@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K12_HUMAN: (2015-10-12 )
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
Atome Classification :
(88 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140--..--..---------.-.---------.150...---------.-----------...160-------..----...------...--.170.......180-.-......190.......200.---.--..-.----------------..210----------------.......220.......230-........240.......250.......-260--.......270-...---......280.---..---....290.......300...-....310...-....320......---.330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MACLHETRTPSPSF
G
G
F
V
S
T
L
S
E
A
S
M
RKLDPDTSDCTPEKDL
T
P
T
H
V
L
Q
L
HEQDAGGPGGAAGS
P
E
S
R
A
S
RVR
A
D
E
V
R
L
Q
CQSGS
G
F
L
E
G
L
F
G
C
L
R
P
V
W
T
M
I
G
K
AYS
T
E
H
K
Q
Q
Q
E
D
L
W
EV
P
F
E
E
ILD
L
Q
WVGSGAQ
G
A
V
F
L
G
--RF--HG---------
E
-
E
---------
V
A
V
K
K
V
R
---------
D
-----------
L
K
E
T
---------
D
I
----
K
H
L
------
R
KL--KHP
N
I
I
T
FKGVCTQ-A-
P
C
Y
C
I
L
M
E
F
CAQ
G
Q
L
Y
E
V
L
R---A--GR-P----------------V
T
P
S
L
----------------
L
V
D
WSMGIAGG
M
N
Y
L
H
L
H
K
--
I
I
H
R
DLKSP
N
M
L
I
T
YD
D
V
V
K
ISDFGTSK-ELS--DKST
K
M
S
F---AG
T
---
V
A
W
M
A
P
E
V
IR---NE---PVSEKV
D
I
W
S
F
G
V
V
L
W
E
L
L
T-GEIPYKDVDS-
S
A
I
I
W
G
VGSN
S
L
H---LPVPSSCP
D
G
F
K
I
L
L
R
Q
C
WNSKPRN
R
P
S
F
R
Q
I
L
L
HLDIASADVLST
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
V
K
L
H
F
E
K
IKSE
G
T
C
L
H
R
L
E
E
E
L
V
M
R
R
R
E
E
L
R
H
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
AN
N
L
Y
M
E
L
N
A
L
M
L
Q
L
E
L
K
E
R
E
L
L
R
R
E
Q
A
L
E
R
RCPGLLKPHPSRGLLH
G
N
T
M
E
K
L
I
K
KRNVPQKLSPHSKRPDI
L
K
T
E
S
L
L
P
K
L
D
A
A
L
SGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGP
S
A
W
E
AC
P
P
A
L
R
G
L
H
H
D
L
L
L
R
K
MSSSS
P
D
L
L
S
A
A
LGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGV
G
L
L
GTGREGTSGRGGSRAGSQHL
T
P
A
A
L
L
Y
R
A
A
V
T
R
S
Q
KRGISSEEEEGEVDS
E
V
E
LTSSQRW
P
Q
S
L
N
M
R
Q
S
L
S
T
FSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERS
D
D
M
C
SQGSEIPLDP
P
P
S
EVIPGPEPSSLPI
P
H
Q
E
L
L
R
ERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
5
PsiBlast_PDB
77.48
38%
-109
- C2 -
4CQE
1
?
A:
[4-270]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
MQ--
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.00
38%
-113
- C2 -
4JVG
1
BRAF_HUMAN
B:
[9-276]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-------------------
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.15
38%
-116
- C2 -
3C4C
1
B:
[5-272]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
---------------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.53
38%
-111
- C2 -
4JVG
1
BRAF_HUMAN
C:
[9-276]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
--------------------
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.29
38%
-105
- C2 -
3C4C
1
BRAF_HUMAN
A:
[5-272]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.05
38%
-114
- C2 -
4CQE
1
?
B:
[3-270]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
----
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.89
38%
-106
- C2 -
4WO5
1
B:
[27-292]
---------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.75
36%
-112
- C2 -
3IDP
1
B:
[22-291]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.43
37%
-118
- C2 -
4KSP
1
BRAF_HUMAN
A:
[6-274]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
71.98
37%
-111
- C2 -
5CT7
1
?
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.80
32%
-93
- C2 -
5A46
2
?
B:
[25-329]
-----------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
--
E
A
--
I
G
LDKPN
R
V
--
T
-
K
---------
V
A
V
K
M
L
K
S--------
D
-----------
A
T
E
K
---------
D
L
----
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
-
P
L
Y
-
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
--
R
R
-
P
PHNPE
E
Q
---------
L
S
S
K
D
----------------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
HI
D
Y
Y
K
K
T
T
N
---
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
R
---
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-
L
F
K
L
L
K
E
G
H
R
---
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
N
Q
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.58
36%
-110
- C2 -
3II5
1
B:
[29-298]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.46
38%
-108
- C2 -
4JVG
1
BRAF_HUMAN
A:
[9-276]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
---------------
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
71.21
36%
-100
- C2 -
4EHE
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQ
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
71.08
36%
-104
- C2 -
3II5
1
BRAF_HUMAN
A:
[28-298]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------QL-
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
70.85
36%
-104
- C2 -
3PSD
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.82
36%
-110
- C2 -
4EHG
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQ
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
70.64
36%
-98
- C2 -
4MBJ
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQ
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.59
32%
-101
- C2 -
5AM7
1
FGFR1_HUMAN
A:
[6-309]
-----------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
--
E
A
--
I
G
LDKDKPN
R
V
T
-
K
---------
V
A
V
K
M
L
K
S--------
D
-----------
A
T
E
K
---------
D
L
----
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
--
R
R
-
P
PGP
E
E
Q
----------
L
S
S
K
D
----------------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
HI
D
Y
Y
K
K
T
T
N
---
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
R
---
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-
L
F
K
L
L
K
E
G
H
R
---
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
N
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.58
38%
-103
- C2 -
4WO5
1
BRAF_HUMAN
A:
[25-292]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
-
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
----
F
EQL
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M---
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
70.27
32%
-96
- C2 -
5A46
4
?
A:
[28-329]
--------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
--
E
A
--
I
G
LDKDKPN
R
V
T
-
K
---------
V
A
V
K
M
L
K
S--------
D
-----------
A
T
E
K
---------
D
L
----
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
-
P
L
Y
-
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
--
R
R
-
P
PGLE
E
Q
----------
L
S
S
K
D
----------------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
--I-
D
Y
Y
K
K
T
T
N
---
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
R
---
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-
L
F
K
L
L
K
E
G
H
R
---
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
N
Q
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.12
38%
-106
- C2 -
1UWH
1
BRAF_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
70.00
38%
-105
- C2 -
4JVG
1
D:
[9-276]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQL
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
E
T
K
----------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
---------------
S
---
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.99
38%
-116
- C2 -
3OG7
1
BRAF_HUMAN
A:
[18-284]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
--
S
-------------------
F
E
M
K
K
----------------
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
----
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
69.78
37%
-111
- C2 -
5CT7
1
?
B:
[7-274]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
----------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.63
38%
-103
- C2 -
1UWJ
1
BRAF_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
S
--------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
69.38
38%
-106
- C2 -
1UWH
1
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
PQQLQAFKN
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.37
36%
-110
- C2 -
5C9C
1
?
A:
[30-299]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
APT
P
Q
Q
L
--
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-------------------
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.88
36%
-99
- C2 -
4G9R
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
S
--------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
68.72
36%
-99
- C2 -
4G9R
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
---------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
68.69
36%
-102
- C2 -
3TV4
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
----------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.63
36%
-110
- C2 -
3SKC
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
68.62
36%
-103
- C2 -
4E4X
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
68.46
37%
-105
- C2 -
4H58
1
BRAF_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
68.45
32%
-101
- C2 -
5AM7
1
B:
[6-307]
-----------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
--
E
A
--
I
G
LDKDKPN
R
V
T
-
K
---------
V
A
V
K
M
L
K
S--------
D
-----------
A
T
E
K
---------
D
L
----
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
--
R
R
-
P
PGPE
E
Q
----------
L
S
S
K
D
----------------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------
D
Y
Y
K
K
T
T
N
---
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
R
---
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-
L
F
K
L
L
K
E
G
H
R
---
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.36
36%
-102
- C2 -
3PPK
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.10
36%
-103
- C2 -
4EHG
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQ
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.06
36%
-100
- C2 -
3SKC
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.04
36%
-99
- C2 -
3PSD
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
68.01
32%
-92
- C2 -
4RWK
1
FGFR1_HUMAN
A:
[13-316]
-----------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
--
E
A
--
I
G
LDKDKPN
R
V
T
-
K
---------
V
A
V
K
M
L
K
S--------
D
-----------
A
T
E
K
---------
D
L
----
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
--
R
R
-
P
PGLEYSYNPSHNP
E
E
Q
L
S
S
K
D
----------------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
HI
D
Y
Y
K
K
T
T
N
---
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
R
---
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-
L
F
K
L
L
K
E
G
H
R
---
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
N
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
68.01
36%
-98
- C2 -
3PPJ
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.01
36%
-100
- C2 -
4MBJ
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQ
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
-----L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.99
36%
-98
- C2 -
3PSB
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.97
36%
-99
- C2 -
3PPJ
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
67.92
36%
-104
- C2 -
3PPK
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.77
36%
-99
- C2 -
3TV6
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
67.71
32%
-99
- C2 -
4RWK
1
B:
[13-315]
-----------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
--
E
A
--
I
G
LDKDKPN
R
V
T
-
K
---------
V
A
V
K
M
L
K
S--------
D
-----------
A
T
E
K
---------
D
L
----
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
--
R
R
--Q---------------
L
S
S
K
D
----------------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----I-
D
Y
Y
K
K
T
-----
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
R
---
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-
L
F
K
L
L
K
E
G
H
R
---
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.57
36%
-101
- C2 -
3D4Q
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.47
38%
-103
- C2 -
1UWJ
1
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
---------
V
-----------
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
---------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.44
36%
-101
- C2 -
4MNF
1
BRAF_HUMAN
A:
[42-311]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
-----------------
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
67.40
36%
-99
- C2 -
3TV6
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
--------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
67.40
35%
-123
- C2 -
3P86
1
CTR1_ARATH
A:
[33-290]
----------------------------------------------------------------------------------------------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
--
E
W
--
H
G
---------
S
-
D
---------
V
A
V
K
I
L
M
---------
E
QDFH
A
E
R
V
N
E
F
L
R
E
V
---------
A
I
------
M
------
K
R
L
--
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
-
P
-
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSG
A
--
R
E
-
Q
----------------
L
D
E
R
R
----------------
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
----------------------
G
T
---
P
E
W
M
A
P
E
V
L
R
---
D
E
---
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
-
A
Q
V
V
A
A
V
G
F
K
C
K
R
---
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
67.33
36%
-99
- C2 -
3PRF
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.25
36%
-101
- C2 -
3PRI
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQ
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
67.15
33%
-93
- C2 -
4QRC
1
A:
[29-314]
--------------------------------------------------------------------------------------------------------------------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
--
E
A
--
F
G
---------
M
-
D
PARPD
Q
A
S
T
V
A
V
K
M
L
K
---------
D
NAS
D
K
D
L
A
D
L
-
V
S
E
M
---------
E
V
----
M
K
L
------
I
G
---
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
---
A
--
R
R
-
P
----------------
P
G
P
D
L
SPDGPRSSEGPLS
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
V
H
HI
D
Y
Y
K
K
T
S
N
---
G
R
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
E
---
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-
L
F
S
L
L
R
E
G
H
R
---
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.03
36%
-105
- C2 -
4E26
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
------
F
EQL
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
66.97
36%
-105
- C2 -
4E4X
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
-----L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
66.95
36%
-102
- C2 -
3D4Q
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQL
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
66.84
36%
-100
- C2 -
3Q4C
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
66.54
36%
-101
- C2 -
4PP7
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
66.53
36%
-100
- C2 -
4G9C
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.52
36%
-96
- C2 -
4E26
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
-------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
66.49
36%
-100
- C2 -
3TV4
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.33
36%
-96
- C2 -
4G9C
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
-----------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
66.31
36%
-106
- C2 -
4MNF
1
B:
[42-311]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQL
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
-----------------
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
65.93
36%
-101
- C2 -
3PRI
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQL
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.77
36%
-120
- C2 -
4CSV
1
?
A:
[5-265]
--------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
--
K
W
RN
Y
N
---------
I
-
E
---------
V
A
V
K
T
L
K
---------
E
GTMS
V
E
E
F
---
L
Q
E
A
---------
Q
I
------
M
------
K
K
L
--
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C------------------------
V
N
A
Q
A
----------------
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
----------------------
F
P--
I
K
W
T
A
P
E
A
I
S
---
Y
N
---
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
-
E
R
G
Y
R
---
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
65.72
36%
-98
- C2 -
3PSB
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.62
36%
-105
- C2 -
3IDP
1
BRAF_HUMAN
A:
[22-291]
--------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
N--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
64.95
36%
-100
- C2 -
4EHE
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
----------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
64.73
36%
-98
- C2 -
4PP7
1
BRAF_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K
---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
--
R
W
S
-----L--
S
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
64.65
33%
-107
- C2 -
4QQC
1
A:
[29-314]
--------------------------------------------------------------------------------------------------------------------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
--
E
A
--
F
G
---------
M
-
D
Q
A
S
T
-----
V
A
V
K
M
L
K
---------
D
NAS
D
K
D
L
A
D
L
-
V
S
E
M
---------
E
V
----
M
K
L
------
I
G
---
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
---
A
--
R
R
-
P
----------------
P
G
P
--LS
F
P
V
-----------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
---------------------
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
E
---
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-
L
F
S
L
L
R
E
G
H
R
---
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.15
36%
-99
- C2 -
3PRF
1
B:
[29-299]
-------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
M
L
N
VTAPTPQQL
Q
-----------
A
F
K
N
---------
E
V
----
G
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
---
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
--
I
E
-
T
----------------
K
F
E
M
I
K---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
64.03
34%
-104
- C2 -
4R6V
1
A:
[29-314]
--------------------------------------------------------------------------------------------------------------------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
--
E
A
--
F
G
---------
M
-
D
Q
A
S
T
-----
V
A
V
K
M
L
K
---------
D
NAS
D
K
D
L
A
D
L
-
V
S
E
M
---------
E
V
----
M
K
L
------
I
G
---
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
-
P
L
Y
V
I
L
-
E
C
A
A
K
G
N
L
R
E
F
L
R
---
A
--
R
R
-
P
----------------
P
G
P
--LS
F
P
V
-----------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
---------------------P--
V
K
W
M
A
P
E
A
L
F
---
D
E
---
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-
L
F
S
L
L
R
E
G
H
R
---
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
63.71
34%
-104
- C2 -
4QQ5
1
A:
[29-314]
--------------------------------------------------------------------------------------------------------------------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
--
E
A
--
F
G
---------
M
-
D
Q
A
S
T
-----
V
A
V
K
M
L
K
---------
D
NAS
D
K
D
L
A
D
L
-
V
S
E
M
---------
E
V
----
M
K
L
------
I
G
---
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
-
P
L
Y
V
I
L
-
E
C
A
A
K
G
N
L
R
E
F
L
R
---
A
--
R
R
-
P
----------------
P
G
P
--LS
F
P
V
-----------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
--------------------
L
P--
V
K
W
M
A
P
E
A
L
F
---
D
E
---
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-
L
F
S
L
L
R
E
G
H
R
---
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.86
35%
-102
- C2 -
3PPZ
1
CTR1_ARATH
A:
[33-290]
----------------------------------------------------------------------------------------------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
--
E
W
--
H
G
---------
S
-
D
---------
V
A
V
K
I
L
M
---------
E
AE
R
V
N
E
F
----
L
R
E
V
---------
A
I
------
M
------
K
R
L
--
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
-
P
-
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSG
A
--
R
E
-
Q
----------------
L
D
E
R
R
----------------
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
PP
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
--
T
F
L
S
S
K
S
A
---
A
G
T
---
P
E
W
M
A
P
E
V
L
R
---
D
E
---
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
-
A
Q
V
V
A
A
V
G
F
K
C
K
R
---
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.47
36%
-109
- C2 -
4UEU
1
?
A:
[4-265]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
--
K
W
RN
Y
N
---------
I
-
E
---------
V
A
V
K
T
L
K
---------
E
GTMS
V
E
E
F
---
L
Q
E
A
---------
Q
I
------
M
------
K
K
L
--
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
DC-
E
--
G
H
-
T
----------------
V
N
A
Q
A
----------------
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
-
L
I
--------------
A
K
F
P--
I
K
W
T
A
P
E
A
I
S
---
Y
N
---
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
-
E
R
G
Y
R
---
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
61.43
35%
-101
* C2 *
3OMV
1
RAF1_HUMAN
A:
[31-292]
---------------------------------------------------------------------------------------------------------------------
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
I
L
K
---------
V
-----------
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
----
A
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
-
D
-
N
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
---
V
--
Q
E
-
T
----------------
K
F
Q
M
F
Q---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------P--
T
G
S
---
V
L
W
M
A
P
E
V
I
R
MQD
N
N
---
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
PDL
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
61.08
35%
-111
- C2 -
3SXS
1
A:
[4-256]
----------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
--
K
W
--
K
G
---------
Q
Y
D
---------
V
A
V
K
M
I
K
---------
E
GS---------
M
S
E
D
---------
E
F
F
Q
E
A
Q
T
M
------
M
K
L
--
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
-
E
Y
P
I
Y
-
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
---
S
H-
G
K
-
G
----------------
L
E
P
S
Q
----------------
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
-
Y
V
L
--
D
D
Q
Y
-
V
S
S
---
V
G
T
KFP
V
K
W
S
A
P
E
V
F
H
---
Y
F
---
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
-
S
E
V
V
L
K
V
-
S
Q
G
H
R
---
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
60.49
35%
-113
- C2 -
3SXR
1
BMX_HUMAN
A:
[4-256]
----------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
----
V
V
K
L
G
--
K
W
--
K
G
---------
Q
Y
D
---------
V
A
V
K
M
I
K
---------
E
GS---------
M
S
E
D
---------
E
F
F
Q
E
A
Q
T
M
------
M
K
L
--
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
-
E
Y
P
I
Y
-
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
---
S
H-
G
K
-
G
----------------
L
E
P
S
Q
----------------
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
-
Y
V
L
--
D
D
Q
Y
-
V
S
S
---
V
G
T
KFP
V
K
W
S
A
P
E
V
F
H
---
Y
F
---
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
-
S
E
V
V
L
K
V
-
S
Q
G
H
R
---
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
60.04
35%
-105
- C2 -
3OMV
1
B:
[31-292]
---------------------------------------------------------------------------------------------------------------------
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
--
K
W
--
H
G
---------
D
-----------
V
A
V
K
I
L
K
---------
V
-----------
V
D
P
T
PEQFQAFRN
E
V
----
A
V
L
------
R
K
T
--
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
-
D
-
N
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
---
V
--
Q
E
-
T
----------------
K
F
Q
M
F
Q---------------
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
-
V
------------P--
T
G
S
---
V
L
W
M
A
P
E
V
I
R
MQD
N
N
---
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
PDL
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
57.12
35%
-118
- C2 -
3SXR
1
B:
[4-256]
----------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
------
V
V
K
L
G
--
K
W
--
K
G
---------
Q
Y
D
---------
V
A
V
K
M
I
K
---------
E
GS---------
M
S
E
D
---------
E
F
F
Q
E
A
Q
T
M
------
M
K
L
--
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
-
E
Y
P
I
Y
-
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
---
S
H-
G
K
-
G
----------------
L
E
P
S
Q
----------------
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
-
Y
V
L
--
D
D
Q
Y
-
V
S
S
---
V
G
T
KFP
V
K
W
S
A
P
E
V
F
H
---
Y
F
---
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
-
S
E
V
V
L
K
V
-
S
Q
G
H
R
---
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
54.02
33%
-115
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[6-262]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
--
Y
S
---------
L
-
T
---------
V
A
V
K
T
L
-----------ME
V
E
E
F
-----
L
K
E
A
---------
A
V
------
M
------
K
E
I
--
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
CN
R
Q
-
E
----------------
V
N
A
V
V
----------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
----------------------P--
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
53.35
33%
-96
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[6-262]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---------
L
-
T
---------
V
A
V
K
T
L
K
---------
E
DTME
V
E
E
F
---
L
K
E
A
---------
A
V
------
M
------
K
E
I
--
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
CN
R
Q
-
E
----------------
V
N
A
V
V
----------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
--
T
G
D
T
Y
T
A
H
---
A
G
A
KFP
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
51.13
33%
-98
- C2 -
3OY3
1
ABL1_MOUSE
A:
[6-262]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---------
L
-
T
---------
V
A
V
K
T
L
K
---------
E
DTME
V
E
E
F
---
L
K
E
A
---------
A
V
------
M
------
K
E
I
--
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
CN
R
Q
-
E
----------------
V
S
A
V
V
----------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
--
T
G
D
T
Y
T
A
H
---
A
G
A
KFP
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
50.67
33%
-102
- C2 -
3OY3
1
ABL1_MOUSE
B:
[6-262]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
VW
K
K
--
Y
S
---------
L
-
T
---------
V
A
V
K
T
L
K
---------
E
DTMEVEEF---
L
K
E
A
---------
A
V
------
M
------
K
E
I
--
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
CN
R
Q
-
E
----------------
V
S
A
V
V
----------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
--
T
G
D
T
Y
T
A
H
---
A
G
A
KFP
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
50.41
33%
-101
- C2 -
4TWP
1
ABL1_HUMAN
B:
[1-257]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---------
L
-
T
---------
V
A
V
K
T
L
K
---------
E
DTME
V
E
E
F
---
L
K
E
A
---------
A
V
------
M
------
K
E
I
--
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
CN
R
Q
-
E
----------------
V
N
A
V
V
----------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
--
T
G
D
T
Y
T
A
H
---
A
G
A
KFP
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
46.09
33%
-102
- C2 -
2HZ4
1
ABL1_HUMAN
B:
[6-262]
-------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
K
--
Y
S
---------
L
-
T
---------
V
A
V
K
T
L
K
---------
E
DTMEV
E
E
F
---
L
K
E
A
---------
A
V
------
M
------
K
E
I
--
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
CN
R
Q
-
E
----------------
V
N
A
V
V
----------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
--
T
G
D
T
Y
T
A
H
---
A
G
A
KFP
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
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