------------------
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
7
PsiBlast_PDB
59.64
37%
-113
- C1 -
2W0J
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
T
A
L
P
Q
------------------------------------------------
9
PsiBlast_PDB
59.55
37%
-112
- C1 -
2YIT
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------LN--
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------------------------------------------
40
PsiBlast_CBE
59.35
35%
-103
- C1 -
2WEI
1
?
A:
[29-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
---
K
-
N
K
---
D
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
G
E
L
F
--
D
E
I
I
-----
K
------------------------
R
K
--
R
--------
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
----
N
T
K
-
M
K
-
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
N
--
E
--
Y
---
D
--
I
L
--
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
Q
---------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
----
S
E
-----------------------------------------------------------------
12
PsiBlast_PDB
59.31
37%
-104
- C1 -
2YCF
1
CHK2_HUMAN
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------------------------------------------
102
PsiBlast_CBE
58.88
33%
-104
- C1 -
3LM0
2
ST17B_HUMAN
A:
[29-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
I
L
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
R
---
G
-
Q
D
---
C
R
----
A
E
----
I
L
H
E
I
A
V
L
E
L
A
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
-
G
G
E
I
F
--
S
L
C
L
P
---
E
L
------------------------
A
E
--
M
--------
V
-
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
K
I
----------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
---
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
VG-
E
D
--
N
--
Q
---
E
--
T
Y
--
L
N
I
S
Q
V
N
-------------------
V
D
Y
S
E
E
T
---------
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
----
F
E
N
L
F
H
P
------------------------------------------------------------
80
PsiBlast_CBE
58.83
34%
-99
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
------------R---
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
------------------------
E
S
--
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-------------------
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
72
PsiBlast_CBE
58.72
34%
-101
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
S
---
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
--------------------------------------------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
-----------------------------------------------------------------------
131
HHSearch
58.63
33%
-106
- C1 -
3LM5
1
ST17B_HUMAN
A:
[18-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
E
N
F
N
N
F
Y
I
L
T
-
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
R
---
G
-
Q
D
---
C
R
----
A
E
----
I
L
H
E
I
A
V
L
E
L
A
K
S
C
-
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
-
E
I
F
--
S
L
C
L
P
---
E
L
-------------------------
E
--
M
--------
V
-
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
K
I
----------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
---
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
---
V
G
--
E
--
D
N
Q
-
E
--
T
Y
--
L
N
I
S
Q
V
N
-------------------
V
D
Y
S
E
E
T
---------
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
----
F
E
N
L
---------------------------------------------------------------
16
PsiBlast_PDB
58.31
37%
-107
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
-
G
G
E
L
F
--
D
R
I
L
-----
E
------------------------
R
G
--
V
--------
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
----
N
G
I
-
M
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
E
--
E
--
T
---
E
S
K
L
F
--
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
F
---------
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
----
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
----------------------------------------------
4
PsiBlast_PDB
57.90
37%
-106
- C1 -
4A9T
4
CHK2_HUMAN
A:
[22-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------------------------------------------
22
PsiBlast_CBE
57.89
37%
-103
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
-
G
G
E
L
F
--
D
R
I
L
-----
E
------------------------
R
G
--
V
--------
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
----
N
G
I
-
M
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
E
--
E
--
T
---
E
S
K
L
F
--
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
F
---------
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
----
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-----------------------------------------------
3
PsiBlast_PDB
57.65
37%
-110
- C1 -
2XM9
1
CHK2_HUMAN
A:
[22-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
-
G
G
E
L
F
--
D
K
V
V
G
---
N
K
----------------------------
R
--------
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
--
H
--
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
---------------------------------------------
79
PsiBlast_CBE
57.04
34%
-100
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-
S
----
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
-
G
E
L
--
F
D
F
L
A
---
E
K
----------------------------
L
--------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-----------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
---
L
G
--
D
T
K
Q
---
E
--
T
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
41
PsiBlast_CBE
55.37
32%
-87
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[66-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
A
P
-----
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
----------
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---
K
-
D
K
---
E
E
----------
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
-
G
-
G
E
L
--
F
D
R
I
I
---
D
E
------------------------
S
Y
--
N
--------
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
----
R
E
K
-
L
K
-
V
-
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
LGD
N
D
--
A
--
E
---
T
--
L
N
--
N
-
I
L
A
C
R
-------------------
W
D
L
E
D
E
E
---------
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
----
L
H
S
R
L
--------------------------------------------------------------
42
PsiBlast_CBE
54.93
32%
-85
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
-----
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
----------
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---
K
-
D
K
---
E
E
----------
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
-
G
-
G
E
L
--
F
D
R
I
I
---
D
E
------------------------
S
Y
--
N
--------
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
----
R
E
K
-
L
K
-
V
-
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
LGD
N
D
--
A
--
E
---
T
--
L
N
--
N
-
I
L
A
C
R
-------------------
W
D
L
E
D
E
E
---------
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
----
L
H
S
R
L
S
A
Q
-----------------------------------------------------------