@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LIMK2_HUMAN: (2015-10-11 )
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340...----....350---....----------------.....360..--.--....370.......380.......390.......400.......410.......420.----.-.......430.......440.......450.......460.......470.......480.......490.......500.......510--........520.........530.......540......-...550.....---.--.560.---...-------.----...570.......580.......590.......600.......610.......620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSALAGEDVWRCPGCGDHI
A
P
S
Q
I
W
Y
R
TVNETWHGS
C
F
R
C
S
E
C
Q
D
S
L
T
N
W
Y
YEKDG
K
L
YC
P
K
D
Y
W
G
K
F
G
E
F
C
HG
C
S
LLMTG
P
F
M
V
AGEFKYH
P
E
C
F
A
C
M
S
C
K
V
I
I
EDGD
A
Y
A
L
V
Q
H
A
T
L
Y
C
GKCHNEV
V
L
A
P
M
F
E
RL
S
T
E
S
V
Q
E
QLP
Y
S
V
T
L
I
SMPATTEGRRG
F
S
V
S
V
E
S
ACSNY
A
T
T
V
Q
V
K
E
V
N
R
M
H
ISPNNRNAIHPG
D
R
I
L
E
INGT
P
V
R
T
L
R
V
E
E
V
E
D
A
I
S
Q
T
S
Q
T
L
Q
L
L
IEHD
P
V
S
Q
R
L
D
Q
L
R
L
E
A
R
LA
P
H
MQNAGHPHALSTLD
T
K
E
N
L
E
G
T
L
R
R
R
S
L
RRSNSISKSPGPSSPKE
P
L
L
F
SRDISRSESLRCS
S
S
Y
S
Q
Q
I
F
R
P
C
D
L
I
H
G
E
V
LGKGFFG
Q
A
----
I
K
V
T
H-----KATG----------------
K
V
M
V
M
K
E
L
I
R--C--
D
E
E
T
Q
K
T
F
L
T
E
V
K
V
M
R
SLDH
P
N
V
L
K
F
I
G
V
L
YKD
K
K
L
N
L
L
T
E
Y
IEGG
T
L
K
D
F
L
R
SM--D----P-F
P
W
Q
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
M
C
I
IHRDLNSH
N
C
L
I
K
LD
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
E
E
R
KRAPMEKAT
T
K
K
R
T
L
RKNDRK
K
R
Y
T
VVGNPY---WMAPEMLNG--KSYD
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
--
G
Q
VYAD-PDCL
P
R
T
LDFG---L--
N
V
K
-
L
---
F
W
E
-------K----FVPTDCP
P
A
F
F
P
L
A
A
I
C
C
RLEPESRP
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
ELGIPL
P
A
E
L
E
E
L
D
H
T
V
S
M
QYGLTRDSPP
21
PsiBlast_CBE
98.82
100%
-146
- C3 -
4TPT
1
B:
[1-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
I
H
G
E
V
L
G
K
G
F
F
G
Q
A
----
I
K
V
T
H
-----
K
A
T
G
----------------
K
V
M
V
M
K
E
L
I
R
--
C
--
D
E
E
T
Q
K
T
F
L
T
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
R
S
M
--
D
----
P
-
F
P
W
Q
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
--------------------------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
L
N
G
--
K
S
Y
D
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
--
G
Q
V
Y
A
D
-
P
D
C
L
P
R
T
L
D
F
G
---
L
--
N
V
K
-
L
---
F
W
E
-------
K
----
F
V
P
T
D
C
P
P
A
F
F
P
L
A
A
I
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
I
P
L
P
A
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
L
------
1
PsiBlast_PDB
97.48
100%
-139
- C3 -
4TPT
1
LIMK2_HUMAN
A:
[1-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
I
H
G
E
V
L
G
K
G
F
F
G
Q
A
----
I
K
V
T
H
-----
K
A
T
G
----------------
K
V
M
V
M
K
E
L
I
R
--
C
--
D
E
E
T
Q
K
T
F
L
T
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
R
S
M
--
D
----
P
-
F
P
W
Q
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
-----------------------
K
K
R
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
L
N
G
--
K
S
Y
D
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
--
G
Q
V
Y
A
D
-
P
D
C
L
P
R
T
L
D
F
G
---
L
--
N
V
K
-
L
---
F
W
E
-------
K
----
F
V
P
T
D
C
P
P
A
F
F
P
L
A
A
I
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
I
P
L
P
A
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
-------
2
PsiBlast_PDB
85.77
67%
-127
- C3 -
3S95
11
LIMK1_HUMAN
A:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
H
R
I
F
R
P
S
D
L
I
H
G
E
V
L
G
K
G
C
F
G
Q
A
----
I
K
V
T
H
-----
R
E
T
G
----------------
E
V
M
V
M
K
E
L
I
R
--
F
--
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
M
--
D
----
S
Q
Y
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
N
V
V
V
A
D
F
G
L
A
R
L
M
V
--------------------------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
I
N
G
--
R
S
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
--
G
R
V
N
A
D
-
P
D
Y
L
P
R
T
M
D
F
G
---
L
--
N
V
R
-
G
---
F
L
D
-------
R
----
Y
C
P
P
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
-
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
---
41
HHSearch
85.70
67%
-126
- C3 -
3S95
10
LIMK1_HUMAN
A:
[2-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
H
R
I
F
R
P
S
D
L
I
H
G
E
V
L
G
K
G
C
F
G
Q
A
----
I
K
V
T
H
-----
R
E
T
G
----------------
E
V
M
V
M
K
E
L
I
R
--
F
--
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
M
--
D
S---
Q
-
Y
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
N
V
V
V
A
D
F
G
L
A
R
L
M
V
--------------------------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
I
N
G
--
R
S
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
--
G
R
V
N
A
D
-
P
D
Y
L
P
R
T
M
D
F
G
---
L
--
N
V
R
-
G
---
F
L
D
-------
R
----
Y
C
P
P
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
-
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
---
22
PsiBlast_CBE
84.20
67%
-122
- C3 -
3S95
6
B:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
H
R
I
F
R
P
S
D
L
I
H
G
E
V
L
G
K
G
C
F
G
Q
A
----
I
K
V
T
H
-----
R
E
T
G
----------------
E
V
M
V
M
K
E
L
I
R
--
F
--
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
M
--
D
----
S
Q
Y
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
N
V
V
V
A
D
F
G
L
A
R
L
M
V
--------------------------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
I
N
G
--
R
S
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
--
G
R
V
N
A
D
-
P
D
Y
L
P
R
T
M
D
F
G
---
L
--
N
V
R
-
G
---
F
L
D
-------
R
----
Y
C
P
P
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
-
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
---
55
HHSearch
65.20
31%
-104
- C3 -
3CBL
3
A:
[110-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
----
F
S
G
R
L
-----
R
A
D
N
----------------
T
L
V
A
V
K
S
C
R
E
T-
L
--
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
--
G
A---
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
--------
S
G
G
----------
L
R
Q
V
P
V
K
---
W
T
A
P
E
A
L
N
Y
--
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
-----
Y
-
P
N
-
L
S
-
N
---
Q
--
Q
T
R
-
E
---
F
V
E
-------
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
------------------------------
45
HHSearch
62.58
30%
-101
- C3 -
4ITJ
1
RIPK1_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
S
S
D
F
L
E
--------
F
G
K
V
----
S
L
A
F
H
-----
R
T
Q
G
----------------
L
M
-
I
M
K
T
V
Y
K
GP
N
--
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
--
M
----
S
-
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
-------------------------
G
T
L
Y
---
Y
M
A
P
E
H
L
N
D
VN
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
--
A
N
K
E
---
P
-
Y
E
-
N
A
I
A
E
Q
Q
L
I
M
--
A
I
K
S
G
NRP
D
V
--------
D
----
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
----------------------------
48
HHSearch
61.79
30%
-87
- C3 -
4BKJ
10
DDR1_HUMAN
A:
[9-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
----
H
L
C
E
V
-----
D
S
P
Q
DLVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D-
A
--
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
--
Q
LEDP
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----------------------
R
A
V
L
P
I
R
---
W
M
A
W
E
C
I
L
M
--
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
--
M
L
C
R
A
Q
-
P
F
G
Q
L
T
D
E
Q
V
I
---
E
--
N
A
G
-
E
---
F
F
R
DQGRQVY
L
----
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
-----------------------------
7
PsiBlast_PDB
60.51
30%
-105
- C3 -
2QOC
2
A:
[22-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
E
D
-----------
K
I
PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
R
P
S
N
L
L
L
D
Q
S
---------
17
PsiBlast_PDB
60.43
30%
-104
- C3 -
3FXX
1
A:
[49-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
E
D
D
---------
G
K
I
PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
A
A
R
P
S
N
L
L
L
D
-------------
12
PsiBlast_PDB
60.42
30%
-107
- C3 -
4P4C
1
A:
[39-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
-----------------------------------------PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
D
----------------
56
HHSearch
59.84
32%
-91
- C3 -
4CKJ
16
A:
[18-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----
V
K
A
T
A
F
HLKG
R
A
G
Y
----------------
T
T
V
A
V
K
M
L
K
E
N-
A
--
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
--
R
KVR-
A
-
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
------------------
K
R
S
Q
G
R
I
P
V
K
---
W
M
A
I
E
S
L
F
D
--
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
--
P
G
I
P
P
E
R
L
-
F
N
------
L
L
K
-
T
---
G
H
R
-------
M
----
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
R
-----------------------------
14
PsiBlast_PDB
59.49
30%
-104
- C3 -
4TWO
1
A:
[39-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------------------------------PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
D
Q
S
--------------
8
PsiBlast_PDB
59.48
30%
-107
- C3 -
3DZQ
1
A:
[39-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------------------------PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--
L
K
I
I
T
N
L
L
L
D
------------------
9
PsiBlast_PDB
59.28
30%
-106
- C3 -
4G2F
1
A:
[39-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------------------------------PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
-----------------
61
HHSearch
59.06
30%
-93
- C3 -
4NEU
1
RIPK1_HUMAN
A:
[22-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
----
S
L
C
F
H
-----
R
T
Q
G
----------------
L
M
-
I
M
K
T
V
Y
K
--
G
PN
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
--
M
----
S
-
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
C
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
-----------------------------
G
T
L
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
--
A
N
K
E
---
P
-
Y
E
N
A
I
C
E
Q
Q
---
L
I
M
C
I
K
S
G
NRP
D
V
--------
D
----
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
---------
6
PsiBlast_PDB
59.00
30%
-105
- C3 -
2QO9
1
A:
[51-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------------------------
K
I
PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
N
L
L
L
D
------------------
13
PsiBlast_PDB
58.39
30%
-101
- C3 -
4TWN
1
A:
[39-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
E
I
----------------
S
V
A
I
K
T
L
K
V
G
--
Y
--
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
--
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
-----------------------------------
K
I
PIR
W
T
S
P
E
A
I
A
Y
--
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
--
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
---
K
--
A
V
D
-
E
---
G
Y
R
-------
L
----
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
N
L
L
L
D
-----------------
33
Fugue
57.82
30%
-98
- C3 -
1BYG
1
CSK_HUMAN
A:
[15-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
----
M
L
G
D
Y
RG------
N
----------------
K
V
A
V
K
C
I
K
---------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
-
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
GR
S
----
V
-
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------
L
L
----------------
P
V
K
---
W
T
A
P
E
A
L
R
E
--
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
--
S
F
G
R
V
P
-
Y
P
R
I
P
L
-
K
D
V
V
---
P
--
R
V
E
-
K
---
G
Y
K
-------
M
----
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
-----------------------------
24
PsiBlast_CBE
54.78
31%
-96
- C3 -
4CSV
1
?
A:
[19-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
Q
F
G
E
V
----
Y
E
G
K
W
-----
R
N
Y
N
----------------
I
E
V
A
V
K
T
L
K
E
--
G
--
T
M
S
V
E
E
-
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
---------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
--------------------------
F
P
I
K
-------------
W
T
A
P
E
A
I
S
Y
--
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
-
G
M
S
G
S
E
V
I
E
--------
Q
V
E
-
R
---
G
Y
R
-------
M
----
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
--
T
M
F
L
------------------------------
23
PsiBlast_CBE
54.38
31%
-90
- C3 -
4UEU
1
?
A:
[19-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
Q
F
G
E
V
----
Y
E
G
K
W
-----
R
N
Y
N
----------------
I
E
V
A
V
K
T
L
K
E
--
G
--
T
M
S
V
E
E
-
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
--
E
GH--
T
-
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-------------------
A
K
F
P
I
K
-------------
W
T
A
P
E
A
I
S
Y
--
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
-
G
M
S
G
S
E
V
I
E
--------
Q
V
E
-
R
---
G
Y
R
-------
M
----
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
--
T
M
F
-------------------------------