@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K10_HUMAN: (2015-10-12 )
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
Atome Classification :
(83 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..120-........130.......140.......150.......160.......170.......180.---...----...190.....--.----...200.......210.......220.......230.......240.......250.......260--....----...270.......---280.......290......-.300.....--..-310.......320--........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEEEEG
A
V
A
K
EWGTTPAG
P
V
W
T
A
V
F
DYEAAGD
E
E
L
T
LRRG
D
R
V
Q
V
L
S
Q
DCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEI
P
F
H
E
L
Q
L
E
E
I
IGVG
G
F
G
K
V
Y
R
A
L
W-RGE
E
--
V
A
V
K
A
ARLDPEKDPAV
T
A
E
Q
V
C
Q
E
A
R
L
F
GALQHP
N
I
I
A
L
RGACLNPP
H
L
C
L
V
M
E
Y
ARG
G
A
L
S
---
R
V
L----AGRR--V
P
P
H
V
--
L
----
V
N
W
A
V
Q
V
A
RG
M
N
Y
LHNDAPV
P
I
I
H
R
D
L
K
S
I
N
I
L
I
L
E
AIENHN
L
A
D
T
V
L
K
I
T
D
F
G
L
A
R
E
W
H
KTTKMS--AAG
T
----
Y
AWMA
P
E
V
I
R
L
S
L---FSKSS
D
V
W
S
F
G
V
L
L
W
E
L
L
T-GEV
P
Y
R
E
I
D
--
A
L
-
A
V
A
Y
G
VAM
N
K
L
T---LPIPST
C
P
E
P
F
A
R
L
L
E
E
CWDPDPHGRP
D
F
G
S
I
L
K
R
L
E
V
I
E
Q
S
A
L
F
Q
M
P
L
E
S
F
H
S
L
Q
E
D
W
K
L
E
I
Q
H
M
F
D
D
L
R
T
K
E
K
E
L
R
S
R
E
E
E
L
L
R
A
A
Q
E
Q
R
F
Q
E
E
Q
L
R
R
R
E
Q
E
L
A
E
R
E
M
D
I
V
E
R
E
L
H
L
L
M
C
Q
LSQEK
P
R
V
R
K
RKGNF
K
R
S
R
L
L
K
LREGGSHISLPSGF
E
H
K
I
T
V
QASPTLDKRKGSDGASPPASP
S
I
I
P
R
L
R
A
I
R
L
T
P
VDCGGSSSGSSSGGSGTWSRGGPP
K
K
E
E
LVGGKKKGRTWGPSS
T
L
Q
K
E
RVG
G
E
E
R
L
K
GLGEGSKQWSSSAPNLGKSPKHTPIAP
G
F
A
S
L
N
E
M
E
E
F
AEAEDGGSSVPPSPYSTP
S
Y
L
SVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRC
D
L
A
L
L
G
C
A
T
L
L
G
A
VGLGA
D
V
A
E
ARAAD
G
E
E
Q
R
R
W
L
DGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPS
A
T
L
V
S
L
SSVS
D
C
N
S
T
R
S
L
L
RSDSDEAAPAAPSPPPSPPAPTPTPSPSTN
P
L
V
D
L
E
L
E
S
FKKDPRQSLT
P
T
H
V
T
A
A
C
A
VSRGHRRTPSDGALGQRGPPEPAGHGP
G
P
R
D
L
LDFPRLP
D
P
Q
ALFPARRRPPEFPGRP
T
T
L
T
FAPRPRPAASRPRLD
P
W
K
L
VSFG
R
T
L
T
ISPPSRPDTPESPGPPSVQ
P
T
L
L
DMDMEGQNQDSTVPLCGAHGSH
9
PsiBlast_PDB
86.49
38%
-118
- C1 -
3PPZ
1
CTR1_ARATH
A:
[32-298]
------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
-
H
G
S
D
--
V
A
V
K
I
--
L
M
E
----
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
---
R
L
L
H
KSG
A
R
E
Q
--
L
D
E
R
R
--
R
----
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
--------
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
T
F
L
S
S
KS
A
A
G
T
----
P
E
W
M
A
P
E
V
L
R
D
E
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
--
P
A
-
Q
V
V
A
A
V
G
F
K
C
K
R
---
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.06
38%
-124
- C1 -
3P86
1
CTR1_ARATH
A:
[32-298]
------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
-
H
G
S
D
--
V
A
V
K
I
--
L
M
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
---
R
L
L
H
KSG
A
R
E
Q
--
L
D
E
R
R
--
R
----
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
--------
T
V
K
V
C
D
F
-----------------
G
T
----
P
E
W
M
A
P
E
V
L
R
D
E
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
--
P
A
-
Q
V
V
A
A
V
G
F
K
C
K
R
---
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.64
36%
-122
- C1 -
4CSV
1
?
A:
[7-267]
-------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
-
R
N
Y
N
--
I
E
V
A
V
K
T
L
---
K
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
---
D
Y
L
R
D
C-------
V
N
A
Q
A
--
L
----
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
N
V
V
K
V
A
D
F
G
------------------FP--
I
K
W
T
A
P
E
A
I
S
Y
N
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
--
G
S
-
E
V
I
E
Q
V
E
-
R
G
Y
R
---
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
74.67
32%
-113
- C1 -
4HCU
1
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
74.55
32%
-111
- C1 -
4HCT
1
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.09
36%
-115
- C1 -
4UEU
1
?
A:
[7-267]
-------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
-
R
N
Y
N
--
I
E
V
A
V
K
T
L
---
K
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
---
D
Y
L
R
DC-
E
G
H
T
--
V
N
A
Q
A
--
L
----
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
------------
A
KFP-
I
K
W
T
A
P
E
A
I
S
Y
N
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
--
G
S
-
E
V
I
E
Q
V
E
-
R
G
Y
R
---
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.68
32%
-124
- C1 -
4L7S
1
ITK_HUMAN
A:
[8-266]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.68
35%
-110
- C1 -
3CBL
3
A:
[115-374]
------------------------------------------------------------------------------------------------
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D
N
T
L
V
A
V
K
S
C
R
---
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
---
T
F
L
R
T
--
E
G
A
R
--
L
R
V
K
T
--
L
----
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
---
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
--------
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
---
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
--
N
Q
-
Q
T
R
E
F
V
E
K
G
G
-
R
---
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
73.39
32%
-113
- C1 -
4HCV
1
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
73.18
32%
-122
- C1 -
4KIO
3
ITK_HUMAN
C:
[8-266]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.13
32%
-127
- C1 -
1SM2
1
B:
[6-261]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
T
G
-
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
72.81
34%
-112
- C1 -
4MNF
1
B:
[44-313]
-------------------------------------------------------------------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-
H
G
D
---
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
--
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
I
I
E
--
T
K
F
E
M
IK
L
----
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
--------
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-------------
S
----
I
L
W
M
A
P
E
V
I
R
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
--
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.75
32%
-126
- C1 -
3V8W
1
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
--------
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.59
32%
-122
- C1 -
3V5L
1
D:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-------
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
-----------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
72.50
32%
-124
- C1 -
4L7S
1
B:
[8-266]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
72.41
34%
-106
- C1 -
4MNF
1
BRAF_HUMAN
A:
[44-313]
-------------------------------------------------------------------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-
H
G
D
---
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
--
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
I
I
E
--
T
K
F
E
M
I
K
L
----
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
--------
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-------------
S
----
I
L
W
M
A
P
E
V
I
R
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
--
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.34
35%
-112
- C1 -
3CD3
3
A:
[115-374]
------------------------------------------------------------------------------------------------
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D
N
T
L
V
A
V
K
S
C
R
-------
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
---
T
F
L
R
T
--
E
G
A
R
--
L
R
V
K
T
--
L
----
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
---
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
--------
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
--
S
G
G
L
R
Q
VP
V
K
W
T
A
P
E
A
L
N
Y
G
R
---
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
--
N
Q
-
Q
T
R
E
F
V
E
K
G
G
-
R
---
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.28
35%
-109
- C1 -
3BKB
7
A:
[115-374]
------------------------------------------------------------------------------------------------
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D
N
T
L
V
A
V
K
S
C
R
---
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
---
T
F
L
R
T
--
E
G
A
R
--
L
R
V
K
T
--
L
----
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
---
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
--------
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
--
S
G
G
L
RQVP
V
K
W
T
A
P
E
A
L
N
Y
G
R
---
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
--
N
Q
-
Q
T
R
E
F
V
E
K
G
G
-
R
---
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
72.26
32%
-126
- C1 -
1SNU
1
B:
[6-261]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
T
G
-
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
72.07
32%
-109
- C1 -
3QRJ
1
ABL1_HUMAN
B:
[14-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
71.90
32%
-115
- C1 -
3T9T
3
A:
[9-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.72
32%
-122
- C1 -
4PP9
1
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
-----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
71.65
32%
-110
- C1 -
2G1T
1
ABL1_HUMAN
C:
[11-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.50
32%
-119
- C1 -
1SNU
1
ITK_HUMAN
A:
[6-263]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
T
G
-
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.50
32%
-116
- C1 -
3MJ2
1
A:
[8-261]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
---
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
71.41
32%
-113
- C1 -
2G1T
1
ABL1_HUMAN
A:
[11-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.38
32%
-125
- C1 -
3V8W
1
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
------
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.34
32%
-108
- C1 -
3PYY
1
ABL1_HUMAN
A:
[22-286]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
71.23
32%
-127
- C1 -
3V5J
1
B:
[8-266]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
---------
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
71.21
32%
-123
- C1 -
3V8T
1
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
--------
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
71.14
32%
-120
- C1 -
4PQN
2
A:
[8-261]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
---
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
71.06
32%
-113
- C1 -
4M13
1
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
71.06
32%
-111
- C1 -
4M14
2
A:
[11-266]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.05
32%
-111
- C1 -
4M0Z
2
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
70.98
32%
-121
- C1 -
1SM2
1
ITK_HUMAN
A:
[6-263]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
T
G
-
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.86
32%
-120
- C1 -
4PP9
1
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.69
32%
-114
- C1 -
2HYY
1
ABL1_HUMAN
C:
[9-271]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
-
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
---
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
70.69
32%
-122
- C1 -
3V5J
1
ITK_HUMAN
A:
[8-264]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
--
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
-
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.65
32%
-119
- C1 -
3PYY
3
ABL1_HUMAN
B:
[22-286]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
-----------------
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.63
32%
-122
- C1 -
4KIO
2
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
-----------
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.49
32%
-112
- C1 -
2G1T
1
ABL1_HUMAN
B:
[11-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
70.46
32%
-110
- C1 -
3OY3
1
ABL1_MOUSE
B:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
70.41
32%
-111
- C1 -
1OPL
1
ABL1_HUMAN
B:
[260-518]
------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
---
D
Y
L
R
E
C-
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
70.28
32%
-120
- C1 -
3V8T
1
ITK_HUMAN
A:
[8-264]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
-----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
---------
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
70.24
32%
-110
- C1 -
2HYY
1
ABL1_HUMAN
A:
[9-271]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
-
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
70.22
32%
-110
- C1 -
3KFA
1
ABL1_MOUSE
B:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
70.20
32%
-122
- C1 -
3V5L
1
ITK_HUMAN
A:
[8-262]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
---------
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
70.15
32%
-111
- C1 -
2HYY
1
ABL1_HUMAN
D:
[9-271]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
--
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.07
32%
-108
- C1 -
4M12
1
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
69.91
32%
-124
- C1 -
4RFM
1
A:
[8-264]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
---
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
69.85
32%
-111
- C1 -
3IK3
1
ABL1_MOUSE
B:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.84
32%
-113
- C1 -
4XEY
1
ABL1_HUMAN
B:
[126-385]
------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
------
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
---
D
Y
L
R
E
C-
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
69.82
32%
-124
- C1 -
4MF1
1
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
--------
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
---
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
-----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.73
32%
-110
- C1 -
4M15
2
A:
[11-266]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
69.51
32%
-122
- C1 -
4MF1
1
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
--------
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
---
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
69.48
32%
-111
- C1 -
3KFA
1
ABL1_MOUSE
A:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
69.43
32%
-112
- C1 -
2G1T
1
ABL1_HUMAN
D:
[11-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.30
32%
-122
- C1 -
3V5L
1
ITK_HUMAN
C:
[8-262]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
68.77
32%
-108
- C1 -
3OY3
1
ABL1_MOUSE
A:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
68.67
32%
-113
- C1 -
3KF4
1
ABL1_MOUSE
B:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
------
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
68.53
32%
-110
- C1 -
3UE4
1
ABL1_HUMAN
B:
[11-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
68.46
32%
-126
- C1 -
4KIO
2
ITK_HUMAN
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
68.36
32%
-112
- C1 -
4XEY
1
ABL1_HUMAN
A:
[126-385]
------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
---
D
Y
L
R
E
C-
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
68.17
32%
-109
- C1 -
2HZ4
1
ABL1_HUMAN
B:
[9-271]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
68.00
32%
-110
- C1 -
2QOH
1
ABL1_MOUSE
A:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
67.86
32%
-108
- C1 -
4M0Y
2
A:
[11-267]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.76
32%
-128
- C1 -
4PPC
2
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
---------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
67.47
32%
-114
- C1 -
4TWP
1
ABL1_HUMAN
B:
[4-268]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
67.08
32%
-117
- C1 -
3IK3
1
ABL1_MOUSE
A:
[9-273]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
------
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
66.84
32%
-110
- C1 -
2HIW
1
ABL1_HUMAN
A:
[11-274]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
66.81
32%
-122
- C1 -
3MJ1
1
A:
[8-261]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
----------------
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
---
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.77
38%
-109
- C1 -
4O91
1
M3K7_HUMAN
A:
[5-258]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
A
K
D
--
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
---
N
V
L
----
H
G
A
E
--
P
L
P
Y
Y
--
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
----------------
G
S
----
A
A
W
M
A
P
E
V
F
E
G
S
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
F
-
R
I
M
W
A
V
H
-
N
G
T
R
---
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.29
38%
-110
- C1 -
2YIY
1
M3K7_HUMAN
A:
[5-258]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
A
K
D
--
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
---
N
V
L
----
H
G
A
E
--
P
L
P
Y
Y
--
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
----------------
G
S
----
A
A
W
M
A
P
E
V
F
E
G
S
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
F
-
R
I
M
W
A
V
H
-
N
G
T
R
---
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
66.09
32%
-126
- C1 -
4MF0
2
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
---------
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
65.12
32%
-124
- C1 -
4PPA
2
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
65.03
32%
-104
- C1 -
3UE4
1
ABL1_HUMAN
A:
[11-275]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
65.00
32%
-119
- C1 -
4PPB
2
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.79
32%
-124
- C1 -
4QD6
2
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
-----------
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.59
32%
-120
- C1 -
4PPC
2
B:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
---------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
-------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.41
32%
-123
- C1 -
4MF0
2
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
---------
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
----------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
63.35
32%
-110
- C1 -
2HIW
1
ABL1_HUMAN
B:
[11-274]
-------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y
S
--
L
T
V
A
V
K
T
L
---
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
R
Q
E
--
V
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
---
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
---
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
62.89
32%
-127
- C1 -
4PPA
2
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
61.52
32%
-120
- C1 -
4PPB
2
ITK_HUMAN
A:
[8-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
--
V
A
I
K
T
I
------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
T
Q
R
GL
F
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
S
-
E
V
V
E
D
I
S
-
T
G
F
R
---
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------