@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPSH2_HUMAN: (2015-10-11 )
MGCGASRKVVPGPPALAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90......----.----.-----100-..--.--..-...110...-....120.......130.......140.......150--------------..----------------..--------....160.......170.......180.......190-...-..-..200.......210.---.....---...220.......230....--...240.......250.......260---.......-270.......280.......290.......300.......310.......320-----.....-----...--330.......340.......350.......360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGCGASRKVVPGPPA
L
A
W
AKHEGQNQAGVGGAGP
G
P
E
A
A
A
Q
A
A
Q
R
I
Q
V
A
R
F
RAKFD
P
R
V
L
A
R
Y
D
I
K
A
L
IGTGSF
S
R
V
V
R
V
EQKTTKK
P
F
A
I
K
V
M
E
T
R
----
E
----R-----E
G
--
R
E
--
A
--
C
V
-
S
E
L
S
V
L
R
R
V
-
S
H
R
Y
I
V
Q
L
M
E
I
FETED
Q
V
Y
M
V
M
E
LAT
G
G
E
L
F
D
R
L
I
A---------------QG----------------SF--------
T
E
R
D
A
V
R
I
L
Q
M
V
A
D
G
I
R
Y
L
H
A
L
Q
I
T
HRNLKPE
N
L
L
Y
Y-HPG-EE-
S
K
I
L
I
T
DFGLAYS--G---KKSGD---
W
T
M
K
TLCGTPEYI
A
P
E
V
L
LR--KPY
T
S
A
V
D
M
W
A
L
G
V
I
T
Y
A
L
L
S
GFLPF---DD
E
S
Q
T
R
-
L
Y
R
K
I
LKGKYNYTGEPWP
S
I
S
H
L
A
K
D
F
I
D
K
L
L
I
LEAGHRMSAGQALDH
P
W
V
I
------
T
MAAG-----
S
S
M
--
K
N
L
Q
R
A
I
S
R
N
L
M
Q
RASPHSQSPGSAQSSKSHYS
H
K
S
RHMWSKRN
L
R
I
V
E
S
P
L
S
A
LL
22
PsiBlast_CBE
88.15
45%
-136
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[20-294]
--------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------------
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
--------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------
A
G
-----
D
T
A
LD
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-------------------------
5
PsiBlast_PDB
87.66
45%
-136
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[20-294]
--------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------------------
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------
A
G
-----
D
T
A
LD
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------------------------------------
23
PsiBlast_CBE
86.36
45%
-133
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-294]
--------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------------------
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
G
--------------
G
---
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------
A
G
-----
D
T
A
LD
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------------------------------------
3
PsiBlast_PDB
84.73
45%
-134
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[20-294]
--------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
----------------------------E
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------
A
G
-----
D
T
A
LD
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-------------------------
21
PsiBlast_CBE
82.67
45%
-132
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[24-298]
--------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
----
A
---------------------
S
I
E
N
E
I
A
V
L
R
K
I
-
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
Q
D
-
E
E
-
S
K
I
M
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
------
G
D
T
A
L
-----
N
----
K
N
I
H
E
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
-----------------------------
1
PsiBlast_PDB
80.39
45%
-130
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[24-298]
--------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
----
A
------------------
S
--
S
I
E
N
E
I
A
V
L
R
K
I
-
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
Q
D
-
E
E
-
S
K
I
M
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
------
G
D
T
A
L
-----
N
----
K
N
I
H
E
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
-----------------------------
6
PsiBlast_PDB
78.70
45%
-129
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
--------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----------------------------
S
M
E
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
G
L
--
S
--
K
---
M
E
D
P
G
-----------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------
A
-------------------------------------------------------------------
8
PsiBlast_PDB
78.39
41%
-121
- C1 -
2W4O
1
KCC4_HUMAN
A:
[55-338]
--------------------------------------------------------------
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
--
K
----
K
--------------------------
I
G
V
L
L
R
L
-
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
Y
Y
--------
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
-
T
P
A
-
P
D
-
A
P
L
K
I
A
D
F
--------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
---
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
------
G
K
A
A
N
FVHM
D
T
A
Q
--
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------------------------------
127
HHSearch
77.73
44%
-128
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[11-277]
-----------------------------------------------------
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------------------
S
--
M
E
-
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
G
----------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
-
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
G
L
S
K
M
--
E
---
D
P
G
-------------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------
88
PsiBlast_CBE
77.11
36%
-123
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-285]
--------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
SRAS
R
-----
R
G
V
S
R
E
--
E
--
I
E
-
R
E
V
S
I
L
R
Q
V
-
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
--
I
---
E
D
G
V
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
------
P
V
D
N
Q
-----
Q
A
M
--
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
---------------------------------------
93
PsiBlast_CBE
76.85
36%
-120
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[32-294]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
----------------------------------------------------------------------
60
PsiBlast_CBE
76.62
36%
-118
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[15-288]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------
K
P
--
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
------------------------------
63
PsiBlast_CBE
76.33
36%
-117
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[13-286]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------
K
P
--
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------
99
PsiBlast_CBE
75.16
35%
-116
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[13-286]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------
K
P
--
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------
104
PsiBlast_CBE
75.12
36%
-120
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[13-275]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
------------------------------------------------------------------
97
PsiBlast_CBE
74.33
36%
-117
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
------------------------------------------------------------------
70
PsiBlast_CBE
74.09
34%
-112
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[14-302]
--------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
SRAS
R
-----
R
G
VC
R
E
--
E
--
I
E
-
R
E
V
S
I
L
R
Q
V
-
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
--
I
---
E
D
G
V
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
PVD
T
Q
Q
A
M
V
R
R
-----
E
S
V
--
V
N
L
E
N
-
F
K
K
Q
Y
V
--------------------------------------------
95
PsiBlast_CBE
74.08
36%
-118
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
Q
F
E
K
------------------------------------------------------------------
61
PsiBlast_CBE
74.08
36%
-118
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[13-286]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------
K
P
--
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------
137
HHSearch
73.66
32%
-126
- C1 -
3HKO
2
?
A:
[24-335]
----------------------------------------------------------
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
----
K
I
R
Q-------
K
D
--
V
E
--
R
--
I
K
-
T
E
V
R
L
M
K
K
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SI-
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
-
T
N
K
--
S
-
F
E
I
K
L
V
D
F
G
L
S
K
E
--
F
YKL
N
N
G
-----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
---
P
G
V
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
------
Q
F
S
D
K
-----
I
Y
K
--
M
S
------------------------------------------------------
134
HHSearch
73.58
40%
-110
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
---------------------------------------------------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
---------------------
S
--
S
--
L
E
-
N
E
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
G
----------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
-
T
P
E
-
E
N
-
S
K
I
M
I
T
D
F
G
L
S
K
M
--
E
---
Q
N
G
------
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
------
G
N
T
A
L
-----
H
----
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
-
F
A
K
S
-------------------------------------
71
PsiBlast_CBE
73.46
34%
-114
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[14-302]
--------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
SRAS
R
-----
R
G
VC
R
E
--
E
--
I
E
-
R
E
V
S
I
L
R
Q
V
-
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
E
----------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
--
I
---
E
D
G
V
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
PVD
T
Q
Q
A
M
V
R
R
-----
E
S
V
--
V
N
L
E
N
-
F
K
K
Q
Y
V
--------------------------------------------
54
PsiBlast_CBE
73.37
40%
-121
- C1 -
3MA6
1
?
A:
[33-293]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-
K
-----
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
-
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
K
-------------------------------------------------------------------
59
PsiBlast_CBE
73.15
38%
-130
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[96-346]
-------------------------------------------------------------------
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
----
M
-----
K
D
--
K
E
--
E
--
V
K
-
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---------------
E
S
Y---------------
N
L
--------
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
-
N
R
--
D
A
-
K
Q
I
K
I
I
D
F
G
L
A
R
R
--
Y
---
K
P
R
E
-----
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
--
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
---
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
------
D
H
K
L
H
-----
S
R
L
----------------------------------------------------------
57
PsiBlast_CBE
72.83
36%
-120
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[6-281]
--------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
----
K
----
L
-----
S
A
--
R
D
H
Q
K
--
L
E
-
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
S
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
---
Q
--
G
D
QQA
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
------
Q
R
S
T
V
-----
A
S
M
--
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------
58
PsiBlast_CBE
72.73
35%
-116
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[28-307]
---------------------------------------------------------
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
----
K
----
L
-----
S
A
--
R
D
H
Q
K
--
L
E
-
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
C
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
---
E
Q
Q
A
----
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
------
Q
R
S
T
V
-----
A
S
M
--
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------
98
PsiBlast_CBE
72.38
36%
-118
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
------
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
------------------------------------------------------------------
101
PsiBlast_CBE
72.35
36%
-116
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
F
---------------------------------------------------------------------
94
PsiBlast_CBE
71.65
36%
-116
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
-----
K
------------------------------------------------------------
102
PsiBlast_CBE
71.37
36%
-117
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
------------------------------------------------------------------
56
PsiBlast_CBE
71.34
36%
-119
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[6-281]
--------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
----
K
----
L
-----
S
A
--
R
D
HQ
K
--
L
E
-
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
S
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
---
Q
--
G
D
QQA
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
------
Q
R
S
T
V
-----
A
S
M
--
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------
105
PsiBlast_CBE
71.19
36%
-113
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[13-275]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
------------------------------------------------------------------
100
PsiBlast_CBE
70.62
36%
-117
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
P
Q
F
E
------------------------------------------------------------------
52
PsiBlast_CBE
69.36
39%
-115
- C1 -
2WEI
1
?
A:
[23-280]
-------------------------------------------------------------
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
----
S
----
A
-----
K
N
--
K
D
--
T
S
T
I
L
-
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---------------
R
K
----------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
-
S
K
E
-
K
D
-
C
D
I
K
I
I
D
F
G
L
S
T
C
--
F
---
Q
Q
N
T
-----
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
-
L
R
--
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
---
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
S
E
------------------------------------------------------------------
42
PsiBlast_CBE
68.63
40%
-118
- C1 -
3UPX
1
?
A:
[27-287]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-
K
-----
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
A
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
K
V
-----
P
S
L
--
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
53
PsiBlast_CBE
68.58
40%
-117
- C1 -
3MA6
1
?
B:
[33-293]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-------
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
A
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
--------------------------------------------------------------------
50
PsiBlast_CBE
68.52
40%
-114
- C1 -
4MXA
1
?
A:
[28-288]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-
K
-----
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
A
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
K
E
-----
Q
I
S
--
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
55
PsiBlast_CBE
67.76
36%
-122
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[6-281]
--------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
----
K
----
L
-----
S
A
--
R
D
H
Q
K
--
L
E
-
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
E
----------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
-
S
K
S
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
---
Q
--
G
D
QQA
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
------
Q
R
---------
S
M
--
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------
107
PsiBlast_CBE
67.61
36%
-128
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[13-275]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
----------------
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------
44
PsiBlast_CBE
67.60
40%
-114
- C1 -
3T3U
5
?
A:
[27-287]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-
K
-----
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
A
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
K
E
-----
Q
I
S
--
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
39
PsiBlast_CBE
66.97
40%
-117
- C1 -
3V5P
1
?
A:
[27-287]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-
K
-----
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
A
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
K
V
-----
P
S
L
--
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
109
PsiBlast_CBE
66.94
36%
-130
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[13-275]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RT-----------------
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
E
----------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
-V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
-----------------
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------
47
PsiBlast_CBE
66.82
40%
-113
- C1 -
3N51
3
?
A:
[27-287]
-------------------------------------------------------------
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
VKQ-
K
-----
T
D
--
K
E
--
S
--
L
L
-
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
K
----------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
---
E
A
S
K
-----
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
------
T
Y
T
K
E
-----
Q
I
S
--
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
24
PsiBlast_CBE
66.44
45%
-116
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[16-265]
-------------------------------------------------------------------
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-----------------------
S
--
L
E
-
N
E
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
G
----------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
-
T
P
E
-
E
N
-
S
K
I
M
I
T
D
F
G
L
S
--------
K
M
E
Q
N
---
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
------
G
N
T
A
L
-----
H
R
D
--
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-----------------------------------------
103
PsiBlast_CBE
66.39
36%
-116
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[12-274]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS
S
----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
---
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
F
G
N
E
---
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------
P
Q
F
--------------------------------------------------------------------
123
HHSearch
66.12
33%
-120
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-292]
---------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
----
K
----
F
T
S
SPG
L
S
--
T
E
--
D
--
L
K
-
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
---------------
R
A
D
A
G
F
------------
V
Y
--------
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
-
S
K
E
-
N
S
-
A
P
V
K
L
G
G
F
G
V
A
I
Q
--
L
---
G
E
S
G
----
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
---
Y
G
T
-
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
------
E
R
D
R
Y
-----
A
Y
K
--
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
--------------------------------------
106
PsiBlast_CBE
64.68
36%
-135
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[13-275]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------------------VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
---------------
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------
108
PsiBlast_CBE
63.58
36%
-124
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[13-275]
--------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
RTKS-----
R
-----
R
G
VS
R
E
--
D
--
I
E
-
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
------------------
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
---
D
---------------
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
---
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----------------------------------------------------------------------------
75
PsiBlast_CBE
57.25
36%
-117
- C1 -
4D9T
1
A:
[24-282]
--------------------------------------------------------------
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
----
K
----
R
-----
D
P
--
T
E
---------
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
---------------
Q
K
----------------
F
F
--------
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
-
N
P
-
E
S
I
R
I
C
D
F
G
F
A
K
Q
--
L
---
R
A
E
N
G
---
L
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
--
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
ANG
P
D
D
T
P
E
E
-
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
------
H
W
D
Q
L
-----
P
Q
Y
--
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
-------------------------------
74
PsiBlast_CBE
55.83
36%
-122
- C1 -
4D9U
1
A:
[24-282]
--------------------------------------------------------------
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
----
K
----
R
-----
D
P
--
T
E
---------
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
---------------
Q
K
----------------
F
F
--------
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
-
N
P
-
E
S
I
R
I
C
D
F
G
F
A
K
Q
--
L
---
R
A
E
N
G
---
L
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
--
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
ANG
P
D
D
T
P
E
E
-
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
------
H
W
D
Q
L
-----
P
Q
Y
--
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
------------------------------