@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCD3_HUMAN: (2015-10-10 )
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540---.......550.......560.......570.......580---.........590.......600.......--610---......----.----620......-.630........640..----.....650.-..-.-.-..660......------------------------------------...670........680.......690.......700.......710........720..-.....----730-.......740.......750-.--........760.......770....--.--.--.--780----.--.--.--......790-----------------.......---------..800.......810.......820.......830..-----.....-----840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSANNSPPSAQKSV
L
P
T
A
I
P
A
VLPAASPCSSPKTG
L
S
A
RLSNGSFSAPSLTNSRGS
V
H
T
V
S
F
L
L
Q
IGLTRE
S
V
T
I
E
A
Q
E
L
S
L
S
A
V
K
D
L
V
C
S
I
V
Y
Q
KFPECG
F
F
G
M
Y
D
K
I
L
L
FRHDM
N
S
E
N
I
L
Q
L
I
T
S
A
D
EIHEG
D
L
V
E
V
V
L
S
A
L
A
T
V
EDFQIR
P
H
T
L
Y
V
H
SYKA
P
T
F
C
D
Y
C
G
E
M
L
W
G
L
V
RQGLKCEGCGLNYH
K
R
C
A
FKIPNNC
S
G
V
R
K
R
RLSNVSLPGPGLSVPRPLQPE
Y
V
ALPSEESHVHQE
P
S
KRIPSWSGR
P
I
W
M
E
K
M
V
M
C
R
VKV
P
H
T
F
A
VHSYT
R
P
T
I
C
Q
Y
C
K
R
L
L
K
G
L
F
RQGMQCKDCK
F
N
C
H
K
R
C
A
S
KV
P
R
D
C
LG
E
V
T
FNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPED
K
M
F
F
LDPSDLDV
E
R
D
E
E
A
V
K
TISPSTSNN
I
P
L
M
R
V
V
Q
S
I
K
H
TKRKSSTMVKEG
W
M
V
H
Y
TSRDNL
R
K
R
H
Y
W
RL
D
S
K
C
L
T
L
FQNESGS
K
Y
Y
K
EI
P
L
S
E
I
L
RISSPRDFTNISQGSNP
H
C
F
E
I
ITD
T
M
V
Y
F
V
GENNGDSSHN
P
V
L
A
ATGV
G
L
D
V
A
Q
S
W
E
K
A
I
R
Q
ALMPVTPQASVCT---SPGQGKDHKDLS
T
S
I
SVSN
C
Q
I
QENV
D
I
S
T
V
Y
Q
I
F
A
D
E
-----VLGSG
Q
F
G
I
V
YGGKHRKTG
R
D
V
A
I
K
V
I
D
K
--MRF---P
T
K
Q
E
S
----
Q
----
L
R
N
E
V
A
I
L
Q
-NL-HHPG
I
V
N
L
E
C
M
FET----
P
E
R
V
F
V
V
M
E
-
K
L
-
H
-
G
-
D
M
L
--
E
M
I
L
S
S
------------------------------------
E
K
S
R
L
-
P
E
R
I
T
K
F
M
V
T
Q
I
L
V
A
L
R
NL
H
F
K
N
I
V
HCDLKPE
N
V
L
L
ASAE-PFPQ
V
K
LCD
F
G
F
A
-
R
I
I
G
E
----
K
S
F
-
R
R
S
VVGT
P
A
Y
L
A
P
E
V
L
R
S---K--GYNRSLD
M
W
S
V
G
V
I
I
Y
V
SLSGTFPF--N--E--D--E------
D
--
I
--
N
--
D
Q
I
QN
A
A
-------------------FMYPPN
P
---------
W
R
E
ISG
E
A
I
D
L
I
N
N
L
L
Q
V
K
M
R
K
R
YSVDKSLS
H
P
W
L
Q
D
-----
Y
Q
T
W
L
-----
D
L
R
E
F
E
T
R
IGE
R
Y
ITHESDD
A
R
W
E
I
H
A
Y
THNLVY
P
K
H
F
I
MAPNPDDMEEDP
34
PsiBlast_CBE
69.09
34%
-107
- C1 -
3MFR
1
CSKP_HUMAN
A:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------
33
PsiBlast_CBE
68.81
34%
-107
- C1 -
3MFS
1
CSKP_HUMAN
A:
[18-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRY
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------
32
PsiBlast_CBE
67.64
34%
-104
- C1 -
3MFU
1
CSKP_HUMAN
A:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
SS
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------
50
PsiBlast_CBE
66.49
33%
-106
- C1 -
3C0H
1
CSKP_HUMAN
B:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
TSS
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
CF
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
PETVE
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------
18
PsiBlast_PDB
65.78
34%
-115
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------------
S
----
M
E
N
E
I
A
V
L
H
-
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
V
--------------------------------------
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
D
P
----
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
--
E
--
N
------
D
A
K
L
--
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------
56
PsiBlast_CBE
65.64
34%
-96
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
K
D
T
Q
Q
-----
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------
49
PsiBlast_CBE
65.53
33%
-104
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------
53
PsiBlast_CBE
65.35
33%
-106
- C1 -
3C0G
1
CSKP_HUMAN
A:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
V
L
A
A
V
S
F
Y
G
------------------------------
100
PsiBlast_CBE
65.05
33%
-99
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
-
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
-
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
---------------------------------------------------------
51
PsiBlast_CBE
64.72
33%
-105
- C1 -
3C0H
1
CSKP_HUMAN
A:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------
52
PsiBlast_CBE
64.15
33%
-108
- C1 -
3C0G
1
CSKP_HUMAN
B:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
-
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
--
K
--
E
------
R
--
L
--
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
G
D
P
--------------------
20
PsiBlast_PDB
63.82
34%
-119
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--
E
----------------------
N
E
I
A
V
L
H
-
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
V
--------------------------------------
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
-----------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
--
E
--
N
------
D
A
K
L
--
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-----
D
T
A
L
D
-----
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------
6
PsiBlast_PDB
63.53
39%
-107
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------N---
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------
104
PsiBlast_CBE
63.12
33%
-96
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
---------------------------------------------------------
96
PsiBlast_CBE
62.98
33%
-97
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
K
--------------------------------------------------------
97
PsiBlast_CBE
62.97
33%
-96
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
Q
F
E
K
---------------------------------------------------------
90
PsiBlast_CBE
62.85
35%
-103
- C1 -
3MA6
1
?
A:
[29-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
RQ
V
K
Q
---
K
T
D
K
E
S
----
L
----
L
R
-
E
V
Q
L
L
K
-
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
S
--------------------------------------
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-----
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
---
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
GA
N
--
E
--
Y
------
D
--
I
--
L
--
K
K
V
E
K
G
K
-------------------
Y
T
F
E
L
P
Q
---------
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
----------------------------------------------------------
99
PsiBlast_CBE
62.63
33%
-97
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
-
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
---------------------------------------------------------
106
PsiBlast_CBE
62.61
33%
-113
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------------VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
----------------------------------------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
93
PsiBlast_CBE
62.36
33%
-93
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
--
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
---------------------------------------------------------
9
PsiBlast_PDB
62.26
39%
-106
- C1 -
2CN5
1
CHK2_HUMAN
A:
[22-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--
R
----------------N---
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
----------------------------------------
44
PsiBlast_CBE
62.22
35%
-103
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[18-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
S
R
R
G
VC
R
E
E
----
I
E
R
E
V
S
I
L
R
-
Q
V
-
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
-
L
V
-
S
-
G
-
G
E
L
--
F
D
F
L
A
Q
------------------------------------
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
I
T
A
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
-----
V
D
T
Q
Q
-----
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
--------------------------------
4
PsiBlast_PDB
62.07
39%
-108
- C1 -
2YIR
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------LN--
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
-----------------------------------
45
PsiBlast_CBE
62.06
35%
-103
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[18-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
S
R
R
G
VC
R
E
E
----
I
E
R
E
V
S
I
L
R
-
Q
V
-
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
-
L
V
-
S
-
G
-
G
E
L
--
F
D
F
L
A
Q
------------------------------------
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
----
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
I
T
A
V
S
-------------------
Y
D
F
D
E
E
F
---------
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
-----
V
D
T
Q
Q
-----
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
--------------------------------
68
PsiBlast_CBE
62.04
34%
-108
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
-------
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
-
L
L
-
K
H
S
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
------------------------------------
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
----
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
E
--
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
--
D
--
Q
H-----
K
--
L
--
Y
--
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
E
---------
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
-----
R
S
T
V
A
-----
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-----------------------------
41
PsiBlast_CBE
62.03
35%
-104
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[33-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
-
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
------------------------------------
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
E
----
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
--
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
--
D
--
Q
H
-----
K
--
L
--
Y
--
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
E
---------
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
-----
R
S
T
V
A
-----
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
----------------------------
7
PsiBlast_PDB
61.87
39%
-106
- C1 -
2YCS
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------N---
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------
103
PsiBlast_CBE
61.86
33%
-93
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
F
------------------------------------------------------------
69
PsiBlast_CBE
61.75
34%
-107
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
-------
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
-
L
L
-
K
H
S
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
------------------------------------
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
----
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
E
--
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
--
D
--
Q
H
-----
K
--
L
--
Y
--
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
E
---------
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
-----
R
S
T
V
A
-----
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-----------------------------
2
PsiBlast_PDB
61.61
39%
-108
- C1 -
2YCR
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------N---
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
----------------------------------
23
PsiBlast_CBE
61.59
34%
-116
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
-
F
R
D
------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------
N
E
I
A
V
L
H
-
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
V
--------------------------------------
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
------------
G
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
--
E
--
N
------
D
A
K
L
--
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-----
D
T
A
L
D
-----
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------
102
PsiBlast_CBE
61.27
33%
-96
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
---------------------------------------------------------
89
PsiBlast_CBE
60.71
35%
-99
- C1 -
3MA6
1
?
B:
[29-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
YKGQR
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
RQ
V
K
Q
----
T
D
K
E
S
----
L
----
L
R
-
E
V
Q
L
L
K
-
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
S
--------------------------------------
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
A
----
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
---
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
GA
N
--
E
--
Y
------
D
--
I
--
L
--
K
K
V
E
K
G
K
-------------------
Y
T
F
E
L
P
Q
---------
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
-----------------------------------------------------------
105
PsiBlast_CBE
60.60
33%
-97
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
-------------------------------------------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
----
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
Q
F
-----------------------------------------------------------
5
PsiBlast_PDB
60.53
39%
-107
- C1 -
2YIT
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------LN--
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------
8
PsiBlast_PDB
60.47
39%
-100
- C1 -
2YCF
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------N---
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------
26
PsiBlast_CBE
60.21
35%
-98
- C1 -
2WEI
1
?
A:
[29-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
--
A
S
A
---
K
N
K
D
T
S
----
T
----
I
L
R
E
V
E
L
L
K
-
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
--------------------------------------
K
R
K
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
----
N
T
K
-
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
---
T
---
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG
K
--
N
--
E
--
Y
------
D
--
I
--
L
--
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
Q
---------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
---------------------------------------------------------
107
PsiBlast_CBE
60.03
33%
-97
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
-
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
------------------------------------
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
----------------
P
E
F
V
A
P
E
I
V
N
Y
---
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
--
D
T
K
Q
------
E
--
T
--
L
--
A
N
V
S
A
V
N
-------------------
Y
E
F
E
D
E
Y
---------
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
123
HHSearch
59.92
30%
-95
- C1 -
3HKO
2
?
A:
[23-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
K
K
Y
H
L
--
K
G
-----
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
--
N
K
I
R
Q---
K
D
V
E
----
R
----
I
K
T
E
V
R
L
M
K
-
K
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
----
E
Q
Y
I
C
L
V
M
E
-
L
C
-
H
-
G
G
H
L
L
--
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
-
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
-
S
-
F
E
I
K
L
V
D
F
G
L
S
-
K
E
F
Y
K
LNNG--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
---
T
NE
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
--
P
--
G
VN
D
--
A
------
D
--
T
--
I
--
S
Q
V
L
N
K
K
-------------------
L
C
F
E
N
P
N
---------
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
-----
F
S
D
K
I
-----
Y
K
M
S
-----------------------------------------------
11
PsiBlast_PDB
59.86
39%
-99
- C1 -
4A9T
4
CHK2_HUMAN
A:
[22-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------P
A
L
N
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-------------------------------
10
PsiBlast_PDB
59.53
39%
-104
- C1 -
2XM9
1
CHK2_HUMAN
A:
[22-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------P
A
L
N
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
--------------------------------
3
PsiBlast_PDB
59.37
39%
-106
- C1 -
2W0J
1
CHK2_HUMAN
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------N---
V
E
T
E
I
E
I
L
K
-
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
------------------------------------
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
--
H
--
R
TQV---
S
--
L
--
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
-----
K
F
Q
D
L
L
S
E
E
N
E
T
A
L
P
Q
-----------------------------------
16
PsiBlast_PDB
59.07
37%
-106
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
--
S
---------------
S
----
L
E
N
E
I
A
V
L
K
-
K
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
L
--------------------------------------
E
R
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
----
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
E
--
E
--
T
------
E
S
K
L
--
F
--
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
F
---------
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
-----
N
T
A
L
H
-----
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
---------------------------------
127
HHSearch
58.67
32%
-104
- C1 -
3LM5
1
ST17B_HUMAN
A:
[26-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
N
F
Y
I
L
T
-
S
K
-----
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
--
R
R
R
---
G
Q
D
C
R
A
----
E
----
I
L
H
E
I
A
V
L
E
-
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
-
Y
A
-
A
G
G
-
E
I
F
--
S
L
C
L
P
E
------------------------------------
L
-
E
M
V
-
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
K
I
--------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
---
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
--
V
--
G
--
E
--
D
N
Q
----
E
--
T
--
Y
--
L
N
I
S
Q
V
N
-------------------
V
D
Y
S
E
E
T
---------
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
-----
W
D
F
E
N
-----
L
--------------------------------------------------
135
HHSearch
58.35
31%
-95
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[14-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
L
--
G
-----
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
------------
V
K
E
----
T
----
T
L
R
E
L
K
M
L
R
-
T
L
-
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
----
R
G
K
L
Y
L
V
F
E
-
Y
V
-
E
-
K
-
N
M
L
--
E
L
L
E
E
M
-------------------------------------
P
N
G
V
-
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
----
D
V
L
K
L
C
D
F
G
F
A
-
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
---
A
--
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
--
P
--
G
--
E
--
S
------
E
--
I
D
Q
L
--
F
T
I
Q
K
V
L
GPLP
S
E
Q
M
K
L
F
Y
S
NPRFHG
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
-----
Q
R
L
----------------------------------------------------------
119
HHSearch
57.83
31%
-81
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIP
A
P
P
A
P
F
D
H
R
I
V
T
A
----------
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
-----
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
--
R
G
-----
M
K
D
K
E
----
E
----
V
K
N
E
I
S
V
M
N
-
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
-
Y
V
-
D
-
G
G
E
L
F
--
D
R
I
I
D
-------------------------------------
E
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
----
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
--
L
--
G
--
D
--
N
D
A
----
E
--
T
--
L
--
N
N
I
L
A
C
R
-------------------
W
D
L
E
D
E
E
---------
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-----
H
K
L
H
S
-----
R
L
S
A
Q
----------------------------------------------
22
PsiBlast_CBE
56.95
37%
-101
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
--
S
---------------
S
----
L
E
N
E
I
A
V
L
K
-
K
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
L
--------------------------------------
E
R
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
----
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
E
--
E
--
T
------
E
S
K
L
--
F
--
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
F
---------
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
-----
N
T
A
L
H
-----
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
----------------------------------
54
PsiBlast_CBE
55.94
33%
-92
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[85-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
S
F
Y
T
V
S
K
T
E
-----
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
--
R
G
M
---
K
D
K
E
E
----------
V
K
N
E
I
S
V
M
N
-
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
-
Y
V
-
D
-
G
-
G
E
L
--
F
D
R
I
I
D
------------------------------------
E
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
----
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
--
L
--
G
--
D
--
N
------
D
--
A
--
E
T
L
N
N
I
L
A
C
R
-------------------
W
D
L
E
D
E
E
---------
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-----
H
K
L
H
S
-----
R
L
-------------------------------------------------
137
HHSearch
47.54
33%
-94
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[67-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
-----
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
----------
P
----
K
----
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
-
C
L
D
G
-
G
-
E
L
F
--
S
R
I
Q
D
R
---------------------------------------
A
F
-
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
E
T
T
----------------
P
Y
Y
V
A
P
E
V
L
G
P
---
E
--
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
S
--
N
--
H
GLAISP
G
--
M
--
K
--
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
E
---------
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-----
S
T
K
V
P
-----
Q
T
P
L
H
T
S
R
V
L
K
E
D
--------------------------------------