@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LATS2_HUMAN: (2015-10-11 )
MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680......---.690.......700.......710.......720........730.......740.......750.......760.......770.......780.......790.......800.......810---.......820.......830.......840.......850.......860....------...870.......880.......----890.......900.......910.......920.......930.......940.......950-.-..-....960.--.-.......970.......980.-....-.-..990.......1000......1010......1020......1030......1040......1050......1060......1070......1080.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRPKTFPATTYSG
N
S
R
Q
R
L
Q
E
I
R
E
G
LKQPSKSSVQGLPAGPNSDTSL
D
A
KVLGSK
D
A
T
R
Q
Q
Q
Q
M
RATPKFG
P
Y
Q
K
A
L
R
E
I
R
Y
S
LLPFANESGT
S
A
A
A
E
V
N
R
Q
M
L
Q
E
L
V
NAGC
D
Q
E
M
A
G
R
A
L
K
QTGS
R
S
I
E
A
A
L
E
Y
I
S
KMGYLDP
R
N
E
Q
I
V
R
V
I
K
QTSPGKGLMPTPVTRRPSFEGTGD
S
F
A
S
Y
HQLSGTPYEGPSFGADG
P
T
A
L
E
EMP
R
P
Y
V
D
Y
LFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGR
P
H
L
LVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAA
H
Q
L
H
V
LGSRSQVFASDSP
P
Q
S
LLTPSRNSL
N
V
D
L
Y
ELGS
T
S
V
Q
QW
P
A
A
T
L
A
R
RDSLQKPGLEAPPRA
H
V
A
FRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPN
T
V
T
A
V
T
A
A
H
I
LH
P
V
K
S
V
R
V
LRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEE
H
A
L
ALGGAGA
F
P
L
D
V
EYGGPDRRCPPPPY
P
K
H
L
L
LRSKSEQY
D
L
D
S
L
C
A
G
M
E
Q
S
L
RAGPNEPEGGDKSRKSAKGDKGGKD
K
K
QIQTSPVPVRKNS
R
D
E
E
K
R
E
S
R
IKSYS
P
Y
A
F
K
F
F
M
E
Q
H
V
E
N
V
I
K
T
Y
Q
Q
K
V
N
R
R
L
Q
L
E
Q
E
M
A
KAGLC
E
A
E
Q
E
Q
M
R
K
I
L
Y
QKES
N
Y
N
R
L
K
R
A
KMDK
S
M
F
V
K
I
K
T
L
GIG
A
F
G
E
V
C
L
A
C
KV---D
T
H
A
L
Y
A
M
K
T
L
R
K
K
DVLNRNQ
V
A
H
V
K
A
E
R
D
I
L
-AEADN
E
W
V
V
K
L
Y
Y
SFQDKD
S
L
Y
F
V
M
D
YIPG
G
D
M
M
S
L
L
I
R
M
E
V
F
P
E
H
L
A
R
F
Y
I
A
E
L
T
L
A
I
E
S
V
H
K
M
G
F
IHRDIKPD
N
I
L
I
DLDG
H
I
K
L
T
D
F
GL---CTG
F
R
WTHNS
K
Y
Y
QKGSHVRQDSM
E
P
S
D
L
W
D
D
V
SNCRCG
D
R
L
K
T
L
E
Q
R
A
R
K
Q
H
Q
------
R
C
L
A
H
S
LVGTPNYI
A
P
E
V
L
L
R
K
G
----
Y
T
Q
L
C
D
W
W
S
V
G
V
I
L
F
E
M
L
VGQPPFLAPTPTE
T
Q
L
K
V
I
NWEN
T
L
HI
P
A
Q
V
K
LS
P
E
A
R
D
L
I
T
K
L
C
-C-SA-DHRLG--R--N-GADDLKAHP
F
F
S
AIDF
S
S
D
-I-RKQP-A-PYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHP
E
H
A
F
Y
E
F
T
F
R
R
F
FDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
3
PsiBlast_PDB
85.04
46%
-98
- C3 -
4LQQ
1
CBK1_YEAST
A:
[37-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
L
K
I
E
N
F
Y
Q
S
S
V
K
Y
A
I
E
R
N
E
R
R
V
E
L
E
T
E
L
T
S
H
N
W
S
E
E
R
K
S
R
Q
L
S
S
L
G
K
K
E
S
Q
F
L
R
L
R
R
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
----------------
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
---
S
T
G
F
H
K
T
H
D
S
N
Y
--------------------------------
L
T
M
S
N
R
Q
Q
I
Q
T
W
R
KSR
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
-
H
A
-
D
Q
R
L
G
--
R
--
H
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
-
R
Q
V
E
-
A
-
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
-
P
T
D
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
E
Y
S
R
F
D
Y
-------------------------------------------------------------
1
PsiBlast_PDB
83.83
46%
-100
- C3 -
4LQS
1
CBK1_YEAST
A:
[46-456]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
S
S
V
K
Y
A
I
E
R
N
E
R
R
V
E
L
E
T
E
L
T
S
H
N
W
S
E
E
R
K
S
R
Q
L
S
S
L
G
K
K
E
S
Q
F
L
R
L
R
R
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
----------------
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
---
S
T
G
F
H
K
T
H
D
S
N
Y
------------------------------------
N
R
Q
Q
I
Q
T
W
R
KSR
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
-
H
A
-
D
Q
R
L
G
--
R
--
H
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
-
R
Q
V
E
-
A
-
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
-
P
T
D
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
T
Y
S
R
F
D
Y
-------------------------------------------------------------
2
PsiBlast_PDB
82.83
46%
-90
- C3 -
4LQP
1
CBK1_YEAST
A:
[37-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
L
K
I
E
N
F
Y
Q
S
S
V
K
Y
A
I
E
R
N
E
R
R
V
E
L
E
T
E
L
T
S
H
N
W
S
E
E
R
K
S
R
Q
L
S
S
L
G
K
K
E
S
Q
F
L
R
L
R
R
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
------------
L
-
A
G
S
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
---
S
T
G
F
H
K
T
H
D
S
N
Y
-----------------------------------------
Q
TWRKSR
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
-
H
A
-
D
Q
R
L
G
--
R
--
H
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
W
N
T
--
I
-
R
Q
V
E
-
A
-
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
-
P
T
D
E
L
E
N
V
P
D
S
P
A
M
F
I
G
Y
E
Y
S
R
F
D
Y
------------------------------------------------------------
25
PsiBlast_CBE
81.90
38%
-103
- C3 -
3D9V
1
ROCK1_HUMAN
B:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------
27
PsiBlast_CBE
81.13
38%
-105
- C3 -
2ETK
1
ROCK1_HUMAN
B:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------
12
PsiBlast_PDB
80.95
36%
-116
- C3 -
4L6Q
1
ROCK2_HUMAN
A:
[49-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
--------------------------
D
E
T
G
M
V
H
C
D
--------------------------
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
H
W
D
N
I
-
R
E
T
A
-
A
-
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
V
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------
38
PsiBlast_CBE
80.61
36%
-111
- C3 -
4L6Q
1
ROCK2_HUMAN
B:
[49-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
--------------------------
D
E
T
G
M
V
H
C
D
--------------------------
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
H
W
D
N
I
-
R
E
T
A
-
A
-
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
V
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------
7
PsiBlast_PDB
80.17
38%
-107
- C3 -
3D9V
1
ROCK1_HUMAN
A:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------
5
PsiBlast_PDB
80.07
38%
-109
- C3 -
2ETK
1
ROCK1_HUMAN
A:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------
26
PsiBlast_CBE
79.55
38%
-104
- C3 -
2ETR
1
ROCK1_HUMAN
B:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------
4
PsiBlast_PDB
78.82
38%
-106
- C3 -
2ESM
1
ROCK1_HUMAN
A:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------
28
PsiBlast_CBE
78.77
38%
-102
- C3 -
2ESM
1
ROCK1_HUMAN
B:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------
6
PsiBlast_PDB
78.46
38%
-108
- C3 -
2ETR
1
ROCK1_HUMAN
A:
[48-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
M
K
M
---------
N
K
E
G
M
V
R
C
D
T
A
-------------------------------------------
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
-
D
R
-
E
V
R
L
G
--
R
--
N
-
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
-
R
D
T
V
-
A
-
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------
20
PsiBlast_PDB
75.40
34%
-95
- C3 -
1XH5
3
KAPCA_BOVIN
A:
[14-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
----------------------------------
R
V
K
G
R
T
W
T
L
----------------
C
------
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
19
PsiBlast_PDB
74.80
34%
-95
- C3 -
1SVH
1
KAPCA_BOVIN
A:
[14-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
----------------------------------
R
V
K
G
R
T
W
T
L
----------------
C
------
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
40
PsiBlast_CBE
74.67
38%
-108
- C3 -
5D9K
2
?
A:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
-------------------------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.57
34%
-92
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[16-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
17
PsiBlast_PDB
74.17
34%
-94
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[16-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
42
PsiBlast_CBE
74.12
38%
-99
- C3 -
5D9L
2
?
A:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
E
-------------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.87
34%
-93
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[16-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
16
PsiBlast_PDB
73.85
34%
-96
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[16-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
47
PsiBlast_CBE
73.17
35%
-106
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[29-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
39
PsiBlast_CBE
72.93
38%
-105
- C3 -
5D9K
2
?
B:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
E
------------------------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------------------------------------------------
44
PsiBlast_CBE
72.91
38%
-94
- C3 -
4NW5
1
KS6A3_HUMAN
A:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
E
S
I
D
------------------------
H
E
------
K
K
-
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.64
35%
-110
* C3 *
2UZT
1
KAPCA_BOVIN
A:
[29-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
43
PsiBlast_CBE
72.60
38%
-93
- C3 -
4NW6
1
KS6A3_HUMAN
A:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
E
S
I
D
------------------------
H
E
------
K
K
-
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.44
34%
-100
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[16-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
------
A
H
L
D
Q
--
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
49
PsiBlast_CBE
71.99
35%
-106
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[29-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
48
PsiBlast_CBE
70.52
35%
-104
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[29-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
AKR
V
K
G
R
T
W
T
-----------------------------------------------------------
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
--
G
K
V
R
F
P
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
-
D
L
-
T
K
R
F
G
NL
K
--
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
-
Y
Q
R
K
V
E
-
A
-
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------
45
PsiBlast_CBE
70.46
38%
-94
- C3 -
4NUS
1
KS6A3_HUMAN
A:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
E
S
I
D
------------------------
H
E
------
K
K
-
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
------------------------------------------------------------------------------------
41
PsiBlast_CBE
68.68
38%
-98
- C3 -
3G51
1
KS6A3_MOUSE
A:
[20-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
----------
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
-------------------------
S
K
E
S
I
------------------------------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
-
K
R
N
P
-
A
N
R
L
G
--
A
GP
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
-
Y
-
R
R
E
I
-
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.73
32%
-101
- C3 -
2R5T
1
SGK1_HUMAN
A:
[34-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
-----------------------------------------------
N
I
E
H
------
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
----
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
-
Q
-
K
D
R
T
K
R
L
G
A-
K
--
D
-
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
-
I
-
N
K
K
I
T
P
-
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------
52
PsiBlast_CBE
65.06
32%
-103
- C3 -
3HDM
1
SGK1_HUMAN
A:
[34-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
-----------------------------------------------
N
I
E
H
------
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
----
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
-
Q
-
K
D
R
T
K
R
L
G
A-
K
--
D
-
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
-
I
-
N
K
K
I
T
P
-
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------
51
PsiBlast_CBE
63.63
32%
-102
- C3 -
3HDN
1
SGK1_HUMAN
A:
[34-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
-----------------------------------------------
N
I
E
H
------
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
----
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
-
Q
-
K
D
R
T
K
R
L
G
A-
K
--
D
-
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
-
I
-
N
K
K
I
T
P
-
P
F
N
P
-------------------------------------------------------------------------------------------------