@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KS6A5_HUMAN: (2015-10-11 )
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
Atome Classification :
(47 SA)
----------------------------------------------------------------------------------------------------------------......----.-----..10........20........30........40..----------------....-...50.......-.60........70......-..80........-90........100.......110........120...-....130.......140.----....-.--.150.......160.......-170.......180.......190.......200.......210........220.......230.----......240.......250..------.....260.......270..------.....280.......290.......300.......310.......320---.......330.......340.......350...----....360.......370.........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------MEEEGG----S-----SGGAAGTSADGGDGG
E
Q
L
L
T
V
K
H
E
LRTANLTG
H
-
A
E
----------------KVGI-E
N
F
E
L
L
K
V
LGTG-AY
G
K
V
F
L
V
R
K
ISGHDT
G
K
L
-
Y
A
M
K
V
L
K
K
A
T
I
V
-
Q
KAKTTEH
T
R
T
E
R
Q
V
L
E
H
I
R
Q-S
P
F
L
V
T
L
H
Y
A
FQTE
T
-
K
L
H
L
I
L
D
YIN
G
G
E
L
F
T
H
L
----
S
Q
R
E
-R--FT
E
H
E
V
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
-
K
L
G
I
I
Y
R
D
I
K
L
E
N
I
L
LDSNG
H
V
V
L
T
DFGLS
K
E
F
V
A
D
E
T
E
R
A
-
Y
S
F
CG
T
I
E
Y
MA
P
D
I
VRGGDSGHD----K
A
V
D
W
W
S
L
G
V
L
M
Y
E
L
LTGAS
P
------
F
T
VDGEKN
S
Q
A
E
I
S
R
R
I
L
KS------EPPY
P
Q
E
M
S
A
L
A
K
D
L
I
Q
R
L
L
MKD
P
K
K
RLGCGPR
D
A
D
E
I
K
E
H
L
F
FQKI
N
---
W
D
DL
A
A
KKVPAPF
K
P
V
I
RDEL
D
V
S
N
F
A
E
E
F
T
EM----DPTYSPAALPQ
S
S
E
K
--
L
F
Q
G
Y
S
FV
A
P
S
I
L
FKRNAAVI
D
P
L
Q
F
H
MGVERPG
V
T
N
V
A
R
S
A
MMKDSPF
Y
Q
HYDLDLKDKPLGEG
S
F
S
I
C
R
K
C
V
HKKSNQ
A
F
A
V
K
I
I
S
K
R
MEAN
T
Q
K
E
I
T
A
L
K
LCEGHP
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
LN
G
G
E
L
F
E
R
I
K
K
KKHF
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
HRDLKPE
N
L
L
F
TDEND
N
L
E
I
K
I
I
DFGFARLKPPDNQPLKT
P
C
F
T
L
HYA
A
P
E
L
LNQNGYDESC
D
L
W
S
L
G
V
I
L
Y
T
M
LSGQVPFQSHDRSL
T
C
T
S
A
V
E
I
M
K
K
I
KKGDFSFE
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
LTVDPNK
R
L
KMSGL
R
Y
N
E
W
L
QDGSQLSSNPLM
T
P
D
ILGSS
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
KREGFCLQNVDK
A
P
L
A
K
R
R
K
MKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNP
E
T
L
F
QFSDSVA
4
PsiBlast_PDB
76.18
52%
-91
- C1 -
4L43
1
KS6B1_HUMAN
A:
[13-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-------------
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
----
T
P
V
--------
S
A
N
Q
--
V
F
L
G
F
A
Y
V
A
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.19
52%
-92
- C1 -
4L46
1
KS6B1_HUMAN
A:
[13-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
----
T
P
V
-----------
Q
--
V
F
L
G
F
T
Y
V
A
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.88
52%
-85
- C1 -
4L44
1
KS6B1_HUMAN
A:
[13-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
----
T
--------
S
E
S
A
N
Q
--
V
F
L
G
F
A
Y
V
A
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.56
51%
-94
- C1 -
4L42
1
KS6B1_HUMAN
A:
[13-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
-
V
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-------------------------------------
E
--
M
F
R
D
F
E
Y
I
A
D
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.53
53%
-88
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
72.45
31%
-80
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------RD
R
K
Y
L
A
R
LKLPPLSKC
E
A
L
R
E
S
LDLGFEGMCLEQ
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
ADDAL
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
----
L
FCSFL
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
-
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
-
D
W
F
L
D
F
R
V
L
G
R
G
-
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
-
Y
A
C
K
K
L
N
K
K
R
L
K
-
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
--
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
YNVD
E
D
N
P
-
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
-
K
A
G
Q
T
K
T
-
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
--
E
E
Y
D
----
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
------
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
------
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
----------
D
S
R
T
V
Y
A
K
----
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
--
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.81
52%
-99
- C1 -
5D9K
2
?
A:
[26-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--------------
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.48
53%
-92
- C1 -
3WE4
1
KS6B1_HUMAN
A:
[15-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
----
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.10
53%
-91
- C1 -
3WF6
1
KS6B1_HUMAN
A:
[15-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.86
53%
-90
- C1 -
3WF8
2
KS6B1_HUMAN
A:
[15-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.78
52%
-97
- C1 -
5D9K
2
?
B:
[26-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.68
53%
-91
- C1 -
3WF9
2
KS6B1_HUMAN
A:
[15-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.14
52%
-98
- C1 -
3G51
1
KS6A3_MOUSE
A:
[17-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
---------
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-------------
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
69.98
53%
-88
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
69.91
45%
-101
- C1 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
-
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
G
R
Y
-
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
L
Q
N
S
R
H
--
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
----
S
R
E
R
-
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
------
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
------
F
Y
----
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.86
53%
-88
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[14-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.80
53%
-96
- C1 -
3A62
1
KS6B1_HUMAN
A:
[13-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
---------------
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
69.43
31%
-75
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
KDLF
Q
-----
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
----------------
P
V
T
K
-
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
-
Y
A
C
K
K
L
E
K
K
R
I
K
-
K
R
-
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
--
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
-
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
----
Y
H
M
G
-
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
---
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
--
E
R
Y
T
----
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
------
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
------
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
----
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.22
53%
-86
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
----
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
68.99
53%
-88
- C1 -
5D9L
2
?
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.97
39%
-94
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[41-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.64
53%
-88
- C1 -
3WF5
1
KS6B1_HUMAN
A:
[15-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
-
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
68.31
38%
-99
- C1 -
4Q9Z
1
B:
[1-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
-
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
---
E
F
K
K
T
N
Q
F
-
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
----
Q
S
C
H
-
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
-
K
T
-
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
------
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
------
F
H
G
Q
D
E
E
----
E
L
F
H
S
I
R
M
D
------
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
----
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
------------------------N-
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.18
39%
-94
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[41-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
67.90
39%
-95
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[41-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
67.87
53%
-86
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
67.47
53%
-88
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.34
39%
-95
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[26-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
67.22
39%
-101
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[41-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
66.82
39%
-97
* C1 *
2UZT
1
KAPCA_BOVIN
A:
[26-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
66.46
50%
-103
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
-
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
-
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
N
H
--
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
Q
G
H
S
----
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.32
53%
-99
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
----------------
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
66.19
39%
-95
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[26-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
66.05
39%
-98
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[41-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.65
50%
-106
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
-
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
-
Y
A
M
K
V
L
---------------------
I
L
A
D
V
N
H
--
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
Q
G
H
S
----
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
63.65
39%
-92
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[26-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
-
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
I
G
-
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
-
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
----
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.64
51%
-90
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[7-304]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
----
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
------
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.14
54%
-94
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[1-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
------------------------
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-------------
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.11
50%
-100
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
E
----------------
K
A
D
P
-
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
-----------
I
L
A
D
V
N
H
--
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
Q
G
H
S
----
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
62.39
50%
-88
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[7-305]
------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
A
I
T
H
H
V
K
E
----
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
--------
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
------
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.08
53%
-87
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
E
E
V
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.61
50%
-89
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
----
G
H
--
E
----------------
K
A
D
P
-
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
-
Y
A
M
K
V
L
K
K
A
T
L
---
K
V
R
D
R
V
R
-----
D
I
L
V
E
V
N
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
----
S
K
E
V
-
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
----
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
R
R
G
H
T
----
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
------
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
61.53
43%
-103
- C1 -
2R5T
1
SGK1_HUMAN
A:
[39-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
----
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-----
Q
R
E
-
R
C-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
--
K
Q
P
Y
D
----
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
----
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
60.68
43%
-100
- C1 -
3HDN
1
SGK1_HUMAN
A:
[39-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
----
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-----
Q
R
E
-
R
C-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
--
K
Q
P
Y
D
----
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
----
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
60.41
37%
-87
- C1 -
1CDK
2
KAPCA_PIG
A:
[8-350]
--------------------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
-----------------------
H
-L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
--
K
E
T
G
-
N
H
-
F
A
M
K
I
L
D
K
Q
K
V
V
K
--
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
----
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
------KGYN
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
---YPPFFA
D
-------
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
PS------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
--------
N
E
K
C
G
K
--
E
F
S
E
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
58.84
43%
-98
- C1 -
3HDM
1
SGK1_HUMAN
A:
[39-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
----
H
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-----
Q
R
E
-
R
C-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
--
K
Q
P
Y
D
----
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
----
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
58.58
53%
-87
- C1 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
-
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
-
F
A
M
K
V
L
K
K
------------------------
K
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
-
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
G
H
N
----
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------