@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K11_HUMAN: (2015-10-12 )
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP
Atome Classification :
(90 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.....--.-.--140........-.150......------.160.......170.......180......-.190.......200---...----.--...--210...--.----....220.......230.......240.......250.......260.......270--.-..-.....280-.-...----....290......---.300.......310.....-..320....-----...330.......340........350.......360.......370.......--380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
P
L
K
S
L
F
LKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANP
V
W
T
A
L
FDYEPSGQDELALRKGD
R
V
E
V
L
SRDAAISGDEGWWAGQVGGQVGIFPS
N
Y
V
SRGGGPPP
C
E
V
A
S
F
Q
E
L
R
L
E
E
V
IGIGGF
G
K
V
YRGSWR--
G
-
E
--
L
--
V
A
V
KAARQ-DPDE
D
I
S
V
T
A
------
E
S
V
R
Q
E
A
R
L
F
A
M
LAHP
N
I
I
A
L
K
A
V
CLEEP
N
-
L
C
L
V
M
EYAAGG
P
L
S
---
R
A
L----A--GRR--V-
P
P
H
V
--
L
----
V
N
W
A
V
Q
I
A
RG
M
H
Y
L
H
C
E
A
L
V
P
V
I
H
R
DLKSN
N
I
L
L
L
QPIESDDMEH
K
T
L
K
I
T
DFG
L
A
---
R
-
E
W
-
H
K
TTQMS--A-AG
T
----
Y
AWMA
P
E
V
I
K
AST---FSKGS
D
V
W
S
F
G
V
L
L
W
E
L
L
T-GEVPYRG
I
D
-----
C
L
A
V
A
Y
G
V
A
V
N
K
L
TL-PIPST
C
P
E
P
F
A
Q
L
M
A
D
C
WAQDPHRRP
D
F
A
S
I
L
Q
Q
L
E
A
L
--
E
A
Q
V
L
R
EMP
R
D
S
F
H
S
M
Q
E
G
W
K
R
E
I
Q
G
L
F
D
E
L
R
A
K
E
K
E
L
L
S
R
E
E
E
L
T
R
A
A
R
E
Q
R
S
Q
A
E
Q
L
R
R
R
E
H
L
L
A
Q
W
E
L
E
V
F
E
R
E
L
T
L
L
L
Q
Q
V
DRER
P
H
V
R
R
R
RGTFKRSKLRARDGGERISMPLDF
K
H
R
I
T
V
QASPGLDRRR
N
V
F
E
VGPGDSPTF
P
R
F
R
A
I
QLEPAEP
G
Q
A
WGRQSPRRLEDSSNGE
R
R
A
C
W
AWGPSSPKPGEAQNG
R
R
RSRMDE
A
T
W
Y
LDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSG
T
P
K
L
I
Q
R
A
L
L
R
G
T
A
L
L
A
S
LGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPS
P
L
I
C
F
SLKTPDSPPTPA
P
L
L
L
DLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPS
P
L
R
SRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGG
P
Q
D
C
R
A
Q
T
K
DMGAQAPWVPEAGP
14
PsiBlast_PDB
85.65
35%
-111
- C3 -
3CBL
3
A:
[110-372]
--------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
-
D
N
T
L
--
V
A
V
K
S
C
R
E
-
T
L
P
P
D
L
K
A
---------
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
---
T
F
L
R
T
--
E
--
G
A
R
--
L
-
R
V
K
T
--
L
----
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
---
C
I
H
R
D
L
A
A
R
N
C
L
V
--------
T
E
K
N
V
L
K
I
S
D
F
G
M
S
---
R
-
E
E
-
A
D
G
V
Y
A
A
--
S
-
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
---
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-----
N
Q
Q
T
R
E
F
V
E
K
G
G
-
R
L
-
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
--
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.31
35%
-111
- C3 -
3CD3
3
A:
[110-372]
--------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
-
D
N
T
L
--
V
A
V
K
S
C
R
-----
P
D
L
K
A
---------
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
---
T
F
L
R
T
--
E
--
G
A
R
--
L
-
R
V
K
T
--
L
----
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
---
C
I
H
R
D
L
A
A
R
N
C
L
V
--------
T
E
K
N
V
L
K
I
S
D
F
G
M
S
---
R
-
E
E
-
A
D
G
V
Y
A
A
--
S
-
G
G
L
R
Q
VP
V
K
W
T
A
P
E
A
L
N
Y
G
R
---
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-----
N
Q
Q
T
R
E
F
V
E
K
G
G
-
R
L
-
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
--
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.93
36%
-112
- C3 -
3PPZ
1
CTR1_ARATH
A:
[38-296]
-------------------------------------------------------------------------------------------------------------------
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--
G
-
S
--
D
--
V
A
V
K
I
L
M
E
------
A
E
R
V
N
------
E
F
L
R
E
V
A
-
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
---
R
L
L
H
KSG
A
--
R
E
Q
--
L
-
D
E
R
R
--
R
----
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
-
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
-------
D
K
K
Y
-
T
V
K
V
C
D
F
G
L
S
---
R
-
L
K
-
A
S
T
F
L
S
S
KS
A
-
A
G
T
----
P
E
W
M
A
P
E
V
L
R
D
E
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
-----
P
A
Q
V
V
A
A
V
G
F
K
C
K
R
L
-
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
--
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.84
35%
-110
- C3 -
3BKB
7
A:
[110-372]
--------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
-
D
N
T
L
--
V
A
V
K
S
C
R
E
-
T
L
P
P
D
L
K
A
---------
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
---
T
F
L
R
T
--
E
--
G
A
R
--
L
-
R
V
K
T
--
L
----
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
---
C
I
H
R
D
L
A
A
R
N
C
L
V
--------
T
E
K
N
V
L
K
I
S
D
F
G
M
S
---
R
-
E
E
-
A
D
G
V
Y
A
A
--
S
-
G
G
L
RQVP
V
K
W
T
A
P
E
A
L
N
Y
G
R
---
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-----
N
Q
Q
T
R
E
F
V
E
K
G
G
-
R
L
-
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
--
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
83.72
35%
-122
- C3 -
3PYY
3
ABL1_HUMAN
B:
[27-282]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
------------
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
-----------------------
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.56
37%
-121
- C3 -
4CSV
1
?
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
-
Y
--
N
I
E
V
A
V
K
T
L
K
E
-
G
-----
T
M
S
V
------
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
------------
V
-
N
A
Q
A
--
L
----
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
N
V
V
K
V
A
D
F
G
------------------------FP--
I
K
W
T
A
P
E
A
I
S
Y
N
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-----
G
S
E
V
I
E
Q
V
E
-
R
G
Y
R
M
-
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
--
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.25
33%
-110
- C3 -
1OPL
1
ABL1_HUMAN
B:
[260-518]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
N
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
83.05
34%
-109
- C3 -
3QRI
1
ABL1_HUMAN
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.86
35%
-108
- C3 -
1IEP
1
ABL1_MOUSE
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
82.74
35%
-118
- C3 -
3DK3
1
ABL1_MOUSE
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
----------
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
F
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-----
P
S
Q
V
-
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
82.71
35%
-112
- C3 -
3PYY
1
ABL1_HUMAN
A:
[27-282]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
----------
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
82.70
34%
-122
- C3 -
4RFM
1
A:
[8-263]
-------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
--
N
K
D
--
K
--
V
A
I
K
T
I
R
E
-
G
-----
A
M
S
E
------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
--
T
Q
R
GL
F
-
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
-
E
A
--
S
V
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---
R
------------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-----
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
--
A
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
82.28
35%
-106
- C3 -
2G1T
1
ABL1_HUMAN
C:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
82.27
35%
-108
- C3 -
3OY3
1
ABL1_MOUSE
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.27
35%
-109
- C3 -
1OPJ
2
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
82.00
35%
-110
- C3 -
4XEY
1
ABL1_HUMAN
B:
[126-381]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
----
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.90
33%
-104
- C3 -
1OPK
3
ABL1_MOUSE
A:
[221-489]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
N
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
81.87
35%
-110
- C3 -
1OPJ
2
ABL1_MOUSE
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.80
33%
-107
- C3 -
2FO0
3
ABL1_HUMAN
A:
[218-486]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
N
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
81.78
35%
-108
- C3 -
2G1T
1
ABL1_HUMAN
A:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.72
36%
-117
- C3 -
3P86
1
CTR1_ARATH
A:
[38-296]
-------------------------------------------------------------------------------------------------------------------
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--
G
-
S
--
D
--
V
A
V
K
I
L
M
E
-
Q
-
D
F
H
A
E
R
V
N
------
E
F
L
R
E
V
A
-
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
---
R
L
L
H
KSG
A
--
R
E
Q
--
L
-
D
E
R
R
--
R
----
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
-
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
-------
D
K
K
Y
-
T
V
K
V
C
D
F
-----------------------
G
T
----
P
E
W
M
A
P
E
V
L
R
D
E
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
-----
P
A
Q
V
V
A
A
V
G
F
K
C
K
R
L
-
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
--
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
81.70
35%
-105
- C3 -
3OMV
1
RAF1_HUMAN
A:
[37-299]
-------------------------------------------------------------------------------------------------------------------
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
I
L
K
V
V
D
P
T
P
E
---
Q
F
------
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
M
T
K
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
K
H
L
----
H
--
V
Q
E
--
T
-
K
F
Q
M
FQ
L
----
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
--------
T
V
K
I
G
D
F
G
L
A
---
T
V-------------P
T
G
S
----
V
L
W
M
A
P
E
V
I
R
M
Q
D
NNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
--
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
--
Q
H
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
81.70
34%
-110
- C3 -
2HYY
1
ABL1_HUMAN
C:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-------
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
---
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.63
33%
-104
- C3 -
1OPL
2
ABL1_HUMAN
A:
[260-528]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
N
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
81.61
35%
-110
- C3 -
3K5V
2
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
-
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
81.59
35%
-104
- C3 -
2G1T
1
ABL1_HUMAN
B:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
K
F
P-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
81.54
34%
-113
- C3 -
3MJ2
1
A:
[8-261]
-------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
--
N
K
D
--
K
--
V
A
I
K
T
I
R
E
-
G
-----
A
M
S
E
------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
--
T
Q
R
GL
F
-
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
-
E
A
--
S
V
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---
R
-
F
V
-
L
D
D
Q
Y
T
S
--
S
-
T
G
T
KFP-
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-----
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
81.54
34%
-110
- C3 -
3CS9
1
ABL1_HUMAN
D:
[18-273]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
81.54
35%
-113
- C3 -
4WA9
1
ABL1_HUMAN
B:
[15-270]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
81.50
35%
-111
- C3 -
4XEY
1
ABL1_HUMAN
A:
[126-381]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
81.41
35%
-122
- C3 -
1BYG
1
CSK_HUMAN
A:
[19-276]
----------------------------------------------------------------------------------------------------------------
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
--
G
-
N
--
K
--
V
A
V
K
C
I
K
N
-
D
------
A
--------
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
--G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
---
D
Y
L
----
R
S
R
G
R
S
--
V
L
G
G
D
C
--
L
----
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
---
H
R
D
L
A
A
R
N
V
L
V
--------
S
E
D
N
V
A
K
V
S
D
F
G
L
---------------------
L
P
----
V
K
W
T
A
P
E
A
L
R
E
K
K
---
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-----
L
K
D
V
V
P
R
V
E
-
K
G
Y
K
M
-
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
--
K
T
H
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
81.41
34%
-104
- C3 -
2HZ0
1
ABL1_HUMAN
A:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
81.36
35%
-107
- C3 -
3KFA
1
ABL1_MOUSE
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
81.32
35%
-107
- C3 -
2G1T
1
ABL1_HUMAN
D:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
81.24
34%
-107
- C3 -
3QRJ
1
ABL1_HUMAN
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
81.20
35%
-109
- C3 -
2G2H
1
ABL1_HUMAN
B:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
P
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
81.14
34%
-121
- C3 -
4MF1
1
ITK_HUMAN
A:
[8-263]
-------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
--
N
K
D
--
K
--
V
A
I
K
T
I
---------
A
M
S
E
------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
--
T
Q
R
GL
F
-
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
-
E
A
--
S
V
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
Q
V
I
K
V
S
D
F
G
M
-----------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-----
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
--
A
A
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
81.12
34%
-118
- C3 -
2HZ0
1
ABL1_HUMAN
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
----------
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
-----------------------P---
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
80.99
35%
-105
- C3 -
1IEP
1
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.96
35%
-105
- C3 -
3OY3
1
ABL1_MOUSE
A:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
80.91
34%
-111
- C3 -
3CS9
1
ABL1_HUMAN
A:
[18-273]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
----------
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
80.90
35%
-116
- C3 -
3DK3
1
ABL1_MOUSE
B:
[12-267]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
-----
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
F
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-----
P
S
Q
V
-
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.88
35%
-106
- C3 -
3KFA
1
ABL1_MOUSE
A:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
80.87
34%
-117
- C3 -
4PQN
2
A:
[8-261]
-------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
--
N
K
D
--
K
--
V
A
I
K
T
I
R
E
-
G
-----
A
M
S
E
------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
--
T
Q
R
GL
F
-
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
-
E
A
--
S
V
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-----
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
80.81
34%
-110
- C3 -
3QRK
1
ABL1_HUMAN
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
80.71
35%
-101
- C3 -
3UE4
1
ABL1_HUMAN
A:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.55
35%
-111
- C3 -
3MS9
2
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
------------
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
---
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
80.42
35%
-102
- C3 -
2G2H
1
ABL1_HUMAN
A:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
P
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
80.39
34%
-108
- C3 -
2HYY
1
ABL1_HUMAN
A:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
--
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
80.38
35%
-105
- C3 -
1M52
3
ABL1_MOUSE
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
80.36
35%
-106
- C3 -
2HIW
1
ABL1_HUMAN
A:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
80.23
35%
-111
- C3 -
1FPU
1
ABL1_MOUSE
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-------
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
80.22
34%
-122
- C3 -
3CS9
1
ABL1_HUMAN
B:
[18-273]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
---------
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
------------------------P---
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
80.21
35%
-107
- C3 -
1M52
1
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
80.17
34%
-111
- C3 -
2HYY
1
ABL1_HUMAN
D:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
--------
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
80.16
35%
-111
- C3 -
2QOH
1
ABL1_MOUSE
A:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
----
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.00
35%
-108
- C3 -
2V7A
1
ABL1_HUMAN
A:
[15-270]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
79.99
34%
-119
- C3 -
4MF1
1
B:
[8-263]
-------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
--
N
K
D
--
K
--
V
A
I
K
T
I
---------
A
M
S
E
------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
--
T
Q
R
GL
F
-
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
-
E
A
--
S
V
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---
R
------------------FP--
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-----
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
--
A
A
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
79.94
34%
-109
- C3 -
2HZI
1
ABL1_HUMAN
A:
[18-273]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
79.89
35%
-112
- C3 -
2QOH
1
ABL1_MOUSE
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
----
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.87
35%
-109
- C3 -
3IK3
1
ABL1_MOUSE
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
79.70
35%
-102
- C3 -
2G2I
1
ABL1_HUMAN
A:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
P
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
79.61
35%
-107
- C3 -
3UE4
1
ABL1_HUMAN
B:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
79.57
35%
-109
- C3 -
1FPU
1
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
79.39
35%
-108
- C3 -
3OMV
1
B:
[37-299]
-------------------------------------------------------------------------------------------------------------------
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
I
L
K
V
V
D
P
T
P
E
---
Q
F
------
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-
M
T
K
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
K
H
L
----
H
--
V
Q
E
--
T
-
K
F
Q
M
FQ
L
----
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
--------
T
V
K
I
G
D
F
G
L
A
---
T
V-------------P
T
G
S
----
V
L
W
M
A
P
E
V
I
R
M
Q
D
NNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
NRDQI
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
--
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
--
Q
H
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.39
35%
-109
- C3 -
3K5V
2
ABL1_MOUSE
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
----
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
79.31
35%
-100
- C3 -
2G2F
1
ABL1_HUMAN
A:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
P
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
79.28
35%
-110
- C3 -
2HIW
1
ABL1_HUMAN
B:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
SL
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
DYL
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.25
35%
-112
- C3 -
3MS9
2
ABL1_MOUSE
B:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
----
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
79.19
34%
-125
- C3 -
3MJ1
1
A:
[8-261]
-------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
--
N
K
D
--
K
--
V
A
I
K
T
I
-----------------------
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
---
D
Y
L
----
R
--
T
Q
R
GL
F
-
A
A
E
T
--
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
-
E
A
--
S
V
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
Q
V
I
K
V
S
D
F
-------------------------P---
V
K
W
A
S
P
E
V
F
S
F
S
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-----
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
79.17
34%
-116
* C3 *
2HZI
1
ABL1_HUMAN
B:
[18-273]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
----------
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
79.02
36%
-124
- C3 -
3OG7
1
BRAF_HUMAN
A:
[32-286]
--------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
M
---------
L
N
V
T
A
PT
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
--
A
S
------
F
E
M
K
K
L
----
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
--------
H
E
D
N
T
V
K
I
G
D
F
G
----------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---NP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
--
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
--
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
78.85
34%
-110
- C3 -
2HZ4
1
ABL1_HUMAN
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
78.85
34%
-110
- C3 -
4TWP
1
ABL1_HUMAN
B:
[9-264]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
78.79
34%
-105
- C3 -
2HYY
1
ABL1_HUMAN
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-------
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.63
37%
-112
- C3 -
4UEU
1
?
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
-
Y
--
N
I
E
V
A
V
K
T
L
K
E
-
G
-----
T
M
S
V
------
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
----
E
--
G
H
T
--
V
-
N
A
Q
A
--
L
----
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
N
V
V
K
V
A
D
F
G
L
A
---
R
-
L
I
--------------
A
KFP-
I
K
W
T
A
P
E
A
I
S
Y
N
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-----
G
S
E
V
I
E
Q
V
E
-
R
G
Y
R
M
-
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
--
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.58
35%
-116
- C3 -
3IK3
1
ABL1_MOUSE
A:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.57
35%
-104
- C3 -
2HZN
1
ABL1_MOUSE
A:
[19-274]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
---
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
78.40
35%
-110
- C3 -
4XLI
1
?
A:
[9-264]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
----------
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
----
S
--
R
E
E
--
V
-
T
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
V
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
T
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.38
34%
-111
- C3 -
4O91
1
M3K7_HUMAN
A:
[3-261]
-------------------------------------------------------------------------------------------------------------
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
R
--
A
-
K
--
D
--
V
A
I
K
Q
I
E
S
-
E
S
E
R
K
A
F
I
V
------------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
---
N
V
L
----
H
--
G
A
E
--
P
-
L
P
Y
Y
--
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
----------------------
G
S
----
A
A
W
M
A
P
E
V
F
E
G
S
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
-----
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
--
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
78.10
35%
-105
- C3 -
2G2F
1
ABL1_HUMAN
B:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
P
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
78.07
35%
-109
- C3 -
3KF4
1
ABL1_MOUSE
B:
[14-269]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
----
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
S
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
77.92
35%
-115
- C3 -
4WO5
1
B:
[40-294]
--------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
M
---------
L
N
V
T
A
PT
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
--
A
S
E
--
T
-
K
F
E
M
K
K
L
----
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
--------
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T-------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
M
Q
D
SNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
--
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
--
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
77.75
35%
-112
- C3 -
4XLI
1
?
B:
[9-264]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
V
G
V
W
K
KY
S
-
L
--
T
--
V
A
V
K
T
L
K
E
-
D
-----
T
M
E
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
DYL
R
E
C
----
S
--
R
E
E
--
V
-
T
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
V
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
T
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
77.70
35%
-118
- C3 -
4JVG
1
D:
[24-278]
--------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
M
---------
L
N
V
T
A
PTPQQL
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
--
A
S
E
--
T
-
K
F
E
M
KK
L
----
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
--------
H
E
D
N
T
V
K
I
G
D
F
G
L
A
TVK
S
-----------------
S
----
I
L
W
M
A
P
E
V
I
R
M
Q
D
SNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
NRDQI
I
E
M
V
G
R
G
S
L
S
P
D
L
S
--
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
--
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.21
34%
-112
- C3 -
2YIY
1
M3K7_HUMAN
A:
[3-261]
-------------------------------------------------------------------------------------------------------------
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
R
--
A
-
K
--
D
--
V
A
I
K
Q
I
E
S
-
E
S
E
R
K
A
F
I
V
------------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
---
N
V
L
----
H
--
G
A
E
--
P
-
L
P
Y
Y
--
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
----------------------
G
S
----
A
A
W
M
A
P
E
V
F
E
G
S
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
-----
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
--
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
77.14
35%
-121
- C3 -
4WO5
1
BRAF_HUMAN
A:
[40-294]
--------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
M
---------
L
N
V
T
A
PT
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
--
A
S
E
----
K
F
E
M
K
K
L
----
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
--------
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
-
R
W
S--
F
E
Q
L
S
-----
G
S
----
I
L
W
M
A
P
E
V
I
R
M
--NP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
NR
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
--
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
--
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
77.13
35%
-105
- C3 -
2G2I
1
ABL1_HUMAN
B:
[16-271]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
T
L
K
E
-
D
T
M
E
-----
V
------
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
P
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
75.63
36%
-120
- C3 -
4FK3
1
BRAF_HUMAN
A:
[32-286]
--------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
-
D
-----
V
A
V
K
M
---------
L
N
V
T
A
PT
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
---
H
H
L
----
H
--
A
S
E
--
T
-
K
F
E
M
K
K
L
----
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
--------
H
E
D
N
T
V
K
I
G
D
F
G
----------------
S
-----
G
S
----
I
L
W
M
A
P
E
V
I
R
M
--NP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
--
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
73.10
35%
-106
- C3 -
4WA9
1
ABL1_HUMAN
A:
[15-270]
-------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
--
K
-
Y
S
L
T
--
V
A
V
K
--------------------------------
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
--
R
Q
E
--
V
-
N
A
V
V
--
L
----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
---
I
H
R
D
L
A
A
R
N
C
L
V
--------
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---
R
-
L
M
-
T
G
D
T
Y
T
A
--
H
-
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
Y
N
K
---
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
------
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------