@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KSYK_HUMAN: (2015-10-11 )
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Atome Classification :
(107 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.....-.-.-200.......-----210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390..---.---.--.....400.......410.......420.....-..430.......440.-...-....450.......460-..--.----.----...-.470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.....-.-.580.......590.......600.......610.......620.......630...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASSGMADSANHL
P
F
F
F
GNI
T
R
E
E
A
E
D
Y
L
V
QGGMS
D
G
L
Y
L
L
R
QSRNYLG
G
F
A
L
S
VAHGRKA
H
H
Y
T
I
E
R
ELNG
T
Y
A
IAGGRTHA
S
P
A
D
L
C
H
YHSQESD
G
L
V
C
L
LKKPFNRPQGVQPKTG
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
TWNL
Q
G
Q
A
L
E
Q
A
I
I
SQK
P
Q
L
E
K
L
I
A
T
T
AHEKMPWFHGKISREES
E
Q
I
V
L
I
G
SKTN
G
K
F
L
I
R
A
R-D-N-NG
S
Y
A
L
C
L
L
H-----EG
K
V
L
H
Y
R
IDKDKTGKLSIPEGK
K
F
D
T
L
W
Q
L
V
E
H
YSYKAD
G
L
L
R
V
L
TV
P
C
Q
KIGTQGNVNFGGRPQLPGSHPATWSA
G
G
I
I
S
R
I
K
SYSFPKPGHRKSSPAQGNRQES
T
V
SFNPYEPELAPWAADKGPQREALPMDTEVYESPYA
D
P
E
EIRPK
E
V
Y
LDR
K
L
L
T
L
EDKELGSGNF
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
KNEAND
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
QL-DN
P
Y
I
V
R
M
I
G
ICEA-E-
S
W
M
-
L
V
M
E
M
A
ELG
P
L
N
K
Y
L
Q
--QN--R----H----VK
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
ESNF
V
H
R
D
LAAR
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
LRADE
N
Y
Y
KAQTHGKWP
V
K
W
YA
P
E
C
I
N
Y
YKFSSKSD
V
W
S
F
G
V
L
M
W
E
A
F
SYGQKPYRGMK-G-
S
E
V
T
A
M
L
EKGERMGCPAGC
P
R
E
M
Y
D
L
M
N
L
C
W
T
YDVENRPG
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
DVVN
126
HHSearch
96.45
100%
-112
- C3 -
4FL3
1
KSYK_HUMAN
A:
[9-635]
--------
S
A
N
H
L
P
F
F
F
G
N
I
T
R
E
E
A
E
D
Y
L
V
Q
G
G
M
S
D
G
L
Y
L
L
R
Q
S
R
N
Y
L
G
G
F
A
L
S
V
A
H
G
R
K
A
H
H
Y
T
I
E
R
E
L
N
G
T
Y
A
I
A
G
G
R
T
H
A
S
P
A
D
L
C
H
Y
H
S
Q
E
S
D
G
L
V
C
L
L
K
K
P
F
N
R
P
Q
G
V
Q
P
K
T
G
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
T
W
N
L
Q
G
Q
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
-
N
G
S
Y
A
L
C
L
L
H
-----
E
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
----------------------------------------------------------------------------
R
E
A
L
P
M
D
T
E
V
F
E
S
P
F
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
-------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
2
PsiBlast_PDB
96.24
99%
-112
- C3 -
4FL3
1
KSYK_HUMAN
A:
[9-635]
--------
S
A
N
H
L
P
F
F
F
G
N
I
T
R
E
E
A
E
D
Y
L
V
Q
G
G
M
S
D
G
L
Y
L
L
R
Q
S
R
N
Y
L
G
G
F
A
L
S
V
A
H
G
R
K
A
H
H
Y
T
I
E
R
E
L
N
G
T
Y
A
I
A
G
G
R
T
H
A
S
P
A
D
L
C
H
Y
H
S
Q
E
S
D
G
L
V
C
L
L
K
K
P
F
N
R
P
Q
G
V
Q
P
K
T
G
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
T
W
N
L
Q
G
Q
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
-
N
G
S
Y
A
L
C
L
L
H
-----
E
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
----------------------------------------------------------------------------
R
E
A
L
P
M
D
T
E
V
F
E
S
P
F
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
-------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
1
PsiBlast_PDB
94.91
100%
-107
- C3 -
4FL2
1
KSYK_HUMAN
A:
[10-636]
--------
S
A
N
H
L
P
F
F
F
G
N
I
T
R
E
E
A
E
D
Y
L
V
Q
G
G
M
S
D
G
L
Y
L
L
R
Q
S
R
N
Y
L
G
G
F
A
L
S
V
A
H
G
R
K
A
H
H
Y
T
I
E
R
E
L
N
G
T
Y
A
I
A
G
G
R
T
H
A
S
P
A
D
L
C
H
Y
H
S
Q
E
S
D
G
L
V
C
L
L
K
K
P
F
N
R
P
Q
G
V
Q
P
K
T
G
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
T
W
N
L
Q
G
Q
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
-
N
G
S
Y
A
L
C
L
L
H
-----
E
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
I
G
T
Q
------------------------------------------------------------------------
R
E
A
L
P
M
D
T
E
V
Y
E
S
P
Y
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
127
HHSearch
74.76
56%
-95
- C3 -
2OZO
1
ZAP70_HUMAN
A:
[2-602]
------
P
D
P
A
A
H
L
P
F
F
Y
G
S
I
S
R
A
E
A
E
E
H
L
K
L
A
G
M
A
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
F
H
H
F
P
I
E
R
Q
L
N
G
T
Y
A
I
A
G
G
K
A
H
C
G
P
A
E
L
C
E
F
Y
S
R
D
P
D
G
L
P
C
N
L
R
K
P
C
N
R
P
S
G
L
E
P
Q
P
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
W
K
L
E
G
E
A
L
E
Q
A
I
I
S
Q
A
P
Q
V
E
K
L
I
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
-
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------------------------------------------------------------------------------
M
D
T
S
V
F
E
S
P
F
S
D
P
E
E
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
---
R
---
K
--
K
Q
I
D
V
A
I
K
V
L
K
Q
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
-
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G-
K
R
--
E
----
E
----
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
--------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
4
PsiBlast_PDB
74.67
53%
-95
- C3 -
2OZO
1
ZAP70_HUMAN
A:
[2-602]
------
P
D
P
A
A
H
L
P
F
F
Y
G
S
I
S
R
A
E
A
E
E
H
L
K
L
A
G
M
A
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
F
H
H
F
P
I
E
R
Q
L
N
G
T
Y
A
I
A
G
G
K
A
H
C
G
P
A
E
L
C
E
F
Y
S
R
D
P
D
G
L
P
C
N
L
R
K
P
C
N
R
P
S
G
L
E
P
Q
P
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
W
K
L
E
G
E
A
L
E
Q
A
I
I
S
Q
A
P
Q
V
E
K
L
I
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
-
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------------------------------------------------------------------------------
M
D
T
S
V
F
E
S
P
F
S
D
P
E
E
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
---
R
---
K
--
K
Q
I
D
V
A
I
K
V
L
K
-
Q
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
-
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
--
G
K
--
R
E---
E
----
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
--------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
3
PsiBlast_PDB
73.86
54%
-94
- C3 -
4K2R
1
ZAP70_HUMAN
A:
[2-602]
------
P
D
P
A
A
H
L
P
F
F
Y
G
S
I
S
R
A
E
A
E
E
H
L
K
L
A
G
M
A
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
F
H
H
F
P
I
E
R
Q
L
N
G
T
Y
A
I
A
G
G
K
A
H
C
G
P
A
E
L
C
E
F
Y
S
R
D
P
D
G
L
P
C
N
L
R
K
P
C
N
R
P
S
G
L
E
P
Q
P
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
W
K
L
E
G
E
A
L
E
Q
A
I
I
S
Q
A
P
Q
V
E
K
L
I
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
-
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
S
-----------------------------------------------------------------------
D
K
P
R
--
P
M
P
M
D
T
S
V
Y
E
S
P
Y
S
D
P
E
E
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
---
R
---
K
--
K
Q
I
D
V
A
I
K
V
L
K
-
Q
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
-
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
--
G
K
--
R
E---
E
----
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
-----------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
29
PsiBlast_CBE
67.66
99%
-124
- C3 -
4RX9
2
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
---
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
T
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
-
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
8
PsiBlast_PDB
67.42
100%
-122
- C3 -
3TUC
1
A:
[16-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
-------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
--
33
PsiBlast_CBE
67.20
100%
-120
- C3 -
3SRV
2
B:
[6-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---
15
PsiBlast_PDB
67.04
100%
-120
- C3 -
3FQH
1
KSYK_HUMAN
A:
[11-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
-----
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
-
12
PsiBlast_PDB
66.57
100%
-121
- C3 -
1XBB
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
31
PsiBlast_CBE
66.40
99%
-118
- C3 -
4RX8
3
A:
[12-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
T
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
-
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
9
PsiBlast_PDB
66.39
100%
-118
- C3 -
3TUD
1
A:
[21-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
------------------
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
30
PsiBlast_CBE
66.37
99%
-117
- C3 -
5CXZ
2
?
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
-----
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
T
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
-
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
32
PsiBlast_CBE
65.99
99%
-119
- C3 -
4PX6
1
A:
[12-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
----------
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
T
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
28
PsiBlast_CBE
65.96
100%
-124
- C3 -
3FQH
1
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
----
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
--
19
PsiBlast_PDB
65.95
100%
-117
- C3 -
4FYO
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
36
PsiBlast_CBE
65.88
100%
-120
- C3 -
4PV0
1
A:
[1-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
--
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
25
PsiBlast_CBE
65.73
100%
-117
- C3 -
4I0R
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
-
E
L
G
S
G
---
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
10
PsiBlast_PDB
65.64
99%
-115
- C3 -
3EMG
1
A:
[21-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
------
V
V
K
T
V
A
V
K
I
L
K
-------
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
----
134
HHSearch
65.59
99%
-117
- C3 -
4FYO
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
20
PsiBlast_PDB
65.35
100%
-119
- C3 -
4FZ6
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
--
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
13
PsiBlast_PDB
65.33
100%
-119
- C3 -
1XBC
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
38
PsiBlast_CBE
65.32
99%
-117
- C3 -
3SRV
4
KSYK_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
--
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
------
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
-
6
PsiBlast_PDB
65.29
100%
-119
- C3 -
3VF8
1
A:
[21-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
----------
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
27
PsiBlast_CBE
65.24
100%
-123
- C3 -
4FZ7
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
--
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
17
PsiBlast_PDB
65.24
100%
-113
- C3 -
4FL1
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
5
PsiBlast_PDB
65.20
100%
-118
- C3 -
3TUB
1
A:
[20-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
-------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
--
18
PsiBlast_PDB
65.17
100%
-117
- C3 -
4FYN
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
-
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
34
PsiBlast_CBE
65.15
100%
-116
- C3 -
4DFN
1
A:
[1-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
26
PsiBlast_CBE
64.90
100%
-113
- C3 -
4GFG
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
35
PsiBlast_CBE
64.84
100%
-117
- C3 -
4DFL
2
A:
[1-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
---
T
V
K
K
G
Y
Y
--
Q
M
----------
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
7
PsiBlast_PDB
64.41
100%
-116
- C3 -
3VF9
1
A:
[22-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
------
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
22
PsiBlast_CBE
64.39
100%
-117
- C3 -
4PUZ
1
KSYK_HUMAN
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
--
16
PsiBlast_PDB
64.20
100%
-119
- C3 -
3FQS
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
24
PsiBlast_CBE
64.17
100%
-118
- C3 -
4I0S
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
21
PsiBlast_CBE
63.03
100%
-117
- C3 -
4PUZ
1
B:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
14
PsiBlast_PDB
62.36
100%
-116
- C3 -
3FQE
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
37
PsiBlast_CBE
62.18
100%
-112
- C3 -
4F4P
1
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
----------------
V
K
T
V
A
V
K
I
L
K
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
23
PsiBlast_CBE
61.41
100%
-114
- C3 -
4I0T
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
---
K
---
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
-
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
--
Q
N
--
R
----
H
----
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
-----
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
131
HHSearch
60.80
40%
-101
- C3 -
1OPK
3
ABL1_MOUSE
A:
[101-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
-
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
---------
P
---
T
I
----------------------------
Y
G
----------
V
-----------------------------
S
P
N
Y
D
K
W
E
M
-------
E
R
T
D
I
T
M
K
-
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
--------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
-
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
--
E
C
NR
Q
----
E
----
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
132
HHSearch
60.63
36%
-100
- C3 -
2H8H
1
SRC_HUMAN
A:
[145-524]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
-
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
-------------
Q
T
----------------------------
Q
G
L
----------------------
A
K
-------------------
D
-------
A
W
E
I
P
R
E
S
L
R
L
E
-
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-----------
G
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
-
P
I
Y
-
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
--
G
E
TG
K
----
Y
----
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
129
HHSearch
58.01
37%
-94
- C3 -
1QCF
1
HCK_HUMAN
A:
[67-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
-
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
-------------
K
---------------------
P
W
E
----------------------------------
K
---------------
D
-------
A
W
E
I
P
R
E
S
L
K
L
E
-
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-----------
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
-
P
I
Y
-
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
--
S
D
E
G
S
----
K
----
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
--
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
135
HHSearch
57.58
62%
-105
- C3 -
1U59
1
A:
[2-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
-----------
K
Q
I
D
V
A
I
K
V
L
K
Q
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
-
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G-
K
R
--
E
----
E
----
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
45
PsiBlast_CBE
56.92
61%
-102
- C3 -
1U59
1
A:
[2-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
-----------
K
Q
I
D
V
A
I
K
V
L
K
-
Q
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
-
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
--
G
K
--
R
----
E
E---
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
141
HHSearch
55.51
34%
-96
* C3 *
4AOJ
1
NTRK1_HUMAN
A:
[39-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
N
LLP--------
K
M
L
V
A
V
K
A
L
K
E
A
--
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
-
P
L
L
-
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
--
S
H
--
G
PDPG
P
----
L
G
L
-
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-
91
PsiBlast_CBE
54.97
42%
-98
- C3 -
4D4V
2
FAK1_CHICK
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
70
PsiBlast_CBE
53.98
42%
-104
- C3 -
4GU9
1
FAK1_HUMAN
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
90
PsiBlast_CBE
53.90
42%
-104
- C3 -
4D4V
2
B:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
65
PsiBlast_CBE
53.25
42%
-105
- C3 -
4KAB
1
FAK1_HUMAN
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
84
PsiBlast_CBE
52.88
42%
-101
- C3 -
4D5H
1
FAK1_CHICK
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
68
PsiBlast_CBE
52.73
42%
-97
- C3 -
4K8A
1
FAK1_HUMAN
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
--
78
PsiBlast_CBE
52.71
42%
-101
- C3 -
2J0M
1
?
B:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
56
PsiBlast_CBE
52.67
42%
-96
- C3 -
2ETM
1
B:
[20-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
73
PsiBlast_CBE
52.56
42%
-97
- C3 -
4I4E
1
A:
[23-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P------
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
114
PsiBlast_CBE
52.15
43%
-94
- C3 -
4RIW
1
D:
[39-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
-
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
58
PsiBlast_CBE
52.10
42%
-99
- C3 -
4KAO
1
B:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
63
PsiBlast_CBE
52.06
42%
-101
- C3 -
3PXK
1
FAK1_HUMAN
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
75
PsiBlast_CBE
52.05
42%
-102
- C3 -
4EBW
1
A:
[46-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
-------
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
92
PsiBlast_CBE
52.04
42%
-101
- C3 -
4D4S
1
B:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
97
PsiBlast_CBE
51.95
42%
-94
- C3 -
2JKO
1
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
85
PsiBlast_CBE
51.86
42%
-100
- C3 -
4D58
1
?
B:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
71
PsiBlast_CBE
51.75
42%
-95
- C3 -
4Q9S
1
A:
[23-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
106
PsiBlast_CBE
51.71
43%
-92
- C3 -
3BCE
2
C:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
G
---
E
---
T
--
V
K
I
P
V
A
I
K
I
L
-
N
E
T
T
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
-
T
I
Q
-
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
--
E
H
--
K
D---
N
----
I
G
S
-
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
-
D
E
K
E
Y
N
A
D
G
--
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
-
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
69
PsiBlast_CBE
51.66
42%
-95
- C3 -
4GU9
1
B:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
--
98
PsiBlast_CBE
51.64
42%
-92
- C3 -
2JKK
1
?
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-
101
PsiBlast_CBE
51.39
43%
-96
- C3 -
2R4B
1
ERBB4_HUMAN
A:
[44-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
G
---
E
---
T
--
V
K
I
P
V
A
I
K
I
L
-
N
------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
-
T
I
Q
-
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
--
E
H
--
K
D---
N
----
I
G
S
-
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
-
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
-
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
80
PsiBlast_CBE
51.35
42%
-93
- C3 -
3BZ3
1
A:
[15-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P-----------
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
59
PsiBlast_CBE
51.28
42%
-99
- C3 -
4KAO
1
FAK1_HUMAN
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P----------
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
62
PsiBlast_CBE
51.26
42%
-99
- C3 -
3PXK
1
B:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
74
PsiBlast_CBE
51.24
42%
-93
- C3 -
1MP8
1
A:
[23-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P---------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
55
PsiBlast_CBE
51.16
42%
-94
- C3 -
2IJM
1
FAK1_HUMAN
A:
[20-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
60
PsiBlast_CBE
51.00
42%
-96
- C3 -
4GU6
1
B:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
72
PsiBlast_CBE
50.93
42%
-95
- C3 -
4I4F
2
A:
[23-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P----------
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
96
PsiBlast_CBE
50.86
42%
-95
- C3 -
4BRX
1
FAK1_CHICK
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-
108
PsiBlast_CBE
50.72
43%
-96
- C3 -
3BBT
1
D:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
VP-----
E
---
T
--
V
K
I
P
V
A
I
K
I
L
-
N
E
---
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
-
T
I
Q
-
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
--
E
H
--
K
D---
N
----
I
G
S
-
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
-----------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
-
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
143
HHSearch
50.70
39%
-92
- C3 -
4CKJ
16
A:
[14-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
K
W
E
F
P
R
K
N
L
V
L
G
-
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
--
F
H
---
L
KGR
A
--
G
Y
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
--
E
S
--
R
KVR-
A
----
L
T
M
-
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
-
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
-
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
R
-
77
PsiBlast_CBE
50.62
42%
-93
- C3 -
2JKQ
1
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
95
PsiBlast_CBE
50.56
42%
-93
- C3 -
4C7T
1
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-
54
PsiBlast_CBE
50.50
42%
-98
- C3 -
2IJM
1
B:
[20-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
100
PsiBlast_CBE
50.45
43%
-95
- C3 -
2R4B
1
B:
[44-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
G
---
E
---
T
--
V
K
I
P
V
A
I
K
I
L
--------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
-
T
I
Q
-
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
--
E
H
--
K
D---
N
----
I
G
S
-
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
-
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
-
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
76
PsiBlast_CBE
50.40
42%
-95
- C3 -
4EBV
3
A:
[46-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
52
PsiBlast_CBE
50.39
44%
-97
- C3 -
4CSV
1
?
A:
[8-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
S
E
I
T
L
E
R
K
-
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
--
R
N
---
Y
---
N
--
I
--
E
V
A
V
K
T
L
K
E
G
T
M
S
---
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C--------------
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
-
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
----
117
Fugue
50.37
41%
-108
- C3 -
1BYG
1
CSK_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
-
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG--------------
N
K
V
A
V
K
C
I
K
-----
N
D
-
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
-E
E
-
G
L
Y
-
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
--
S
R
--
G
RS--
V
----
L
G
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L--
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
-
110
PsiBlast_CBE
50.23
43%
-90
- C3 -
4RIY
1
D:
[39-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
-
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
99
PsiBlast_CBE
50.14
43%
-90
- C3 -
3IKA
1
EGFR_HUMAN
A:
[25-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
-
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
50
PsiBlast_CBE
50.09
39%
-92
- C3 -
2J0J
1
FAK1_CHICK
A:
[373-646]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
--------
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
-
D
-----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
148
HHSearch
49.89
35%
-94
- C3 -
4OTW
1
A:
[11-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
T
E
L
R
K
L
-
K
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
--
I
P
---
E
---
G
ES
I
K
I
P
V
C
I
K
V
I
E
D
K
S
G
R
-
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
C
P
G
-
S
-
S
L
Q
-
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
--
Q
H
R-
G
----
A
----
L
G
P
-
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
----------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
-
L
-
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
D
P
P
R
115
PsiBlast_CBE
49.86
43%
-99
- C3 -
4RIW
1
EGFR_HUMAN
B:
[39-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
66
PsiBlast_CBE
49.77
42%
-91
- C3 -
4K9Y
1
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
-
D
S
T
Y
Y
K
A
-
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
57
PsiBlast_CBE
49.77
42%
-92
- C3 -
2ETM
1
FAK1_HUMAN
A:
[20-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
64
PsiBlast_CBE
49.69
42%
-95
- C3 -
4KAB
1
B:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-
146
HHSearch
49.51
42%
-95
- C3 -
3POZ
1
A:
[21-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
--
I
P
----------
V
K
I
P
V
A
I
K
E
L
--------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
109
PsiBlast_CBE
49.42
43%
-99
- C3 -
3BBT
1
ERBB4_HUMAN
B:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
G
---
E
---
T
--
V
K
I
P
V
A
I
K
I
L
-
N
E
--
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
-
T
I
Q
-
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
--
E
H
--
K
D---
N
----
I
G
S
-
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
---------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
-
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
113
PsiBlast_CBE
49.41
43%
-98
- C3 -
4RIX
1
EGFR_HUMAN
B:
[39-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
51
PsiBlast_CBE
49.18
44%
-95
- C3 -
4UEU
1
?
A:
[8-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
S
E
I
T
L
E
R
K
-
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
--
R
N
---
Y
---
N
--
I
--
E
V
A
V
K
T
L
K
E
G
T
M
S
---
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
DC
E
G
--
H
----
T
----
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
-
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----
111
PsiBlast_CBE
48.86
43%
-93
- C3 -
4RIY
1
EGFR_HUMAN
B:
[39-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
112
PsiBlast_CBE
48.85
43%
-95
- C3 -
4RIX
1
D:
[39-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
-
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
105
PsiBlast_CBE
48.75
43%
-100
- C3 -
4I24
1
EGFR_HUMAN
A:
[23-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
--------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
53
PsiBlast_CBE
48.65
42%
-97
- C3 -
2JKM
1
A:
[18-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
67
PsiBlast_CBE
48.39
42%
-91
- C3 -
4K8A
1
B:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-
103
PsiBlast_CBE
48.34
43%
-94
- C3 -
4G5P
1
EGFR_HUMAN
A:
[24-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
-
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
147
HHSearch
48.31
36%
-88
- C3 -
1T46
1
?
A:
[20-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
--
Y
G
LIK
S
---
D
--
A
A
M
T
V
A
V
K
M
L
K
P
S
-
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
-
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
--
R
K
--
R
----
D
SFLA
L
D
L
-
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
-
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
-
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
61
PsiBlast_CBE
47.72
42%
-88
- C3 -
4GU6
1
FAK1_HUMAN
A:
[21-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
-------
N
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
Y
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
-
D
S
T
Y
Y
K
A
-
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
79
PsiBlast_CBE
47.32
39%
-91
- C3 -
2J0K
1
FAK1_CHICK
B:
[373-646]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
--------
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P--
E
---
N
--
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
-
P
V
W
-
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
--
V
R
--
K
----
F
----
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
-
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
102
PsiBlast_CBE
46.95
43%
-94
- C3 -
2JIU
1
EGFR_HUMAN
A:
[22-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
-
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
104
PsiBlast_CBE
46.24
43%
-90
- C3 -
4I24
1
B:
[23-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
E
G
---
E
---
K
--
V
K
I
P
V
A
I
K
E
L
R
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
-
T
V
Q
-
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
--
E
H
--
K
D---
N
----
I
G
S
-
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R