@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KS6A3_HUMAN: (2015-10-11 )
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100..-.....110.....--..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...-....230.......240..----.....250.......260.......270.......280-........290.........300.......310.......320.......330.......340.......350.......360.......370.......380........390.......400.......410.......420.......430.......440.......450.......460-.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620..----.....630.......640.......650.......660.......670.......680.......690..----.....700.......710.......720.......730.......740
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
L
A
Q
L
A
D
P
W
Q
K
MAVESPSDSAE
N
G
Q
Q
I
M
DEPMGEEEINPQTE
E
V
S
I
K
E
I
A
I
T
H
H
V
KEGHEKA
D
P
S
Q
F
E
L
L
K
V
L
GQGSF
G
K
V
F
L
V
K
KISGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
D
R
V
R
T
K
M--ER
D
I
L
V
EVNH
P
F
I
V
K
L
H
Y
A
FQTE
G
K
L
Y
L
I
L
D
F
LRG
G
D
L
F
T
R
L
S
K
E
VMF
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
RDLKPE
N
I
L
LDEEG
H
I
K
L
T
DFGLSKESI
D
H
E
K
K
A
-
Y
S
F
CG
T
V
E
Y
M
A
P
E
V
V
NRRG----HTQSA
D
W
W
S
F
G
V
L
M
F
E
M
L
TGTLPFQGK
D
R
K
E
T
M
T
M
I
L
--
K
AKLGMPQF--L
S
P
E
A
Q
S
L
L
R
M
L
F
KRNPANRLGAGP
D
G
V
E
E
I
K
R
H
SFFSTI
D
W
N
K
L
Y
R
R
EIHPPFKPATGRPED
T
F
Y
FDPEFTAKTPKDSPGIPPSA
N
A
H
Q
-
L
FRG
F
S
F
V
A
I
TSDD
E
S
Q
A
M
Q
T
V
G
V
H
S
I
V
Q
Q
L
H
RNSIQFTDGYE
V
K
E
DIGVG
S
Y
S
V
C
K
R
C
I
H
K
ATN
M
E
F
A
V
K
I
IDKSKRD
P
T
E
-
E
I
E
I
L
L
RYGQHP
N
I
I
T
L
K
DVYDDG
K
Y
V
Y
V
V
T
E
L
MK
G
G
E
L
L
D
K
I
L
R
Q
K
F
F
S
E
REA
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
AQG
V
V
HRDLKPS
N
I
L
Y
VDESGNP
E
S
I
R
I
CDF
G
F
A
K
Q
L
RAEN
G
L
L
MTPCYTANFV
A
P
E
V
L
K
RQGY
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
LTGYTPFANGPDD----
T
P
E
E
I
L
A
R
IGSG
K
F
S
LSGGYWNS
V
S
D
T
A
K
D
L
V
S
K
M
LHVD
P
H
Q
R
L
T
A
A
L
V
LRHP
W
I
V
HWDQL
P
Q
Y
QLNRQD----A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
LNRNQSPVLEPV
G
R
S
T
L
A
Q
R
RG
I
K
K
I
TSTAL
7
PsiBlast_PDB
83.35
100%
-91
- C3 -
4NW5
1
KS6A3_HUMAN
A:
[15-323]
--------------------------------------------------
A
I
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.51
100%
-100
- C3 -
4NUS
1
KS6A3_HUMAN
A:
[17-323]
----------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.47
100%
-92
- C3 -
4NW6
1
KS6A3_HUMAN
A:
[15-323]
--------------------------------------------------
A
I
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
D
R
V
R
T
K
M
--
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.59
99%
-103
- C3 -
4D9T
1
A:
[17-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
R
D
P
T
E
-
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
D
----
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
----
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
---------------------------
2
PsiBlast_PDB
76.43
99%
-105
- C3 -
4D9U
1
A:
[10-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
Q
L
H
R
N
S
I
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
R
D
P
T
E
-
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
D
----
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
----
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
--------------------------
38
PsiBlast_CBE
59.70
42%
-85
- C3 -
4RA5
3
KPCT_HUMAN
A:
[7-301]
-------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
-
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
-
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
D
N
P
F
Y
P
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
S
M
D
-
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
51.69
42%
-95
- C3 -
3KN5
1
KS6A5_HUMAN
A:
[19-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
K
R
M
E
A
N
T
Q
K
E
I
T
A
L
K
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
-
I
K
I
I
D
F
G
F
A
R
L
K
P
P
----------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-----CT--
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
Q
D
G
S
Q
L
S
S
N
P
L
M
T
P
D
I
L
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
-----------------------
44
PsiBlast_CBE
51.40
42%
-97
- C3 -
3KN5
1
B:
[19-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
K
R
M
E
A
N
T
Q
K
E
I
T
A
L
K
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
-
I
K
I
I
D
F
G
F
A
R
L
K
P
P
----------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
LTCT
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
Q
D
G
S
Q
L
S
S
N
P
L
M
T
P
D
ILGS
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
-----------------------
60
PsiBlast_CBE
51.39
33%
-57
- C3 -
4L6Q
1
ROCK2_HUMAN
A:
[17-401]
---
A
L
I
R
D
P
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
--
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
--
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
--
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
AE
I
S
K
H
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
--
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
---
V
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------