@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K14_HUMAN: (2015-10-12 )
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...-----....390.......400.......410.......420.......430...---...------.---440......-----.450.......460.......470.......480.......490.......500.......-510.......520.......530.......540.......550.......560.......570.......580.......590....---...600..--..-----...610.......620......-.630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQS
S
V
Y
K
L
E
AVEKSPVFC
G
K
W
E
I
L
N
D
V
I
TKGTAKEGSEAGP
A
A
I
S
I
I
A
Q
AECENSQEFSPTFS
E
R
I
F
I
AGSKQYSQSE
S
L
D
QI
P
N
N
VAHATEG
K
M
A
R
V
C
WKGK
R
R
S
K
A
R
K
K
R
K
KKSS
K
S
L
A
HAG
V
A
LAKPLPRTPEQES
C
T
I
PVQEDESPLGAPYVRNTPQFTKPLKEPG
L
G
Q
L
C
F
K
Q
L
G
E
GLRPAL
P
R
S
E
L
H
K
L
I
S
P
L
Q
C
L
N
H
V
W
K
LHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPH
P
L
E
S
F
L
G
K
L
ACVDSQKPLPDP
H
L
S
K
L
ACVDSPKPLPGPHL
E
P
S
C
L
SRGAHEKF
S
V
E
E
Y
L
V
H
A
L
QGSVSSGQ
A
H
S
L
T
S
L
A
K
T
W
A
ARGSRSREPSPKTEDNE
G
V
L
L
T
EK-----LKPV
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
RLGRGSFGEVHRM
E
D
KQ
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
A
------
E
---
E
L
M
A
CAGLT-----SP
R
I
V
P
L
YGAVREG
P
W
V
N
I
F
M
E
L
LEGG
S
L
G
Q
L
V
K
EQGCLPE
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
SR-RILHGDVKAD
N
V
L
LSSDGS
H
A
A
L
CDFG
H
A
V
C
LQPDGLGKSLLTGDYIPGTETHMA
P
E
V
VLGRSCDA
K
V
D
V
W
S
S
C
C
M
M
L
H
M
LNGC
H
P
W
---
T
Q
FFRG
P
L
--
C
L
-----
K
IASEPPPVREIPPSCAP
L
T
A
Q
-
A
I
Q
E
G
L
R
KEPI
H
R
V
S
A
A
E
LG
G
K
V
N
R
A
L
Q
Q
VGGLKSPWRGEYKEPRHPPPNQAN
Y
H
Q
T
LHAQPRELSPRAPGPR
P
A
E
ETTGRAPKLQPPLPPEPPEPNKSPP
L
T
LSKEESGMWEPLPLSSLEPAPARNPSSPERKATV
P
E
Q
E
L
Q
Q
L
E
I
E
L
F
L
N
SLSQPFS
L
E
E
Q
E
Q
I
L
S
C
LSIDSLSLSDDSEKNPSKASQSS
R
D
T
L
S
S
G
V
H
S
W
S
S
Q
A
EARSSSW
N
M
V
L
ARGRPTDTPSYFN
G
V
K
V
Q
I
Q
SLNGE
H
L
H
I
R
E
F
H
R
V
KV
G
D
I
ATGISSQI
P
A
A
A
F
S
LVTKDGQ
P
V
R
Y
D
M
EVPDSGI
D
L
Q
C
T
LAPDG
S
F
A
W
S
W
R
VKHGQLENRP
104
Fugue
92.72
100%
-90
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
A
------
E
---
E
L
M
A
C
A
G
L
T
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
-------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
F
F
R
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.48
99%
-90
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
A
------
E
---
E
L
M
A
C
A
G
L
T
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
-------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
F
F
R
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
90.84
99%
-90
- C1 -
4DN5
3
M3K14_HUMAN
B:
[9-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
A
------
E
---
E
L
M
A
C
A
G
L
T
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
-------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
F
F
R
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
87.80
87%
-88
- C1 -
4G3E
1
M3K14_MOUSE
B:
[8-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
A
S
L
A
K
T
W
S
--------------
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
V
------
E
---
E
L
V
A
C
A
G
L
S
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
Q
P
D
G
L
G
K
S
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
---
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
L
K
S
P
W
K
G
E
Y
K
E
P
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.43
87%
-87
- C1 -
4G3F
1
A:
[3-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
V
S
S
G
Q
A
H
S
L
A
S
L
A
K
T
W
S
---------
G
P
E
T
E
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
V
------
E
---
E
L
V
A
C
A
G
L
S
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
Y
F
R
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
L
K
S
P
W
K
G
E
Y
K
E
P
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.80
87%
-88
- C1 -
4G3E
1
M3K14_MOUSE
A:
[8-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
A
S
L
A
K
T
W
S
--------------
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
V
------
E
---
E
L
V
A
C
A
G
L
S
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
Q
-------------
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
Y
F
-
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
L
K
S
P
W
K
G
E
Y
K
E
P
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.00
86%
-85
- C1 -
4G3G
1
M3K14_MOUSE
A:
[16-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
V
S
S
G
Q
A
H
S
L
A
S
L
A
K
T
W
S
---------
G
P
E
T
E
D
N
E
G
V
L
L
T
E
K
-----
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
M
T
H
Q
P
R
L
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
---
F
R
V
------
E
---
E
L
V
A
C
A
G
L
S
-----
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
Y
F
R
G
P
L
--
C
L
-----
K
I
A
S
E
P
P
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
L
K
S
P
W
K
G
E
Y
K
E
P
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
49.49
31%
-90
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[12-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
T
Q
K
Q
K
VGE
L
K
D
D
D
F
E
K
I
S
E
---------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
KP
A
I
R
N
------
Q
I
I
R
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
------
F
V
------
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G---
A
I
F
E
--
L
--
L
D
-----
Y
I
V
N
E
P
P
P
--
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
49.09
31%
-91
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[14-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
---
K
P
A
I
R
N
Q
I
I
R
---
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
M
A
N
S
F
V
------
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP------
P
M
--
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
--
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
45.89
31%
-88
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[17-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
---
K
P
A
I
R
N
Q
I
I
R
---
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
-
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
------
M
A
N
E
-
V
-
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
---
P
P
M
A
I
F
E
L
--
L
D
-----
Y
I
V
N
E
P
P
P
--
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
45.00
31%
-86
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[17-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
---
K
P
A
I
R
N
Q
I
I
R
---
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
-
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
------
M
A
N
E
---
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
---
P
P
M
A
I
F
E
L
--
L
D
-----
Y
I
V
N
E
P
P
P
--
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
43.50
33%
-86
- C1 -
4O27
1
STK24_HUMAN
B:
[13-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
E
F
V
-----
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
--
L
F
-----
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
K
-
E
-
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
42.81
31%
-87
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[17-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
---
K
P
A
I
R
N
Q
I
I
R
---
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
-
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
------
M
A
N
E
F
V
-
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
---
P
P
M
A
I
F
E
L
--
L
D
-----
Y
I
V
N
E
P
P
P
--
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
42.68
31%
-93
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[14-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
---
K
P
A
I
R
N
Q
I
I
R
---
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
M
A
N
S
F
V
------
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P---------
M
--
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
--
K
L
P
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
42.64
31%
-76
- C1 -
3GGF
1
STK26_HUMAN
A:
[30-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
-
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
-----
G
T
P
F
W
M
A
P
E
V
I
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
--
L
F
-----
L
I
P
K
N
N
P
P
T
--
L
V
G
D
F
T
K
S
F
K
E
-
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
42.60
31%
-78
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[28-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
P
K
------
K
---
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
-
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
-
V
K
L
T
D
F
G
F
--------
S
K
R
S
T
M
V
-----
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
--
E
N
P
L
R
A
L
Y
-----
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
-
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
41.89
31%
-77
- C1 -
3GGF
1
STK26_HUMAN
B:
[30-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
-
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
-----
G
T
P
F
W
M
A
P
E
V
I
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
--
L
F
-----
L
I
P
K
N
N
P
P
T
--
L
V
G
D
F
T
K
S
F
K
E
-
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
41.07
31%
-86
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[17-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
---
K
P
A
I
R
N
Q
I
I
R
---
E
L
Q
V
L
H
E
C
N
-----
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
-
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
------
M
A
N
E
F
V
-
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
---
P
P
M
A
I
F
E
L
--
L
D
-----
Y
I
V
N
E
P
P
P
--
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
38.05
32%
-81
- C1 -
4NZW
1
STK25_HUMAN
B:
[27-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
EIED
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
-
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
-
V
K
L
A
A
F
G
V
A
G
-------------------
T
P
F
W
M
A
P
E
V
I
K
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
H
P
M
R
V
--
L
F
-----
L
I
P
K
N
S
P
P
T
L
E
G
Q
H
S
-
K
P
F
-
K
E
-
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
27.78
33%
-58
- C1 -
4QML
2
STK24_HUMAN
A:
[36-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
-----
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
--
L
F
-----
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
-
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
25.05
33%
-59
- C1 -
4QMN
1
STK24_HUMAN
A:
[36-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
-----
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
--
L
F
-----
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
-
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
24.18
33%
-59
- C1 -
4QMM
3
STK24_HUMAN
A:
[36-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
-----
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
-----
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
--
L
F
-----
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
-
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------