@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KS6C1_HUMAN: (2015-10-11 )
MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920-.......930.......940.......950---...---.-------.-------.---...-------960.--.....------.970--....-...980.......990.....------..1000----...-----.-------.---.---------1010-----...--------...----...1020--------......1030......1040.-.-.....1050......1060...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
Y
R
E
R
SA
D
L
A
R
F
Y
TVTEPQRHPR
G
Y
T
V
Y
K
V
T
A
R
V
V
SRR
N
P
E
D
V
Q
E
I
I
V
W
KR
Y
S
D
F
K
K
L
H
K
E
L
W
Q
I
H
K
N
L
F
R
H
SELFP
P
F
AK
G
I
V
FGRF
D
E
T
V
I
E
E
R
R
Q
C
A
E
D
L
L
Q
FSANIPALYN
S
K
Q
L
E
D
F
F
KGGIINDSSELIGPAEAHS
D
S
L
I
D
TFPECSTEGFSSDS
D
L
V
S
L
T
V
D
V
D
S
L
A
E
L
D
DGMASNQNSP
I
R
T
F
G
LNLSSDSSALGAVASDSEQS
K
T
E
E
E
R
E
SRSLFPGSLKPKLG
K
R
D
Y
L
E
K
A
G
E
L
I
K
L
A
LKKEEED
D
Y
E
A
A
S
D
F
Y
R
K
G
V
D
L
L
L
E
GVQGESSP
T
R
R
E
A
V
K
R
R
T
A
E
Y
L
M
R
A
E
S
I
S
S
L
YGKPQLDDVSQPPGSLSSRPLWNLR
S
P
A
E
E
L
K
A
F
R
V
L
G
V
I
D
K
V
L
L
VMDTRT
E
Q
T
F
I
L
K
G
L
R
K
S
S
E
YSRNR
K
T
I
IPRCV
P
N
M
V
C
L
H
K
Y
IISEE
S
V
F
L
V
L
Q
HAEGG
K
L
W
S
Y
I
S
K
F
L
NRSPEESF
D
I
K
E
VKKP
T
L
A
K
V
H
LQQPTSSPQDSSSFESRGSDGG
S
M
L
K
ALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSS
S
E
E
E
C
T
T
S
Y
L
T
L
C
N
EYGQEKIEPGSLNEEPFMKTEGNGV
D
T
K
A
I
K
SF
P
A
H
LAADSDSPST
Q
L
R
A
H
E
L
K
FFPND
D
P
E
AVSSPRTSDSLSRSKNSP
M
E
F
F
RIDSKD
S
A
S
E
L
L
G
L
D
F
G
E
K
L
Y
S
L
KSEPLK
P
F
F
TLPDGDSASRSFNTSE
S
K
V
E
F
K
AQDTISRGSDDSV
P
V
I
S
FKDAAFDDVSGTDEGRP
D
L
L
V
NLPGE
L
E
S
T
R
E
A
AAMGPTKFTQTN
I
G
I
I
E
N
KLLEAP
D
V
L
C
L
RL
S
T
E
Q
C
Q
A
H
E
E
KG
I
E
E
LSDPSGPKSYS
I
T
E
K
HYAQEDP
R
M
L
F
V
A
A
VDHSSSGD
M
S
LLPSSDPKFQ
G
L
G
V
V
E
S
A
VTANN
T
E
E
S
L
F
R
I
CSPLSGA
N
E
YIASTDTLKT
E
E
V
L
L
F
TDQTD
D
L
A
KEE
P
T
S
L
F
QRDSETKGES
G
L
V
LEG
D
K
E
I
H
Q
I
F
E
D
L
D
K
K
L
A
L
A
SRFYI
P
E
G
C
I
Q
R
W
A
A
E
M
V
V
A
L
D
A
L
H
R-E
G
I
V
CRDLNPN
N
I
L
LNDRG
H
I
Q
L
T
Y
FS
R
-----
W
S
E
---V-------E-------D---SC
D
-------
S
D
A
I
--
E
R
M
YC------APEV--GAIT-EETEAC
D
W
W
S
L
G
A
V
L
F
E
LLTG------
K
T
L
V
E
C
----HPA-----G-------I---N---------T--------HTT--------LN
M
----
P
E
C
V
S
E
E
--------
A
R
S
L
I
Q
Q
L
L
QFN
P
L
E
R
L
G
A-G-V-A
G
V
E
D
IKSHPFFTPV
D
W
A
E
LMR
130
HHSearch
72.52
35%
-75
- C1 -
3PFQ
1
KPCB_RAT
A:
[438-610]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
CKENI
W
D
G
---
V
TT-----
K
-------
T
---
F
C
G
-------
T
------
P
D
Y
I
------
A
P
E
I
--
I
A
Y
Q
-
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
------
Q
A
P
F
E
-------------
G
-------
E
---
D
---------
E
D
E
L
F
Q
S
I
M
E
H
N
--------
V
A
Y
----
P
K
S
M
S
K
E
--------
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
-
G
-
P
-
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
137
HHSearch
72.01
42%
-83
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[121-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
---------------------EK-
K
A
Y
-------
S
F
C
G
--
T
V
E
Y
M
------
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
----
K
D
R
-----
K
E
T
-----
M
T
M
-
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
23
PsiBlast_CBE
71.77
36%
-86
- C1 -
3A60
1
KS6B1_HUMAN
B:
[126-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
-------------------
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
12
PsiBlast_PDB
71.67
38%
-79
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[132-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
------------------------------------
G
--
T
V
E
Y
M
------
A
P
E
V
--
V
N
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
------
S
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
L
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
T
E
--------
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
29
PsiBlast_CBE
70.67
36%
-88
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[114-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
-------------------TIEYM-
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
C
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
1
PsiBlast_PDB
70.64
40%
-79
- C1 -
5D9K
2
?
A:
[134-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
--------------------------------------------
C
GTVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
120
HHSearch
70.13
34%
-85
- C1 -
4GV1
4
AKT1_HUMAN
A:
[104-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
-----
C
K
E
---
G
IKDGATM
K
-------
T
---
F
C
G
-------
T
------
P
E
Y
L
------
A
P
E
V
--
L
E
D
N
-
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
------
R
L
P
F
Y
N
--------------------
Q
---
D
---------
H
E
K
L
F
E
L
I
L
M
E
E
--------
I
R
F
----
P
R
T
L
G
P
E
--------
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
11
PsiBlast_PDB
69.78
38%
-73
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[132-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
------------------------------------
G
--
T
V
E
Y
M
------
A
P
E
V
--
V
N
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
------
S
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
L
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
T
E
--------
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
124
HHSearch
69.71
39%
-88
- C1 -
2R5T
1
SGK1_HUMAN
A:
[135-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
-----
C
K
E
---
N
-------
I
-------
E
H
N
S
T
T
S
-------
T
F
C
G
--
T
P
E
Y
L
------
A
P
E
V
--
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
------
L
P
P
F
Y
-------------
S
-------
R
---
N
---------
T
A
E
M
Y
D
N
I
L
N
K
P
--------
L
Q
L
----
K
P
N
I
T
N
S
--------
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
---
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
7
PsiBlast_PDB
69.53
40%
-83
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[129-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
-----------------------
S
----------
E
K
K
--
A
Y
S
F
C
GTVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
10
PsiBlast_PDB
69.44
38%
-74
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[132-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
------------------------------------
G
--
T
V
E
Y
M
------
A
P
E
V
--
V
N
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
------
S
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
L
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
T
E
--------
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
20
PsiBlast_PDB
69.23
36%
-86
- C1 -
3A60
1
KS6B1_HUMAN
A:
[126-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
--------------------------------------------TIEYM-
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
8
PsiBlast_PDB
69.11
40%
-84
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[129-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
-----------------------------------
E
K
K
--
A
Y
S
F
C
GTVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
6
PsiBlast_PDB
69.05
40%
-73
- C1 -
5D9L
2
?
A:
[134-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
--------------------------------------------GTVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
21
PsiBlast_CBE
68.61
40%
-72
- C1 -
5D9K
2
?
B:
[134-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
-------------------------------------------
C
GTVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
121
HHSearch
68.05
34%
-75
- C1 -
4DC2
1
KPCI_MOUSE
A:
[149-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
-----
C
K
E
GLR
P
-------
G
-------
D
---
T
T
S
-------
T
F
C
G
--
T
P
N
Y
I
------
A
P
E
I
--
L
R
G
E
-
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
------
R
S
P
F
D
I
----
V
G
S
-----------------
N
T
E
D
Y
L
F
Q
V
I
L
--------
E
K
Q
--------
I
R
I
----
P
R
S
L
S
V
K
--------
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
2
PsiBlast_PDB
68.05
40%
-67
- C1 -
3G51
1
KS6A3_MOUSE
A:
[128-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
-----------------------
S
I
-------------------TVEYM-
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
135
HHSearch
67.83
33%
-82
- C1 -
3V5W
1
ARBK1_HUMAN
A:
[288-462]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
-----
A
C
D
---
F
-------
S
K
K
K
P
H
--
A
---
S
V
G
-------
T
------
H
G
Y
M
------
A
P
E
V
--
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
D
K
H
E
---
I
D
R
M
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
128
HHSearch
67.62
37%
-73
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[119-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
---
S
-------
I
-------
H
D---
T
H
-------
T
F
C
G
--
T
I
E
Y
M
------
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
T
G
----
E
N
R
-----
K
K
T
-----
I
---
D
K
I
-------
L
--------
K
C
K
--------
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
19
PsiBlast_PDB
67.59
36%
-79
- C1 -
3A62
1
KS6B1_HUMAN
A:
[126-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
------------------------------------------
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
KC
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
22
PsiBlast_CBE
67.39
36%
-83
- C1 -
3A61
1
KS6B1_HUMAN
A:
[126-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------------------------------------------GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
3
PsiBlast_PDB
67.31
40%
-73
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[134-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
-----------------------
S
I
D
-------
H
E
K
K
--
A
Y
S
F
C
GTVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
4
PsiBlast_PDB
67.24
40%
-72
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[134-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
-----------------------
S
I
D
-------
H
E
K
K
--
A
Y
S
F
C
G
TVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
15
PsiBlast_PDB
66.93
36%
-83
- C1 -
3WF6
1
KS6B1_HUMAN
A:
[128-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
KC
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
126
HHSearch
66.85
33%
-86
- C1 -
3TXO
1
A:
[120-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
-----
C
K
E
---
G
-------
I
-------
C
----------------
G
--
T
P
D
Y
I
------
A
P
E
I
--
L
Q
E
M
-
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
------
H
A
P
F
E
A
----
E
N
E
D
D
L
F
E
A
-------
I
-------------
L
--------
N
D
E
--------
V
V
Y
----
P
T
W
L
H
E
D
--------
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
-
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
13
PsiBlast_PDB
66.59
36%
-77
- C1 -
3WE4
1
KS6B1_HUMAN
A:
[128-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
-----
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
KC
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
26
PsiBlast_CBE
66.57
36%
-83
- C1 -
4L44
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
--------------
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
5
PsiBlast_PDB
66.24
40%
-66
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[134-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-----
S
K
E
-----------------------
S
I
D
-------
H
E
K
K
--
A
Y
S
F
C
G
TVEYM
A
P
E
V
--
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
------
T
L
P
F
Q
G
KD
R
K
E
T
M
-----
T
-------
M
---
I
---------
L
--------
K
A
K
--------
L
G
M
----
P
Q
F
L
S
P
E
--------
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
25
PsiBlast_CBE
65.32
36%
-73
- C1 -
4L46
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
------
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
28
PsiBlast_CBE
65.25
36%
-79
- C1 -
4L42
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
88
PsiBlast_CBE
65.19
37%
-81
- C1 -
3HDN
1
SGK1_HUMAN
A:
[144-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
-----
C
K
E
N--
I
-------
E
-------
H
---
N
S
T
-------
T
S
T
F
CG
T
P
E
Y
L
------
A
P
E
V
--
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
LPPFYS
R
N
T
A
E
M
----
Y
D
N
-----
I
-------
L
---
N
-------------------
K
P
--------
L
Q
L
----
K
P
N
I
T
N
S
--------
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
-
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
14
PsiBlast_PDB
65.07
36%
-73
- C1 -
3WF5
1
KS6B1_HUMAN
A:
[128-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
KC
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
27
PsiBlast_CBE
64.92
36%
-80
- C1 -
4L43
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
--------------------GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
90
PsiBlast_CBE
64.52
37%
-82
- C1 -
2R5T
1
SGK1_HUMAN
A:
[144-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
-----
C
K
E
N--
I
-------
E
-------
H
---
N
S
T
-------
T
S
T
F
CG
T
P
E
Y
L
------
A
P
E
V
--
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
LPPFYS
R
N
T
A
E
M
----
Y
D
N
-----
I
-------
L
---
N
-------------------
K
P
--------
L
Q
L
----
K
P
N
I
T
N
S
--------
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
-
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
129
HHSearch
64.42
34%
-75
- C1 -
1XJD
1
A:
[114-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
-----
C
K
E
---
N
-------
M
LGDAKTN
T
---
F
C
G
-------
T
------
P
D
Y
I
------
A
P
E
I
--
L
L
G
Q
-
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
------
Q
S
P
F
H
-------------
G
-------
Q
---
D
---------
E
E
E
L
F
H
S
I
R
M
D
N
--------
P
F
Y
----
P
R
W
L
E
K
E
--------
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-------
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
24
PsiBlast_CBE
64.40
36%
-72
- C1 -
4L45
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
--------------------GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
C
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
103
PsiBlast_CBE
64.08
31%
-70
- C1 -
4MK0
1
ARBK1_HUMAN
A:
[249-429]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
------
R
-----
I
S
D
---
L
-------
G
-------
L
---
A
C
D
FSK
K
K
P
H
A
S
V
G
--
T
H
G
Y
M
------
A
P
E
V
LQ
K
G
V
A
-
Y
D
S
S
A
-
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
D
K
H
E
I
D
R
M
---
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
17
PsiBlast_PDB
63.99
36%
-78
- C1 -
3WF8
2
KS6B1_HUMAN
A:
[128-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
KC
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
98
PsiBlast_CBE
63.87
31%
-81
- C1 -
3PWY
1
PDPK1_HUMAN
A:
[131-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
-----
A
K
V
---
L
S
P---------------------------
S
F
V
G
--
T
A
Q
Y
V
------
S
P
E
L
--
L
T
E
K
-
S
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
------
L
P
P
F
R
A
----
G
N
E
-----
Y
-------
L
---
I
---------
F
--------
Q
K
I
--------
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
--------
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
-
M
-
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
102
PsiBlast_CBE
63.82
32%
-79
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[291-458]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
------
R
-----
I
S
D
---
L
-------
G
-------
L
---
A
C
D
FSKKKPH
A
S
V
G
--
T
H
G
Y
M
------
A
P
E
V
LQ
K
G
V
A
-
Y
D
S
S
A
-
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
DK
H
E
I
D
R
M
---
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
31
PsiBlast_CBE
63.81
36%
-75
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
96
PsiBlast_CBE
63.77
32%
-73
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[290-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
------
R
-----
I
S
D
---
L
-------
G
-------
L
---
A
C
D
FSK
K
K
P
H
A
S
V
G
--
T
H
G
Y
M
------
A
P
E
V
LQ
K
G
V
A
-
Y
D
S
S
A
-
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
D
K
H
E
I
D
R
M
---
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
105
PsiBlast_CBE
63.64
31%
-84
- C1 -
3ION
1
PDPK1_HUMAN
A:
[132-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
-----
A
K
V
---
L
S------------------------------
V
G
--
T
A
Q
Y
V
------
S
P
E
L
--
L
T
E
K
-
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
------
L
P
P
F
R
A
----
G
N
E
-----
Y
-------
L
---
I
---------
F
--------
Q
K
I
--------
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
--------
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
-
M
-
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
89
PsiBlast_CBE
63.51
37%
-77
- C1 -
3HDM
1
SGK1_HUMAN
A:
[144-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
-----
C
K
E
N--
I
-------
E
-------
H
---
N
S
T
-------
T
S
T
F
CG
T
P
E
Y
L
------
A
P
E
V
--
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
LPPFYS
R
N
T
A
E
M
----
Y
D
N
-----
I
-------
L
---
N
-------------------
K
P
--------
L
Q
L
----
K
P
N
I
T
N
S
--------
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
-
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
106
PsiBlast_CBE
63.46
31%
-77
- C1 -
2R7B
2
PDPK1_HUMAN
A:
[132-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
-----
A
K
V
---
L
------------------------------
F
V
G
--
T
A
Q
Y
V
------
S
P
E
L
--
L
T
E
K
-
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
------
L
P
P
F
R
A
----
G
N
E
-----
Y
-------
L
---
I
---------
F
--------
Q
K
I
--------
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
--------
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
-
M
-
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
101
PsiBlast_CBE
63.45
32%
-78
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[291-458]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
------
R
-----
I
S
D
---
L
-------
G
-------
L
---
A
C
D
FSKKKPH
A
S
V
G
--
T
H
G
Y
M
------
A
P
E
V
LQ
K
G
V
A
-
Y
D
S
S
A
-
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
D
K
H
E
I
D
R
M
---
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
30
PsiBlast_CBE
63.35
36%
-75
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[127-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
K
CK
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
18
PsiBlast_PDB
63.29
36%
-76
- C1 -
3WF9
2
KS6B1_HUMAN
A:
[128-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-----
C
K
E
-----------------------
S
I
H
-------
D
G
T
V
--
T
H
T
F
C
GTIEYM
A
P
E
I
--
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
------
A
P
P
F
--------
T
-----
G
-------
E
---
N
---------
R
--------
K
K
T
I
D
K
I
L
KC
K
L
N
L
----
P
P
Y
L
T
Q
E
--------
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
107
PsiBlast_CBE
63.24
31%
-82
- C1 -
3NAX
1
PDPK1_HUMAN
A:
[128-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
-----
A
K
V
---
L
S
PESK--
Q
-------
A
---
R
A
----------------
Q
Y
V
------
S
P
E
L
--
L
T
E
K
-
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
------
L
P
P
F
R
A
----
G
N
E
-----
Y
-------
L
---
I
---------
F
--------
Q
K
I
--------
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
--------
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
-
M
-
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
95
PsiBlast_CBE
62.88
32%
-71
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[290-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
------
R
-----
I
S
D
---
L
-------
G
-------
L
---
A
C
D
F
SK
K
K
P
H
A
S
V
G
--
T
H
G
Y
M
------
A
P
E
V
LQ
K
G
V
A
-
Y
D
S
S
A
-
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
D
K
H
E
I
D
R
M
---
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
93
PsiBlast_CBE
62.56
32%
-69
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[291-458]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
------
R
-----
I
S
D
---
L
-------
G
-------
L
---
A
C
D
FSKKKPH
A
S
V
G
--
T
H
G
Y
M
------
A
P
E
V
LQ
K
G
V
A
-
Y
D
S
S
A
-
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
------
H
S
P
F
R
Q
----
H
K
T
-----
K
D
K
H
E
I
D
R
M
---
T
---------
L
--------
T
M
A
--------
V
E
L
----
P
D
S
F
S
P
E
--------
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
87
PsiBlast_CBE
32.55
34%
28
- C1 -
3NYN
1
GRK6_HUMAN
A:
[285-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
-----
A
V
H
---
V
-------
P
-------
E
G
Q
-
T
I
K
-------
G
R
V
G
--
T
V
G
Y
M
------
A
P
E
V
--
V
K
N
E
-
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
------
Q
S
P
F
Q
-------
K
-----
K
-------
I
---
K
---------
R
--------
E
E
V
--------
E
R
L
----
V
K
E
V
P
E
E
Y
S
ERFS
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
86
PsiBlast_CBE
30.87
34%
27
- C1 -
3NYN
1
GRK6_HUMAN
B:
[285-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
-----
A
V
H
---
V
-------
P
-------
E
GQ-
T
I
K
-------
G
R
V
G
--
T
V
G
Y
M
------
A
P
E
V
--
V
K
N
E
-
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
------
Q
S
P
F
Q
-------
K
-----
K
-------
I
---
K
---------
R
--------
E
E
V
--------
E
R
L
----
V
K
E
V
P
E
E
YSERFSPQ
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
85
PsiBlast_CBE
30.38
34%
30
- C1 -
3NYO
1
GRK6_HUMAN
A:
[285-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
-----
A
V
H
---
V
-------
P
-------
E
G
Q
-
T
I
K
-------
G
R
V
G
--
T
V
G
Y
M
------
A
P
E
V
--
V
K
N
E
-
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
------
Q
S
P
F
Q
-------
K
-----
K
-------
I
---
K
---------
R
--------
E
E
V
--------
E
R
L
----
V
K
E
V
P
E
E
Y
S
ERFS
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
84
PsiBlast_CBE
29.72
34%
33
- C1 -
3NYO
1
GRK6_HUMAN
B:
[285-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
-----
A
V
H
---
V
-------
P
-------
E
GQ-
T
I
K
-------
G
R
V
G
--
T
V
G
Y
M
------
A
P
E
V
--
V
K
N
E
-
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
------
Q
S
P
F
Q
-------
K
-----
K
-------
I
---
K
---------
R
--------
E
E
V
--------
E
R
L
----
V
K
E
V
P
E
E
YSERFSPQ
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A