@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPSH1_HUMAN: (2015-10-11 )
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......---130----.----..------.--.--..-140-........150.......160.......170.......180....---------------.--------------.--.190------.........200.......210.......220.....-..230-.-.......240..---..---...250.......260.......270-........280.......290......---.300..-.....310.......320.......330.......340.......350.......360.......370......-.380.......390.......400.......410.......420..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGCGTSKVLPEPPK
D
V
Q
L
D
L
V
KKVEPFSG
T
K
S
D
V
Y
K
H
F
I
T
E
VDSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPSEP
P
R
R
A
R
V
A
K
Y
R
AKFDPR
V
T
A
K
Y
D
I
K
A
L
IGRGSF
S
R
V
V
R
V
EHRATRQ
P
Y
A
I
K
M
I
---
E
T
K
----
Y
----
R
E
------
G
--
R
--
E
V
-
C
E
--
S
E
L
R
V
L
R
R
V
R
H
A
N
I
I
Q
L
V
E
V
F
ETQE
R
V
Y
M
V
M
E
LAT
G
G
E
L
F
D
R
I
I
A---------------K--------------G--SF--------T
E
R
D
A
T
R
V
L
Q
M
V
L
D
G
V
R
Y
L
H
A
LGITHRDLKPE
N
L
L
Y
Y-HPG-T-D-
S
K
I
I
I
T
DFGLAS---AR---KKGDD
C
L
M
KTTCGTPEYIA
P
E
V
L
V
R--KPYTNS
V
D
M
W
A
L
G
V
I
A
Y
I
L
LSGTMPFE---DD
N
R
T
R
-
L
Y
R
Q
I
LRGKYSYSGEPWP
S
V
S
N
L
A
K
D
F
I
D
R
L
LTVDPG
A
R
M
T
A
L
Q
A
LRHP
W
V
V
S
M
A
A
S
S
S
M
K
N
L
H
R
S
I
S
Q
N
L
L
K
R
-
A
S
S
R
C
QSTK
S
A
Q
STRSSRSTRS
N
K
S
R
R
V
R
E
R
E
L
R
E
L
N
L
R
Y
Q
Q
QYNG
4
PsiBlast_PDB
86.94
46%
-130
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[20-299]
-------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
-
D
-
S
K
I
M
I
S
D
F
-------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
--
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------------------------------------------
2
PsiBlast_PDB
86.57
45%
-116
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[20-314]
-------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
---------------------------
E
--
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
-
D
-
S
K
I
M
I
S
D
F
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
--
K
N
I
H
Q
S
V
S
E
Q
-
I
K
K
-
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
----------------------------
21
PsiBlast_CBE
86.44
48%
-129
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[24-301]
-------------------------------------------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
----
A
--------------------S
I
E
--
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
Q
D
-
E
-
E
-
S
K
I
M
I
S
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
--
K
N
I
H
E
S
V
S
A
Q
I
R
K
N
-
F
A
K
S
K
W
R
Q
A
F
N
A
T
---------------------------------
23
PsiBlast_CBE
86.32
46%
-128
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-299]
-------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
-------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
-
D
-
S
K
I
M
I
S
D
F
G
-------------
G
--
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
--
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------------------------------------------
22
PsiBlast_CBE
84.77
45%
-117
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[20-314]
-------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
--------------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
-
D
-
S
K
I
M
I
S
D
F
------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
--
K
N
I
H
Q
S
V
S
E
Q
-
I
K
K
-
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
----------------------------
134
HHSearch
82.85
48%
-128
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[11-277]
----------------------------------------------------------------------------------------
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
--------------------------
S
-
M
E
--
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
-
D
-
S
K
I
M
I
S
D
F
G
L
S
K
---
M
E
---
D
P
G
----------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------
5
PsiBlast_PDB
80.80
48%
-134
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
-------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
--------------------------
S
-
M
E
--
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
-
D
-
S
K
I
M
I
S
D
F
G
L
S
K
---
M
E
---
D
P
G
----------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------
7
PsiBlast_PDB
79.19
43%
-122
- C1 -
2W4O
1
KCC4_HUMAN
A:
[55-332]
-------------------------------------------------------------------------------------------------
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
-----
K
----
K
---------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
--
Y
Y
--------
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
-
T
P
A
-
P
-
D
-
A
P
L
K
I
A
D
F
------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
---
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
N
F
----
V
H
M
D
T
A
Q
K
K
L
Q
E
-
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
----------------------------
30
PsiBlast_CBE
79.16
39%
-105
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[28-316]
--------------------------------------------------------------------------------------------
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
---
N
T
K
----
K
----
L
S
------
A
--
R
D
H
Q
K
-
L
E
--
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
--------------
E
--
Y
Y
--------
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
C
-
K
-
G
-
A
A
V
K
L
A
D
F
G
L
A
----
I
E
---
V
Q
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
--
M
H
R
Q
E
T
V
E
C
L
R
K
-
F
N
A
R
R
K
L
K
G
-------------------------------------
103
PsiBlast_CBE
78.97
41%
-117
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------
109
PsiBlast_CBE
78.72
39%
-117
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[9-285]
--------------------------------------------------------------------------------------------
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
----
Q
SRAS
R
R
------
G
VC
R
--
E
E
-
I
E
--
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
--------------
E
--
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
K
N
-
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
---
E
I
---
E
D
G
V
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
-
Q
Y
V
-------------------------------------------
110
PsiBlast_CBE
78.09
39%
-119
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[9-285]
--------------------------------------------------------------------------------------------
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
----
Q
SRAS
R
R
------
G
VC
R
--
E
E
-
I
E
--
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
--------------
E
--
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
K
N
-
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
---
E
I
---
E
D
G
V
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
-
Q
Y
V
-------------------------------------------
141
HHSearch
77.98
42%
-111
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
--------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
------------------------
S
S
-
L
E
--
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
--------------
G
--
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
-
T
P
E
-
E
-
N
-
S
K
I
M
I
T
D
F
G
L
S
K
---
M
E
---
Q
N
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
--
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
-
F
A
-
K
S
-----------------------------------------
52
PsiBlast_CBE
77.46
41%
-124
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[15-277]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
-
F
A
A
A
K
-----------------------------------------
11
PsiBlast_PDB
76.94
39%
-111
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
---
N
T
K
----
K
----
L
S
------
A
--
R
D
H
Q
K
-
L
E
--
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
--------------
E
--
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
C
-
K
-
G
-
A
A
V
K
L
A
D
F
G
L
A
----
I
E
---
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
--
M
H
R
Q
E
T
V
E
C
L
K
K
-
F
N
A
R
R
K
L
K
--------------------------------------
132
HHSearch
76.66
41%
-123
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[7-278]
-------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
----
R
----
T
K
SSRRGV
S
--
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
-
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
-
F
A
A
R
------------------------------------------
26
PsiBlast_CBE
76.58
39%
-112
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-289]
---------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
---
N
T
K
----
K
----
L
S
------
A
--
R
D
H
Q
K
-
L
E
--
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
--------------
E
--
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
C
-
K
-
G
-
A
A
V
K
L
A
D
F
G
L
A
----
I
E
---
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
--
M
H
R
Q
E
T
V
E
C
L
K
K
-
F
N
A
R
R
K
L
K
--------------------------------------
144
HHSearch
76.17
34%
-126
- C1 -
3HKO
2
?
A:
[24-337]
---------------------------------------------------------------------------------------------
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
---
N
K
N
----
K
I
R
Q--
K
------
D
--
V
--
E
R
-
I
K
--
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
SI-
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
-
T
N
K
---
S
-
F
E
I
K
L
V
D
F
G
L
S
K
---
E
F
YKL
N
N
G
--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
---
G
V
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
-----------------------------------------------------------
43
PsiBlast_CBE
76.17
38%
-105
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[13-302]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
-
F
A
A
R
------------------------------------------
25
PsiBlast_CBE
75.82
40%
-105
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-289]
---------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
----
K
----
L
S
------
A
--
R
DH
Q
K
-
L
E
--
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
--------------
E
--
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
S
-
K
-
G
-
A
A
V
K
L
A
D
F
G
L
A
----
I
E
---
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
--
M
H
R
Q
E
T
V
D
C
L
K
K
-
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------
10
PsiBlast_PDB
75.79
40%
-106
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
----
K
----
L
S
------
A
--
R
D
H
Q
K
-
L
E
--
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
--------------
E
--
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
S
-
K
-
G
-
A
A
V
K
L
A
D
F
G
L
A
----
I
E
---
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
--
M
H
R
Q
E
T
V
D
C
L
K
K
-
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------
107
PsiBlast_CBE
75.59
40%
-121
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
-
F
A
A
R
------------------------------------------
97
PsiBlast_CBE
75.56
41%
-122
- C1 -
3MA6
1
?
A:
[33-291]
------------------------------------------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
----
Q
----
K
T
------
D
--
K
--
E
S
-
L
L
--
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
--
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
-
D
-
A
N
I
R
I
I
D
F
G
L
S
T
HFE-
S
---
K
K
-----
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
-----------------------------------------------------------------
8
PsiBlast_PDB
75.43
40%
-117
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
----
K
----
L
S
------
A
--
R
D
H
Q
K
-
L
E
--
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
--------------
E
--
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
S
-
K
-
G
-
A
A
V
K
L
A
D
F
G
L
A
----
I
E
---
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
--
M
H
R
Q
E
T
V
D
C
L
K
K
-
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
-----------------------
92
PsiBlast_CBE
75.35
41%
-119
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-------------------------------------------------------------------
42
PsiBlast_CBE
75.21
39%
-113
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[21-294]
-----------------------------------------------------------------------------------
T
V
F
R
Q
E
---
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------------------------------------------------------------
105
PsiBlast_CBE
75.09
41%
-116
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
------------------------------------------------------------------
86
PsiBlast_CBE
75.01
41%
-116
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
106
PsiBlast_CBE
73.73
41%
-117
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
------------------------------------------------------------------
81
PsiBlast_CBE
73.59
41%
-116
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
79
PsiBlast_CBE
73.51
41%
-112
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
E
K
----------------------------------------------------------------
99
PsiBlast_CBE
73.13
41%
-114
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
100
PsiBlast_CBE
72.88
41%
-113
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
69
PsiBlast_CBE
72.53
41%
-117
- C1 -
3N51
3
?
A:
[27-285]
------------------------------------------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
----
Q
----
K
T
------
D
--
K
--
E
S
-
L
L
--
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
--
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
-
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-----
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
-
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
102
PsiBlast_CBE
72.52
41%
-112
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
96
PsiBlast_CBE
72.40
41%
-117
- C1 -
3MA6
1
?
B:
[33-291]
------------------------------------------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
----
Q
-----
T
------
D
--
K
--
E
S
-
L
L
--
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
--
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
-
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-----
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
------------------------------------------------------------------
101
PsiBlast_CBE
72.33
41%
-112
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
78
PsiBlast_CBE
72.24
41%
-112
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
K
---------------------------------------------------------------
83
PsiBlast_CBE
72.09
41%
-113
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
89
PsiBlast_CBE
71.94
41%
-125
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
-------------
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------
98
PsiBlast_CBE
71.90
41%
-109
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------------------------------------------------------------
84
PsiBlast_CBE
71.87
41%
-110
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
F
-------------------------------------------------------------------
82
PsiBlast_CBE
71.78
41%
-115
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
-------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
85
PsiBlast_CBE
71.67
41%
-113
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
76
PsiBlast_CBE
71.55
41%
-109
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
----------------------------------------------------------------
18
PsiBlast_PDB
71.48
41%
-108
- C1 -
2WEI
1
?
A:
[16-280]
-----------------------------------------------------------------------------------------
F
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
A
----
S
----
A
K
------
N
--
K
--
D
T
-
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---------------
R
--------------
K
--
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
-
S
K
E
-
K
-
D
-
C
D
I
K
I
I
D
F
G
L
S
T
---
C
F
---
Q
Q
N
T
K
--
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-
R
--
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
----------------------------------------------------------------
88
PsiBlast_CBE
71.15
41%
-133
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
------------------------VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
------------
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------
91
PsiBlast_CBE
70.92
41%
-125
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RT------------------
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
--
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
--
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
--------------
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------
90
PsiBlast_CBE
70.77
41%
-122
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[13-275]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS-----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
------------------
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
------------
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------
24
PsiBlast_CBE
70.64
46%
-111
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[16-275]
------------------------------------------------------------------------------------------------------
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
S
------------------------
S
-
L
E
--
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
--------------
G
--
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
-
T
P
E
-
E
-
N
-
S
K
I
M
I
T
D
F
G
L
S
K
---
M
E
---
Q
N
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
------
L
H
R
D
I
Y
P
S
V
S
L
Q
-
I
Q
K
N
F
A
K
---------------------------------------
61
PsiBlast_CBE
70.56
41%
-123
- C1 -
3V5P
1
?
A:
[27-285]
------------------------------------------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
----
Q
----
K
T
------
D
--
K
--
E
S
-
L
L
--
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
--
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
-
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-----
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
-
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
87
PsiBlast_CBE
70.36
41%
-113
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
RTKS
S
----
R
R
------
G
VS
R
--
E
D
-
I
E
--
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
-
V
P---
R
I
K
I
I
D
F
G
L
A
H
---
K
I
---
D
F
G
N
E
--
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
------------------------------------------------------------------
64
PsiBlast_CBE
70.24
41%
-121
- C1 -
3UPX
1
?
A:
[27-285]
------------------------------------------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
----
Q
----
K
T
------
D
--
K
--
E
S
-
L
L
--
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
--
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
-
D
-
A
N
I
R
I
I
D
F
G
L
S
T
HFE
A
S
---
K
K
-----
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
-
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
32
PsiBlast_CBE
62.98
42%
-114
- C1 -
4D9U
1
A:
[19-282]
--------------------------------------------------------------------------------------------
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
----
K
----
R
D
------
P
--
T
--
E
E
-
I
E
--
I
---
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
---------------
Q
--------------
K
--
F
F
--------
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
-
N
-
P
-
E
S
I
R
I
C
D
F
G
F
A
K
----
Q
---
L
R
A
E
N
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
--
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
D
T
P
E
E
-
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
-
M
A
A
T
Y
S
A
L
N
R
N
Q
----------------------------------
33
PsiBlast_CBE
62.94
42%
-111
- C1 -
4D9T
1
A:
[19-282]
--------------------------------------------------------------------------------------------
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
----
K
----
R
D
------
P
--
T
--
E
E
-
I
E
--
I
---
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
---------------
Q
--------------
K
--
F
F
--------
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
-
N
-
P
-
E
S
I
R
I
C
D
F
G
F
A
K
----
Q
---
L
R
A
E
N
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
--
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
D
T
P
E
E
-
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
-
M
A
A
T
Y
S
A
L
N
R
N
-----------------------------------