@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KS6A4_HUMAN: (2015-10-11 )
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Atome Classification :
(92 SA)
-------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40.-.......50........60-........70..-......80........90....--....100.......110.......120......----.--130........140.......150.-......160.......170.......180.......190...-....200.......210.---......220.......230.....------..240.......250.....------..260.......270.......280.......290.......300...---....310.......320...---------....330.......340.........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------MGDEDDDE
S
C
A
V
E
L
R
I
T
EANLTGHEEKVSVEN
F
E
L
L
K
V
LGTG-AY
G
K
V
F
L
V
R
KAGGH
D
A
G
K
L
-
Y
A
M
K
V
L
R
K
A
A
L
V
-
Q
R
A
K
T
Q
E
HT
R
T
E
R
S
V
L
E
L
V
R
QA--
P
F
L
V
T
L
H
Y
A
FQTD
A
K
L
H
L
I
L
D
YVSG
G
E
M
F
T
H
L
Y
----
Q
--
R
Q
-
Y
F
K
EA
E
V
R
V
YGG
E
I
V
L
A
L
E
H
L
H
-
K
L
G
I
I
Y
R
D
L
K
L
E
N
V
L
LDSEG
H
I
V
L
T
DFGL
S
K
E
F
L
T
E
E
K
E
R
T
F
-
S
F
CG
T
I
E
Y
M
A
P
E
I
I
RSKT---GHGK
A
V
D
W
W
S
L
G
I
L
L
F
E
L
LTGAS
P
------
F
T
LEGERN
T
Q
A
E
V
S
R
R
I
LKC------SPPFPPR
I
G
P
V
A
Q
D
L
L
Q
R
L
LCK
D
P
K
K
RLGAGPQ
G
A
Q
E
V
RNHPFFQG
L
D
---
W
V
A
L
A
A
R
KIPAPF
R
P
Q
I
R
SE---------LDV
G
N
F
A
E
E
F
T
RLEP--VYSPPGSPPPGDP
R
I
FQ
G
Y
S
FV
A
P
S
I
L
FDHNN
A
V
MTDGLEAPGAGDRP
G
R
A
A
V
A
R
S
A
MMQDSP
F
F
Q
Q
Y
ELDLREPALGQG
S
F
S
V
C
R
R
C
R
QRQS
G
Q
E
F
A
V
K
I
L
S
R
R
LEAN
T
Q
R
E
V
A
A
L
R
L
C
Q
SHP
N
V
V
N
L
H
E
V
H
H
D
Q
L
H
T
Y
L
V
L
E
L
LRG
G
E
L
L
E
H
I
R
K
KRHF
S
E
S
E
A
S
Q
I
L
R
S
L
V
S
A
V
S
F
M
H
E
EAG
V
V
HRDLKPE
N
I
L
YADDTPGA
P
V
K
I
I
DFG
F
A
RLRPQSPGVPMQT
P
C
F
T
L
QYA
A
P
E
L
L
A
QQGYDESC
D
L
W
S
L
G
V
I
L
Y
M
M
LSGQVPFQGASGQGG
Q
S
Q
A
A
E
I
M
C
KIREG
R
F
SLD
G
E
A
WQ
G
V
S
E
E
A
K
E
L
V
R
G
L
LTVDP
A
K
R
L
K
LEGLRGSSWLQDGSARSSPPLR
T
P
D
V
LESS
G
P
A
V
R
SGL
N
A
T
F
M
AFNRGKRE
G
F
F
L
KSVENA
P
L
A
K
R
R
K
Q
K
L
R
S
A
T
ASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
6
PsiBlast_PDB
81.73
50%
-102
- C1 -
4L46
1
KS6B1_HUMAN
A:
[9-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
----
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
---------
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
--
V
------------
Q
V
F
L
G
F
T
Y
V
A
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.41
50%
-100
- C1 -
4L43
1
KS6B1_HUMAN
A:
[10-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
---------
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
--
V
---------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.20
50%
-92
- C1 -
4L44
1
KS6B1_HUMAN
A:
[10-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
-----
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
---------
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
-----------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
75.30
40%
-102
- C1 -
1REJ
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.90
49%
-99
- C1 -
4L42
1
KS6B1_HUMAN
A:
[13-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
---------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.52
52%
-98
- C1 -
3WF9
2
KS6B1_HUMAN
A:
[15-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
74.32
41%
-99
- C1 -
4IE9
2
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
74.31
41%
-102
- C1 -
2VO7
2
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.80
41%
-102
- C1 -
2C1B
1
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
73.74
41%
-98
- C1 -
1XH5
3
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
73.28
40%
-95
- C1 -
3O7L
2
KAPCA_MOUSE
B:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
----
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
73.26
41%
-100
- C1 -
1XH6
1
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
73.16
41%
-99
- C1 -
3P0M
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
73.01
41%
-97
- C1 -
3OWP
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.01
52%
-96
- C1 -
3WE4
1
KS6B1_HUMAN
A:
[15-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
---
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.89
40%
-98
- C1 -
3IDB
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
72.78
41%
-97
- C1 -
3POO
2
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-------------
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.77
41%
-95
- C1 -
3AGL
1
KAPCA_HUMAN
B:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
72.68
41%
-94
- C1 -
3OOG
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
72.54
41%
-95
- C1 -
3OVV
2
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
72.49
41%
-99
- C1 -
1SVH
1
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.47
50%
-107
- C1 -
3G51
1
KS6A3_MOUSE
A:
[5-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
K
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
-----------
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-------------
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.43
40%
-91
- C1 -
4HPT
1
KAPCA_MOUSE
E:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
72.30
40%
-94
- C1 -
1RE8
2
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.27
41%
-96
- C1 -
3ZO4
4
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
71.96
40%
-94
- C1 -
3OW3
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.85
52%
-94
- C1 -
3WF8
2
KS6B1_HUMAN
A:
[15-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.79
52%
-92
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
---
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
71.78
40%
-95
- C1 -
3IDC
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
71.72
40%
-94
- C1 -
3FJQ
1
KAPCA_MOUSE
E:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.70
40%
-93
- C1 -
2GU8
1
KAPCA_HUMAN
A:
[19-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.62
41%
-97
- C1 -
2C1A
1
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
71.54
41%
-95
- C1 -
2QUR
1
KAPCA_MOUSE
A:
[32-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
P
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
A
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
71.51
40%
-98
- C1 -
4NTT
1
KAPCA_MOUSE
B:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.46
41%
-96
- C1 -
1YDS
1
KAPCA_BOVIN
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
71.41
40%
-95
- C1 -
1JBP
2
KAPCA_MOUSE
E:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
E
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.41
41%
-92
- C1 -
1YDR
1
KAPCA_BOVIN
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.32
52%
-95
- C1 -
3WF6
1
KS6B1_HUMAN
A:
[15-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
71.28
41%
-92
- C1 -
3MVJ
1
KAPCA_HUMAN
A:
[61-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
71.26
41%
-97
- C1 -
3OXT
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.16
52%
-92
- C1 -
3WF5
1
KS6B1_HUMAN
A:
[15-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
70.95
51%
-88
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.90
41%
-96
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
70.83
41%
-92
- C1 -
3VQH
2
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.79
51%
-92
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
70.76
40%
-97
- C1 -
1REK
2
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
70.72
41%
-102
- C1 -
4IJ9
1
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.71
51%
-103
- C1 -
3A62
1
KS6B1_HUMAN
A:
[13-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
---------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
70.17
40%
-96
- C1 -
4NTT
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
70.10
41%
-92
* C1 *
3AGM
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
70.08
40%
-95
- C1 -
1BX6
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
70.05
41%
-94
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.00
50%
-100
- C1 -
5D9K
2
?
B:
[26-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
69.98
41%
-94
- C1 -
3L9L
1
KAPCA_HUMAN
B:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.90
50%
-100
- C1 -
5D9K
2
?
A:
[26-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--------------
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
---------------
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
69.82
41%
-96
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
69.81
40%
-95
- C1 -
1FMO
1
KAPCA_MOUSE
E:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.75
40%
-93
- C1 -
2ERZ
1
KAPCA_MOUSE
E:
[33-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
69.64
41%
-94
- C1 -
1YDT
1
KAPCA_BOVIN
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
69.63
41%
-94
- C1 -
1XH8
1
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.60
51%
-89
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[15-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
---------
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
69.54
51%
-88
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[15-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
---------
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.41
51%
-100
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
----------
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
69.33
41%
-93
- C1 -
3L9L
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
69.27
41%
-90
- C1 -
3AGL
1
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
69.20
41%
-98
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.06
51%
-91
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[17-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
---------
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
69.05
40%
-93
- C1 -
1ATP
1
KAPCA_MOUSE
E:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
69.00
41%
-94
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
68.78
41%
-94
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
68.64
51%
-100
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
-------
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.63
51%
-105
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
----------------
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
68.55
41%
-90
- C1 -
3MVJ
1
KAPCA_HUMAN
E:
[61-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
68.54
40%
-97
- C1 -
1BKX
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
68.15
41%
-97
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.90
40%
-96
- C1 -
4DIN
1
KAPCA_MOUSE
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
67.77
51%
-102
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[7-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
--------
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Fugue
67.56
32%
-76
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
------
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
-
Y
A
C
K
K
L
E
K
K
R
I
K
-
K
R
-
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
-
S
--
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
----
H
MG
Q
A
-
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
--
P
E
G
Q
T
I
K
-
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
---
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
------
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
------
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
----------
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
--
T
G
S
V
---
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.37
41%
-97
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
67.35
53%
-103
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[1-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-------------
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
66.33
49%
-104
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
-
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
L
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
66.11
49%
-108
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
-
Y
A
M
K
V
L
---------------------
I
L
A
D
V
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
L
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
65.26
41%
-90
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
----
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.00
51%
-86
- C1 -
5D9L
2
?
A:
[13-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
---------
E
D
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
64.68
32%
-72
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------RD
R
K
Y
L
A
R
LKLPPLSKC
E
A
L
R
E
S
LDLGFEGMCLEQ
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
ADDAL
R
P
Q
K
A
Q
A
L
R
A
A
YLEPQAQLFCSFLD
A
E
T
V
A
R
A
R
AGGLF
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
--
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
-
G
F
G
E
V
F
A
C
Q
M
K
A
---
T
G
K
L
-
Y
A
C
K
K
L
N
K
K
R
L
K
-
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
NVDE
D
--
N
P
-
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
Q
T
K
T
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
------
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
------
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
YAKNGAFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SG
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.03
51%
-96
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.98
49%
-102
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
-
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
-------------
I
L
A
D
V
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
L
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
63.83
43%
-107
- C1 -
2R5T
1
SGK1_HUMAN
A:
[39-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
----
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
--
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
----
R
--
E
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
---
S
R
N
T
-
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
60.40
43%
-102
- C1 -
3HDM
1
SGK1_HUMAN
A:
[39-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
----
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
--
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
----
R
--
E
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
---
S
R
N
T
-
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Fugue
60.10
38%
-91
- C1 -
1CDK
2
KAPCA_PIG
A:
[8-350]
--------------------------------------------------------------------------------------------------------------------------------K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
K
--
E
T
G
-
N
H
-
F
A
M
K
I
L
D
K
Q
K
V
V
K
--
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
---NF
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
---
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--KGY--
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
---YPPFFA
D
-------
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
PS------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
-----
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
58.36
43%
-104
- C1 -
3HDN
1
SGK1_HUMAN
A:
[39-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
----
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
--
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
----
R
--
E
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
---
S
R
N
T
-
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
57.99
51%
-91
- C1 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------