@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LMTK1_HUMAN: (2015-10-11 )
MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLARDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEPKLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPRAPLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA
Atome Classification :
(74 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140---.----.-....----.150---.......-160.......-170.......180.......190......-----.200.......210....-------...220...--.--.-..230--..---......240.......250.......260----..---......270.......-280.......290.......300........310.......320.......330.......340.......350.......360-.........370.......-380......-..390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSSFFNPSFAFSSHFDPDGAPLSELSWPS
S
L
A
V
V
A
V
S
F
S
G
L
F
A
V
I
V
L
M
L
A
C
L
C
C
KKGGIG
F
K
E
FENAEG
D
E
Y
A
A
D
L
AQGSPATAAQNGP
D
V
Y
V
L
PLTEVSLPMAKQPGR
S
V
Q
L
L
KSTDVG
R
H
S
L
L
Y
L
K
E
IGRGWFG
K
V
F
L
G
---
E
----
V
-NSG
I
----
S
S
A
Q
---
V
V
V
K
E
L
Q
-
A
S
A
S
V
Q
E
Q
M
Q
-
F
L
E
EV
Q
P
Y
R
A
L
K
H
S
N
L
L
Q
C
L
A
Q
C
A
EVT
P
Y
-----
L
L
V
MEFCP
L
G
D
L
K
G
Y
L
R
S
-------
C
R
V
A
E
SMAP--
D
--
P
-
R
T
L
Q
---
R
M
---
A
C
E
V
A
C
G
V
L
H
LHRNNFV
H
S
D
L
A
L
R
N
C
L
L-----T
A
---
D
L
T
V
K
IGDYG
L
A
H
C
K
Y
-RE
D
Y
F
V
T
A
D
Q
L
W
V
P
L
R
W
I
A
P
E
-
L
V
D
E
V
HS
N
L
L
V
V
D
QTKSG
N
V
W
S
L
G
V
T
I
W
E
L
F
E
LGTQPYPQHSDQ
Q
V
L
A
Y
T
V
R
E
Q
QLKLPK---P
Q
L
Q
L
T
L
S
D
R
W
Y
E
V
M
Q
F
C
W-LQ-PEQRP
T
-
A
E
E
V
H
L
L
L
S
Y
L
CAKGA
T
E
A
E
E
E
F
E
R
R
W
RSLRPGGGGVGPGPGAA
G
P
M
L
G
G
V
V
E
L
A
AASS
F
P
L
L
E
Q
FAGDGFHADGD
D
V
L
T
V
T
ETSRGL
N
F
E
Y
K
WEAGRGAEAFPATLSPG
R
T
A
R
L
Q
E
L
CAPDGAPPG
V
V
P
V
LSAHSPSLG
S
E
Y
F
I
R
L
EEAAPAAGHDPDCAGCAPSPPATADQDDDSDGS
T
A
A
S
L
A
M
E
P
LLGHGPPVDVPWGRGDHYP
R
R
SLARDPLCPSRSPSPSAGPLSLAEGGAEDADW
G
V
A
A
F
C
P
A
F
F
EDPLGTSPLGSSGAPPLPLT
G
E
D
E
L
E
E
V
G
A
R
R
A
A
QRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPEPGYPGE
P
L
L
G
L
QAASAQEPGCCPGL
P
H
LCSAQGLAPA
P
C
L
VTPSWTETASSGGDHPQAEPKLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGG
E
V
S
A
I
K
L
A
SALNGSSSSPEVEAPSSEDE
D
T
A
EATS
G
I
FTDTSSDGLQARRP
D
V
V
P
A
F
R
S
L
Q
K
QVGTPDSLDSLDIPSSASDGG
Y
E
V
FSPSATGPSGGQPRALDSGYDTENYE
S
P
E
F
V
L
K
E
A
QEGC
E
P
Q
A
F
A
E
L
A
SEGEGPGPE
T
R
L
S
T
S
LSGLNEKNPYRDSA
Y
F
S
D
L
E
AEAEATSGPEKKCGGDRAPGPELGLPSTGQPSE
Q
V
C
LRPGVSGEAQGSGPGEVLP
P
L
L
QLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSC
S
Q
F
F
L
LTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPRA
P
L
R
LALPGL
P
A
ALEGRPEEEEEDSEDSDESDE
E
L
R
C
Y
SVQEPSEDSEEEAPAV
P
V
V
V
AES
Q
S
A
R
N
L
R
S
L
L
K
M
P
S
L
L
S
E
T
F
C
E
D
L
E
R
K
K
K
A
V
S
FFD
D
V
T
V
Y
L
FDQES
P
T
R
ELGEPFPGAKESPP
T
F
LRGSPGSPSAPNRPQQADGSPNGST
A
E
EGGGFAWDDDFP
L
M
T
A
K
A
A
F
A
M
ALDPAAPAPAAPTPTPAPFS
R
F
TVSPAPTS
R
F
S
I
T
HVSDSDAESKRGPEAGAGGESKEA
49
PsiBlast_CBE
81.29
32%
-106
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[38-317]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
H
N
L
L
P----
K
M
L
---
V
A
V
K
A
L
K
--
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
GPD-----------
P
--
G
--
P
-
L
G
L
G
---
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
---
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
--------
Y
A
I
M
R
G
C
W
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
78.69
31%
-112
- C1 -
3TCP
1
MERTK_HUMAN
A:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
----P
K
P
--
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
77.85
32%
-101
- C1 -
4AOJ
1
C:
[38-317]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
H
N
L
L
PQ--
D
K
M
L
---
V
A
V
K
A
L
K
--
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
GPD--------------
G
--
P
-
L
G
L
G
---
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
-----------------
M
L
P
I
R
W
M
P
P
E
--------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
--------
Y
A
I
M
R
G
C
W
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
77.61
36%
-98
- C1 -
4IBM
1
?
B:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
---
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.30
36%
-99
- C1 -
4IBM
1
?
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
77.14
31%
-107
- C1 -
3BPR
1
MERTK_HUMAN
B:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
-
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
---P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.08
36%
-102
- C1 -
3EKK
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
-------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
76.86
31%
-114
- C1 -
2P0C
2
MERTK_HUMAN
A:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
--
E
F
G
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
------------E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
------IP
K
P
-
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
76.11
32%
-104
- C1 -
4AT5
2
A:
[10-287]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
Y
N
L
---------K
I
L
V
A
V
K
T
L
K
--
D
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
--
V
L
M
A
E
G
N
P
P
--
T
--
E
-
L
T
Q
S
---
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
---
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
-
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
--------
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.98
36%
-94
- C1 -
3ETA
1
B:
[12-286]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
75.96
31%
-104
- C1 -
3BPR
1
D:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
---------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
75.91
32%
-97
- C1 -
4PMT
1
A:
[5-284]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
H
N
L
-----
D
K
M
L
---
V
A
V
K
A
L
-----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
GPDAKL
L
A
G
G
E
D
V
A
P
--
G
--
P
-
L
G
L
G
---
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
---
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
-
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
--------
Y
A
I
M
R
G
C
W
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.63
32%
-106
- C1 -
4AT3
1
A:
[10-287]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
Y
N
L
C
--------K
I
L
V
A
V
K
T
L
----
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
--
V
L
M
A
--
N
P
P
--
T
--
E
-
L
T
Q
S
---
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
---
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
-
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
--------
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
75.15
31%
-107
- C1 -
2P0C
1
B:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
------------E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
------IP
K
P
-
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
75.09
31%
-107
- C1 -
3BRB
2
B:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.06
36%
-101
- C1 -
3EKN
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
75.05
32%
-104
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[38-317]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
H
N
L
L
P----
K
M
L
---
V
A
V
K
A
L
K
--
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
GPD--------------
G
--
P
-
L
G
L
G
---
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
---
G
L
V
V
K
I
G
D
F
--------------------
L
P
I
R
W
M
P
P
E
--------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
--------
Y
A
I
M
R
G
C
W
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
75.00
31%
-105
- C1 -
3BPR
1
MERTK_HUMAN
A:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
-------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
74.69
31%
-110
- C1 -
3TCP
1
B:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
---------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.19
32%
-104
- C1 -
4AT4
1
A:
[10-287]
-----------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
Y
N
L
C
--------K
I
L
V
A
V
K
T
L
K
--
D
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
--
V
L
M
A
---
P
P
--
T
--
E
-
L
T
Q
S
---
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
---
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
-
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
--------
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.96
36%
-96
- C1 -
3ETA
1
INSR_HUMAN
A:
[12-286]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
73.84
31%
-112
- C1 -
4MHA
1
B:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
----
L
K
Q
E
D
G
----
T
S
L
K
---
V
A
V
K
T
M
K
---------------------
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
73.39
32%
-95
- C1 -
4YPS
1
A:
[7-291]
------------------------------------------------------------------------------------------------------------------
I
R
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
---
E
----
C
-
H
N
L
L
----
D
K
M
L
---
V
A
V
K
A
L
-----
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
GPDAK
L
L
A
G
G
E
D
V
A
P
--
G
--
P
-
L
G
L
G
---
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
---
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
-
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
--------
Y
A
I
M
R
G
C
W
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.24
36%
-99
- C1 -
1I44
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
-----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.05
32%
-87
- C1 -
4DCE
1
B:
[23-298]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
Y
E
G
---
Q
----
V
--
S
------
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.86
35%
-95
- C1 -
1IR3
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
72.69
31%
-112
- C1 -
4M3Q
1
B:
[26-306]
------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
---
N
----
L
K---------
S
L
K
---
V
A
V
K
T
M
-------------
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
-----K
P
---
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-------
S
R
L
E
T
G
P
K
H
--
I
--
P
L
Q
T
L
L
---
K
F
---
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
---
D
M
T
V
C
V
A
D
F
G
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
--------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
-----
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
-
P
L
D
R
P
T
-
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.52
32%
-97
- C1 -
4YNE
2
A:
[7-291]
------------------------------------------------------------------------------------------------------------------
I
R
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
----
C
-
H
N
L
L
P---
D
K
M
L
---
V
A
V
K
A
L
K
--
E
-----
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
GPDAK
L
L
A
G
G
E
D
V
A
P
--
G
--
P
-
L
G
L
G
---
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
------
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
--------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
--------
Y
A
I
M
R
G
C
W
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.50
34%
-101
- C1 -
3LW0
2
D:
[11-280]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
-----------
P
-
P
S
L
S
---
K
M
IQM
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.76
34%
-101
- C1 -
3LW0
3
IGF1R_HUMAN
B:
[11-280]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
-----------
P
-
P
S
L
S
---
K
M
IQM
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.49
34%
-100
- C1 -
3LW0
3
IGF1R_HUMAN
C:
[11-280]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
-----------
P
-
P
S
L
S
---
K
M
IQM
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.08
33%
-91
- C1 -
4CSV
1
?
A:
[7-264]
----------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
----
W
-
R
N
------
Y
N
I
E
---
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
----
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
-----
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-------
C
-------
V
--
N
--
A
-
Q
A
L
L
---
D
M
---
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
---
N
N
V
V
K
V
A
D
F
G
------------------
F
-
P
I
K
W
T
A
P
E
-
A
I
S
Y
N
R
F
S
I
-------
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
--
E
R
G
Y
R
M
P
R
---
P
Q
---
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
-
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.88
35%
-94
- C1 -
3BU5
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
70.17
32%
-83
- C1 -
2XB7
1
A:
[8-283]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
-------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
---------------
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.13
32%
-85
- C1 -
4CTC
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
---------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.01
35%
-92
- C1 -
1GAG
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
69.86
33%
-84
- C1 -
2YFX
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.84
32%
-86
- C1 -
4CTB
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
69.80
32%
-84
- C1 -
3AOX
5
A:
[33-308]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
----
V
--
S
-------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
69.46
32%
-80
- C1 -
4CNH
2
B:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
-------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
-----
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
S
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
69.46
34%
-97
- C1 -
3I81
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
-
E
N
N
P
V
L
A
--
P
-
P
S
L
S
---
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.45
32%
-81
- C1 -
4FNZ
1
A:
[17-292]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
----
V
--
S
G
-----
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.32
32%
-86
- C1 -
4DCE
1
ALK_HUMAN
A:
[23-298]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
----
V
--
S
--P---
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
---------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
69.21
32%
-85
- C1 -
4MKC
3
A:
[57-332]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
------
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.04
35%
-90
- C1 -
2Z8C
1
A:
[10-284]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
68.86
34%
-93
- C1 -
3NW6
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
M
E
N
N
P
VL
A
--
P
-
P
S
L
S
---
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
68.77
32%
-83
- C1 -
4FOD
2
A:
[23-298]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
------
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
68.63
34%
-97
- C1 -
3NW7
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
M
E
N
N
P
V
L
A
--
P
-
P
S
L
S
---
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.97
33%
-81
- C1 -
4CLJ
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
-------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.89
33%
-83
- C1 -
4CD0
1
A:
[31-306]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
-------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
67.63
34%
-89
- C1 -
4UXL
1
A:
[41-302]
----------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
F
G
E
V
Y
E
G
---
T
A
V
DI
L
-
G
V
G
S
----
G
E
I
K
---
V
A
V
K
T
L
K
-
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
-----
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-------
A
R
M
A
T
F
Y
G
P
LL
T
--
L
-
V
D
L
V
---
D
L
---
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
SVKDY
T
S
---
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
-
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
--------
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
--------
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
-
A
Q
E
P
D
Q
R
P
T
-
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
67.59
32%
-82
- C1 -
4CLI
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
67.42
32%
-83
- C1 -
4ANS
1
A:
[31-306]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
67.03
34%
-87
- C1 -
3ZBF
1
A:
[41-302]
----------------------------------------------------------------------------------------------------------------------------------
L
G
S
---
G
E
V
Y
E
G
---
T
A
V
DI
L
-
G
V
G
S
----
G
E
I
K
---
V
A
V
K
T
L
K
-
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
-----
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-------
A
R
M
A
T
F
Y
G
P
LL
T
--
L
-
V
D
L
V
---
D
L
---
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
SVKDY
T
S
---
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
--------
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
--------
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
-
A
Q
E
P
D
Q
R
P
T
-
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
66.71
32%
-81
- C1 -
4CMU
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
66.40
32%
-88
- C1 -
4CNH
1
ALK_HUMAN
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
------
E
V
Y
E
G
---
Q
----
V
--
S
-------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
----------
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
66.39
32%
-78
- C1 -
3LCT
3
A:
[34-309]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
G
M
PNDP
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
66.20
32%
-87
- C1 -
4FNY
1
A:
[20-292]
---------------------------------------------------------------------------------------------------------------
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
----
V
--
S
G
------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
------
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
66.16
32%
-78
- C1 -
4FOB
1
A:
[43-318]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
------
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
-----
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
66.15
32%
-82
- C1 -
4CMO
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
65.94
32%
-83
- C1 -
4CCU
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
----
V
----------
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.83
35%
-88
- C1 -
1RQQ
1
INSR_HUMAN
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
65.30
31%
-82
- C1 -
3SXS
1
A:
[4-255]
----------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
---
K
----
W
-
K
G
Q
Y
----
D
V
A
V
---
K
M
I
K
E
-----
G
S
M
S
E
D
-
E
-
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
-----
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-----------
H
G
K
G
L
--
E
--
P
-
S
Q
L
L
---
E
M
---
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
--
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
-
V
F
H
-------
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
---
S
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
65.28
33%
-84
* C1 *
4UEU
1
?
A:
[7-264]
----------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
----
W
-
R
N
------
Y
N
I
E
---
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
----
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
-----
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-------
C
---
E
G
H
T
V
--
N
--
A
-
Q
A
L
L
---
D
M
---
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
---
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
K
F
-
P
I
K
W
T
A
P
E
-
A
I
S
Y
N
R
F
S
I
-------
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
--
E
R
G
Y
R
M
P
R
---
P
Q
---
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
-
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
64.59
34%
-94
- C1 -
3QQU
1
IGF1R_HUMAN
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
--------------
P
S
L
S
---
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
63.89
32%
-78
- C1 -
3LCS
3
A:
[34-309]
------------------------------------------------------------------------------------------------------------
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
----
V
--
S
G
M
PNDP
S
P
L
Q
---
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-------
T
R
P
R
P
S
Q
P
S
--
S
--
L
-
A
M
L
D
L
L
-
H
V
---
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
-----
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
-
A
F
M
E
G
I
F
-------
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
--------
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
-
P
E
D
R
P
N
-
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
62.64
34%
-96
- C1 -
1JQH
1
IGF1R_HUMAN
B:
[15-284]
----------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
--------
V
-
A
K
G
V
VKDE
P
E
T
R
---
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-------
L
R
P
-----------
P
-
P
S
L
S
---
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
---
D
F
T
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
--------
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
--------
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
-
P
K
M
R
P
S
-
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
60.89
31%
-88
- C1 -
2HYY
1
ABL1_HUMAN
C:
[20-263]
---------------------------------------------------------------------------------------------------------------------------------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
----
W
-
K
K
------
Y
S
L
T
---
V
A
V
K
T
L
K
-
E
-
T
--
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
-----
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-------
C
N
R
Q
E
V
N
A
V
--------
V
L
L
---
Y
M
---
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
Y
T
A
H
A
G
A
K
F
-
P
I
K
W
T
A
P
E
--------
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
--
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
-
P
S
D
R
P
S
-
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
60.83
31%
-85
- C1 -
3SXR
1
BMX_HUMAN
A:
[4-255]
----------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
----
V
V
K
L
G
---
K
----
W
-
K
G
Q
Y
----
D
V
A
V
---
K
M
I
K
E
-----
G
S
M
S
E
D
-
E
-
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
-----
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-----------
H
G
K
G
L
--
E
--
P
-
S
Q
L
L
---
E
M
---
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
--
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
-
V
F
H
-------
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
---
S
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
60.79
31%
-88
- C1 -
3SXR
1
B:
[4-255]
----------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
------
V
V
K
L
G
---
K
----
W
-
K
G
Q
Y
----
D
V
A
V
---
K
M
I
K
E
-----
G
S
M
S
E
D
-
E
-
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
-----
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-----------
H
G
K
G
L
--
E
--
P
-
S
Q
L
L
---
E
M
---
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
--
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
-
V
F
H
-------
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
---
S
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
57.90
31%
-84
- C1 -
2HYY
1
ABL1_HUMAN
D:
[20-263]
---------------------------------------------------------------------------------------------------------------------------------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
----
W
-
K
K
------
Y
S
L
T
---
V
A
V
K
T
L
K
-
E
----
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
-----
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-------
C
N
R
Q
E
V
N
A
V
--------
V
L
L
---
Y
M
---
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
D
T
Y
T
A
H
A
G
A
K
F
-
P
I
K
W
T
A
P
E
--------
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
--
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
-
P
S
D
R
P
S
-
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
57.12
31%
-79
- C1 -
4TWP
1
ABL1_HUMAN
B:
[15-258]
---------------------------------------------------------------------------------------------------------------------------------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
----
W
-
K
K
------
Y
S
L
T
---
V
A
V
K
T
L
K
-
E
D
T
--
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
-----
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-------
C
N
R
Q
E
V
N
A
V
--------
V
L
L
---
Y
M
---
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
D
T
Y
T
A
H
A
G
A
K
F
-
P
I
K
W
T
A
P
E
--------
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
--
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
-
P
S
D
R
P
S
-
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
56.58
31%
-74
- C1 -
2HZ0
1
ABL1_HUMAN
A:
[20-263]
---------------------------------------------------------------------------------------------------------------------------------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
----
W
-
K
K
------
Y
S
L
T
---
V
A
V
K
T
L
K
-
E
D
T
--
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
-----
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-------
C
N
R
Q
E
V
N
A
V
--------
V
L
L
---
Y
M
---
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
D
T
Y
T
A
H
A
G
A
K
F
-
P
I
K
W
T
A
P
E
--------
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
--
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
-
P
S
D
R
P
S
-
F
A
E
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.41
35%
-54
- C1 -
4XLV
1
?
A:
[35-309]
----------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
----
I
-
I
K
G
E
----
A
E
T
R
---
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-------
L
R
P
E
A
E
N
N
P
--
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
---
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
--------
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
--------
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------