@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LMTK3_HUMAN: (2015-10-12 )
MPAPGALILLAAVSASGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN
Atome Classification :
(82 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150-....-------..-------...160--........-.170.....-..180.......190.......200.----...-...210.......220....----..-------.230..-.....----240......--.250.......260.......270..-----.....280.......290.......300.......310.......320.......330.......340.....-..350.......360---.........370..-----.....380.-........390-.-.-.....400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPAP
G
A
L
I
L
L
A
AVSASGCLASPAHPDGFALGRAPLAP
P
Y
A
V
V
L
I
SC
S
G
L
L
A
F
I
F
L
L
L
T
C
L
C
CKRGDVG
F
K
EFENPEGEDCSGEYTPPAEETSSSQSLP
D
V
Y
I
L
P
L
A
E
VSLPMPAPQPSHSDMTTPLGL
S
R
Q
H
L
S
Y
L
Q
E
IGSGW
F
G
K
V
I
L
G
---
E
I
F
S-------DY-------
T
P
A
Q
----
V
V
V
K
E
L
R
A-SAG
P
L
E
Q
R
K
-
F
I
S
E
A
Q
P
YRSLQHP
N
V
L
Q
C
L
G
L
C
V
E
T
----
L
P
F
-
L
L
I
M
E
F
C
Q
L
G
D
L
K
R
Y
L
R
AQR----PP-------EGLSPE-LP
P
R
D
----
L
R
T
L
Q
R
M
G
L
--
E
I
A
R
G
L
A
H
L
HSHNY
V
H
S
D
L
A
L
R
N
C
LL-----TS
D
L
T
V
R
IGDYGLAHSNYKE
D
Y
Y
L
T
P
E
R
L
W
I
P
LRWA
A
P
E
L
L
G
E
LH
G
T
F
M
V
V
DQSRESNI
W
S
L
G
V
T
L
W
E
L
F
E
FG-A
Q
P
Y
RHL
S
D
E
E
V
L
-----
A
F
V
V
R
Q
Q
H
V
K
LARP-----RLKLP
Y
--
A
-
D
Y
W
Y
D
I
L
Q
S
CW-R-P-PAQRPSASD
L
Q
L
Q
L
T
Y
L
L
SERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPD
D
V
L
T
V
TESSRGL
N
L
E
C
L
W
E
K
A
RRGAGRGGGAPAWQPASAPPAPHANPSN
P
F
Y
E
ALSTP
S
V
L
P
V
ISARSPSVSS
E
Y
Y
I
R
LEEHGSPPEPLFPNDWDPLDPGVPAPQAPQA
P
S
E
V
P
Q
L
V
S
E
TWASPLFPAPRPFPAQSSASG
S
F
L
L
SGWDPEGRGAGETLAG
D
P
A
E
V
LGERGTAPWVE
E
E
E
E
EEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDD
S
S
L
R
A
ERGSLADLPMAPPASA
P
P
E
F
L
D
P
L
M
GAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREK
P
T
F
V
V
Q
V
S
T
E
Q
L
L
M
S
L
R
E
D
V
T
R
N
L
LGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVN
G
V
T
V
LENGDQRAPG
I
E
E
K
AAENGALGS
P
E
R
E
E
K
V
L
ENGELTP
P
R
R
E
E
K
ALENGELRSPEAG
E
K
V
L
VNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAP
S
A
VVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEM
P
R
L
F
L
DLGPPQG
N
S
E
Q
I
K
A
R
L
S
R
L
SLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDED
E
E
E
D
E
E
AAAPGAAAGPRGPGRARAAPV
P
V
V
V
SSADA
D
A
A
R
P
L
R
G
L
L
KSPRGADEPE
D
S
E
L
E
R
K
R
K
M
V
S
FHG
D
V
T
V
Y
L
FDQETPTNE
L
S
V
QAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFE
W
A
EDFPLLPPPGPP
L
C
F
SRFSVSPALETPGPPARAPDARPAGPVEN
39
PsiBlast_CBE
84.13
35%
-119
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[38-317]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
-
H
-------
N
L
-------
L
P
--K
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
-
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
----
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
----
P
D
-----------
P
---
G
P
L
G
----
L
G
Q
L
L
A
V
A
S
--
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
--
L
Y
R
K
F
-----
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
-----
D
C
I
T
--
Q
G
R
E
L
E
R
P
-----
R
A
C
P
P
E
--
V
----
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
82.06
35%
-116
- C1 -
4AOJ
1
C:
[38-317]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
-
H
-------
N
L
-------
L
P
-
Q
D
K
M
L
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
-
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
----
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
----
P
D
---------------
G
P
L
G
----
L
G
Q
L
L
A
V
A
S
--
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
--
L
Y
R
K
F
-----
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
-----
D
C
I
T
--
Q
G
R
E
L
E
R
P
-----
R
A
C
P
P
E
--
V
----
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.52
35%
-112
- C1 -
4AT3
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
--------
N
L
-------
C
---K
I
L
-
V
A
V
K
T
L
----
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
----
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
----
P
D
-------
A
V
L
M
A
--
N
P
P
T
E
----
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
-----
E
C
I
T
--
Q
G
R
V
L
Q
R
P
-----
R
---
T
C
--
P
-
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.14
35%
-108
- C1 -
4AT5
2
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
--------
N
L
-----------K
I
L
-
V
A
V
K
T
L
K
--
D
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
----
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
----
P
D
-------
A
V
L
M
A
E
G
N
P
P
T
E
----
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
-----
E
C
I
T
--
Q
G
R
V
L
Q
R
P
-----
R
---
T
C
--
P
-
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.86
35%
-119
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[38-317]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
-
H
-------
N
L
-------
L
P
--K
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
-
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
----
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
----
P
D
---------------
G
P
L
G
----
L
G
Q
L
L
A
V
A
S
--
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
-------------------
L
P
I
R
W
M
P
P
E
S
I
--
L
Y
R
K
F
-----
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
-----
D
C
I
T
--
Q
G
R
E
L
E
R
P
-----
R
A
C
P
P
E
--
V
----
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.70
35%
-115
- C1 -
4YNE
2
A:
[12-291]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
-
H
-------
N
L
-------
L
P
--D
K
M
L
V
A
V
K
A
L
K
E
------
R
Q
-
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
----
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
----
P
D
AK
L
L
A
G
G
E
D
V
A
P
---
G
P
L
G
----
L
G
Q
L
L
A
V
A
S
--
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
--
L
Y
R
K
F
-----
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
-----
D
C
I
T
--
Q
G
R
E
L
E
R
P
-----
R
A
C
P
P
E
--
V
----
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.22
35%
-112
- C1 -
3LW0
3
IGF1R_HUMAN
B:
[12-276]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
VAK
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
-----------------
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.15
35%
-113
- C1 -
3LW0
3
IGF1R_HUMAN
C:
[12-276]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
VAK
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
-----------------
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.00
35%
-114
- C1 -
3LW0
2
IGF1R_HUMAN
A:
[12-276]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
-----------------
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
79.75
35%
-109
- C1 -
4PMT
1
A:
[5-284]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
-
H
-------
N
L
-----------D
K
M
L
V
A
V
K
A
L
-----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
----
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
----
P
D
AKLLAGG
E
D
V
A
P
---
G
P
L
G
----
L
G
Q
L
L
A
V
A
S
--
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
--
L
Y
R
K
F
-----
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
-----
D
C
I
T
Q
G
R
--
E
L
E
R
P
-----
R
A
C
P
P
E
--
V
----
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.65
35%
-112
- C1 -
3LW0
2
D:
[12-276]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
VAK
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
-----------------
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.60
35%
-107
- C1 -
3ETA
1
B:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-------
G
E
-------
A
E
T
R
----
V
A
V
K
T
V
N
E
-
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
----
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
-------
A
E
N
N
P
G
-
R
P
P
P
T
----
L
Q
E
M
I
Q
M
A
A
--
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
--
G
V
F
-----
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
K
F
V
M
D
G
G
Y
--
L
D
Q
P
DNCP
E
R
V
T
-----------
D
L
M
R
M
C
W
-
Q
F
N
-
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.11
35%
-108
- C1 -
3ETA
1
INSR_HUMAN
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-------
G
E
-------
A
E
T
R
----
V
A
V
K
T
V
N
E
-
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
----
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
-------
A
E
N
N
P
G
-
R
P
P
P
T
----
L
Q
E
M
I
Q
M
A
A
--
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
--
G
V
F
-----
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
K
F
V
M
D
G
G
Y
--
L
D
Q
P
DNCP
E
R
V
T
-----------
D
L
M
R
M
C
W
-
Q
F
N
-
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.68
35%
-112
- C1 -
3EKN
1
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-------
G
E
-------
A
E
T
R
----
V
A
V
K
T
V
N
E
-
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
----
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
-------
A
E
N
N
P
G
-
R
P
P
P
T
----
L
Q
E
M
I
Q
M
A
A
--
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
--
G
V
F
-----
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
K
F
V
M
D
G
G
Y
--
L
D
Q
P
DNCP
E
R
V
T
-----------
D
L
M
R
M
C
W
-
Q
F
N
-
P
N
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
78.55
34%
-104
- C1 -
4UXL
1
A:
[32-305]
---------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
---
T
A
V
D
ILGV---
G
S
-------
G
E
I
K
----
V
A
V
K
T
L
K
K
-
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
----
E
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
----
M
A
-------
T
F
Y
G
P
L
----
L
T
----
L
V
D
L
V
D
L
C
V
--
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
SVKDY
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
--
M
D
G
I
F
-----
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
-
H
Q
P
Y
P
A
H
S
N
L
D
V
L
-----
N
Y
V
--
Q
T
G
G
R
L
E
P
P
-----
R
-
N
C
P
-----
D
D
L
W
N
L
M
T
Q
C
W
A
Q
-
E
-
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.48
35%
-113
- C1 -
3I81
1
A:
[15-279]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
--------
E
N
N
P
V
-
L
A
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
78.22
34%
-106
- C1 -
3ZBF
1
A:
[32-305]
---------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
---
T
A
V
D
ILGV---
G
S
-------
G
E
I
K
----
V
A
V
K
T
L
K
K
-
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
----
E
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
----
M
A
-------
T
F
Y
G
P
L
----
L
T
----
L
V
D
L
V
D
L
C
V
--
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
SVKDY
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
------------
L
P
V
R
W
M
A
P
E
S
L
--
M
D
G
I
F
-----
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
-
H
Q
P
Y
P
A
H
S
N
L
D
V
L
-----
N
Y
V
--
Q
T
G
G
R
L
E
P
P
-----
R
-
N
C
P
-----
D
D
L
W
N
L
M
T
Q
C
W
A
Q
-
E
-
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.10
35%
-112
- C1 -
4AT4
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
--------
N
L
-------
C
---K
I
L
-
V
A
V
K
T
L
K
--
D
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
----
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
----
P
D
-------
A
V
L
M
A
---
P
P
T
E
----
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
-----
E
C
I
T
--
Q
G
R
V
L
Q
R
P
-----
R
---
T
C
--
P
-
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.04
35%
-110
- C1 -
3NW7
1
A:
[15-279]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
-------
M
E
N
N
P
V
-
L
A
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
77.86
32%
-113
- C1 -
5BVN
1
?
A:
[18-313]
---------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
V
D
S
----------------
H
P
L
L
----
V
A
V
K
I
L
R
P
-
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
----
D
P
L
-
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
LEDK-----------------
P
T
I
S
----
Y
P
M
L
L
H
V
A
A
--
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
--
L
M
G
K
F
-----
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
---------
P
A
--
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
-
E
-
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
77.24
35%
-111
- C1 -
1I44
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-------
G
E
-------
A
E
T
R
----
V
A
V
K
T
V
N
E
-
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
----
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
-------
A
E
N
N
P
G
-
R
P
P
P
T
----
L
Q
E
M
I
Q
M
A
A
--
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
--
G
V
F
-----
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
K
F
V
M
D
G
G
Y
--
L
D
Q
P
DNCP
E
R
V
T
-----------
D
L
M
R
M
C
W
-
Q
F
N
-
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.99
35%
-113
- C1 -
3EKK
1
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-------
G
E
-------
A
E
T
R
----
V
A
V
K
T
V
N
E
-
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
----
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
----
P
E
-------
A
E
N
N
P
G
-
R
P
P
P
T
----
L
Q
E
M
I
Q
M
A
A
--
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
-----
A
H
D
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
--
G
V
F
-----
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
K
F
V
M
D
G
G
Y
--
L
D
Q
P
DNCP
E
R
V
T
-----------
D
L
M
R
M
C
W
-
Q
F
N
-
P
N
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
76.02
32%
-108
- C1 -
5BVW
1
?
A:
[18-313]
---------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
V
D
S
----------------
H
P
L
L
----
V
A
V
K
I
L
R
P
-
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
----
D
P
L
-
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
LEDK-----------------
P
T
I
S
----
Y
P
M
L
L
H
V
A
A
--
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
--
L
M
G
K
F
-----
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
---------
P
A
--
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
-
E
-
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.91
35%
-110
- C1 -
1JQH
1
IGF1R_HUMAN
B:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----
P
-----------------
P
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
75.37
35%
-108
- C1 -
3QQU
1
IGF1R_HUMAN
B:
[9-273]
-------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-------
D
E
-------
P
E
T
R
----
V
A
I
K
T
V
N
E
-
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
----
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----------------------
P
S
----
L
S
K
M
I
Q
M
A
G
--
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
-----
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
--
G
V
F
-----
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
-----
R
F
V
M
--
E
G
G
L
L
D
K
P
-----
D
-
N
C
P
-----
D
M
L
F
E
L
M
R
M
C
W
-
Q
Y
N
-
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
75.23
32%
-105
- C1 -
5BVK
1
?
A:
[18-313]
---------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
V
D
S
----------------
H
P
L
L
----
V
A
V
K
I
L
R
P
-
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
----
D
P
L
-
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
LEDK-----------------
P
T
I
S
----
Y
P
M
L
L
H
V
A
A
--
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
--
L
M
G
K
F
-----
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
---------
P
A
--
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
-
E
-
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
74.35
35%
-110
- C1 -
3BPR
1
D:
[42-311]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
K
Q
E------
D
G
-------
T
S
L
K
----
V
A
V
K
T
M
K
--------
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SS-----P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
----
L
E
-------
T
G
--
P
K
-
H
I
P
------
L
Q
T
L
L
K
F
M
V
--
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
-------
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
-
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
-----
D
Y
L
L
H
G
H
------------
R
L
K
Q
P
E
DC
L
-
D
E
L
Y
E
I
M
Y
S
C
W
-
R
-
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.14
34%
-106
- C1 -
4M15
2
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
73.99
32%
-103
- C1 -
4BKJ
10
B:
[9-304]
---------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
V
D
S
PQDLVSL
D
F
PLNVRKG
H
P
L
L
----
V
A
V
K
I
L
R
P
-
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
----
D
P
L
-
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
LEDK----------------
G
P
T
I
S
----
Y
P
M
L
L
H
V
A
A
--
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
--
L
M
G
K
F
-----
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
---------
P
A
--
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
-
E
-
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
73.86
34%
-106
- C1 -
3T9T
3
A:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.68
34%
-106
- C1 -
4M0Y
2
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.65
35%
-111
- C1 -
3BPR
1
MERTK_HUMAN
A:
[42-311]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
K
Q
E------
D
G
-------
T
S
L
K
----
V
A
V
K
T
M
K
------
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SS-----P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
----
L
E
-------
T
G
--
P
K
-
H
I
P
------
L
Q
T
L
L
K
F
M
V
--
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
-------
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
-
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
-----
D
Y
L
L
H
G
H
------------
R
L
K
Q
P
E
DC
L
-
D
E
L
Y
E
I
M
Y
S
C
W
-
R
-
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
73.55
34%
-105
- C1 -
4M14
2
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
73.36
34%
-105
- C1 -
3V8W
1
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
------
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
72.98
35%
-112
- C1 -
3BPR
1
MERTK_HUMAN
B:
[42-311]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
E
F
G
S
V
M
E
G
---
N
L
K
Q
E------
D
G
-------
T
S
L
K
----
V
A
V
K
T
M
K
L
-------
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
-------P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
----
L
E
-------
T
G
--
P
K
-
H
I
P
------
L
Q
T
L
L
K
F
M
V
--
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
-------
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
-
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
-----
D
Y
L
L
H
G
H
------------
R
L
K
Q
P
E
DC
L
-
D
E
L
Y
E
I
M
Y
S
C
W
-
R
-
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.70
34%
-111
- C1 -
4RFM
1
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
72.60
34%
-106
- C1 -
4M0Z
2
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
72.57
34%
-103
- C1 -
4M12
1
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
72.45
34%
-107
- C1 -
3QGW
1
ITK_HUMAN
A:
[29-278]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
D
-------
K
V
A
I
----
K
T
I
K
E
------
G
S
M
S
E
D
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
------------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.45
34%
-103
- C1 -
4MF1
1
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
------
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.43
34%
-129
- C1 -
3V5Q
1
NTRK3_HUMAN
A:
[12-279]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
---
E
C
Y
--------
N
L
-------
S
P
T
K
D
K
M
L
V
A
V
K
A
L
---
P
T
--
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
----
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
----
P
--------------------ELG-
L
S
Q
M
L
H
I
A
S
--
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
-
K
Q
P
W
F
Q
L
S
N
T
E
V
I
-----
E
C
I
T
--
Q
G
R
V
L
E
R
P
-----
R
V
---
C
--
P
-
K
E
V
Y
D
V
M
L
G
C
W
Q
R
-
E
-
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
72.32
34%
-109
- C1 -
3V5J
1
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
-------
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.22
34%
-103
- C1 -
3MJ2
1
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
72.17
34%
-106
- C1 -
3V8W
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
----
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
-
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
72.04
34%
-105
- C1 -
4M13
1
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
71.89
34%
-106
- C1 -
4HCT
1
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
71.87
34%
-100
- C1 -
4HCV
1
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
71.83
35%
-107
- C1 -
3BRB
2
B:
[42-311]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
K
Q
E------
D
G
-------
T
S
L
K
----
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
SQ
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
----
L
E
-------
T
G
--
P
K
-
H
I
P
------
L
Q
T
L
L
K
F
M
V
--
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
-------
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
-
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
-----
D
Y
L
L
H
G
H
------------
R
L
K
Q
P
E
DC
L
-
D
E
L
Y
E
I
M
Y
S
C
W
-
R
-
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
71.67
34%
-107
- C1 -
4HCU
1
A:
[12-261]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
-
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
R
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
71.41
34%
-108
- C1 -
1SNU
1
B:
[7-256]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
71.37
33%
-103
- C1 -
4L7S
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
71.32
33%
-111
- C1 -
3SXS
1
A:
[5-255]
-------------------------------------------------------------------------------------------------------------------------------
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
---
K
W
K
G
-------
Q
Y
-------
D
V
A
V
----
K
M
I
K
E
------
G
S
M
S
E
D
E
-
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
----
Y
P
I
-
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
------
G
-------
K
G
L
E
P
S
------------
Q
L
L
E
M
C
Y
--
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
-----
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
-
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
-------
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
-
K
M
P
Y
D
L
Y
T
N
S
E
V
V
------
L
K
V
S
Q
G
H
-
R
L
Y
R
P
-----
H
L
A
-----
S
-
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
71.22
34%
-106
- C1 -
3V5J
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
--
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
-
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
-
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
71.15
34%
-105
- C1 -
3V8T
1
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
------
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
70.89
34%
-108
- C1 -
1SM2
1
B:
[7-256]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
70.67
34%
-108
- C1 -
3V5L
1
ITK_HUMAN
C:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
70.66
34%
-101
- C1 -
1SNU
1
ITK_HUMAN
A:
[7-256]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.53
33%
-106
- C1 -
4PP9
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
70.46
33%
-106
- C1 -
4KIO
3
ITK_HUMAN
C:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
70.34
34%
-108
- C1 -
3V5L
1
D:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
-----
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
-----------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
70.08
33%
-106
- C1 -
4PP9
1
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.06
34%
-104
- C1 -
1SM2
1
ITK_HUMAN
A:
[7-256]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
69.99
34%
-101
- C1 -
4PQN
2
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
------------------
F
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
69.94
33%
-105
- C1 -
4L7S
1
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
69.79
34%
-103
- C1 -
4MF1
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
------
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.58
34%
-100
- C1 -
3QGW
1
B:
[29-278]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
D
-------
K
V
A
I
----
K
T
I
K
E
------
G
S
M
S
E
D
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
69.51
33%
-108
- C1 -
4KIO
2
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
---------
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.48
34%
-105
- C1 -
3V5L
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
-------
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
69.31
34%
-102
* C1 *
3QGY
1
ITK_HUMAN
A:
[29-278]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
D
-------
K
V
A
I
----
K
T
I
K
E
------
G
S
M
S
E
D
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
68.77
33%
-108
- C1 -
4KIO
2
ITK_HUMAN
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
68.58
35%
-112
- C1 -
4MHA
1
B:
[42-311]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
K
Q
E------
D
G
-------
T
S
L
K
----
V
A
V
K
T
M
K
---------------------
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
SQG
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
----
L
E
-------
T
G
--
P
K
-
H
I
P
------
L
Q
T
L
L
K
F
M
V
--
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
-----
R
D
D
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
-------
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
-
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
-----
D
Y
L
L
H
G
H
------------
R
L
K
Q
P
E
DC
L
-
D
E
L
Y
E
I
M
Y
S
C
W
-
R
-
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
67.93
34%
-95
- C1 -
3QGY
1
B:
[29-278]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
D
-------
K
V
A
I
----
K
T
I
K
E
------
G
S
M
S
E
D
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
67.30
34%
-106
- C1 -
3V8T
1
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
R
E
---
G
A
M
S
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
------
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
66.91
34%
-105
- C1 -
3MJ1
1
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
---------------
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
-
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.20
34%
-95
- C1 -
4YMJ
4
NTRK3_HUMAN
A:
[12-279]
-------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
--------
N
L
-------
S
P
T
K
D
K
M
L
V
A
V
K
A
L
K
D
-
P
T
--
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
----
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
----
P
--------------------GELG
L
S
Q
M
L
H
I
A
S
--
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
-----
G
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
T
D
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
-
K
Q
P
W
F
Q
L
S
N
T
E
V
I
-----
E
C
I
T
--
Q
G
R
V
L
E
R
P
-----
R
V
---
C
--
P
-
K
E
V
Y
D
V
M
L
G
C
W
Q
R
-
E
-
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
63.90
33%
-110
- C1 -
4PPC
2
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
--------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.46
33%
-106
- C1 -
4PPA
2
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
61.36
33%
-109
- C1 -
4PPA
2
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
60.84
33%
-104
- C1 -
4QD6
2
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
---------
E
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
60.49
33%
-102
- C1 -
4PPC
2
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
--------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
------
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
--------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.46
33%
-110
- C1 -
4PPB
2
ITK_HUMAN
A:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
59.39
33%
-101
- C1 -
4PPB
2
B:
[9-258]
------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
N
-------
K
----------
D
K
----
V
A
I
K
T
I
----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
----
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------------
G
L
F
A
A
-----------
E
T
L
L
G
M
C
L
--
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
-----
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------
P
V
K
W
A
S
P
E
V
-------
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
P
Y
E
N
R
S
N
S
E
V
V
-----
E
D
I
--
S
T
G
F
R
L
Y
K
P
-----
R
L
A
-----
S
-
T
H
V
Y
Q
I
M
N
H
C
W
-
K
-
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------