@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LATS1_HUMAN: (2015-10-11 )
MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720...---....730.......740...--....750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850-.........860.......870.......880.......890.......900.......910.......920....----...930.......940.......950.......960.......970.......980.......-990......--.--.-1000-.......1010.....-.-1020.......1030......1040----.........1050......1060......1070......1080......1090......1100......1110......1120......1130
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKRSEKPE
G
Y
R
QMRPKTFPASNYTV
S
S
R
Q
M
L
Q
E
I
R
E
S
L
R
NLSKPS
D
A
A
K
A
E
H
N
M
S
KMSTED
P
R
QVRNPPKFG
T
H
H
K
A
L
Q
E
I
R
N
S
LLPFANETNSSRSTSEV
N
P
Q
M
L
Q
D
L
Q
AAGF
D
E
D
M
V
I
Q
A
L
Q
KTNN
R
S
I
E
A
A
I
E
F
I
S
KMSYQD
P
R
R
E
Q
M
A
A
A
AARPINASMKPG
N
V
Q
Q
S
V
N
R
K
QSWKG
S
K
ESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSG
S
G
I
S
A
F
V
QAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSG
N
M
E
Y
V
I
S
RISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQ
P
I
I
MQSSSKFNFPSGRPGMQNGTGQ
T
D
F
M
I
HQNVVPAGTVNRQPPPPYPLTAANGQSP
S
A
LQTGGSAAPSSYTNGSIP
Q
S
MMVPNRNSH
N
M
E
L
Y
N
I
SVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSA
T
T
V
T
A
IT
P
A
P
I
Q
Q
P
V
K
S
M
R
VL
K
P
E
L
Q
T
ALAPTHPSWIPQPIQTVQPSPFPEGTASN
V
T
VMPPVAEAPNYQGPPPPY
P
K
H
L
LHQNPSVPP
Y
E
SISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTS
P
I
T
VRKNK
K
D
E
E
R
R
E
S
R
I
QSY
S
P
Q
A
F
K
F
F
M
E
Q
H
V
E
N
V
L
K
S
H
Q
Q
R
L
H
R
K
K
Q
L
E
N
E
M
M
RVGLSQ
D
A
Q
D
Q
M
R
K
M
L
C
QKES
N
Y
I
R
L
K
RAKMDK
S
M
F
V
K
I
K
T
L
GIG
A
F
G
E
V
C
L
ARKV---DTK
A
L
Y
A
T
KTL
R
K
K
D
V
L
L
R
N
--
Q
V
A
H
V
K
A
E
R
D
I
L
AEADN
E
W
V
V
R
L
Y
Y
S
FQDKD
N
L
Y
F
V
M
D
YIPG
G
D
M
M
S
L
L
I
RMGI
F
P
E
S
L
A
R
F
Y
I
A
E
L
T
C
A
V
E
S
V
H
K
M
G
F
IHRDIKPD
N
I
L
IDRDG
H
I
K
L
T
D
F
GLC---TG
F
R
WTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRL
K
P
L
E
R
R
A
A
R
Q
H
Q
R
C
L
A
H
S
LVGTPNYI
A
P
E
V
L
L
RTG----
Y
T
Q
L
C
D
W
W
S
V
G
V
I
L
F
E
M
L
VGQPPFLAQTPL
E
T
Q
M
K
V
I
N
W
QTSLHIPPQAKLSP
E
A
S
D
L
I
I
K
LC-R-G
P
E
D
RLG--K--N-G
A
D
--EIKAHP
F
F
K
TID
F
S
S
D
-
L
-
R
Q
Q
-
S
A
SYIPKITHPTDTSNFD-------PV
D
P
D
KLWSDDNEEENV
N
D
T
L
N
G
W
YKNGKHP
E
H
A
F
Y
E
F
T
F
R
R
F
FDDNGYPYNYPKP
I
E
Y
E
YINSQGSEQQSDEDDQNTGSEIKNRDLVYV
34
PsiBlast_CBE
79.76
39%
-98
- C2 -
3D9V
1
ROCK1_HUMAN
B:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
---------------------------------------------------------
36
PsiBlast_CBE
78.91
39%
-98
- C2 -
2ETK
1
ROCK1_HUMAN
B:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
---------------------------------------------------------
3
PsiBlast_PDB
78.61
44%
-78
- C2 -
4LQQ
1
CBK1_YEAST
A:
[37-463]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
L
K
I
E
N
F
Y
Q
S
S
V
K
Y
A
I
E
R
N
E
R
R
V
E
L
E
T
E
L
T
S
H
N
W
S
E
E
R
K
S
R
Q
L
S
S
L
G
K
K
E
S
Q
F
L
R
L
R
R
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
-----------------
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
---
T
G
F
H
K
T
H
D
S
N
Y
-----------------------
L
T
M
S
N
R
Q
Q
I
Q
T
W
R
K
S
R
---
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
-
H
A
D
Q
R
L
G
--
R
--
H
G
G
A
D
--
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
-
R
Q
V
-
E
A
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
--------
P
T
D
---------
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
E
Y
S
R
F
D
Y
---------------------------------------------------------
53
PsiBlast_CBE
78.50
34%
-95
- C2 -
4L43
1
KS6B1_HUMAN
A:
[20-340]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----------------------
K
E
S
---------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
-
N
A
A
S
R
L
G
--
A
--
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
-
L
A
R
K
V
-
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
SKFT
R
Q
T
P
V
-------------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
------------------------------------------------------------
35
PsiBlast_CBE
77.93
39%
-97
- C2 -
2ETR
1
ROCK1_HUMAN
B:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
---------------------------------------------------------
1
PsiBlast_PDB
77.81
44%
-78
- C2 -
4LQS
1
CBK1_YEAST
A:
[46-463]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
S
S
V
K
Y
A
I
E
R
N
E
R
R
V
E
L
E
T
E
L
T
S
H
N
W
S
E
E
R
K
S
R
Q
L
S
S
L
G
K
K
E
S
Q
F
L
R
L
R
R
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
-----------------
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
---
T
G
F
H
K
T
H
D
S
N
Y
---------------------------
N
R
Q
Q
I
Q
T
W
R
K
S
R
---
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
-
H
A
D
Q
R
L
G
--
R
--
H
G
G
A
D
--
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
-
R
Q
V
-
E
A
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
--------
P
T
D
---------
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
T
Y
S
R
F
D
Y
---------------------------------------------------------
10
PsiBlast_PDB
76.97
39%
-103
- C2 -
3D9V
1
ROCK1_HUMAN
A:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------------------------------------------------------
37
PsiBlast_CBE
76.27
39%
-97
- C2 -
2ESM
1
ROCK1_HUMAN
B:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
---------------------------------------------------------
7
PsiBlast_PDB
76.03
39%
-100
- C2 -
2ESM
1
ROCK1_HUMAN
A:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------------------------------------------------------
13
PsiBlast_PDB
75.97
37%
-92
- C2 -
4NW5
1
KS6A3_HUMAN
A:
[17-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
S
I
D
H
E
K
K
------------------------------------
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------
P
-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.91
44%
-73
- C2 -
4LQP
1
CBK1_YEAST
A:
[37-463]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
L
K
I
E
N
F
Y
Q
S
S
V
K
Y
A
I
E
R
N
E
R
R
V
E
L
E
T
E
L
T
S
H
N
W
S
E
E
R
K
S
R
Q
L
S
S
L
G
K
K
E
S
Q
F
L
R
L
R
R
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
--------------
L
A
G
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
---
T
G
F
H
K
T
H
D
S
N
Y
--------------------------------
Q
T
W
R
K
S
R
---
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
-
H
A
D
Q
R
L
G
--
R
--
H
G
G
A
D
--
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
-
R
Q
V
-
E
A
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
--------
P
T
D
---------
E
L
E
N
V
P
D
S
P
A
M
F
I
G
Y
E
Y
S
R
F
D
Y
--------------------------------------------------------
52
PsiBlast_CBE
75.77
34%
-93
- C2 -
4L44
1
KS6B1_HUMAN
A:
[20-340]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----------------------
K
E
S
I
----------------------------
H
-----
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
-
N
A
A
S
R
L
G
--
A
--
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
-
L
A
R
K
V
-
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T-------------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
------------------------------------------------------------
8
PsiBlast_PDB
75.65
39%
-105
- C2 -
2ETK
1
ROCK1_HUMAN
A:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------------------------------------------------------
14
PsiBlast_PDB
75.03
37%
-91
- C2 -
4NW6
1
KS6A3_HUMAN
A:
[17-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
S
I
D
H
E
K
K
------------------------------------
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------
P
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.90
39%
-103
- C2 -
2ETR
1
ROCK1_HUMAN
A:
[65-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
--
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
-------------------------
M
K
M
N
K
E
----
G
M
V
R
C
--------------------
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
E
V
R
L
G
--
R
--
N
-
G
V
E
--
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
-
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------------------------------------------------------
38
PsiBlast_CBE
74.39
37%
-102
- C2 -
5D9K
2
?
B:
[26-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
-----------------------------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------
P
-----------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.48
37%
-103
- C2 -
5D9K
2
?
A:
[26-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------------------------------------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
-------
P
-----------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.77
37%
-89
- C2 -
4NUS
1
KS6A3_HUMAN
A:
[17-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
S
I
D
H
E
K
K
------------------------------------
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
-------
P
-----------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.73
37%
-86
- C2 -
5D9L
2
?
A:
[17-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
------------------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
-------
P
-----------------------------------------------------------------------------------------
54
PsiBlast_CBE
70.92
32%
-82
- C2 -
3FHI
1
KAPCA_MOUSE
A:
[13-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
------
A
Q
L
D
Q
--
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
-------
G
F
--------------------------------------------
A
K
R
V
K
G
R
T
W
T
--
L
A
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
N
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-------
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------
50
PsiBlast_CBE
70.79
34%
-87
* C2 *
2UZT
1
KAPCA_BOVIN
A:
[24-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
D
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
42
PsiBlast_CBE
70.69
33%
-77
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[16-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
N
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
46
PsiBlast_CBE
69.86
33%
-74
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[16-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
N
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
39
PsiBlast_CBE
69.75
36%
-100
- C2 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
------------------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
-
N
P
A
N
R
L
G
--
S
GP
D
-
G
A
E
--
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
69.65
34%
-84
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[24-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
D
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
49
PsiBlast_CBE
69.25
34%
-88
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[24-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
D
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
44
PsiBlast_CBE
68.20
33%
-84
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[16-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
N
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
43
PsiBlast_CBE
68.10
33%
-79
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[16-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
N
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
40
PsiBlast_CBE
67.94
36%
-93
- C2 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
--------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
------------------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
-
N
P
A
N
R
L
G
--
S
GP
D
-
G
A
E
--
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
67.90
34%
-84
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[24-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
D
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
45
PsiBlast_CBE
67.87
33%
-74
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[16-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
--
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
KRV
K
G
R
T
W
T
-----------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
----
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
--
N
-
G
V
N
--
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
-
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
-----------------
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------
18
PsiBlast_PDB
67.50
37%
-92
- C2 -
4EL9
1
KS6A3_MOUSE
A:
[12-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-
R
-----
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
S
---
E
K
K
------------------------------------
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
-
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.06
37%
-92
- C2 -
3UBD
1
KS6A3_MOUSE
A:
[11-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
-------
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
-----
K
K
------------------------------------
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
-
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.55
37%
-92
- C2 -
4GUE
1
KS6A3_MOUSE
A:
[12-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
--
R
V
---------
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
-----
K
K
------------------------------------
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
-
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.09
37%
-89
- C2 -
3G51
1
KS6A3_MOUSE
A:
[11-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
------------
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
S
I
-----------------------------------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
-
N
P
A
N
R
L
G
--
A
GP
D
-
G
V
E
--
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
65.62
36%
-98
- C2 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
---------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
-----------
E
------------------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
---
P
Q
F
-
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
-
N
P
A
N
R
L
G
--
S
GP
D
-
G
A
E
--
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------