@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LMTK2_HUMAN: (2015-10-11 )
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD
Atome Classification :
(70 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150..---....---.160---------.......170.......180.......190.......200.......210.......220.....-.---.----------230.----......240-..----....-..250.......260.......270.-----......280.......290.......300.......310.......320.......330.......340.......350.......360.......370---.......380.........390.-.-......-400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPG
P
P
A
L
R
R
R
L
L
L
L
L
L
V
L
L
IAGSAGAAPLPQTGAGEAPP
A
A
EVSS
S
F
V
I
L
C
V
C
S
L
I
I
L
I
V
L
I
A
N
C
V
S
C
CKDPEI
D
F
K
E
FEDNFDDEIDFTPPAEDTPSVQSP
A
E
V
F
T
L
SVPNISLPAPSQFQ
P
S
V
E
G
L
K
S
Q
V
A
R
H
S
L
N
Y
I
Q
E
IGNGW
F
G
K
V
L
L
G
---EIYT---
G
T
S
V
---------
A
R
V
I
V
K
E
L
K
ASANP
K
E
Q
DTFLKNG
E
P
Y
Y
I
LQHP
N
I
L
Q
C
V
G
Q
C
V
E
A
I
P
Y
L
L
V
F
E
FC
D
L
G
D
L
K
A
Y
L
R
-
S
---
E
----------
Q
E
HM----RG
D
S
Q
T
M
L
--
L
Q
----
R
M
A
C
-
E
V
A
A
G
L
A
A
M
H
K
L
H
F
L
H
S
D
L
A
L
R
N
C
FL-----TSDL
N
V
K
VGDYGI
G
F
S
R
Y
K
E
D
YIETDD
K
K
V
F
P
L
RWT
A
P
E
L
V
T
S
F
Q
D
R
LLTADQTKYS
N
I
W
S
L
G
V
T
L
W
E
L
F
D
N
AAQPYSNLS
N
L
D
V
L
N
Q
V
I
R
E
RDTKLPK---PQLEQPY
S
--
D
R
W
Y
E
V
L
Q
F
C
W-L-S-PEKR
P
A
-
A
E
D
V
H
R
L
L
T
Y
L
R
L
QSQRDSEV
D
F
E
Q
QWNALKPNTNSRDSSNNAA
F
P
I
L
D
H
F
A
R
D
R
L
G
R
E
M
E
E
V
L
T
V
TETSQG
L
S
F
E
Y
V
W
E
A
AKHDHF
D
E
RSRGHLDEGLSY
T
S
I
F
Y
P
V
E
V
F
E
S
SLSDPGPGKQDDSGQDV
P
L
RVP
G
V
V
P
VFDAHNLSVG
S
D
Y
Y
I
Q
L
EEKSGSN
L
E
LDYPPALLTTDMDNPERTGP
E
L
S
Q
L
T
A
L
R
S
V
E
LEESST
D
E
D
F
FQSSTDPKDSSLPG
D
L
H
VTSGPES
P
F
N
N
I
F
NDVDKSEDLP
S
H
Q
K
I
F
D
L
M
E
LNGVQADFKPATLSSSLDNP
K
E
S
V
I
TGHFEKEK
P
R
KIFDSEPLCLSDNLMHQDNFDPL
N
V
Q
E
L
S
E
N
F
L
F
L
QEKNLLKGSLS
S
K
E
H
I
N
D
L
Q
T
E
L
KNAG
F
T
E
A
M
L
E
T
S
CRNSLDT
E
L
Q
FAENKP
G
L
S
L
L
Q
E
N
VSTKGDDT
D
V
M
L
TGDTL
S
T
S
LQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQP
T
C
L
D
V
IV
P
E
D
C
L
HQDISPD
A
V
T
V
P
V
E
I
LSTDARTHSLDNRSQDSPGESE
E
T
L
R
LTESDS
V
L
A
D
D
I
L
A
S
R
V
SVGSS
L
P
E
L
G
Q
E
L
HNKPFS
E
D
H
H
S
H
R
R
L
E
K
N
L
E
A
V
E
T
L
N
Q
LNS
K
D
A
A
K
E
A
G
L
V
S
ALSSDSTS
Q
D
S
L
L
E
D
SLSAPFPASEPSLETPDSLES
V
D
V
H
E
A
L
L
D
S
L
GSHTPQKLVPPDKPADSGYETENLESPE
W
T
LHPAPEGTADSEPATTGDGGHSGLPPN
P
V
I
V
I
SDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEP
E
K
R
SEEVPGTSP
S
A
L
V
L
V
QEQPLPEPVLPEQSPAA
Q
D
S
C
L
E
A
RKSQP
D
E
S
C
L
S
A
LHNSSD
L
E
L
R
ATPEPAQTGVPQQVHPTEDEASSP
W
S
V
L
N
A
ELSSGDDFETQDDRP
C
T
L
ASTGTN
T
N
E
L
L
A
Y
T
N
S
A
L
D
K
S
L
S
SHSEGPKLKEPDIE
G
K
Y
L
G
KLGVSGMLDLSEDGMDADEEDENSDDS
D
E
D
L
R
A
F
N
LHSLSSESEDETEHP
V
P
I
I
L
SNED
G
R
H
L
R
S
L
LKPTAANAPDPL
P
E
D
W
K
K
EK
K
A
V
T
F
FD
D
V
T
V
Y
L
FDQETP
T
K
ELGPCGGEACGPDLSGPAPASG
S
P
Y
L
S
R
C
INSESSTDEEGGGFEWDDDFSPDPF
M
S
K
T
T
S
N
L
LSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPAN
I
A
S
F
S
L
T
HL
T
D
S
D
I
EQGGSSEDGEKD
4
PsiBlast_PDB
91.70
32%
-84
- C1 -
4PMP
1
A:
[4-284]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
N
LL----
K
---------
M
L
V
A
V
K
A
L
K
----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPDAKLLAGG
E
D
V
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.97
32%
-89
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
N
LLP---
K
---------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPD---------------
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.72
34%
-78
- C1 -
4AT5
2
A:
[9-287]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
N
L-----
K
---------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
---
H
----------
G
P
D
A
V
L
M
A
E
G
N
P
P
T
E
L
--
T
Q
S
Q
M
L
H
I
A
Q
-
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
---
S
I
M
Y
R
K
F
T
T
E
----
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
TC-
P
Q
---------
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
89.41
32%
-85
- C1 -
4AOJ
1
C:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
N
LLP-
Q
D
K
---------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPD----------------
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.21
32%
-86
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
N
LLP---
K
---------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPD----------------
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
-------------------
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
88.50
31%
-82
- C1 -
3SXS
1
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
---
K
W
K
G
---
Q
Y
D
V
---------
A
V
K
M
I
K
E
G
S
M
S
-----
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
----------------
H
G
----
K
G
L
E
P
S
Q
L
--
L
E
-----
M
C
Y
-
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
-------
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
---
S
--
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.42
34%
-80
- C1 -
3EKN
1
A:
[14-287]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
---
G
E
A
E
---------
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
-
S
L
RP
E
----------
A
E
N
N
----
P
G
R
P
P
P
T
L
Q
E
M
I
----
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.41
34%
-81
- C1 -
4AT3
1
A:
[9-287]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
N
LC----
K
---------
I
L
V
A
V
K
T
L
--
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
---
H
----------
G
P
D
A
V
L
M
A--
N
P
P
T
E
L
--
T
Q
S
Q
M
L
H
I
A
Q
-
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
---
S
I
M
Y
R
K
F
T
T
E
----
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
TC-
P
Q
---------
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
88.31
34%
-87
- C1 -
3EKK
1
A:
[14-287]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
---
G
E
A
E
---------
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
-
S
L
RP
E
----------
A
E
N
N
----
P
G
R
P
P
P
T
L
Q
E
M
I
----
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
87.45
33%
-80
- C1 -
3ZBF
1
A:
[24-307]
----------------------------------------------------------------------------------------------------------------------------
I
E
N
L
P
A
-
F
P
R
E
K
L
T
L
R
L
L
L
G
S
---
G
--------
E
V
Y
E
---
G
T
A
V
DILGVGSGE
I
K
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
---
R
----------
M
A
T
F
----
Y
G
P
L
L
T
L
V
--
D
L
----
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
SVKDY
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
------------
L
P
V
R
W
M
A
P
E
---
S
L
M
D
G
I
F
T
T
Q
----
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
--
Q
T
G
G
R
L
E
P
---
P
---
R
N
C
P
--
D
D
L
W
N
L
M
T
Q
C
W
-
A
-
Q
E
P
D
Q
R
P
T
----
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.00
34%
-78
- C1 -
4AT4
1
A:
[9-287]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
N
LC----
K
---------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
---
H
----------
G
P
D
A
V
L
M
A---
P
P
T
E
L
--
T
Q
S
Q
M
L
H
I
A
Q
-
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
---
S
I
M
Y
R
K
F
T
T
E
----
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
TC-
P
Q
---------
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
86.39
31%
-84
- C1 -
3SXR
1
B:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
------
V
V
K
L
G
---
K
W
K
G
---
Q
Y
D
V
---------
A
V
K
M
I
K
E
G
S
M
S
-----
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
----------------
H
G
----
K
G
L
E
P
S
Q
L
--
L
E
-----
M
C
Y
-
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
-------
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
---
S
--
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
85.98
31%
-85
- C1 -
3SXR
1
BMX_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
----
V
V
K
L
G
---
K
W
K
G
---
Q
Y
D
V
---------
A
V
K
M
I
K
E
G
S
M
S
-----
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
----------------
H
G
----
K
G
L
E
P
S
Q
L
--
L
E
-----
M
C
Y
-
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
-------
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
---
S
--
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
85.46
33%
-79
- C1 -
4CSV
1
?
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
-
W
R
---
N
Y
N
I
----------
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
--
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
---
C
------------------
V
-
N
A
Q
A
L
L
--------
D
M
A
A
-
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
N
V
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
A
I
S
--
Y
N
R
F
-----
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
--
E
R
G
Y
R
M
P
R
---
P
---
Q
G
C
P
--
E
E
I
Y
E
L
M
L
Q
C
W
N
K
-
S
-
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.32
34%
-85
- C1 -
1I44
1
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
---
G
E
A
E
---------
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
-
S
L
RP
E
----------
A
E
N
N
----
P
G
R
P
P
P
T
L
Q
E
M
I
----
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
85.17
33%
-81
- C1 -
4UXL
1
A:
[24-307]
----------------------------------------------------------------------------------------------------------------------------
I
E
N
L
P
A
-
F
P
R
E
K
L
T
L
R
L
L
L
G
S
G
A
F
G
--------
E
V
Y
E
---
G
T
A
V
DILGVGSGE
I
K
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
---
R
----------
M
A
T
F
----
Y
G
P
L
L
T
L
V
--
D
L
----
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
SVKDY
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
---
S
L
M
D
G
I
F
T
T
Q
----
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
--
Q
T
G
G
R
L
E
P
---
P
---
R
N
C
P
--
D
D
L
W
N
L
M
T
Q
C
W
-
A
-
Q
E
P
D
Q
R
P
T
----
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.94
32%
-84
- C1 -
4YNE
2
A:
[11-291]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
N
LLP--
D
K
---------
M
L
V
A
V
K
A
L
K
E
-----
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPDAK
L
L
A
G
G
E
D
V
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.94
32%
-82
- C1 -
4PMT
1
A:
[4-284]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
N
L----
D
K
---------
M
L
V
A
V
K
A
L
---------
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPDAKLLAGG
E
D
V
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
83.76
34%
-77
- C1 -
3QGW
1
B:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.30
32%
-81
- C1 -
4YPS
1
A:
[11-291]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
---
E
C
H
N
LL---
D
K
---------
M
L
V
A
V
K
A
L
---
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
---
H
GPDAK
L
L
A
G
G
E
D
V
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
80.68
34%
-76
- C1 -
3QGW
1
ITK_HUMAN
A:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
80.51
34%
-69
- C1 -
3QGY
1
B:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
80.20
34%
-77
- C1 -
3QGY
1
ITK_HUMAN
A:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
79.47
33%
-69
- C1 -
4UEU
1
?
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
-
W
R
---
N
Y
N
I
----------
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
--
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
---
C
----------
E
G
H
T
----
V
-
N
A
Q
A
L
L
--------
D
M
A
A
-
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
----------
A
K
-
F
P
I
K
W
T
A
P
E
A
I
S
--
Y
N
R
F
-----
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
--
E
R
G
Y
R
M
P
R
---
P
---
Q
G
C
P
--
E
E
I
Y
E
L
M
L
Q
C
W
N
K
-
S
-
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
79.16
34%
-66
- C1 -
4L7S
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
79.10
33%
-71
- C1 -
3V8T
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
---
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
79.08
34%
-67
- C1 -
4L7S
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
79.04
34%
-68
- C1 -
4PP9
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
78.45
34%
-69
- C1 -
4PP9
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
78.37
34%
-70
- C1 -
4KIO
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
------
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
78.30
33%
-67
- C1 -
3V8W
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
-
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
78.22
33%
-73
- C1 -
3V5J
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
--
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
--
S
T
G
-
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
77.90
34%
-73
- C1 -
4KIO
2
ITK_HUMAN
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
77.61
33%
-72
- C1 -
3V5L
1
ITK_HUMAN
C:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
77.48
33%
-70
- C1 -
3V5L
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
77.47
33%
-72
- C1 -
3V5J
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
77.39
33%
-70
- C1 -
3V8T
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
77.19
33%
-64
- C1 -
4M14
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
77.14
33%
-74
- C1 -
3V5L
1
D:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
--
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
-----------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
77.13
33%
-67
- C1 -
3V8W
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
---
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
76.98
33%
-73
- C1 -
1SNU
1
B:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
76.39
33%
-65
- C1 -
4M13
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
76.38
33%
-67
- C1 -
4M0Z
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
76.32
33%
-67
- C1 -
1SM2
1
ITK_HUMAN
A:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
76.09
33%
-67
- C1 -
3T9T
3
A:
[10-260]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
75.99
33%
-63
- C1 -
4M12
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
75.94
33%
-77
- C1 -
4RFM
1
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
75.84
33%
-63
- C1 -
3MJ2
1
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.70
33%
-67
- C1 -
4MF1
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
---
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
75.62
33%
-64
- C1 -
4M0Y
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
75.50
33%
-74
- C1 -
3MJ1
1
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
-------------
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
75.35
34%
-68
- C1 -
4KIO
3
ITK_HUMAN
C:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
--------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
75.13
33%
-64
- C1 -
4M15
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
74.92
33%
-60
- C1 -
4HCV
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
74.89
33%
-65
* C1 *
1SNU
1
ITK_HUMAN
A:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.15
33%
-67
- C1 -
4MF1
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
---
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
73.40
33%
-74
- C1 -
1SM2
1
B:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
72.93
33%
-65
- C1 -
4HCT
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
72.08
33%
-66
- C1 -
4PQN
2
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
70.99
33%
-66
- C1 -
4HCU
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
68.45
34%
-78
- C1 -
4PPC
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
66.66
34%
-71
- C1 -
4MF0
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
65.77
34%
-68
- C1 -
4QD6
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
------
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.14
34%
-68
- C1 -
4MF0
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
62.96
34%
-74
- C1 -
4PPA
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
62.48
34%
-72
- C1 -
4PPB
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.45
33%
-51
- C1 -
4XLV
1
?
A:
[35-308]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
---
G
E
A
E
---------
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
-
S
L
RP
E
----------
A
E
N
N
----
P
G
R
P
P
P
T
L
Q
E
M
I
----
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.06
34%
-69
- C1 -
4PPC
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
61.35
34%
-71
- C1 -
4PPA
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
60.91
34%
-68
- C1 -
4PPB
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
---
K
D
K
V
---------
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
---
Q
------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
-
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------