@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCT_HUMAN: (2015-10-11 )
MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
Atome Classification :
(61 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290..-...--------..300.......310-.......320.----------.......330---------..-------------......340-------------........350...---------....360.......370.-......380.......390......---.---400--........410......-.-420.......430.....--..440.......450.......460.......470-..----.....480.......490.....-..500.......510.......520.......530......-.540.......550.-----......560.......570.......-----580--.----.......590...--....---600........610.......620.----.----.-----.----.----..630.......640.......650...-----....660.......670......-.680--........690.......700....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
P
F
L
R
IGLSNFDCGSCQSCQGEAV
N
P
Y
C
A
V
L
V
K
E
Y
V
ESEN
G
Q
M
Y
I
QKKPTMYPPWDS
T
F
D
AHINKG
R
V
M
Q
I
I
V
KGK
N
V
D
L
I
S
E
T
T
V
E
L
Y
S
L
A
E
R
C
RKNNGK
T
E
I
W
L
E
LKPQG
R
M
L
M
N
A
R
Y
F
L
E
MSDTKD
M
N
E
F
ET
E
G
F
F
A
L
H
Q
RRGAIKQA
K
V
H
H
V
K
C
H
E
F
T
A
TFFPQ
P
T
F
C
S
V
C
H
E
F
V
WGLNKQGY
Q
C
R
Q
C
N
A
A
I
H
K
K
C
I
D
K
V
I
A
K
CTGSAIN
S
R
E
T
M
F
H
K
E
R
F
KIDMP
H
R
F
K
V
YNYKS
P
T
F
C
E
H
C
G
T
L
L
W
G
L
A
RQGLKCDACGMN
V
H
H
R
C
Q
T
K
V
A
N
L
CGI
N
Q
K
L
M
A
E
A
L
A
M
-
I
E
S
--------
T
Q
Q
A
R
C
L
R
D
T
E
Q
I
F
R
-EGP
V
E
IGL-PC----------SIKNEARPP----------CL-------------PTPGKREP--------------QGISWES
P
L
D
E
V
D
K
---------
M
CHLPEPELNKERP
S
L
Q
I
-
K
L
K
I
E
D
F
I
L
H
K
M
LGKGSF
G
K
V
F
L
A
E
---
F
---KK---TN
Q
F
F
A
I
K
A
LKK
D
V
V
L
M-D-DDV
E
C
T
M
V
E
K
R
V
L
S
L
AWE--HPF
L
T
H
M
F
C
T
F
QTKE
N
L
F
F
V
M
E
Y
LNGG
D
L
M
Y
H
I
Q
S
-
C
H
----KFDL
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
HS-KG
I
V
Y
R
D
L
K
L
D
N
I
L
LDKDG
H
I
K
I
A
DFGM
C
K
E
N
MLGDAKTNT-FCGTPDYI
A
P
E
I
LLG-----QKYNHS
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
IGQSPF-----HG---Q----
D
E
E
E
L
F
H
S
IRMDN--PF
Y
P
---
R
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
VRE
P
E
K
RLG----V----R-----G----D----IRQHPLFREI
N
W
E
E
L
E
R
KEIDPPFRPKV-----KSPFDCSNF
D
K
E
F
LNEKPRL
S
F
A
-
D
R
A
---
L
I
N
S
M
D
Q
N
M
F
R
NFSFMN
P
G
M
E
R
LIS
3
PsiBlast_PDB
87.29
98%
-109
- C1 -
4Q9Z
1
KPCT_HUMAN
A:
[2-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
E
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-----
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
----
V
----
R
-----
G
----
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
-----
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
-
D
R
A
---
L
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
4
PsiBlast_PDB
86.31
98%
-110
- C1 -
4RA5
3
KPCT_HUMAN
A:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
E
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-----
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
----
V
----
R
-----
G
----
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
-----
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
-
D
R
A
---
L
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
71
HHSearch
85.18
100%
-119
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-----
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
----
V
----
R
-----
G
----
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
-----------------------------------------------
Q
N
M
F
R
N
F
S
F
----------
1
PsiBlast_PDB
84.94
99%
-119
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-----
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
----
V
----
R
-----
G
----
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
-----------------------------------------------
Q
N
M
F
R
N
F
S
F
----------
22
PsiBlast_CBE
84.27
98%
-114
- C1 -
4Q9Z
1
B:
[1-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
E
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-----
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
----
V
----
R
-----
G
----
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
-----
K
S
P
F
D
C
S
N
F
D
K
--------------------------
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
--
18
PsiBlast_PDB
71.37
44%
-110
- C1 -
1O6L
1
AKT2_HUMAN
A:
[1-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
-
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
-
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
GPS
D
A
-----
K
----
E
----
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
------
74
HHSearch
71.26
45%
-111
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
-
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
----
G
S
E
D
A
-
K
----
E
----
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-----SME
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
-------
20
PsiBlast_PDB
70.94
43%
-113
- C1 -
2JDR
1
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
-
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
-
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
GPSD
A
-----
K
----
E
----
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
------
19
PsiBlast_PDB
70.15
43%
-112
- C1 -
2JDO
2
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
-
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
-
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
GP
S
D
A
-----
K
----
E
----
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
M
F
E
D
F
D
Y
I
A
D
W
------
70
HHSearch
68.82
48%
-84
- C1 -
3PFQ
1
KPCB_RAT
A:
[102-670]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
D
H
C
G
S
L
L
Y
G
L
I
H
Q
G
M
K
C
D
T
C
M
M
N
V
H
K
R
C
V
M
N
V
P
S
L
C
G
T
D
H
T
E
R
R
G
R
I
Y
I
Q
A
H
I
D
RE
V
L
I
V
V
V
R
D
A
K
N
L
V
P
M
D
P
N
G
L
S
D
P
Y
V
K
L
K
L
I
P
D
PKSES
K
Q
K
T
K
T
I
K
S
S
L
N
P
E
WN
E
T
F
R
F
QLK
E
S
DKD
R
R
L
S
V
E
I
W
D
W
D
L
T
S
R
N
D
F
M
G
S
L
S
F
G
I
S
E
L
Q
K
A
G
V
D
G
W
F
K
L
L
S
Q
E
E
G
EY
F
N
V
P
V
P
P----------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
---
R
---
K
G
---
T
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
P
G
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
----
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
-----
Q
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
-----
E
G
---
E
----
D
E
D
E
L
F
Q
S
I
M
E
H
N
--
V
A
Y
P
---
K
S
-
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
----
C
----
G
P
E
G
E
-
R
----
D
----
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
-----
S
G
R
-
N
A
E
N
F
D
R
F
F
T
R
H
P
P
V
L
T
P
P
-
D
Q
E
---
V
I
R
N
I
D
Q
S
E
F
E
G
F
S
F
V
N
S
E
F
L
K
P
--
76
HHSearch
67.41
45%
-104
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
-----
D
I
VGS
N
----
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
-
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
----
C
----
H
PQT
G
F
A
----
D
----
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
-
D
D
D
---
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
-------
12
PsiBlast_PDB
66.78
43%
-108
- C1 -
3A8W
1
KPCI_HUMAN
A:
[6-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D--------------
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
-
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
----
C
----
H
PQ
T
G
F
A
----
D
----
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
-
D
D
D
---
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
L
------
9
PsiBlast_PDB
66.13
42%
-105
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIVGS-----
N
----
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
-
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
----
C
----
H
PQT
G
F
A
----
D
----
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
-
D
D
D
---
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
-------
15
PsiBlast_PDB
65.53
49%
-104
- C1 -
4OTG
1
A:
[9-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
P
---
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
T
S
AG
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
----
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
D
R
T
S
T
-
F
C
G
T
P
E
F
L
A
P
E
V
L
T
D
-----
T
S
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----
P
G
---
D
----
D
E
E
E
V
F
D
S
I
V
N
D
E
--
V
R
Y
P
---
R
F
-
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
----
S
----
S
E
R
D
A
-
E
----
D
----
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
-----------------
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
---
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
V
A
G
-------
23
PsiBlast_CBE
65.47
48%
-113
- C1 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
L
Q
N
S
-
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
-
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
----
G
-----
S
E
D
A
K
E
----
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
----------------------------------------------
6
PsiBlast_PDB
63.66
56%
-105
- C1 -
4RA4
1
KPCA_HUMAN
A:
[15-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
---
R
---
K
G
---
T
E
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
L
D
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
----
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
V
T
T
R
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
-----
Q
P
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
F
-----
D
G
---
E
----
D
E
D
E
L
F
Q
S
I
M
E
H
N
--
V
S
Y
P
---
K
S
-
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
----
C
GP
E
G
E
-----
R
----
D
----
V
R
E
H
A
F
F
R
R
I
D
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
---------------------
G
Q
P
V
L
T
P
P
-
D
Q
L
---
V
I
A
N
I
D
Q
S
D
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
--
16
PsiBlast_PDB
63.20
49%
-109
- C1 -
4OTI
1
A:
[9-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
P
---
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
T
S
AG
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
----
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
-------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----
P
G
---
D
----
D
E
E
E
V
F
D
S
I
V
N
D
E
--
V
R
Y
P
---
R
F
-
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
----
S
----
S
ERD
A
-
E
----
D
----
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
-----
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
---
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
V
A
G
-------
73
HHSearch
62.48
55%
-102
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
---
V
---
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
--
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
----
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
-----
E
A
---
E
----
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
W
-
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
----
S
----
L
TQGG
E
H
----
A
----
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
-
D
E
G
---
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
-------
87
HHSearch
62.29
48%
-112
- C1 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
L
Q
N
S
-
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
-
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
GSE
D
A
-----
K
----
E
----
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
----------------------------------------------
11
PsiBlast_PDB
61.66
43%
-106
- C1 -
3ZH8
4
KPCI_HUMAN
A:
[2-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIV-------
N
----
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
-
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
----
C
----
H
PQ
T
G
F
A
----
D
----
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
---------------
Q
L
T
P
D
-
D
D
D
---
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
L
L
M
----
5
PsiBlast_PDB
61.41
54%
-101
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
---
V
---
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
--
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
----
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
-----
E
A
---
E
----
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
W
-
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
SL--
T
----
Q
-----
G
----
G
E
H
A
-
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
-
D
E
G
---
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
-------
26
PsiBlast_CBE
60.85
45%
-114
- C1 -
2R5T
1
SGK1_HUMAN
A:
[29-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
N
P
-
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
---
R
----
N
T
A
E
M
Y
D
N
I
-
L
N
K
--
P
L
Q
L
---
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
----
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
-----
S
G
-----------------------------------------------------
29
PsiBlast_CBE
59.79
41%
-95
- C1 -
4L43
1
KS6B1_HUMAN
A:
[14-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPGD
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
--------------
S
A
N
Q
-
V
F
L
G
F
A
Y
V
A
P
S
------
75
HHSearch
58.28
43%
-113
- C1 -
2R5T
1
SGK1_HUMAN
A:
[33-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
-
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
D
F
M
-
E
----
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
-----
S
G
-----------------------------------------------------
27
PsiBlast_CBE
57.21
40%
-106
- C1 -
4L42
1
KS6B1_HUMAN
A:
[14-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
---------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
------
24
PsiBlast_CBE
57.07
45%
-114
- C1 -
3HDN
1
SGK1_HUMAN
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
N
P
-
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
---
R
----
N
T
A
E
M
Y
D
N
I
-
L
N
K
--
P
L
Q
L
---
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
----
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--------------------------------------------------------------
83
HHSearch
57.05
38%
-94
- C1 -
3C4Z
1
RK_BOVIN
A:
[180-510]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
---
M
---
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
--
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
-
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
-
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
-----
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
-----
R
A
---
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
---
D
K
-
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
----
F
----
R
-----
D
GSC
D
G
----
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
RTVYA
K
N
----
G
A
F
S
--------
G
-------
V
---
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
82
HHSearch
56.52
38%
-85
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[37-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
NLKN
G
----
V
-----
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
---------
C
G
K
E
F
T
E
F
------------
25
PsiBlast_CBE
56.36
45%
-110
- C1 -
3HDM
1
SGK1_HUMAN
A:
[29-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
N
P
-
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
---
R
----
N
T
A
E
M
Y
D
N
I
-
L
N
K
--
P
L
Q
L
---
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
----
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
-----
S
G
-----------------------------------------------------
28
PsiBlast_CBE
55.14
41%
-92
- C1 -
4L44
1
KS6B1_HUMAN
A:
[14-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-----
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPGD
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
--------------
S
E
S
A
N
Q
-
V
F
L
G
F
A
Y
V
A
P
S
------
80
HHSearch
54.83
35%
-87
- C1 -
4AW2
3
MRCKA_RAT
A:
[68-407]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
-
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
L
---
K
N
---
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
--
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
----
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGK
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
-----
Y
A
---
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
K
ER
F
Q
F
P
TQV
T
D
-
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
----
Q
----
N
-----
G
I
E
--
D
----
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
-----
S
S
P
T
D
T
S
N
F
D
V
D
---------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
55
PsiBlast_CBE
54.70
38%
-87
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[48-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
35
PsiBlast_CBE
54.39
42%
-108
- C1 -
5D9K
2
?
A:
[32-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
KIS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
-----------
F
Y
F
D
P
--------------------------------------------
53
PsiBlast_CBE
54.34
38%
-94
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[48-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
42
PsiBlast_CBE
54.34
42%
-102
- C1 -
5D9L
2
?
A:
[32-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
-----
G
R
P
E
D
T
F
Y
F
D
P
--------------------------------------------
51
PsiBlast_CBE
53.92
38%
-89
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[48-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
56
PsiBlast_CBE
53.72
38%
-90
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[33-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KDGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
38
PsiBlast_CBE
53.34
43%
-109
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
KVT
R
---
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
-
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
----
G
-----
P
----
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------
40
PsiBlast_CBE
52.93
43%
-108
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VT
R
---
P
D
---
S
G
H
L
Y
A
M
K
V
L
---------------------
I
L
A
D
V
-
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
----
G
-----
P
----
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------
36
PsiBlast_CBE
52.83
42%
-96
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----
Q
S
-----------------------------------------------------
34
PsiBlast_CBE
52.80
42%
-109
- C1 -
5D9K
2
?
B:
[32-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
KIS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
D
P
--------------------------------------------
86
HHSearch
52.67
43%
-96
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
---
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
----
G
P
G
D
A
-
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----
Q
------------------------------------------------------
45
PsiBlast_CBE
52.54
42%
-99
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[32-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
KIS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
GV
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
-----------
F
Y
F
D
P
--------------------------------------------
58
PsiBlast_CBE
52.52
38%
-88
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[33-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KDGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
37
PsiBlast_CBE
52.47
42%
-98
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----
Q
S
-----------------------------------------------------
59
PsiBlast_CBE
52.45
38%
-91
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[33-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KDG
V
-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
93
HHSearch
52.03
43%
-106
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[15-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
-
R
V
------
D
I
L
V
E
-
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
PD
G
V
-
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------
44
PsiBlast_CBE
51.58
42%
-94
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[32-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
IS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
D
P
--------------------------------------------
39
PsiBlast_CBE
51.50
43%
-109
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VT
R
---
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
--------------
I
L
A
D
V
-
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
----
G
-----
P
----
D
GA
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------
43
PsiBlast_CBE
51.47
42%
-91
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[32-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
D
P
--------------------------------------------
33
PsiBlast_CBE
51.24
42%
-105
- C1 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
KIS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
-----------
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
------------
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------
52
PsiBlast_CBE
51.17
38%
-88
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[48-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
48
PsiBlast_CBE
50.70
43%
-107
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
IS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
----------
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------
57
PsiBlast_CBE
50.37
38%
-84
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[33-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KDG
V
-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
54
PsiBlast_CBE
50.24
38%
-86
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[48-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
-
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
-
E
K
C
---
G
K
E
F
S
E
F
------------------
49
PsiBlast_CBE
50.20
43%
-104
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
IS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
R
-------
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------
47
PsiBlast_CBE
50.15
43%
-107
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[26-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
IS
G
---
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
R
V
--------
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
----
G
-----
P
----
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------
30
PsiBlast_CBE
48.02
41%
-105
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
----------------
A
E
R
N
I
L
E
-
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
--------------------------------------------------------------
41
PsiBlast_CBE
44.84
42%
-105
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[1-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-------------------------------------------------------------
32
PsiBlast_CBE
44.02
41%
-101
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
E
-
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
--------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
--------------------------------------------------------------
31
PsiBlast_CBE
40.52
41%
-94
- C1 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
-
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
----
A
GPG
D
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-------------------------------------------------------------