@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LTK_HUMAN: (2015-10-12 )
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
Atome Classification :
(79 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.-...-...510.-......520.......530..-.--....540....--...550.....-..560......-.570...----....580....-...590.......600.....-------..------610------..---.-----.--.....620.......630.......640.......650.....--..660.......670.......680.......690.......700.......710.......720....-...730.......740.......750.......760.......770...---....780.-......790.......800.......810.......820.......830.......840.......850.......860..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
C
W
G
Q
L
L
V
W
FGAA
G
A
I
L
CSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEG
S
W
L
F
STCGASGRHGPTQTQCDGAYAG
T
S
V
V
V
T
VGAAG
Q
L
R
G
V
Q
L
W
RVPGPG
Q
Y
L
I
S
AYGAAGGK
G
A
K
N
H
L
S
R
A
H
G
V
F
V
S
A
I
F
SLGLG
E
S
L
Y
I
L
V
GQQGEDACPGGSPE
S
Q
L
V
C
LGESR
A
V
E
E
H
AAMDGSEGVPGSRRWAGGGGGGGG
A
T
Y
V
F
R
V
RAGEL
E
P
L
L
V
A
AGGG
G
R
A
Y
LRPRDRGRTQA
S
P
E
K
L
ENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAG
R
S
L
Q
EGAEGGQ
G
C
S
E
A
W
A
T
LGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGED
G
V
S
F
IHPS
S
E
L
F
L
Q
P
L
A
VTENHG
E
V
E
I
R
RHLNCSHCPLRDC
Q
W
Q
A
E
L
Q
L
A
E
CLCPEG
M
E
L
A
VD
N
V
T
C
M
DLHKPPG
P
L
V
L
M
V
A
V
V
A
T
S
T
L
S
L
L
M
V
C
G
V
L
I
L
VK
Q
K
K
WQ
G
L
Q
EMRLPSP
E
L
E
L
S
K
L
R
T
S
A
IRTAPN
P
Y
Y
C
QVGLGPAQSWPLPPGVT-EVS-P
A
N
V
T
L
L
-
R
A
LGHG
A
F
G
E
V
YE
G
L
V
I
GLPG-D--SS
P
L
Q
V
A
I
K
T
L
--
P
E
LCS
P
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
R
H
Q
N
I
V
R
----
C
VGLSLRAT
P
R
-
L
I
L
L
E
L
MSGG
D
M
K
S
F
L
R
HSRP-------HL------G--------QP---
S
-----
P
--
L
V
M
R
D
L
L
Q
L
A
Q
D
I
A
Q
G
C
H
Y
L
E
EN
H
F
I
H
R
D
I
A
A
R
N
C
L
L
SCA
G
P
S
--
R
V
A
KIGDF
G
M
A
R
D
I
Y
R
A
S
Y
YRRGDR
A
L
L
P
V
KWM
P
P
E
A
F
L
E
G
I
FTSKTDS
W
S
F
G
V
L
L
W
E
I
F
SLGYMPYPG-RT
N
Q
E
V
L
D
F
VVGGGRMDPPRGCP
G
P
V
Y
R
I
M
T
Q
C
WQHEPELR
P
S
F
A
S
I
L
E
---
R
L
Q
Y
CTQ
D
-
P
D
V
L
N
S
LLPMELGPTPEEEGTSGLGNRS
L
E
CLRPPQPQEL
S
P
E
K
L
K
SWGGSP
L
G
P
W
L
S
SG
L
K
P
L
K
SRGLQPQNLWNPTYRS
7
PsiBlast_PDB
90.54
73%
-112
- C1 -
3LCS
3
A:
[30-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
-
D
--
P
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------
5
PsiBlast_PDB
90.46
72%
-113
- C1 -
4MKC
3
A:
[50-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------
13
PsiBlast_PDB
90.34
73%
-117
- C1 -
4FNY
1
A:
[20-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
---------
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
--------------------------
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------
10
PsiBlast_PDB
90.32
73%
-111
- C1 -
4FOD
2
A:
[8-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
T
I
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
-----------------------------------------------------------------
2
PsiBlast_PDB
90.21
72%
-115
- C1 -
4FOC
1
A:
[36-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------
4
PsiBlast_PDB
89.59
72%
-110
- C1 -
3L9P
4
A:
[50-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
--------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------
33
PsiBlast_CBE
89.39
74%
-117
- C1 -
2XB7
1
A:
[3-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
----------
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------
1
PsiBlast_PDB
89.35
72%
-114
- C1 -
4FOB
1
A:
[36-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
--------------------
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------
3
PsiBlast_PDB
89.03
73%
-113
- C1 -
3AOX
5
A:
[19-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
M
T
D
Y
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
----
G
E
V
Y
E
G
Q
V
S
----------
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------
6
PsiBlast_PDB
88.77
73%
-109
- C1 -
3LCT
3
A:
[27-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
-
D
--
P
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------
11
PsiBlast_PDB
88.66
73%
-112
- C1 -
4FNZ
1
A:
[10-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
--------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------
9
PsiBlast_PDB
88.14
73%
-111
- C1 -
4DCE
1
ALK_HUMAN
A:
[16-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
--------
P
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------
21
PsiBlast_CBE
87.97
73%
-116
- C1 -
4DCE
1
B:
[17-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
T
S
S
I
S
-----
D
L
K
-
E
V
P
-
R
K
N
I
T
L
I
-
R
G
L
G
H
----
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
----
C
I
G
V
S
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
P
------
S
--------
Q
P
---
S
-----
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------
42
PsiBlast_CBE
73.83
43%
-110
- C1 -
3LW0
3
IGF1R_HUMAN
B:
[7-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
43
PsiBlast_CBE
73.35
43%
-110
- C1 -
3LW0
2
IGF1R_HUMAN
A:
[7-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
71
PsiBlast_CBE
73.30
41%
-112
- C1 -
4PMP
1
A:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
-------
K
M
L
V
A
V
K
A
L
--
K
-----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
A
------
K
LLAGGEDV
A
P
---
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
H
H
H
H
-----------------------------------------------------------------------------
41
PsiBlast_CBE
72.83
43%
-109
- C1 -
3LW0
3
IGF1R_HUMAN
C:
[7-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
68
PsiBlast_CBE
72.46
39%
-114
- C1 -
4AT4
1
A:
[7-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-
H
I
K
-
R
H
N
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
-------
K
I
L
V
A
V
K
T
L
--
K
D
-
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
----
F
Y
G
V
C
V
E
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------
D
A
V
L
M
A-----------
P
P
---
T
-----
E
--
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
---
L
L
Q
N
L
A
K
A
-
S
P
V
Y
L
D
I
L
G
------------------------------------------------------------------------
50
PsiBlast_CBE
72.31
43%
-110
- C1 -
3I81
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
-------
E
--------
N
N
P
V
L
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
67
PsiBlast_CBE
72.24
39%
-110
- C1 -
4AT5
2
A:
[7-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-
H
I
K
-
R
H
N
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
--------
K
I
L
V
A
V
K
T
L
--
K
D
-
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
----
F
Y
G
V
C
V
E
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------
D
A
V
L
M
AE
G
N
--------
P
P
---
T
-----
E
--
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
---
L
L
Q
N
L
A
K
A
-
S
P
V
Y
L
D
I
L
G
------------------------------------------------------------------------
38
PsiBlast_CBE
72.07
43%
-109
- C1 -
3NW6
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
------
E
--------
N
N
PVL
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
51
PsiBlast_CBE
71.92
40%
-117
- C1 -
3LVP
2
IGF1R_HUMAN
A:
[39-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--------
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
------
E
----------PVL
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
40
PsiBlast_CBE
71.79
43%
-109
- C1 -
3LW0
2
D:
[7-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
69
PsiBlast_CBE
71.66
39%
-112
- C1 -
4AT3
1
A:
[7-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-
H
I
K
-
R
H
N
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
-------
K
I
L
V
A
V
K
T
L
-----
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
----
F
Y
G
V
C
V
E
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------
D
A
V
L
M
A--
N
--------
P
P
---
T
-----
E
--
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
---
L
L
Q
N
L
A
K
A
-
S
P
V
Y
L
D
I
L
G
------------------------------------------------------------------------
39
PsiBlast_CBE
71.66
43%
-110
- C1 -
3NW5
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
------
E
--------
N
N
P
V
L
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
84
PsiBlast_CBE
71.64
39%
-114
- C1 -
2I0V
1
A:
[39-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
W
E
F
P
R
N
---------
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
-
E
--
D
A
V
L
K
V
A
V
K
M
L
--
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
----
L
L
G
A
C
T
H
G
G
P
V
-
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
------------------------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
A
Q
E
----------------------------------------------------------------------------------
61
PsiBlast_CBE
71.52
44%
-112
- C1 -
3EKK
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
--------------------------------------------------------------------
70
PsiBlast_CBE
71.16
41%
-112
- C1 -
4PMT
1
A:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-------
D
K
M
L
V
A
V
K
A
L
------------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
A
------
K
LLAGGEDV
A
P
---
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
H
H
H
H
-----------------------------------------------------------------------------
63
PsiBlast_CBE
71.02
41%
-111
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[35-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
------
K
M
L
V
A
V
K
A
L
--
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
---------------------
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
P
P
V
Y
-----------------------------------------------------------------------------
62
PsiBlast_CBE
70.90
41%
-110
- C1 -
4AOJ
1
C:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
----
Q
D
K
M
L
V
A
V
K
A
L
--
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
---------------------
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
P
P
-------------------------------------------------------------------------------
37
PsiBlast_CBE
70.86
43%
-107
- C1 -
3NW7
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
------
E
--------
N
N
P
V
L
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
64
PsiBlast_CBE
70.60
41%
-115
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
------
K
M
L
V
A
V
K
A
L
--
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
-----------------
P
---
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
P
P
-------------------------------------------------------------------------------
66
PsiBlast_CBE
70.58
41%
-111
- C1 -
4YNE
2
A:
[9-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-----
D
K
M
L
V
A
V
K
A
L
--
K
E
------
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
A
------
K
L
L
A
G
G
EDV
A
P
---
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------
65
PsiBlast_CBE
70.49
41%
-104
- C1 -
4YPS
1
A:
[9-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-
H
I
K
-
R
R
D
I
V
L
K
-
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
L
------
D
K
M
L
V
A
V
K
A
L
------
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
----
F
F
G
V
C
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
A
------
K
L
L
A
G
G
EDV
A
P
---
G
-----
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
-
P
P
V
------------------------------------------------------------------------------
53
PsiBlast_CBE
70.48
43%
-105
- C1 -
4D2R
1
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
------
E
--------
N
N
P
V
L
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
49
PsiBlast_CBE
70.20
43%
-106
- C1 -
1JQH
1
IGF1R_HUMAN
B:
[11-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
56
PsiBlast_CBE
69.55
44%
-104
- C1 -
1I44
1
A:
[9-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------
83
PsiBlast_CBE
68.94
39%
-105
- C1 -
2I0Y
1
?
A:
[39-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
W
E
F
P
R
N
---------
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
-
E
--
D
A
V
L
K
V
A
V
K
M
L
--
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
----
L
L
G
A
C
T
H
G
G
P
V
-
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
------------------------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
A
Q
E
----------------------------------------------------------------------------------
44
PsiBlast_CBE
68.92
43%
-106
- C1 -
2OJ9
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
---------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
60
PsiBlast_CBE
68.77
44%
-106
- C1 -
3EKN
1
A:
[10-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------
75
PsiBlast_CBE
68.70
38%
-113
- C1 -
4K33
1
A:
[32-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
-
R
A
R
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
I
G
I
D
K
-
D
RA
A
K
P
V
T
V
A
V
K
M
L
--
K
D
D
A
T
D
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
G
G
P
L
-
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
PGLDYSF
D
T
------
S
-------------
E
-----
Q
--
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
V
L
T
V
-
T
--------------------------------------------------------------------------------
35
PsiBlast_CBE
68.66
49%
-116
- C1 -
4UXL
1
A:
[34-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
L
R
-
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
--
S
G
E
I
K
V
A
V
K
T
L
--
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
----
Q
L
G
V
C
L
L
N
E
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
-------
A
T
------
F
--------
Y
G
---
P
-----
L
--
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
-
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
---
Q
L
Q
L
F
R
N
F
-
F
L
N
S
I
Y
K
S
R
------------------------------------------------------------------------
36
PsiBlast_CBE
68.19
49%
-114
- C1 -
3ZBF
1
A:
[34-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
L
R
-
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
--
S
G
E
I
K
V
A
V
K
T
L
--
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
----
Q
L
G
V
C
L
L
N
E
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
-------
A
T
------
F
--------
Y
G
---
P
-----
L
--
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
-
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
---
Q
L
Q
L
F
R
N
F
-
F
L
N
S
I
Y
K
S
R
------------------------------------------------------------------------
48
PsiBlast_CBE
68.05
43%
-112
- C1 -
3QQU
1
IGF1R_HUMAN
A:
[6-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
--------------------------------------------------------------------
99
PsiBlast_CBE
67.89
36%
-109
- C1 -
3TT0
4
B:
[52-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
-
T
S
N
------------------------------------------------------------------------------
80
PsiBlast_CBE
67.85
39%
-107
- C1 -
4R7I
1
?
A:
[51-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
-
E
--
D
A
V
L
K
V
A
V
K
M
L
--
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
----
L
L
G
A
C
T
H
G
G
P
V
-
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
E
-------
A
M
------
L
--------
G
P
---
S
LSG
R
-
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
-----
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
A
------------------------------------------------------------------------------------
55
PsiBlast_CBE
67.79
44%
-100
- C1 -
3ETA
1
INSR_HUMAN
A:
[12-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------
96
PsiBlast_CBE
67.75
36%
-117
- C1 -
3GQL
1
C:
[24-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-----------------------------E----
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-
Q
E
Y
------------------------------------------------------------------------------
58
PsiBlast_CBE
67.69
44%
-100
- C1 -
4IBM
1
?
B:
[10-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
---
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------
46
PsiBlast_CBE
67.66
43%
-104
- C1 -
3QQU
1
IGF1R_HUMAN
C:
[4-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
-----------------VL-
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
--------------------------------------------------------------------
47
PsiBlast_CBE
67.63
43%
-108
- C1 -
3QQU
1
IGF1R_HUMAN
B:
[4-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---------------------------------------
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------
45
PsiBlast_CBE
67.61
43%
-109
- C1 -
3QQU
1
D:
[4-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
A
-
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
--
E
P
E
T
R
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
----
L
L
G
V
V
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
M
-----------------L--
A
-----
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
-
G
F
R
E
V
S
F
Y
Y
S
E
E
N
--------------------------------------------------------------------
101
PsiBlast_CBE
67.09
37%
-112
- C1 -
4RWK
1
B:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
-
T
S
N
------------------------------------------------------------------------------
103
PsiBlast_CBE
66.87
36%
-110
- C1 -
2IVS
5
RET_HUMAN
A:
[19-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
-
R
K
N
L
V
L
G
-
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
-
R
--
A
G
Y
T
T
V
A
V
K
M
L
--
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
----
L
Y
G
A
C
S
Q
D
G
P
L
-
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
VGPGYL------------------------------RA
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
--
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
-
I
P
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
---
D
L
E
K
M
M
V
K
-
R
--------------------------------------------------------------------------------
81
PsiBlast_CBE
66.77
39%
-107
- C1 -
4R7H
1
?
A:
[51-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
-
E
--
D
A
V
L
K
V
A
V
K
M
L
--
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
----
L
L
G
A
C
T
H
G
G
P
V
-
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
E
-------
A
M
------
L
--------
G
P
---
S
LG
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
-----
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
A
Q
-----------------------------------------------------------------------------------
82
PsiBlast_CBE
66.70
39%
-107
- C1 -
4HW7
1
A:
[51-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
-
E
--
D
A
V
L
K
V
A
V
K
M
L
--
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
----
L
L
G
A
C
T
H
G
G
P
V
-
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
E
-------
A
M
------
L
--------
G
P
---
S
G
R
---
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
-----
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
A
------------------------------------------------------------------------------------
98
PsiBlast_CBE
66.51
36%
-101
- C1 -
3GQL
1
FGFR1_HUMAN
A:
[24-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-----------------------------E----
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-
Q
E
Y
L
D
L
S
M
P
L
D
----------------------------------------------------------------------
54
PsiBlast_CBE
66.34
44%
-100
- C1 -
3ETA
1
B:
[12-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------
59
PsiBlast_CBE
65.44
44%
-100
- C1 -
4IBM
1
?
A:
[9-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-
E
V
S
-
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
--
E
A
E
T
R
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
----
L
L
G
V
V
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
A
ENNP--
G
--------
R
P
---
P
-----
P
---
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
--------------------------------------------------------------------
95
PsiBlast_CBE
65.09
37%
-127
- C1 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
--
E
F
G
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
-------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
LGV
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L---------------------------------------------------------------------------------
97
PsiBlast_CBE
64.91
36%
-104
* C1 *
3GQL
1
FGFR1_HUMAN
B:
[24-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-----------------------------PEE--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-
Q
E
-------------------------------------------------------------------------------
92
PsiBlast_CBE
64.91
37%
-122
- C1 -
3BPR
1
MERTK_HUMAN
B:
[25-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
-------P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L
P
D
-------------------------------------------------------------------------------
76
PsiBlast_CBE
64.83
42%
-106
- C1 -
3CBL
3
A:
[115-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
V
L
G
-
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
---
R
L
R
A
-
D
--
N
T
--
L
V
A
V
K
S
C
--
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
----
L
I
G
V
C
T
Q
K
Q
P
I
-
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-------------------
T
--------
E
G
---
A
-----
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
-
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
R
K
R
-
H
--------------------------------------------------------------------------------
102
PsiBlast_CBE
64.73
37%
-101
- C1 -
4RWK
1
FGFR1_HUMAN
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLE---
Y
S
------
Y
--------
N
P
---
S
HNP
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
-
T
S
N
Q
-----------------------------------------------------------------------------
94
PsiBlast_CBE
64.36
37%
-123
- C1 -
2P0C
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
-------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
LGV
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L---------------------------------------------------------------------------------
91
PsiBlast_CBE
63.64
37%
-120
- C1 -
3BPR
1
D:
[24-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
LLGV
C
I
E
M
S
S
-----P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L
P
D
-------------------------------------------------------------------------------
74
PsiBlast_CBE
63.61
38%
-113
- C1 -
3V5Q
1
NTRK3_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-
H
I
K
-
R
R
D
I
V
L
K
-
R
E
L
------
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
--
K
D
K
M
L
V
A
V
K
A
L
--
P
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
----
F
Y
G
V
C
G
D
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-----------------------------------
E
--
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
---
I
L
H
A
L
G
K
A
-
T
P
-------------------------------------------------------------------------------
93
PsiBlast_CBE
63.36
37%
-120
- C1 -
3BPR
1
MERTK_HUMAN
A:
[24-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
-----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L
P
D
-------------------------------------------------------------------------------
100
PsiBlast_CBE
63.05
36%
-104
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[54-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
-
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
KP
N
R
V
T
K
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
----
L
L
G
A
C
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLE---
Y
S
------
Y
--------
N
P
---
S
HNP
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
-
T
S
N
Q
E
----------------------------------------------------------------------------
87
PsiBlast_CBE
63.00
37%
-121
- C1 -
4M3Q
1
B:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
N
L
K
----------
S
L
K
V
A
V
K
T
M
--------------
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
LGV
C
I
--------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L---------------------------------------------------------------------------------
89
PsiBlast_CBE
62.63
37%
-123
- C1 -
3TCP
1
MERTK_HUMAN
A:
[26-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
LL
G
V
C
I
E
------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L
P
D
-------------------------------------------------------------------------------
73
PsiBlast_CBE
62.62
41%
-105
- C1 -
4CSV
1
?
A:
[5-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
---------
S
E
I
T
L
E
-
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-----
K
W
-
R
--
N
Y
N
I
E
V
A
V
K
T
L
--
K
E
G
T
M
S
V
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
----
L
Y
G
V
C
T
K
E
P
P
I
-
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
----------------------------------------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
N
V
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
-
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
---
A
L
E
T
M
F
L
-----------------------------------------------------------------------------------
90
PsiBlast_CBE
61.66
37%
-113
- C1 -
3BRB
2
B:
[24-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L
P
D
-------------------------------------------------------------------------------
77
PsiBlast_CBE
60.55
42%
-103
- C1 -
3BKB
7
A:
[115-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
V
L
G
-
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
---
R
L
R
A
-
D
--
N
T
--
L
V
A
V
K
S
C
--
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
----
L
I
G
V
C
T
Q
K
Q
P
I
-
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-------------------
T
--------
E
G
---
A
-----
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
-
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
R
K
R
-
H
--------------------------------------------------------------------------------
72
PsiBlast_CBE
60.43
41%
-104
- C1 -
4UEU
1
?
A:
[3-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
K
W
E
I
P
R
---------
S
E
I
T
L
E
-
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-----
K
W
-
R
--
N
Y
N
I
E
V
A
V
K
T
L
--
K
E
G
T
M
S
V
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
----
L
Y
G
V
C
T
K
E
P
P
I
-
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
-------
H
---------------------------
T
--
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
-
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
---
A
L
E
T
M
F
------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.07
37%
-113
- C1 -
3TCP
1
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
--------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
LL
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L---------------------------------------------------------------------------------
85
PsiBlast_CBE
58.85
37%
-114
- C1 -
4MHA
1
B:
[26-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
-
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
--
Q
E
-
D
--
G
T
S
L
K
V
A
V
K
T
M
--
K
--------------------
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
-------
E
T
------
G
---------
P
---
K
-----
H
--
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
-
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
L
E
S
L
P
--------------------------------------------------------------------------------
78
PsiBlast_CBE
48.84
38%
-74
- C1 -
4YMJ
4
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-
H
I
K
-
R
R
D
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
--
K
D
K
M
L
V
A
V
K
A
L
K
D
P
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
----
F
Y
G
V
C
G
D
G
-
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------------------------G----
E
--
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
---
I
L
H
A
L
G
K
A
-
T
P
I
Y
-----------------------------------------------------------------------------
79
PsiBlast_CBE
47.09
38%
-72
- C1 -
4YMJ
4
NTRK3_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-
H
I
K
-
R
R
D
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
--
K
D
K
M
L
V
A
V
K
A
L
K
D
P
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
----
F
Y
G
V
C
G
D
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------------------------G----
E
--
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
T
D
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
---
I
L
H
A
L
G
K
A
-
T
--------------------------------------------------------------------------------