@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K15_HUMAN: (2015-10-12 )
MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
Atome Classification :
(80 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.-.-.....690.-----......700.......710....------...720.......730..-.....-------740-----......--...750.......760.......770.......780..--.....790.......800---.........810.......820---......-..830.......840.......-------------850--....-...860--..--..----....870---.---.---------.-----------.-...880..---...-..890.......900.....-..910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGG
G
P
R
R
A
L
R
A
V
Y
V
RSESSQGGAAGG
P
E
A
G
A
R
Q
C
L
L
R
A
CEAEG
A
H
LTSVPFGELDFG
E
T
A
V
L
D
AFYDA
D
V
A
V
V
D
M
S
DVSRQP
S
L
F
Y
H
LGVRESFDMAN
N
V
I
L
Y
HDTDAD
T
A
L
S
L
K
D
M
V
TQKNTASSG
N
Y
Y
F
I
P
Y
IVTPCADYFCCE
S
D
A
Q
R
R
A
S
E
YMQP
N
W
D
N
I
L
G
P
L
C
M
P
L
V
D
R
F
I
S
L
L
K
DIHV
T
S
C
V
Y
Y
K
E
T
L
L
N
D
I
R
K
A
R
E
KYQ
G
E
E
L
A
K
E
L
A
R
I
K
L
RMDN
T
E
V
L
T
S
D
I
I
I
N
L
L
L
S
YRDI
Q
D
Y
D
A
M
V
K
L
V
E
T
L
E
MLPTCDLADQH
N
I
K
F
H
Y
A
F
A
LNRRNSTG
D
R
E
K
A
L
Q
I
M
L
Q
V
L
Q
SCDHPGP
D
M
F
C
L
C
G
R
I
Y
K
D
I
FLDSDCKDDTSR
D
S
A
I
E
W
Y
R
K
G
F
E
L
Q
S
S
L
YSGI
N
L
A
V
L
L
I
VAGQ
Q
F
E
T
S
L
E
L
R
K
I
G
V
R
L
N
S
L
LGRKG
S
L
E
K
M
N
N
YW
D
V
G
Q
F
F
S
V
S
M
L
A
H
D
V
G
K
A
V
Q
A
A
E
R
L
FKLKP
P
V
W
Y
L
R
S
L
V
Q
N
L
L
L
I
R
R
F
K
K
T
I
I
EHS
P
R
Q
E
R
L
N
F
W
L
D
I
I
F
E
A
T
N
E
VTNGLRF
P
V
L
V
IEPTKVYQ
P
S
Y
V
S
INNEAE
E
R
T
V
S
L
W
HV
S
P
T
E
M
K
Q
M
H
EWNFTASSIKGISLSKFDE
R
C
C
F
L
Y
V
HDNSD
D
F
Q
I
Y
FS
T
E
E
Q
C
S
R
F
F
S
L
V
K
E
M
I
TNTAG
S
T
V
E
L
EGETDG
D
T
L
E
Y
EYDHDANG
E
R
V
V
LGKG
T
Y
G
I
V
Y
AGRDLS
N
Q
V
R
I
A
I
K
EI-P-ERDSRYSQ
P
-----
L
H
E
E
I
A
L
H
K
Y
L
K
H
R
N
I
V
Q
Y
L
G
SV------SEN
G
Y
I
K
I
F
M
EQVPG
G
S
L
-
S
A
L
L
R
-------S-------KWGPMK--E
P
T
I
K
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
ENQ
I
V
H
R
DIKG
D
N
V
L
V
N
TY--S
G
V
V
K
I
SDFGTSKRLA-----GVNP
C
T
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
-I---DQGPRG-YGAP
A
D
I
W
S
L
G
C
T
I
I
EMATSKP-------------
P
F
H
--ELGE-P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
IHPE---I---
P
---------
E
-----------
A
-
L
S
A
E
A
R
A
F
---
I
L
S
-CFEPDPHKRA
T
T
A
E
L
L
R
E
G
F
-
L
R
Q
VNKGKKN
R
I
A
FKPSEGP
R
G
V
V
L
A
LPTQGEPMATSSSEHGSVSPDSDAQ
P
D
A
L
F
E
RTRA
P
R
H
H
L
G
H
L
LSVPDESSALEDRGLASSPEDRDQ
G
L
F
L
L
RKDSE
R
R
A
I
L
Y
K
I
L
WE
E
Q
N
Q
V
A
S
N
L
Q
E
C
V
A
QSSE
E
L
H
L
S
V
G
H
I
K
Q
I
I
G
I
L
R
D
F
IRSPE
H
R
V
M
A
T
T
I
S
K
L
K
V
D
L
DFDSSS
I
S
Q
I
H
L
V
L
FG
F
Q
D
A
V
N
K
I
L
R
NHLIR
P
H
W
M
F
A
M
D
N
I
I
R
R
A
V
Q
A
A
V
T
I
L
I
P
E
L
R
A
HFEPTCETEGVDK
D
M
D
E
A
EEGYPPATGPGQEAQ
P
H
Q
Q
H
L
S
L
Q
L
G
E
L
R
Q
E
T
N
R
L
L
E
H
L
V
E
K
E
R
E
Y
Q
N
L
L
R
Q
T
L
E
Q
K
T
Q
E
L
Y
H
L
Q
L
K
L
KSNCITENPAGPYGQR
T
D
K
E
L
I
D
W
L
R
LQGA
D
A
K
T
I
E
K
I
V
EEGY
T
L
S
D
I
L
N
E
I
T
K
E
D
L
R
Y
L
R
L
R
G
G
L
L
C
R
L
W
S
A
V
S
Q
Y
R
R
A
Q
E
ASETKDKA
26
PsiBlast_CBE
88.89
82%
-62
- C1 -
4BIC
2
B:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------------
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.60
82%
-64
- C1 -
4BIB
1
B:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.29
82%
-61
- C1 -
4BIC
2
M3K5_HUMAN
A:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
-----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.11
82%
-59
- C1 -
4BIE
2
M3K5_HUMAN
A:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
-------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.14
83%
-61
- C1 -
2CLQ
1
B:
[14-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.05
82%
-60
- C1 -
4BID
1
B:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.93
82%
-64
- C1 -
4BIE
2
B:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.93
82%
-61
- C1 -
4BIB
3
M3K5_HUMAN
A:
[11-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
-------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.85
82%
-62
- C1 -
4BID
1
M3K5_HUMAN
A:
[11-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
-------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.73
83%
-57
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[14-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
D
S
---
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.46
82%
-64
- C1 -
4BF2
1
B:
[28-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
--------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------------
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.83
82%
-60
- C1 -
4BHN
2
B:
[27-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.39
82%
-60
- C1 -
4BF2
2
M3K5_HUMAN
A:
[28-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-
P
-
E
---------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
-------------
P
F
Y
--
E
L
G
E
-
P
Q
A
A
M
---
F
K
--
V
G
----
M
F
K
V
H
P
E
---
I
---
P
---------
E
-----------
S
-
M
S
A
E
A
K
A
F
---
I
L
K
-
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.12
33%
-59
- C1 -
4B6L
1
PLK3_HUMAN
A:
[16-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
-
P
-
Q
--
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
------
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
-
A
H
I
W
K
-------
A
-------
R
H
T
-
L
L
--
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
-
T
E
--
N
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
-
L
---
L
R
--
Q
G
-
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
-------------
P
F
E
TA
D
L
K
E
-
T
Y
R
C
I
---
K
Q
--
V
---------
H
Y
T
---
L
---
P
---------
A
-----------
S
-
L
S
L
P
A
R
Q
L
---
L
A
A
-
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
-
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.81
33%
-59
- C1 -
4I6B
1
PLK2_HUMAN
A:
[35-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
------
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
-
A
H
I
L
K
-------
A
-------
R
-
K
V
L
T
--
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
--
Q
G
-
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
-------------
P
F
E
TT
N
L
K
E
-
T
Y
R
S
I
---
R
E
--
A
R
----
Y
-----
T
---
M
---
P
---------
S
-----------
S
-
L
L
A
P
A
K
H
L
---
I
A
S
-
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
-
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.47
33%
-56
- C1 -
4I5P
1
PLK2_HUMAN
A:
[35-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
------
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
-
A
H
I
L
K
-------
A
-------
R
-
K
V
L
T
--
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
--
Q
G
-
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
-------------
P
F
E
TT
N
L
K
E
-
T
Y
R
S
I
---
R
E
--
A
R
----
Y
-----
T
---
M
---
P
---------
S
-----------
S
-
L
L
A
P
A
K
H
L
---
I
A
S
-
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
-
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
58.62
34%
-58
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[29-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
Q
-
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
58.01
34%
-52
- C1 -
4OBO
2
M4K4_HUMAN
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
-----
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
----------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
58.01
34%
-46
- C1 -
4U43
1
M4K4_HUMAN
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
E
D
E
E
E
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPP
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.84
33%
-57
- C1 -
4I5M
1
PLK2_HUMAN
A:
[35-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
------
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
-
A
H
I
L
K
-------
A
-------
R
-
K
V
L
T
--
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
----------------
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
--
Q
G
-
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
-------------
P
F
E
TT
N
L
K
E
-
T
Y
R
S
I
---
R
E
--
A
R
----
Y
-----
T
---
M
---
P
---------
S
-----------
S
-
L
L
A
P
A
K
H
L
---
I
A
S
-
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
-
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
57.25
34%
-47
- C1 -
4RVT
2
M4K4_HUMAN
A:
[33-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
----
E
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
57.21
34%
-57
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[29-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
Q
-
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.09
35%
-56
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
56.95
35%
-58
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-----
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
56.32
34%
-55
- C1 -
4O0R
1
PAK1_HUMAN
A:
[28-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
56.08
34%
-43
- C1 -
4OBP
2
M4K4_HUMAN
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
E
D
E
E
E
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
IKKS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
S
A
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
55.98
34%
-50
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
---------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPP
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
55.97
34%
-43
- C1 -
4U44
2
M4K4_HUMAN
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
E
D
E
E
E
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S---
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
55.77
34%
-45
- C1 -
4ZK5
2
?
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
E
D
E
E
E
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
S
A
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
55.72
35%
-57
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
-----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.72
35%
-58
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
-----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
55.65
32%
-49
- C1 -
5AJQ
2
STK10_HUMAN
A:
[24-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
----
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
MCE
T
M
K
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
55.34
34%
-52
- C1 -
4O0T
1
PAK1_HUMAN
A:
[28-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
54.95
34%
-40
- C1 -
4U45
1
M4K4_HUMAN
A:
[31-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
-
V
T
E
D
E
E
E
E
I
-----
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
K
N
------
T
-------
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
--
N
A
E
V
K
L
V
D
F
G
V
S
A
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
-
I
AC-
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
-------------
P
L
C
--
D
M
-
H
-
P
M
R
A
L
---
F
L
--
I
P
----
R
N
P
P
P
R
L
---
K
---
S
---------
K
-----------
K
-
W
S
K
K
F
F
S
F
---
I
E
G
-
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
54.89
34%
-56
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[29-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
53.56
34%
-59
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[29-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
-------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
53.37
34%
-55
- C1 -
4ZY5
1
PAK1_HUMAN
A:
[29-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
---
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
53.34
33%
-53
- C1 -
4USF
1
?
B:
[24-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
-
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
------
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
-------
E
-------
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
--------------
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
MCE
T
S
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
E
P
P
---
T
LAQ
P
---------
S
-----------
R
-
W
S
S
N
F
K
D
F
---
L
K
K
-
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.19
34%
-55
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[29-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
52.19
33%
-57
- C1 -
4USF
1
?
A:
[24-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
-
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
------
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
-------
E
-------
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
------------------
T
P
Y
W
M
A
P
E
V
-
V
M
C
E----
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
E
P
P
---
T
LAQ
P
---------
S
-----------
R
-
W
S
S
N
F
K
D
F
---
L
K
K
-
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.49
32%
-43
- C1 -
4Y85
1
M3K8_HUMAN
C:
[81-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
-
P
-
V
D
Q
F
K
P
S
----------
D
V
E
I
Q
A
C
F
R
H
E
N
I
A
E
L
Y
G
A
V
------
L
W
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
E
-------
S
--------
C
G
P
M
R
--
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
--
K
A
V
--
L
V
D
F
G
L
S
V
Q
M
T
-----
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
-
I
---
L
C
--
R
G
-
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
-------------
P
W
V
--
K
-
R
Y
-
P
R
S
A
----
Y
P
--
S
Y
----
L
Y
I
I
H
K
Q
---
A
---
P
PLEDIA---
D
-----------
D
-
C
S
P
G
M
R
E
L
---
I
E
A
-
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
-
L
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
51.32
35%
-41
- C1 -
4FZA
3
STK26_HUMAN
B:
[16-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
------
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
-------
A
---------
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
-------------
P
N
S
--
D
M
-
H
-
P
M
R
V
L
---
F
L
--
I
P
----
K
-
N
N
P
P
T
---
L
---
V
---------
G
-----------
D
-
F
T
K
S
F
K
E
F
---
I
D
A
-
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
50.98
32%
-49
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
-
K
--------N----
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
------
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
-------
N
-------
K
--
R
L
K
--
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
EE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
G
T
A
G
-
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
-------------
P
F
S
--
E
-
H
R
-
T
Q
V
S
L
K
D
Q
I
T
--
S
G
----
K
Y
N
F
I
P
E
---
V
---
W
---------
A
-----------
E
-
V
S
E
K
A
L
D
L
---
V
K
K
-
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
50.76
36%
-34
* C1 *
4O27
1
STK24_HUMAN
B:
[14-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
------
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
E
-------
P
---------
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
K
Q
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
-------------
P
H
S
--
E
L
-
H
-
P
M
K
V
L
---
F
L
--
I
P
------
K
N
N
P
P
---
T
---
L
---------
E
-----------
G
N
Y
S
K
P
L
K
E
F
---
V
E
A
-
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
50.38
32%
-43
- C1 -
2YCF
1
CHK2_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
-
K
--------N----
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
------
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
-------
N
-------
K
--
R
L
K
--
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
EE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
G
T
A
G
-
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
-------------
P
F
S
--
E
-
H
R
-
T
Q
V
S
L
K
D
Q
I
T
--
S
G
----
K
Y
N
F
I
P
E
---
V
---
W
---------
A
-----------
E
-
V
S
E
K
A
L
D
L
---
V
K
K
-
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
50.38
32%
-50
- C1 -
4Y83
1
M3K8_HUMAN
B:
[81-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
--
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
-
P
-
V
D
Q
F
K
P
S
----------
D
V
E
I
Q
A
C
F
R
H
E
N
I
A
E
L
Y
G
A
V
------
L
W
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
E
-------
S
--------
C
G
P
M
R
--
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
--
K
A
V
--
L
V
D
F
G
L
S
V
Q
M
T
-----
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
-
I
---
L
C
--
R
G
-
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
-------------
P
W
V
--
K
-
R
Y
-
P
--------
P
--
S
Y
----
L
Y
I
I
H
K
Q
---
A
---
P
PLEDIA---
D
-----------
D
-
C
S
P
G
M
R
E
L
---
I
E
A
-
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
-
L
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
50.34
32%
-43
- C1 -
4Y85
1
M3K8_HUMAN
B:
[81-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
-
P
-
V
D
Q
F
K
P
S
----------
D
V
E
I
Q
A
C
F
R
H
E
N
I
A
E
L
Y
G
A
V
------
L
W
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
E
-------
S
--------
C
G
P
M
R
--
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
--
K
A
V
--
L
V
D
F
G
L
S
V
Q
M
T
-----
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
-
I
---
L
C
--
R
G
-
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
-------------
P
W
V
--
K
-
R
Y
-
P
R
S
A
----
Y
P
--
S
Y
----
L
Y
I
I
H
K
Q
---
A
---
P
PLEDIA---
D
-----------
D
-
C
S
P
G
M
R
E
L
---
I
E
A
-
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
-
L
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
50.23
32%
-48
- C1 -
2YIT
1
CHK2_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
-
K
--------LN---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
------
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
-------
N
-------
K
--
R
L
K
--
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
EE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
G
T
A
G
-
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
-------------
P
F
S
--
E
-
H
R
-
T
Q
V
S
L
K
D
Q
I
T
--
S
G
----
K
Y
N
F
I
P
E
---
V
---
W
---------
A
-----------
E
-
V
S
E
K
A
L
D
L
---
V
K
K
-
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
49.91
35%
-42
- C1 -
4FZF
1
?
B:
[16-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
------
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
-------
A
---------
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
-------------
P
N
S
--
D
M
-
H
-
P
M
R
V
L
---
F
L
--
I
P
----
K
-
N
N
P
P
T
---
L
---
V
---------
G
-----------
D
-
F
T
K
S
F
K
E
F
---
I
D
A
-
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
49.77
36%
-46
- C1 -
3GGF
1
STK26_HUMAN
A:
[31-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
------
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
-------
A
---------
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
D
F
G
V
A
--------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
-------------
P
N
S
--
D
M
-
H
-
P
M
R
V
L
---
F
L
--
I
P
----
K
N
N
-
P
P
T
---
L
---
V
---------
G
-----------
D
-
F
T
K
S
F
K
E
F
---
I
D
A
-
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
49.57
36%
-45
- C1 -
3GGF
1
STK26_HUMAN
B:
[31-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
------
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
-------
A
---------
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
D
F
G
V
A
---------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
-------------
P
N
S
--
D
M
-
H
-
P
M
R
V
L
---
F
L
--
I
P
----
K
N
N
-
P
P
T
---
L
---
V
---------
G
-----------
D
-
F
T
K
S
F
K
E
F
---
I
D
A
-
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
49.54
35%
-49
- C1 -
4NZW
1
STK25_HUMAN
B:
[28-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
-
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
------
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
K
-------
P
---------
G
P
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
-------------------
T
P
F
W
M
A
P
E
V
-
I
---
K
Q
-----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
-------------
P
N
S
--
D
L
-
H
-
P
M
R
V
L
---
F
L
--
I
P
----
K
-
N
S
P
P
T
---
L
---
E
---------
G
-----------
Q
-
H
S
K
P
F
K
E
F
---
V
E
A
-
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
49.51
32%
-51
- C1 -
4USD
1
?
B:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
--------------------
G
T
P
Y
W
M
A
P
E
V
-
V
MC--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
49.49
32%
-48
- C1 -
2CN5
1
CHK2_HUMAN
A:
[24-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
-
K
R
-------N----
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
------
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
-------
N
-------
K
--
R
L
K
--
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
EE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
G
T
A
G
-
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
-------------
P
F
S
--
E
-
H
R
-
T
Q
V
S
L
K
D
Q
I
T
--
S
G
----
K
Y
N
F
I
P
E
---
V
---
W
---------
A
-----------
E
-
V
S
E
K
A
L
D
L
---
V
K
K
-
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
49.34
32%
-42
- C1 -
4Y85
1
M3K8_HUMAN
A:
[81-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
-
P
-
V
D
Q
F
K
P
S
----------
D
V
E
I
Q
A
C
F
R
H
E
N
I
A
E
L
Y
G
A
V
------
L
W
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
E
-------
S
--------
C
G
P
M
R
--
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
--
K
A
V
--
L
V
D
F
G
L
S
V
Q
M
T
-----
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
-
I
---
L
C
--
R
G
-
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
-------------
P
W
V
--
K
-
R
Y
-
P
R
S
A
----
Y
P
--
S
Y
----
L
Y
I
I
H
K
Q
---
A
---
P
PLEDIA---
D
-----------
D
-
C
S
P
G
M
R
E
L
---
I
E
A
-
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
-
L
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
49.07
32%
-39
- C1 -
4AOT
1
STK10_HUMAN
A:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
------------------
G
T
P
Y
W
M
A
P
E
V
-
V
M---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
48.93
32%
-43
- C1 -
4Y83
1
M3K8_HUMAN
A:
[81-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
-
P
-
V
D
Q
F
K
P
S
----------
D
V
E
I
Q
A
C
F
R
H
E
N
I
A
E
L
Y
G
A
V
------
L
W
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
E
-------
S
--------
C
G
P
M
R
--
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
--
K
A
V
--
L
V
D
F
G
L
S
V
Q
M
T
-----
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
-
I
---
L
C
--
R
G
-
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
-------------
P
W
V
--
K
-
R
Y
--------------
Y
----
L
Y
I
I
H
K
Q
---
A
---
P
PLEDIA---
D
-----------
D
-
C
S
P
G
M
R
E
L
---
I
E
A
-
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
-
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
48.87
32%
-50
- C1 -
2YIR
1
CHK2_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
-
K
--------LN---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
------
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
-------
N
-------
K
--
R
L
K
--
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
EE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
G
T
A
G
-
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
-------------
P
F
S
--
E
-
H
R
-
T
Q
V
S
L
K
D
Q
I
T
--
S
G
----
K
Y
N
F
I
P
E
---
V
---
W
---------
A
-----------
E
-
V
S
E
K
A
L
D
L
---
V
K
K
-
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
48.73
33%
-35
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[6-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG---------
T
F
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
---------
M
K
--
V
L
----
M
L
T
L
Q
N
D
---
P
---
P
SLETGVQDK
E
-----------
M
-
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
-
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
K
N
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
48.47
33%
-47
- C1 -
2JFL
6
SLK_HUMAN
A:
[45-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
-
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
------
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
-------
E
-------
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
-----
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
MCE
T
S
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
E
P
P
---
T
LAQ
P
---------
S
-----------
R
-
W
S
S
N
F
K
D
F
---
L
K
K
-
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
48.27
33%
-47
- C1 -
2J51
5
SLK_HUMAN
A:
[45-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
-
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
------
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
-------
E
-------
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
-----
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
M
CE
T
S
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
E
P
P
---
T
LAQ
P
---------
S
-----------
R
-
W
S
S
N
F
K
D
F
---
L
K
K
-
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
47.89
32%
-39
- C1 -
4AOT
1
STK10_HUMAN
B:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
----------------
I
G
T
P
Y
W
M
A
P
E
V
-
V
M-------
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
47.31
31%
-42
- C1 -
1GIJ
1
CDK2_HUMAN
A:
[10-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R----------
A
-----
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
-
T
F
M
D
A
-------
S
-------
A
L
T
G
I
P
--
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
V
T
L
W
Y
R
A
P
E
I
-
L
----
L
G
C
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
LFPGDS
E
I
D
Q
L
F
R
I
F
R
--
T
L
G
T
-
P
D
E
V
V
---
W
P
GV
T
S
----
M
P
D
Y
K
P
S
---
F
---
P
---------
K
W
A
R
Q
D
FSKVVP
P
-
L
D
E
D
G
R
S
L
---
L
S
Q
-
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
-
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
46.97
33%
-34
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[9-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD------------
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
---------
M
K
--
V
L
----
M
L
T
L
Q
N
D
---
P
---
P
SLETG----------------
M
-
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
-
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
46.33
34%
-40
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[17-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD--------
T
F
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
---------
M
K
--
V
L
----
M
L
T
L
Q
N
D
---
P
---
P
SLETGVQDK
E
-----------
M
-
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
-
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
46.28
32%
-41
- C1 -
4EQU
2
STK10_HUMAN
B:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-------------
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
K
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
46.09
34%
-38
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[17-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGDI
T
R
N
-----
F
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
---------
M
K
--
V
L
----
M
L
T
L
Q
N
D
---
P
---
P
SLETGVQDK
E
-----------
M
-
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
-
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
46.01
34%
-37
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[17-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-----------
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
---------
M
K
--
V
L
----
M
L
T
L
Q
N
D
---
P
---
P
SLETGVQDK
E
-----------
M
-
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
-
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
45.69
32%
-36
- C1 -
2J7T
1
STK10_HUMAN
A:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
K
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
45.20
32%
-32
- C1 -
4USE
1
?
A:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
K
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
45.01
35%
-52
- C1 -
4ZJI
1
?
C:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
-
N
------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
44.91
35%
-57
- C1 -
4ZJI
1
?
D:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
--------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
44.81
31%
-43
- C1 -
1GII
1
CDK2_HUMAN
A:
[10-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
V
P
S
T
A
-----
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
-
T
F
M
D
A
-------
S
-------
A
L
T
G
I
P
--
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---
E
G
A
I
K
L
A
D
F
G
L
A
-
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
-
L
----
L
G
C
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
LFPGDS
E
I
D
Q
L
F
R
I
F
R
--
T
L
G
T
-
P
D
E
V
V
---
W
P
GV
T
S
----
M
P
D
Y
K
P
S
---
F
---
P
---------
K
W
A
R
Q
D
FSKVVP
P
-
L
D
E
D
G
R
S
L
---
L
S
Q
-
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
-
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
44.78
35%
-57
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
---
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
----
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
44.54
34%
-37
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[17-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD------------
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
---------
M
K
--
V
L
----
M
L
T
L
Q
N
D
---
P
---
P
SLETGVQDK
E
-----------
M
-
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
-
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
44.35
32%
-33
- C1 -
4BC6
2
STK10_HUMAN
A:
[19-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
K
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
43.83
32%
-33
- C1 -
4USE
1
?
B:
[27-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
------
Y
-----
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
-------
E
-------
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
K
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
-------------
P
H
H
--
E
L
N
--
P
M
R
V
L
---
L
K
--
I
A
------
K
S
D
P
P
TLL
T
---
P
---------
S
-----------
K
-
W
S
V
E
F
R
D
F
---
L
K
I
-
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.59
34%
-33
- C1 -
5D9H
1
?
A:
[18-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
-
L
D
I
I
K
Y
I
V
N
R
GE
H
-------
K
N
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGDV
T
R
-------
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
-
M
K
V
L
M
---
L
T
--
L
Q
NDPP
T
L
E
T
G
V
--------
K
---------
E
-----------
M
-
M
K
K
Y
G
K
S
F
R
K
-
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A
----
K
N
R
E
Y
L
I
E
K
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
43.20
34%
-39
- C1 -
5D9H
1
?
B:
[18-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
-
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
------
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
-
L
D
I
I
K
YIVNRGE
H
-------
K
N
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGDV
T
R
N
-------
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
-
V
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
-------------
P
Y
H
--
K
Y
P
P
-
M
K
V
L
M
---
L
T
--
L
Q
NDPP
T
L
E
T
G
V
E
---
D
---
K
---------
E
-----------
M
-
M
K
K
Y
G
K
S
F
RK-
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A
----
K
N
R
E
Y
L
I
E
K
L
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
43.19
35%
-57
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[30-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
-
N
-
L
---
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
--------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
-------
E
-------
T
C
--
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
---------
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
--
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
-------------
P
Y
----
L
N
E
N
P
L
R
A
L
---
Y
L
--
I
A
----
T
N
G
T
-
P
E
---
L
QN-
P
---------
E
-----------
K
-
L
S
A
I
F
R
D
F
---
L
N
R
-
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------