@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K19_HUMAN: (2015-10-12 )
MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERSH
Atome Classification :
(78 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070...-...-1080.-.-.-....---1090-........1100......1110.-.....1120.......1130-----.......1140...------...-1150-.--...-..----..--1160.......1170......-1180.......1190.-..---...1200......1210......1220.--.-.-..-.1230....-..-----1240--..--.......1250......1260...-.----..1270.......1280.-....---.---1290---.-...----------------..-----------..1300......1310......1320.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSMPK
P
E
R
H
A
E
S
L
L
D
I
C
HDTNSSPT
D
L
M
T
VTKNQ
N
I
I
L
Q
SISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTE
G
V
E
I
T
V
TFPRDVS
P
P
Q
E
M
S
Q
E
D
L
K
E
K
N
L
I
N
S
S
L
Q
E
W
A
Q
A
HAVSHPNEI
E
T
V
E
L
R
K
KKLTMRP
L
V
L
QKEESSRELCNVN
L
G
F
LL
P
R
S
C
L
E
LNISKSVTRED
A
P
H
F
L
K
E
Q
Q
R
K
S
E
EFSTSHMKYSG
R
S
I
K
F
LLPP
L
S
LLPTRS
G
V
L
TIPQNHKF
P
K
E
K
ERNI
P
S
L
T
S
F
V
P
K
L
S
V
S
V
RQSDELSPSNEP
P
G
A
L
V
K
S
L
MDPTLRSSDG
F
I
WSRNMCSFPKT
N
H
H
R
Q
C
L
E
K
EENWK
S
K
E
I
E
ECN
K
I
E
I
T
H
FEKGQSL
V
S
F
E
NLKEGNIPAVREEDIDCHGSKTRKP
E
E
E
N
S
Q
Y
L
S
SRKN
E
S
S
V
A
KNYEQDP
E
I
V
C
TI
P
S
K
F
Q
ETQHSEITPS
Q
D
E
E
M
RNNKAASKRVSLHKNEAME
P
N
N
I
L
E
E
C
T
V
L
K
S
L
S
S
V
VFDD
P
I
D
K
L
P
E
G
C
S
SMET
N
I
K
I
S
I
A
ERAKP
E
M
S
RM
V
P
L
I
H
I
T
FPVDGSPKEPVIAKPSLQTRK
G
T
IHNNH
S
V
N
I
P
VHQEN
D
K
H
K
M
N
S
H
R
S
KLDSKTKTSKKTPQ
N
F
V
I
STEGPIKPTMHKTSI
K
T
Q
I
F
P
ALGLVDPRPWQL
P
R
F
Q
K
K
M
P
Q
I
A
K
K
QSTHRTQKPKKQSF
P
C
I
CKNPGTQKS
C
V
P
L
SVQPTEPRL
N
Y
L
D
L
K
Y
S
D
M
F
K
E
I
N
STANGP
G
I
Y
E
MFGT
P
V
Y
C
H
V
RETERDE
N
T
Y
Y
R
E
I
CSAPSG
R
R
I
T
N
K
C
R
S
S
H
S
E
R
K
S
N
I
R
T
R
L
S
QKKTHMKCPKTSFGIK
Q
E
H
K
V
L
I
SKEKSS
K
A
V
H
S
NLHDIENGDGISEPD
W
Q
IKSSGNEFLSSKDEIHPMNLAQT
P
E
Q
S
MKQNEFPPVS
D
L
S
I
V
E
E
V
SMEESTGDRDISNN
Q
I
L
T
T
S
L
R
D
L
Q
E
L
E
E
L
H
H
QIPFIPSEDSWAVPSEKNS
N
K
Y
V
Q
Q
E
KQNTASLSKV
N
A
S
R
ILTNDLEFDSVSDHSKTLTN
F
S
F
Q
AKQESASSQ
T
Y
Q
Y
W
V
H
YLDHDSLANK
S
I
T
Y
Q
M
FGKTLSG
T
N
S
I
S
Q
E
I
M
D
SVN
N
E
E
L
T
D
E
L
L
G
C
L
A
A
E
L
L
ALDEKDN
N
S
C
Q
K
MANETDPEN
L
N
L
V
L
R
WRGS
T
P
K
E
MGRET
T
K
V
K
I
Q
RHSSG
L
R
I
Y
DREE
K
F
LISN
E
K
K
IFSENSLKSEE
P
I
L
W
TKG
E
I
LGKGAY
G
T
V
Y
-
C
GL-TSQ-
G
-
Q
-
L
-
I
A
V
K
---
Q
V
---ALDTSNK
L
A
A
E
K
E
Y
R
K
L
Q
E
E
V
D
L
-
L
K
A
L
K
H
-
V
N
I
V
A
Y
L
G
T
C
L
Q------E
N
T
V
S
I
F
M
E
FVPGG------
S
I
S
-
S
I
---
I
--
N
RF-GP----L
P
--
E
M
-
V
F
C
K
Y
T
K
Q
I
L
Q
G
V
A
Y
L
H
E-N
C
-
V
V
H
R
DIKGN
N
V
M
L
-M
P
---
T
G
I
I
K
L
I
D
F
G
C
A
R
R
L
A
WAGLNG
T
H
S
D
M
L
--
K
-
S
-MH-GTPYWM
A
P
E
-
V
I-----N-----ES--GYGRKSD
I
W
S
IG
C
T
V
F
EMATGKPP-
L
----
A
S
M
D
R
-
M
A
A
M
F
YIGAHRG-LMPP---L---P-D----H-FS
E
----------------
N
A
-----------
A
D
F
V
R
M
C
L
TRDQHER
P
S
A
L
Q
L
L
K
H
S
F
LERSH
4
PsiBlast_PDB
84.08
42%
-107
- C1 -
4BIC
2
M3K5_HUMAN
A:
[26-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
-----------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--
G
------
E
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
2
PsiBlast_PDB
82.89
42%
-103
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
D
S
---------
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--
G
-----------
E
-
T
-
F
T
-
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
22
PsiBlast_CBE
82.67
42%
-104
- C1 -
4BF2
1
B:
[42-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
---------------
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
1
PsiBlast_PDB
82.64
42%
-107
- C1 -
4BF2
2
M3K5_HUMAN
A:
[42-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
----------------
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
E
E
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
25
PsiBlast_CBE
82.21
42%
-103
- C1 -
4BID
1
B:
[26-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
----------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-----------
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
3
PsiBlast_PDB
82.00
42%
-105
- C1 -
4BIB
3
M3K5_HUMAN
A:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
--------------
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
----------
E
E
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
5
PsiBlast_PDB
81.65
42%
-107
- C1 -
4BID
1
M3K5_HUMAN
A:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
--------------
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
----------
E
E
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
27
PsiBlast_CBE
81.36
42%
-103
- C1 -
4BIB
1
B:
[26-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
----------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-----------
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
23
PsiBlast_CBE
79.88
42%
-106
- C1 -
2CLQ
1
B:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
----------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------------
F
T
-
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
24
PsiBlast_CBE
79.70
42%
-98
- C1 -
4BIE
2
B:
[26-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
-------------
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-
26
PsiBlast_CBE
79.65
42%
-104
- C1 -
4BIC
2
B:
[26-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
----------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-
21
PsiBlast_CBE
78.51
42%
-100
- C1 -
4BHN
2
B:
[42-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
-
D
L
S
-
N
-
Q
-
V
R
I
A
I
K
---
E
I
---
P
E
R
----------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
K
H
-
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
------
S
L
S
-
A
L
---
L
R
-
S
K
W
-
G
P
----
L
K
DN
E
Q
-
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
---
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
F
T
---------
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
-----
K
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
-
F
----
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
--
V
H
P
E
---
I
---
P
-
E
----
S
-
M
S
A
----------------
E
A
-----------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
----
49
PsiBlast_CBE
73.73
35%
-95
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
---------
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
---------
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
69
PsiBlast_CBE
72.42
35%
-94
- C1 -
4U44
2
M4K4_HUMAN
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
E
D
E
E
E
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
48
PsiBlast_CBE
72.01
35%
-97
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
---------
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
---------
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
68
PsiBlast_CBE
71.57
35%
-91
* C1 *
4U45
1
M4K4_HUMAN
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
E
D
E
E
E
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------
N
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
45
PsiBlast_CBE
70.57
35%
-94
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
--------
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------------
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
70
PsiBlast_CBE
70.26
35%
-97
- C1 -
4U43
1
M4K4_HUMAN
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
E
D
E
E
E
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
-------------
N
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
75
PsiBlast_CBE
69.85
35%
-96
- C1 -
4RVT
2
M4K4_HUMAN
A:
[32-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
----
E
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
-------------------
N
-
T
-
F
I
-
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
83
PsiBlast_CBE
69.15
33%
-94
- C1 -
5AJQ
2
STK10_HUMAN
A:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
---
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------
N
L
K
T
----------
F
I
-
G
T
P
Y
W
M
A
P
E
-
V
V
MCETM
K
-----
D
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
35
PsiBlast_CBE
68.88
35%
-89
- C1 -
4FZD
1
STK26_HUMAN
B:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
Q
V
-
V
A
I
K
---
I
I
---
D
L
E
E
A
E
D
E
I
E
D
I
-----
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
---
R
A
-
G
P
----
F
D
--
E
F
-
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
-------
T
--------N
T
-
F
V
-
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-
N
----
S
D
M
H
P
-
M
R
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
V
-
G
----
D
-
F
T
K
----------------
S
F
-----------
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
52
PsiBlast_CBE
68.85
34%
-97
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[23-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
Q
Q
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
--------------
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
44
PsiBlast_CBE
68.84
35%
-96
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
---------
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------------
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
53
PsiBlast_CBE
68.69
34%
-91
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[23-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
------------
Q
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
E
Q
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
59
PsiBlast_CBE
68.54
34%
-93
- C1 -
4P90
1
PAK1_HUMAN
B:
[22-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
----
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
---------------
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
-----------------
S
K
R
--
S
-
E
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
55
PsiBlast_CBE
68.45
34%
-93
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[23-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
Q
-
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
E
Q
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
58
PsiBlast_CBE
68.31
34%
-90
- C1 -
4O0R
1
PAK1_HUMAN
A:
[22-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
Q
Q
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
E
Q
S
K
R
--
S
-
E
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
54
PsiBlast_CBE
68.07
34%
-93
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[23-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
Q
-
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
E
Q
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
57
PsiBlast_CBE
67.81
34%
-83
- C1 -
4O0T
1
PAK1_HUMAN
A:
[22-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
Q
Q
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
E
Q
S
K
R
--
S
-
E
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
60
PsiBlast_CBE
67.71
33%
-95
- C1 -
4USF
1
?
B:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
Q
-
N
K
E
-
T
-
S
-
V
-
L
A
A
A
---
K
V
----
I
D
T
K
----
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
------
A
V
D
-
A
V
---
M
--
L
E
L
E
R
P
----
L
T
--
E
S
-
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
---
D
G
D
I
K
L
A
D
F
G
V
S
A
K
------
N
-------------
F
I
-
G
T
P
Y
W
M
A
P
E
-
V
V
MCETS
K
-----
D
R
--
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
E
P
-
P
T
L
A
---
Q
---
P
-
S
----
R
-
W
S
S
----------------
N
F
-----------
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
72
PsiBlast_CBE
67.26
35%
-95
- C1 -
4OBP
2
M4K4_HUMAN
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
E
D
E
E
E
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------
N
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
71
PsiBlast_CBE
66.78
35%
-100
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
---------------
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
-------------
N
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
66
PsiBlast_CBE
66.53
35%
-92
- C1 -
4ZK5
2
?
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
E
D
E
E
E
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------
N
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
PRL
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
61
PsiBlast_CBE
66.48
33%
-99
- C1 -
4USF
1
?
A:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
Q
-
N
K
E
-
T
-
S
-
V
-
L
A
A
A
---
K
V
----
I
D
T
K
----
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
------
A
V
D
-
A
V
---
M
--
L
E
L
E
R
P
----
L
T
--
E
S
-
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
---
D
G
D
I
K
L
A
D
F
G
V
S
A
K
------------------------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E---------
R
--
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
E
P
-
P
T
L
A
---
Q
---
P
-
S
----
R
-
W
S
S
----------------
N
F
-----------
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
81
PsiBlast_CBE
66.36
33%
-98
- C1 -
4AOT
1
STK10_HUMAN
A:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
------------------------
G
T
P
Y
W
M
A
P
E
-
V
V
M---------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
36
PsiBlast_CBE
66.32
35%
-78
- C1 -
4FZA
3
STK26_HUMAN
B:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
Q
V
-
V
A
I
K
---
I
I
---
D
L
E
E
A
E
D
E
I
E
D
I
-----
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
---
R
A
-
G
P
----
F
D
--
E
F
-
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
N
T
-
F
V
-
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-
N
----
S
D
M
H
P
-
M
R
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
V
-
G
----
D
-
F
T
K
----------------
S
F
-----------
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
56
PsiBlast_CBE
66.12
34%
-88
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[23-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
-----------
Q
Q
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
--
T
C
----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------
P
E
Q
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
78
PsiBlast_CBE
65.99
33%
-102
- C1 -
4USD
1
?
B:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
--
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
--------------------------
G
T
P
Y
W
M
A
P
E
-
V
V
MC--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
90
PsiBlast_CBE
65.71
32%
-97
- C1 -
3MFR
1
CSKP_HUMAN
A:
[30-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
-
R
E
T
-
G
-
Q
-
Q
-
F
A
V
K
---
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
----
L
K
R
E
A
S
I
-
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
------
D
L
C
F
E
I
---
V
--
K
R
A
-
D
A
G
F
V
-
Y
S
--
E
A
-
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-
I
I
H
R
D
V
K
P
E
N
V
L
L
-
A
S
KEN
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
------
V
A
--
G
-
G
-
R
V
-
G
T
P
H
F
M
A
P
E
-
V
V
-----
K
-----
R
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
-
F
Y---
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
--
M
N
P
R
---
Q
---
W
-
S
----
H
-
I
S
E
----------------
S
A
-----------
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
74
PsiBlast_CBE
65.57
35%
-100
- C1 -
4OBO
2
M4K4_HUMAN
A:
[30-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
-
K
G
R
H
V
K
T
-
G
-
Q
-
L
-
A
A
I
K
--------
V
M
D
V
T
----------
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
------
S
I
T
-
D
L
---
V
K
N
T
K
G
-
N
T
----
L
K
--
E
D
-
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
---
N
A
E
V
K
L
V
D
F
G
-------------
R
N
T
F
I
---------
G
T
P
Y
W
M
A
P
E
-
V
I
-----
A
CDENP
D
A
--
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
-
L
----
C
D
M
H
P
-
M
R
A
L
F
L
I
P
R
N
-----
P
P
P
R
L
K
---
S
-
K
----
K
-
W
S
K
----------------
K
F
-----------
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
88
PsiBlast_CBE
65.43
32%
-97
- C1 -
3MFU
1
CSKP_HUMAN
A:
[30-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
-
R
E
T
-
G
-
Q
-
Q
-
F
A
V
K
---
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
----
L
K
R
E
A
S
I
-
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
------
D
L
C
F
E
I
---
V
--
K
R
A
-
D
A
G
F
V
-
Y
S
--
E
A
-
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-
I
I
H
R
D
V
K
P
E
N
V
L
L
-
A
S
KEN
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
------
V
A
--
G
-
G
-
R
V
-
G
T
P
H
F
M
A
P
E
-
V
V
-----
K
-----
R
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
-
F
Y---
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
--
M
N
P
R
---
Q
---
W
-
S
----
H
-
I
S
E
----------------
S
A
-----------
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
10
PsiBlast_PDB
65.10
36%
-76
- C1 -
3A7H
1
STK24_HUMAN
A:
[15-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
34
PsiBlast_CBE
64.39
35%
-82
- C1 -
4FZF
1
?
B:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
Q
V
-
V
A
I
K
---
I
I
---
D
L
E
E
A
E
D
E
I
E
D
I
-----
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
---
R
A
-
G
P
----
F
D
--
E
F
-
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
N
T
-
F
V
-
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-
N
----
S
D
M
H
P
-
M
R
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
V
-
G
----
D
-
F
T
K
----------------
S
F
-----------
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
11
PsiBlast_PDB
64.32
36%
-71
- C1 -
3A7I
1
STK24_HUMAN
A:
[15-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
6
PsiBlast_PDB
64.29
35%
-82
- C1 -
3GGF
1
STK26_HUMAN
A:
[24-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
Q
V
-
V
A
I
K
---
I
I
---
D
L
E
E
A
E
D
E
I
E
D
I
-----
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
---
R
A
-
G
P
----
F
D
--
E
F
-
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
G
D
V
K
L
A
D
F
G
V
A
------------------
R
N
T
-
F
V
-
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-
N
----
S
D
M
H
P
-
M
R
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
V
-
G
----
D
-
F
T
K
----------------
S
F
-----------
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
28
PsiBlast_CBE
64.12
35%
-84
- C1 -
3GGF
1
STK26_HUMAN
B:
[24-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
Q
V
-
V
A
I
K
---
I
I
---
D
L
E
E
A
E
D
E
I
E
D
I
-----
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
---
R
A
-
G
P
----
F
D
--
E
F
-
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
G
D
V
K
L
A
D
F
G
V
A
-------------------N
T
-
F
V
-
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-
N
----
S
D
M
H
P
-
M
R
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
V
-
G
----
D
-
F
T
K
----------------
S
F
-----------
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
80
PsiBlast_CBE
63.93
33%
-96
- C1 -
4AOT
1
STK10_HUMAN
B:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---------------------
I
-
G
T
P
Y
W
M
A
P
E
-
V
V
M--------------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
33
PsiBlast_CBE
63.80
36%
-72
- C1 -
4O27
1
STK24_HUMAN
B:
[7-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
E
F
V
-
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
87
PsiBlast_CBE
63.64
31%
-98
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[33-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
-
K
P
S
-
G
-
L
-
V
-
M
A
R
K
---
L
I
---
H
L
E
I
K
P
A
I
R
-----
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
------
S
L
D
-
Q
V
---
L
--
K
K
A
-
G
R
----
I
P
--
E
Q
-
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
-
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
---
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
------------------
F
V
-
G
T
R
S
Y
M
S
P
E
-
R
L
-----
Q
-----
G
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
-
I
----
G
-------
A
I
F
E
L
L
D
Y
I
V
-
N
E
P
P
P
K
-
L
---
P
-
S
----
G
V
F
S
L
----------------
E
F
-----------
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
89
PsiBlast_CBE
63.06
32%
-99
- C1 -
3MFS
1
CSKP_HUMAN
A:
[30-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
-
R
E
T
-
G
-
Q
-
Q
-
F
A
V
K
---
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
----
L
K
R
E
A
S
I
-
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
------
D
L
C
F
E
I
---
V
--
K
R
A
-
D
A
G
F
V
-
Y
S
--
E
A
-
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-
I
I
H
R
D
V
K
P
E
N
V
L
L
-
A
S
KEN
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
------
V
A
--
G
-
G
-
R
V
-
G
T
P
H
F
M
A
P
E
-
V
V
-----
K
-----
R
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
-
F
Y---
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
--
M
N
P
R
---
Q
---
W
-
S
----
H
-
I
S
E
----------------
S
A
-----------
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
12
PsiBlast_PDB
62.70
36%
-67
- C1 -
3A7J
1
STK24_HUMAN
A:
[15-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
37
PsiBlast_CBE
62.53
35%
-90
- C1 -
4NZW
1
STK25_HUMAN
B:
[21-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
-
K
G
I
-
D
N
H
-
T
K
E
-
V
-
V
A
I
K
---
I
I
---
D
L
E
E
A
E
D
E
I
E
D
I
-----
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
K
P
--
G
P
----
L
E
--
E
T
-
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
-------------------------
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-
N
----
S
D
L
H
P
-
M
R
V
L
F
L
I
P
K
N
S
P
---
P
T
---
L
---
E
-
G
----
Q
-
H
S
K
----------------
P
F
-----------
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
64
PsiBlast_CBE
62.35
33%
-96
- C1 -
2WQN
1
NEK7_HUMAN
A:
[40-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
-
L
L
D
-
G
-
V
-
P
-
V
A
L
K
---
K
V
---
Q
I
---
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
-
L
K
Q
L
N
H
-
P
N
V
I
K
Y
Y
A
S
F
I
E
------
D
N
E
L
N
I
V
L
E
L
A
D
A
G
------
D
L
S
-
R
M
---
I
--
K
H
F
-
K
K
Q
KRL
I
P
--
E
R
-
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
-
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
-
T
A
---
T
G
V
V
K
L
G
D
L
-----------------------------
T
P
Y
Y
M
S
P
E
-
R
I
-----
H
-----
E
N
--
G
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
-
F
----
Y
---
M
-
N
L
Y
S
L
C
K
K
I
E
Q
C
-
D
Y
P
P
---
L
---
P
S
D
----
H
-
Y
S
E
----------------
E
L
-----------
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
46
PsiBlast_CBE
61.28
35%
-91
- C1 -
4ZJI
1
?
D:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
-----
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
---------
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
47
PsiBlast_CBE
60.39
35%
-88
- C1 -
4ZJI
1
?
C:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D-
A
T
-
G
-
Q
-
E
-
V
A
I
K
---
Q
M
---
N
-----
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
-----------
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
79
PsiBlast_CBE
59.35
33%
-91
- C1 -
4EQU
2
STK10_HUMAN
B:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------
N
L
------------
F
I
-
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
-----
D
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
43
PsiBlast_CBE
58.36
35%
-93
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
A
----
Q
-
E
-
V
A
I
K
---
Q
M
---
N
L
Q
---
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
-------------
E
Q
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
---------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
93
PsiBlast_CBE
57.85
31%
-73
- C1 -
4Y83
1
M3K8_HUMAN
A:
[79-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
I
P
R
G
A
F
G
K
V
Y
-
L
A
--------
Q
-
D
-
I
K
T
K
---
K
------
R
M
A
C
K
L
I
P
V
D
Q
F
K
P
--
S
D
V
E
I
-
Q
A
C
F
R
H
-
E
N
I
A
E
L
Y
G
A
V
L
W
------
G
E
T
V
H
L
F
M
E
A
G
E
G
G
------
S
V
L
-
E
K
---
L
--
E
S
C
-
G
P
----
M
R
--
E
F
-
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
-
K
K
-
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
---
T
K
A
V
-
L
V
D
F
G
L
S
V
Q
M
T
--------
E
D
V
Y
F
P
K
-
D
-
L
R
-
G
T
E
I
Y
M
S
P
E
-
V
I
-----
L
-----
C
R
--
G
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
----
K
R
Y
--------
Y
L
Y
I
I
H
K
-
Q
A
P
P
---
L
EDI
A
-
D
----
D
-
C
S
P
----------------
G
M
-----------
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
N
---
63
PsiBlast_CBE
57.09
33%
-86
- C1 -
2J51
5
SLK_HUMAN
A:
[45-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
Q
-
N
K
E
-
T
-
S
-
V
-
L
A
A
A
---
K
V
----
I
D
T
K
----
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
------
A
V
D
-
A
V
---
M
--
L
E
L
E
R
P
----
L
T
--
E
S
-
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
---
D
G
D
I
K
L
A
D
F
G
V
S
A
K
------
N
T
R
T
I
Q
R
R
--
D
-
S
-
F
I
-
G
T
P
Y
W
M
A
P
E
-
V
V
M
CETS
K
-----
D
R
--
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
E
P
-
P
T
L
A
---
Q
---
P
-
S
----
R
-
W
S
S
----------------
N
F
-----------
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
42
PsiBlast_CBE
56.94
35%
-95
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[24-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
-
T
A
M
D
V
-------
E
-
V
A
I
K
---
Q
M
---
N
L
---
P
K
----
K
E
L
--
I
I
N
E
I
L
V
-
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
--------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
------
S
L
T
-
D
V
---
V
--
T
E
T
-
C
-----
M
D
--
E
G
-
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
----------
P
E
Q
S
K
R
--
S
-
T
-
M
V
-
G
T
P
Y
W
M
A
P
E
-
V
V
-----
T
-----
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
-
Y
----
L
N
E
N
P
-
L
R
A
L
Y
L
I
A
T
N
G
---
T
P
E
---
L
QN-
P
-
E
----
K
-
L
S
A
----------------
I
F
-----------
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
92
PsiBlast_CBE
56.13
31%
-76
- C1 -
4Y83
1
M3K8_HUMAN
B:
[79-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
I
P
R
--
F
G
K
V
Y
-
L
A
--------
Q
-
D
-
I
K
T
K
---
K
------
R
M
A
C
K
L
I
P
V
D
Q
F
K
P
--
S
D
V
E
I
-
Q
A
C
F
R
H
-
E
N
I
A
E
L
Y
G
A
V
L
W
------
G
E
T
V
H
L
F
M
E
A
G
E
G
G
------
S
V
L
-
E
K
---
L
--
E
S
C
-
G
P
----
M
R
--
E
F
-
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
-
K
K
-
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
---
T
K
A
V
-
L
V
D
F
G
L
S
V
Q
M
T
--------
E
D
V
Y
F
P
K
-
D
-
L
R
-
G
T
E
I
Y
M
S
P
E
-
V
I
-----
L
-----
C
R
--
G
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
----
K
R
Y
P
-----
P
S
Y
L
Y
I
I
H
K
-
Q
A
P
P
---
L
EDI
A
-
D
----
D
-
C
S
P
----------------
G
M
-----------
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
N
P
--
91
PsiBlast_CBE
55.45
31%
-77
- C1 -
4Y83
1
M3K8_HUMAN
C:
[79-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
I
P
R
---
G
K
V
Y
-
L
A
--------
Q
-
D
-
I
K
T
K
---
K
------
R
M
A
C
K
L
I
P
V
D
Q
F
K
P
--
S
D
V
E
I
-
Q
A
C
F
R
H
-
E
N
I
A
E
L
Y
G
A
V
L
W
------
G
E
T
V
H
L
F
M
E
A
G
E
G
G
------
S
V
L
-
E
K
---
L
--
E
S
C
-
G
P
----
M
R
--
E
F
-
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
-
K
K
-
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
---
T
K
A
V
-
L
V
D
F
G
L
S
V
Q
M
---------
E
D
V
Y
F
P
K
-
D
-
L
R
-
G
T
E
I
Y
M
S
P
E
-
V
I
-----
L
-----
C
R
--
G
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
----
K
R
Y
P
----
Y
P
S
Y
L
Y
I
I
H
K
-
Q
A
P
P
---
L
EDI---------
C
S
P
----------------
G
M
-----------
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
N
---
82
PsiBlast_CBE
54.61
33%
-88
- C1 -
2J7T
1
STK10_HUMAN
A:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------
N
L
K
T
L
Q
K
--------
I
-
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
-----
D
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
84
PsiBlast_CBE
54.53
33%
-89
- C1 -
4BC6
2
STK10_HUMAN
A:
[19-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------
N
L
K
T
L
Q
-------------
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
-----
D
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
96
PsiBlast_CBE
53.46
31%
-91
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[28-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
I
-
G
R
G
A
Y
G
S
V
N
-
K
M
V
H
K
P
S
-
G
-
Q
-
I
-
M
A
V
K
---
R
I
--------
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
-
P
Y
I
V
Q
F
Y
G
A
L
F
R
------
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
Y
V
Y
-
S
V
---
L
--
D
D
V
-------
I
P
--
E
E
-
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
---
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
--------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
-
Y
P----------------------
D
P
P
Q
---
L
---
S
-
N
SEER
E
-
F
S
P
----------------
S
F
-----------
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
77
PsiBlast_CBE
52.20
33%
-87
- C1 -
4USE
1
?
A:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------
N
L
K
T
L
Q
------------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
-----
D
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
85
PsiBlast_CBE
52.05
31%
-73
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
-
K
N
T
-
G
-
Q
-
I
-
V
A
I
K
I
F
Y----------
N
K
I
A
--------
M
R
E
I
K
F
-
L
K
Q
F
H
H
-
E
N
L
V
N
L
I
E
V
F
R
Q
------
K
K
K
I
H
L
V
F
E
F
I
D
H
T
------
V
L
D
-
E
L
---
Q
--
H
Y
C
-
H
G
----
L
E
--
S
K
-
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
-
N
N
-
I
I
H
R
D
I
K
P
E
N
I
L
V
-
S
Q
---
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----------
D
I
Y
--
D
-
D
-
E
V
-
A
T
R
W
Y
R
A
P
E
L
V
L
-----
K
-----
D
T
--
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
-
L
----
P
S
S
S
D
-
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
---
L
---
Q
-
N
----
I
-
F
S
K
SPIFAGVV
L
P
Q
V
Q
H
P
K
N
A
R
K
K
Y
PKLN
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
76
PsiBlast_CBE
47.93
33%
-83
- C1 -
4USE
1
?
B:
[27-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
-
K
A
K
-
N
K
E
T
G
-
A
-
L
-
A
A
A
K
---
V
I
---------
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
------
A
V
D
-
A
I
M
L
E
L
--
D
R
G
-
L
T
----
E
P
--
Q
I
Q
V
V
C
R
---
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
---
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------
N
L
K
T
L
Q
K
-----------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
-----
D
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
-
H
----
H
E
L
N
P
-
M
R
V
L
L
K
I
A
K
S
D
----
P
P
TLL
T
---
P
-
S
----
K
-
W
S
V
----------------
E
F
-----------
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
18
PsiBlast_PDB
45.04
36%
-41
- C1 -
4QMQ
3
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
16
PsiBlast_PDB
44.24
36%
-40
- C1 -
4QMO
4
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
95
PsiBlast_CBE
42.93
31%
-88
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[28-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
I
-
G
R
G
A
Y
G
S
V
N
-
K
M
V
H
K
P
S
-
G
-
Q
-
I
-
M
A
V
K
---
R
I
--------
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
-
P
Y
I
V
Q
F
Y
G
A
L
F
R
------
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
Y
V
Y
-
S
V
---
L
--
D
D
V
-------
I
P
--
E
E
-
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
---
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
-
D
S
I
A
K
T
R
D
----------
A
-
G
C
R
P
Y
M
A
P
E
-
R
I
-----
D
-----
P
----
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
-
Y
PKWN
S
V
F
D
Q
-
L
T
Q
V
V
-----
K
G
-
D
P
P
Q
---
L
---
S
-
N
S
EE
R
E
-
F
S
P
----------------
S
F
-----------
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
15
PsiBlast_PDB
42.58
36%
-35
- C1 -
4QMN
1
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
13
PsiBlast_PDB
42.50
36%
-33
- C1 -
4QML
2
STK24_HUMAN
A:
[25-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
14
PsiBlast_PDB
42.28
36%
-37
- C1 -
4QMM
3
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
17
PsiBlast_PDB
42.14
36%
-39
- C1 -
4QMP
2
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
20
PsiBlast_PDB
41.82
36%
-35
- C1 -
4QMT
2
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
19
PsiBlast_PDB
41.65
36%
-34
- C1 -
4QMS
2
STK24_HUMAN
A:
[22-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
-
K
G
I
-
D
N
R
-
T
-
Q
------
K
---
V
V
---
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
------
S
A
L
-
D
L
---
L
--
E
P
--
G
P
----
L
D
--
E
T
-
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
---
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
T
D
T
Q
I
K
--
R
-
N
-
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
-----
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-
H
----
S
E
L
H
P
-
M
K
V
L
F
L
I
P
K
N
N
P
---
P
T
---
L
---
E
-
G
----
N
-
Y
S
K
----------------
P
L
-----------
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
97
PsiBlast_CBE
41.41
31%
-84
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[28-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
I
-
G
R
G
A
Y
G
S
V
N
-
K
M
V
H
K
P
S
-
G
-
Q
-
I
-
M
A
V
K
---
R
I
--------
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
-
P
Y
I
V
Q
F
Y
G
A
L
F
R
------
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
Y
V
Y
-
S
V
---
L
--
D
D
V
-------
I
P
--
E
E
-
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
---
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
---------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
-
Y
PKW--------
T
Q
V
V
-----
K
G
-
D
P
P
Q
---
L
---
S
-
N
SEER
E
-
F
S
P
----------------
S
F
-----------
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E