@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K13_HUMAN: (2015-10-12 )
MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKHYSSATW
Atome Classification :
(89 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......--.190.--.......---------.200-----.---..------.------...--------..210.......220..-.....230.......240....---.-..-250.........260.......270..--.....280.......290.......300-.......310.---...----...320....---..---.330.......340......-.350......-.360.......370--........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
N
F
Q
E
H
LSCSSSPHLPFSESKTFNG
L
Q
D
E
L
T
AMGNHPS
P
K
L
L
E
D
Q
Q
EKG
M
V
R
T
E
L
I
E
S
VHSP
V
T
T
T
V
L
TSVSED
S
R
D
Q
F
E
N
S
V
L
Q
L
REHDESETAVSQGNSNTVDGESTSGT
E
D
I
K
I
Q
F
SRSGSGSG
G
F
L
E
G
L
F
G
C
L
R
P
V
W
N
I
I
G
K
AYSTD
Y
K
LQQQDTWEV
P
F
E
E
I
S
E
L
Q
W
LGSGAQG
A
V
F
L
GKF
R
--
A
E
--
E
--
V
A
I
K
K
V
R---------EQ-------N---
E
T
------
D
------
I
K
H
--------
L
R
KLKHP
N
I
I
A
F
KGVCT-QA
P
C
Y
C
I
I
M
E
Y
CAH
G
Q
L
Y
E
V
L
R---A-GR-K--IT
P
R
L
L
V
DWST
G
I
A
SG
M
N
Y
L
H
L
H
K
--
I
I
H
R
DLKSP
N
V
L
V
T
HT
D
A
V
K
ISDFGTSK-ELSDKST
K
M
S
F---AG
T
----
V
A
W
M
A
P
E
V
IR---NE---PVSEKV
D
I
W
S
F
G
V
V
L
W
E
L
L
T-GEIPYKDVDS-
S
A
I
I
W
G
VGSN
S
L
H---LPVPSTC
P
D
G
F
K
I
L
M
K
Q
T
W
QSKPRN
R
P
S
F
R
Q
T
L
M
H
LDIASADVLAT
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
V
K
K
H
F
E
K
I
KSEGT
C
I
H
R
L
D
E
E
L
I
R
R
R
R
E
E
L
R
H
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
AN
N
L
Y
M
E
L
S
A
I
M
L
Q
L
E
M
R
E
K
E
L
I
K
R
E
Q
A
V
E
K
KYPGTYKRHPVRPIIH
P
N
A
M
E
K
L
M
K
RKGVPHKSGMQTKRP
D
L
L
RSEGIPTTEVAPTASPLSGSPKMSTSSS
K
S
RYRSKPRHRRGNSRGS
H
S
D
F
A
A
I
L
KNQPAQENSPH
P
T
Y
L
H
Q
A
Q
SQYPSLHH
H
N
S
L
Q
Q
Q
YQQPPPAMSQSHHPRLNMHG
Q
D
I
A
T
C
A
NN
L
R
YFG
P
A
A
A
L
R
S
P
L
S
N
H
A
Q
RQLPGSS
P
D
L
I
S
T
A
M
A
A
D
CWRSSEPDKGQAGPWGCCQADAYD
P
C
LQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHN
P
L
L
ENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQ
R
P
H
R
C
I
S
S
C
Q
SYSTFSSENFSVSDGEEGNTSDHSN
S
P
D
E
L
A
D
K
L
E
D
R
L
A
E
K
L
D
D
L
L
SQTPEI
P
I
D
ISSHSDGL
S
D
K
E
C
A
V
R
R
V
K
T
Q
M
S
L
G
K
L
C
V
E
ERGYENPMQFEESDCDSSDGECSD
A
T
V
R
TNKHYSSATW
6
PsiBlast_PDB
82.99
37%
-90
- C2 -
4CQE
1
?
A:
[4-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
MQ--
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.50
37%
-91
- C2 -
5C9C
1
?
A:
[30-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
APT
P
Q
Q
L
--
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-----------------
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.70
37%
-93
- C2 -
3IDP
1
B:
[22-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
78.45
37%
-92
- C2 -
4EHG
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQ
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
77.91
36%
-80
- C2 -
3TV6
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
--------
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
77.86
36%
-87
- C2 -
3PSD
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.84
37%
-93
- C2 -
4JVG
1
BRAF_HUMAN
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-----------------
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
77.81
36%
-95
- C2 -
4KSP
1
BRAF_HUMAN
A:
[6-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
77.50
37%
-95
- C2 -
3C4C
1
B:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-------------------
S
G
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.38
36%
-87
- C2 -
3PPK
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
77.37
36%
-90
- C2 -
3SKC
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
77.05
36%
-80
- C2 -
3TV6
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.01
37%
-94
- C2 -
4CQE
1
?
B:
[3-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
----
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.99
36%
-83
- C2 -
3PPJ
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
76.88
36%
-86
- C2 -
4E26
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
------
F
EQL
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
76.81
36%
-79
- C2 -
4MBJ
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQ
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
76.76
36%
-91
- C2 -
3II5
1
B:
[29-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-----------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.56
37%
-92
- C2 -
4JVG
1
BRAF_HUMAN
C:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
------------------
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.51
37%
-94
- C2 -
3OG7
1
BRAF_HUMAN
A:
[18-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
-----
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
----
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
76.40
36%
-80
- C2 -
4EHE
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQ
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
76.40
36%
-81
- C2 -
3PSB
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
76.38
36%
-81
- C2 -
3SKC
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.33
37%
-83
- C2 -
4WO5
1
BRAF_HUMAN
A:
[25-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
-
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
----
F
EQL
S
G
S
----
I
L
W
M
A
P
E
V
I
R
M---
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
76.01
36%
-83
- C2 -
3II5
1
BRAF_HUMAN
A:
[28-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------QL-
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.97
37%
-86
- C2 -
4EHG
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQ
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
75.55
36%
-81
- C2 -
3PRF
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.52
37%
-85
- C2 -
3C4C
1
BRAF_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
S
G
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.39
36%
-81
- C2 -
4MBJ
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQ
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
-----L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.34
36%
-84
- C2 -
3PSD
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.29
36%
-83
- C2 -
3D4Q
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.11
37%
-85
- C2 -
4WO5
1
B:
[27-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
----------------
G
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.00
37%
-80
- C2 -
1UWJ
1
BRAF_HUMAN
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
S
------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
74.99
36%
-83
- C2 -
3D4Q
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQL
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.97
36%
-83
- C2 -
4G9C
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.86
38%
-96
- C2 -
4CSV
1
?
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
Y
N
I
E
--
V
A
V
K
T
L
K
---------
E
G
-------
T
---
M
S
V
E
E
F
L
Q
E
------
A
Q
I
--------
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C---------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
---------------------FP--
I
K
W
T
A
P
E
A
I
S
---
Y
N
---
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
-
E
R
G
Y
R
---
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.83
36%
-81
- C2 -
3PRF
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQL
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
--------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.73
37%
-80
- C2 -
4G9R
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
S
------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.50
37%
-86
- C2 -
3IDP
1
BRAF_HUMAN
A:
[22-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
----------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
N--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
74.45
36%
-81
- C2 -
3PPJ
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
74.45
36%
-84
- C2 -
4E4X
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
74.32
37%
-86
- C2 -
1UWH
1
BRAF_HUMAN
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
74.31
36%
-83
- C2 -
3PRI
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQ
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
74.21
36%
-84
- C2 -
3PPK
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
74.18
36%
-90
- C2 -
5CT7
1
?
A:
[7-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-----------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.14
36%
-81
- C2 -
4MNF
1
BRAF_HUMAN
A:
[42-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
---------------
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.10
37%
-86
- C2 -
1UWH
1
B:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQL
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.04
38%
-89
- C2 -
4UEU
1
?
A:
[4-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
Y
N
I
E
--
V
A
V
K
T
L
K
---------
E
G
-------
T
---
M
S
V
E
E
F
L
Q
E
------
A
Q
I
--------
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
DC-
E
-
G
H
-
T
--
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
--
L
I
-------------
A
KFP-
I
K
W
T
A
P
E
A
I
S
---
Y
N
---
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
-
E
R
G
Y
R
---
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
73.99
36%
-79
- C2 -
4G9C
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
---------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
73.94
36%
-84
- C2 -
3PRI
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQL
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.78
36%
-81
- C2 -
4E26
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
-----------
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.76
35%
-86
- C2 -
3PPZ
1
CTR1_ARATH
A:
[30-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--
G
S
--
D
--
V
A
V
K
I
L
M
---------
E
-AE
R
V
---
N
---
E
F
L
R
----
E
------
V
A
I
--------
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
-
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSG
A
-
R
E
-
Q
--
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
PP
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
T
F
L
S
S
K
S
A
---
A
G
T
----
P
E
W
M
A
P
E
V
L
R
---
D
E
---
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
-
A
Q
V
V
A
A
V
G
F
K
C
K
R
---
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
-
A
T
I
M
D
L
L
R
P
L
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.70
36%
-81
- C2 -
3TV4
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
73.68
36%
-83
- C2 -
4PP7
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.58
36%
-83
- C2 -
3TV4
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
----------
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
73.55
37%
-81
- C2 -
1UWJ
1
B:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
-------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.47
36%
-86
- C2 -
4MNF
1
B:
[42-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQL
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
---------------
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
73.24
36%
-90
- C2 -
5CT7
1
?
B:
[7-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
--------------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
73.23
37%
-80
- C2 -
4G9R
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
E
K
-------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
73.06
36%
-83
- C2 -
4EHE
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
----------
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.89
36%
-86
- C2 -
4E4X
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
-----L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
72.65
36%
-80
- C2 -
3Q4C
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.48
36%
-78
- C2 -
4PP7
1
BRAF_HUMAN
A:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTP
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
R
W
S
-----L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.34
36%
-81
- C2 -
3PSB
1
B:
[29-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
----------L--
S
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.20
36%
-85
* C2 *
4H58
1
BRAF_HUMAN
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
I
-
I
E
T
K
--
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
------------
G
S
----
I
L
W
M
A
P
E
V
I
R
---
M
Q
DKN
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
PDL
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
-----
A
S
I
E
L
L
A
R
S
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.91
37%
-86
- C2 -
4JVG
1
D:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPTPQQL
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
-------------
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.38
37%
-86
- C2 -
4JVG
1
BRAF_HUMAN
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
D
-----
V
A
V
K
M
L
N
VTAPT
P
Q
Q
L
Q
A
-------
F
---
K
N
------
E
------
V
G
V
--------
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
---
A
-
S
E
T
K
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-
V
K
S
-------------
S
----
I
L
W
M
A
P
E
V
I
R
MQD
S
N
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
PDL
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
71.15
36%
-81
- C2 -
3CBL
3
A:
[106-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
D
--
N
T
L
V
A
V
K
S
C
R
---------
E
T
-------
L
---
P
P
------
D
------
L
K
A
K
FL
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---
T
E
G
A
-
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
----
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
---
Y
G
---
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
-
Q
Q
T
R
E
F
V
E
K
G
G
-
R
---
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.24
35%
-105
- C2 -
3P86
1
CTR1_ARATH
A:
[32-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--
G
S
--
D
--
V
A
V
K
I
L
M
---------
E
Q
DFH
A
E
R
V
N
---
E
F
L
R
----
E
------
V
A
I
--------
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
-
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSG
A
-
R
E
-
Q
--
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
--------------------
G
T
----
P
E
W
M
A
P
E
V
L
R
---
D
E
---
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
-
A
Q
V
V
A
A
V
G
F
K
C
K
R
---
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
-
A
T
I
M
D
L
L
R
P
L
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
69.65
35%
-87
- C2 -
3SXS
1
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
--
G
Q
Y
-
D
--
V
A
V
K
M
I
K
---------
E
G
-------
S
---
M
S
------
E
D
E
F
F
Q
E
A
Q
T
--------
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
-
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
---
S
H
G
K
-
G
--
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
-
Y
V
L
D
D
Q
Y
-
V
S
S
---
V
G
T
KFP-
V
K
W
S
A
P
E
V
F
H
---
Y
F
---
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
-
S
E
V
V
L
K
V
-
S
Q
G
H
R
---
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
69.14
35%
-90
- C2 -
3SXR
1
BMX_HUMAN
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
K
--
G
Q
Y
-
D
--
V
A
V
K
M
I
K
---------
E
G
-------
S
---
M
S
------
E
D
E
F
F
Q
E
A
Q
T
--------
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
-
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
---
S
H
G
K
-
G
--
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
-
Y
V
L
D
D
Q
Y
-
V
S
S
---
V
G
T
KFP-
V
K
W
S
A
P
E
V
F
H
---
Y
F
---
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
-
S
E
V
V
L
K
V
-
S
Q
G
H
R
---
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
68.83
35%
-94
- C2 -
3SXR
1
B:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
E
L
------
V
V
K
L
G
K
W
K
--
G
Q
Y
-
D
--
V
A
V
K
M
I
K
---------
E
G
-------
S
---
M
S
------
E
D
E
F
F
Q
E
A
Q
T
--------
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
-
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
---
S
H
G
K
-
G
--
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
-
Y
V
L
D
D
Q
Y
-
V
S
S
---
V
G
T
KFP-
V
K
W
S
A
P
E
V
F
H
---
Y
F
---
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
-
S
E
V
V
L
K
V
-
S
Q
G
H
R
---
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
67.21
36%
-84
- C2 -
3BKB
7
A:
[106-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
--
A
D
--
N
T
L
V
A
V
K
S
C
R
---------
E
T
-------
L
---
P
P
------
D
------
L
K
A
K
FL
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---
T
E
G
A
-
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
----
G
G
L
RQVP
V
K
W
T
A
P
E
A
L
N
---
Y
G
---
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
-
Q
Q
T
R
E
F
V
E
K
G
G
-
R
---
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
61.25
34%
-81
- C2 -
4XLI
1
?
A:
[1-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
---------V--
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C-
S
-
R
E
-
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
59.27
34%
-89
- C2 -
3IK3
1
ABL1_MOUSE
A:
[6-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.33
34%
-82
- C2 -
3GVU
2
ABL2_HUMAN
A:
[21-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
EE
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-----
G
D
T
Y
T
-------
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.22
34%
-79
- C2 -
3HMI
1
ABL2_HUMAN
A:
[25-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
EE
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
58.20
34%
-80
- C2 -
2XYN
4
ABL2_HUMAN
B:
[26-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
-----------
D
-------
T
MEV
E
E
------
F
------
L
K
E
AAV-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
EE
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
58.19
34%
-83
- C2 -
3OY3
1
ABL1_MOUSE
B:
[6-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
MEV
E
E
------
F
------
L
K
E
AAV-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
57.06
34%
-86
- C2 -
3IK3
1
ABL1_MOUSE
B:
[6-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
56.21
34%
-80
- C2 -
3OY3
1
ABL1_MOUSE
A:
[6-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
55.97
34%
-76
- C2 -
2XYN
2
ABL2_HUMAN
A:
[26-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
-----------
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
EE
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
55.78
34%
-76
- C2 -
2XYN
4
ABL2_HUMAN
C:
[27-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
------------------
T
MEV
E
E
------
F
------
L
K
E
AAV-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
EE
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
53.88
34%
-83
- C2 -
3K5V
2
ABL1_MOUSE
B:
[11-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
-------------------ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
53.32
34%
-86
- C2 -
3K5V
2
ABL1_MOUSE
A:
[11-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
--------ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
52.65
34%
-86
- C2 -
3MS9
2
ABL1_MOUSE
B:
[11-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
-------------------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
52.44
34%
-87
- C2 -
3MS9
2
ABL1_MOUSE
A:
[11-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
--------------------V--
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
--
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
52.35
34%
-81
- C2 -
4XLI
1
?
B:
[1-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
V
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
MEV
E
E
------
F
------
L
K
E
AAV-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
EC-
S
-
R
E
-
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
D
L
L
E
K
G
Y
R
---
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
49.68
34%
-76
- C2 -
4XEY
1
ABL1_HUMAN
A:
[118-373]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
K
---------
E
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
46.35
34%
-84
- C2 -
2HZN
1
ABL1_MOUSE
A:
[11-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
KY
S
L
--
T
--
V
A
V
K
T
L
-----------
D
-------
T
ME
V
E
E
------
F
------
L
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
N
-
R
QE
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
A
H
---
A
G
A
KFP-
I
K
W
T
A
P
E
S
L
A
---
Y
N
---
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
---
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------