@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KSR2_HUMAN: (2015-10-11 )
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
Atome Classification :
(66 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.....-..690.......700.......710.......720.......730.......740.......750--.......760.......770.......780-........790.-......800........810.......820.......830.......840.......850.......860.......870..-.-.-...880.......-890......------..900.........910.......920.......----930.......940.......950
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDEENMTKSEEQQ
P
L
S
L
Q
K
A
L
Q
Q
C
E
L
V
Q
N
M
I
D
L
SIS
N
L
E
G
L
R
T
KCATSND
L
T
Q
K
E
I
R
T
L
E
S
K
L
V
K
Y
F
S
R
Q
LSC
K
K
K
V
A
L
Q
ERNAELDG
F
P
Q
L
R
H
W
F
R
I
V
D
V
R
K
E
V
L
E
EISPGQL
S
L
E
D
L
L
E
M
T
D
E
Q
V
C
E
T
V
E
K
YGA
N
R
E
E
C
A
R
L
N
A
S
L
S
C
L
R
N
V
HMSGGNLSKQ
D
W
T
I
QWPTTETGKENNPVCPPEP
T
P
W
I
R
T
HLSQSPRV
P
S
K
C
V
Q
H
Y
CHTSPTPGAP
V
Y
T
H
V
D
R
L
T
VDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTP
N
I
V
T
TVTPPGTPPMRKKNKLKPPGTPPPSS
R
K
L
I
H
LIP
G
F
T
A
L
HRSKSHEFQLGHRVDEAHTPKAKKKSK
P
L
N
L
K
I
HSSVGSCENI
P
S
Q
Q
RSP
L
L
S
E
R
S
L
R
S
F
F
VGHAPFLPSTPPVHTEANFSANTLSVPRWSPQI
P
R
R
D
L
G
N
S
I
K
H
R
F
ST
K
Y
W
M
S
Q
T
C
T
VCGKG
M
L
F
G
L
K
CKN
C
K
L
K
CHNKCTKEAPP
C
H
L
L
I
I
HRGDP
A
R
L
V
RTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSP
Q
C
T
R
QQKNFNL
P
A
S
H
Y
Y
K
Y
K
Q
Q
FIFPDVVPVPETPTRA
P
Q
V
I
L
H
PVTSNPILEGN
P
L
L
Q
I
E
VEPTSEN
E
E
VHDEAEESE
D
D
F
E
E
M
N
L
S
L
L
SARSFPRKASQ
T
S
I
F
L
QEWDI
P
F
E
Q
L
E
I
G
E
L
IGKGRFGQVY
H
G
R
W
H
G
-
E
V
A
I
R
L
I
D
IERD
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
TRHE
N
V
V
L
F
MGACMSP
P
H
L
A
I
I
T
S
L
CKG
R
T
L
Y
S
V
VR--D
A
K
I
V
L
DV
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
AK
G
--
I
L
H
K
DLKSK
N
V
F
-YDN
G
K
V
V
-
I
T
DF
G
L
F
S
I
S
G
V
L
Q
AGRRE
D
K
L
R
IQNG
W
L
C
H
L
A
P
E
I
I
R
Q
LSPDTEEDKLPFSKHSD
V
F
A
L
G
T
I
W
Y
E
LHAREWPF-K-T-QPA
E
A
I
I
W
QMGTG-M-KP
N
L
S
QI------GMG--
K
E
I
S
D
I
L
L
F
C
WAFEQEER
P
T
F
T
K
L
M
D
M
L
E
----
K
L
P
K
RNRRLSHPGHFWKSAEL
1
PsiBlast_PDB
94.49
100%
-112
- C3 -
2Y4I
1
B:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
G
-
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
--
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
--
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
--
K
V
V
-
I
T
D
F
G
L
F
S
----------
E
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
--
E
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
-
K
-
T
-
Q
P
A
E
A
I
I
W
Q
M
G
T
G
-
M
-
K
P
N
L
S
Q
I
------
G
M
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
L
-------------------
47
PsiBlast_CBE
74.02
36%
-109
- C3 -
3PSD
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
41
PsiBlast_CBE
73.58
36%
-109
- C3 -
4E26
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
--------------
4
PsiBlast_PDB
73.27
36%
-108
- C3 -
4MNF
1
BRAF_HUMAN
A:
[42-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------
58
PsiBlast_CBE
72.97
36%
-107
- C3 -
3IDP
1
B:
[22-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
----------------
5
PsiBlast_PDB
72.97
35%
-110
- C3 -
3OG7
1
BRAF_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
---
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
----------------
17
PsiBlast_PDB
72.89
36%
-108
- C3 -
3Q4C
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
12
PsiBlast_PDB
72.80
36%
-108
- C3 -
3PSB
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
18
PsiBlast_PDB
72.74
36%
-109
- C3 -
3PSD
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
10
PsiBlast_PDB
72.74
36%
-106
- C3 -
5CT7
1
?
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
2
PsiBlast_PDB
72.73
35%
-97
- C3 -
3C4C
1
BRAF_HUMAN
A:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
S
--------------
26
PsiBlast_CBE
72.66
36%
-111
- C3 -
4MNF
1
B:
[42-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
LLAR
S
--------------------
36
PsiBlast_CBE
72.58
36%
-105
- C3 -
4G9C
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
-----------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
44
PsiBlast_CBE
72.49
36%
-109
- C3 -
3TV6
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
52
PsiBlast_CBE
72.34
36%
-107
- C3 -
3PPJ
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
56
PsiBlast_CBE
72.21
36%
-109
- C3 -
1UWH
1
BRAF_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
55
PsiBlast_CBE
72.02
36%
-108
- C3 -
1UWH
1
B:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
51
PsiBlast_CBE
71.91
36%
-105
- C3 -
3PPK
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
35
PsiBlast_CBE
71.54
36%
-103
- C3 -
4G9C
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
21
PsiBlast_CBE
71.54
35%
-106
- C3 -
3C4C
1
B:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
---------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
S
--------------
15
PsiBlast_PDB
71.47
36%
-107
- C3 -
3PRF
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
23
PsiBlast_CBE
71.33
35%
-104
- C3 -
4JVG
1
BRAF_HUMAN
C:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
L
A
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
S
--------------
53
PsiBlast_CBE
71.21
36%
-108
- C3 -
3D4Q
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
3
PsiBlast_PDB
71.20
35%
-104
- C3 -
4JVG
1
BRAF_HUMAN
B:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
L
A
T
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
S
--------------
48
PsiBlast_CBE
71.14
36%
-105
- C3 -
3PSB
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
60
PsiBlast_CBE
71.12
36%
-106
- C3 -
5C9C
1
?
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
----------------
32
PsiBlast_CBE
71.05
36%
-103
- C3 -
5CT7
1
?
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
61
PsiBlast_CBE
71.01
36%
-101
- C3 -
4G9R
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
13
PsiBlast_PDB
70.95
36%
-107
- C3 -
3PPJ
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
11
PsiBlast_PDB
70.89
36%
-107
- C3 -
3D4Q
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
59
PsiBlast_CBE
70.88
36%
-106
- C3 -
3IDP
1
BRAF_HUMAN
A:
[22-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
----------------
14
PsiBlast_PDB
70.87
36%
-110
- C3 -
3PPK
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
66
PsiBlast_CBE
70.86
36%
-101
- C3 -
1UWJ
1
BRAF_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
24
PsiBlast_CBE
70.71
35%
-103
- C3 -
4JVG
1
BRAF_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
S
--------------
57
PsiBlast_CBE
70.69
36%
-113
- C3 -
4H58
1
BRAF_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
--------------
20
PsiBlast_PDB
70.29
36%
-107
- C3 -
3TV4
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
50
PsiBlast_CBE
70.26
36%
-107
- C3 -
3PRF
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
37
PsiBlast_CBE
70.19
36%
-104
- C3 -
4EHE
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
31
PsiBlast_CBE
70.16
36%
-105
- C3 -
4MBJ
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
63
PsiBlast_CBE
70.15
36%
-105
- C3 -
4EHG
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
19
PsiBlast_PDB
70.10
36%
-105
- C3 -
3SKC
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
33
PsiBlast_CBE
70.02
36%
-100
- C3 -
4PP7
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
25
PsiBlast_CBE
69.96
35%
-99
- C3 -
4WO5
1
B:
[27-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
L
A
T
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
---------------
49
PsiBlast_CBE
69.73
36%
-104
- C3 -
3PRI
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
62
PsiBlast_CBE
69.68
36%
-101
- C3 -
4G9R
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
42
PsiBlast_CBE
69.66
36%
-102
- C3 -
4E26
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
------
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
38
PsiBlast_CBE
69.65
36%
-110
- C3 -
4EHE
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
30
PsiBlast_CBE
69.53
36%
-105
- C3 -
3II5
1
B:
[29-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
54
PsiBlast_CBE
69.45
36%
-104
* C3 *
4KSP
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
--------------
6
PsiBlast_PDB
69.27
35%
-100
- C3 -
4CQE
1
?
A:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
----------------
64
PsiBlast_CBE
69.25
36%
-106
- C3 -
4EHG
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
39
PsiBlast_CBE
69.18
36%
-103
- C3 -
4E4X
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
27
PsiBlast_CBE
69.00
35%
-110
- C3 -
4CQE
1
?
B:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
----------------
40
PsiBlast_CBE
68.96
36%
-111
- C3 -
4E4X
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
34
PsiBlast_CBE
68.91
36%
-110
- C3 -
4PP7
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
22
PsiBlast_CBE
68.88
35%
-101
- C3 -
4JVG
1
D:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
E
L
S
--------------
9
PsiBlast_PDB
68.87
36%
-113
- C3 -
4MBJ
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
43
PsiBlast_CBE
68.69
36%
-104
- C3 -
3TV6
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
16
PsiBlast_PDB
68.55
36%
-104
- C3 -
3PRI
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
65
PsiBlast_CBE
68.53
36%
-100
- C3 -
1UWJ
1
B:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
8
PsiBlast_PDB
68.11
36%
-103
- C3 -
3II5
1
BRAF_HUMAN
A:
[29-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
----------------
46
PsiBlast_CBE
67.93
36%
-102
- C3 -
3SKC
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
68
PsiBlast_CBE
67.07
34%
-103
- C3 -
3OMV
1
RAF1_HUMAN
A:
[29-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
---
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
--
V
Q
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
-
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
---------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
------
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
-
S
H
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
-
Y
A
S
P
D
L
S
K
L
YKNCP
K
A
M
K
--
R
L
V
A
D
----
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-----------------
45
PsiBlast_CBE
66.81
36%
-102
- C3 -
3TV4
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
--
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
-
S
P
D
L
S
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
P
K
-------------
67
PsiBlast_CBE
66.11
34%
-107
- C3 -
3OMV
1
B:
[29-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
---
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
-
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
--
V
Q
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
-
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
---------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
------
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
-
S
H
I
-
N
N
R
D
Q
I
I
F
M
V
G
R
G
-
Y
A
S
P
D
L
S
K
L
YKNCPK
A
M
K
--
R
L
V
A
D
----
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
LLQH
S
L
P
K
-----------------
69
PsiBlast_CBE
65.31
31%
-102
- C3 -
3P86
1
CTR1_ARATH
A:
[32-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
G
S
D
V
A
V
K
I
L
M
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KS
G
A
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
-
V
D
K
K
Y
T
V
K
V
C
D
F
-----------
G
T
P
E
--------
W
---
M
A
P
E
V
L
R
D
---------
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
L
Q
Q
P
W
G
N
-
L
-
N
P
A
Q
V
V
---
A
A
V
G
-
F
-
K
C
K
R
L
E
I
PR----
N
L
N
--
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
----
P
L
I
K
-----------------