@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K3_HUMAN: (2015-10-12 )
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.-......400........410.......-420.-......430....-----....440.......450.-....-.--.----460-..-......470.......480-.......490.......-500-.-.---.......510........520...-....530.......540---.--.-----.-----......550.......560.....---..570.......-----------..580--...-.--...--.590........600..---.-.-.------..610.......620....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
E
Q
E
A
L
N
S
I
M
N
D
L
V
A
L
Q
MNRRHRMPGYETMKNKDTGHSNRQS
D
V
R
I
K
F
EHNG
E
R
R
I
I
A
FSRPVK
Y
E
D
V
E
H
K
V
T
T
VFGQP
L
D
L
H
Y
MNN
E
L
S
I
L
LKN
Q
D
D
L
D
K
A
I
D
I
L
DRSSSM
K
S
L
R
I
L
L
L
SQDRNHNSSSPHSGV
S
R
Q
V
R
I
K
ASQSAGDINTIYQPPEPRS
R
H
L
SVSSQNPGRSSPPPGYV
P
E
R
Q
Q
H
I
A
RQGSYTSINSEGEFIPETS
E
Q
C
MLDPL
S
S
A
ENSLSG
S
C
Q
S
L
DRSADS
P
S
F
R
K
S
R
M
S
R
A
QSFPD
N
R
Q
EYS
D
R
E
T
Q
L
Y
DKGVKGGTY
P
R
R
Y
H
V
S
V
HHKDYSDG
R
R
T
F
P
R
I
R
R
HQG
N
L
F
T
LVPSSRSLSTNGENM
G
L
A
V
Q
Y
LDPRGRLRSADSENA
L
S
V
Q
ERNVPTKSPSAPINWRRG
K
L
LGQGAF
G
R
V
Y
L
C
Y
DVDT
G
R
E
L
A
S
K
Q
V
-
Q
FDPDSPE-TSKE
V
S
A
L
E
C
E
I
Q
L
L
K
NL-
Q
H
E
R
-
I
V
Q
Y
Y
G
C
-
L
R
D
RA-----
E
K
T
L
T
I
F
M
EYMPGG
S
V
K
D
-
Q
L
K
A
-
Y
--
G
----
A
L
--
T
E
-
S
V
T
R
K
Y
T
R
Q
I
L
E
G
M
S
Y
L
H
S-N
M
I
V
H
RDIKG
A
N
I
LRDS-A---G-N---
V
K
LGDFGAS-
K
R
L
Q
T
I
CMSGTGMR-SVTGTPYWMSPEVIS-----G--E-----G-----YGRKA
D
V
W
S
L
G
C
T
V
V
E
M
L
TEKPP
W
---
A
E
Y
--
E
A
M
A
A
I
F
-----------
K
IA-T--QPT-N--PQ
L
--
P
S
-
H
I
S
E
H
G
R
D
F
L
R
R
I
F
---
V
-
E
-
A
------RQRP
S
A
E
E
L
L
T
H
H
F
A
Q
L
MY
25
PsiBlast_CBE
78.27
40%
-78
- C1 -
4BID
1
B:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
26
PsiBlast_CBE
76.93
40%
-76
- C1 -
4BIC
2
B:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
-------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-
8
PsiBlast_PDB
75.99
40%
-75
- C1 -
4BID
1
M3K5_HUMAN
A:
[26-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
-----------
E
-
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
27
PsiBlast_CBE
75.97
40%
-76
- C1 -
4BIB
1
B:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
4
PsiBlast_PDB
75.93
40%
-73
- C1 -
4BF2
2
M3K5_HUMAN
A:
[42-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
----------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
---------
E
-
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
21
PsiBlast_CBE
75.75
40%
-74
- C1 -
4BHN
2
B:
[42-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
----
9
PsiBlast_PDB
75.37
40%
-77
- C1 -
4BIE
2
M3K5_HUMAN
A:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
G
----------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
7
PsiBlast_PDB
75.25
40%
-76
- C1 -
4BIC
2
M3K5_HUMAN
A:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
G
----------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
24
PsiBlast_CBE
75.13
40%
-73
- C1 -
4BIE
2
B:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R-------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-
23
PsiBlast_CBE
74.68
40%
-75
- C1 -
2CLQ
1
B:
[29-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
22
PsiBlast_CBE
74.19
40%
-72
- C1 -
4BF2
1
B:
[42-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R---------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
-------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
125
HHSearch
74.15
35%
-78
* C1 *
4OBO
2
M4K4_HUMAN
A:
[23-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
T
------------
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
-
I
A
T
Y
Y
G
A
-
F
I
K
K
S
-----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
---------------
R
N
-
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
CDENP
D
--
A
-----
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
P
-
R
--
N
P
P
-
P
--
R
L
K
--
S
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
---
V
K
N
-
Y
------
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
5
PsiBlast_PDB
73.25
40%
-76
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[29-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
L
A
G
--------
E
-
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
133
HHSearch
73.16
31%
-74
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[32-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
I
K
-----
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
-
N
S
P
Y
-
I
V
G
F
Y
G
A
-
F
Y
S
-------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
-
V
L
K
K
-
A
--
G
----
R
I
--
P
E
-
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
---
G
-
E
---
I
K
L
C
D
F
G
V
S
-
G
Q
L
I
D
S
-----
M
A
----
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
--
T
-----
H
-----
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
---
P
P
P
D
A
K
E
L
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
-
N
--
E
P
--
P
--
P
K
L
--
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
---
I
K
N
-
P
------
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
52
PsiBlast_CBE
73.10
37%
-75
- C1 -
5AJQ
2
STK10_HUMAN
A:
[18-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
---------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
MKDTP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
6
PsiBlast_PDB
72.66
40%
-68
- C1 -
4BIB
3
M3K5_HUMAN
A:
[26-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
-
I
V
Q
Y
L
G
S
-
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
-
L
L
R
S
K
W
--
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
-
V
---
L
K
I
S
D
F
G
T
S
-
K
R
-----------
E
-
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
-----
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G-
E
P
Q
A
A
M
F
-----------
K
V
G
-
M
--
F
K
V
-
H
--
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
---
E
P
D
-
P
------
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
108
PsiBlast_CBE
72.60
32%
-85
- C1 -
3HX4
3
?
A:
[52-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
--------
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
56
PsiBlast_CBE
71.51
36%
-69
- C1 -
4USF
1
?
B:
[18-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
-
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
-
F
Y
--
Y
-----
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-
E
--
R
----
P
L
--
T
E
-
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
-
D
---
I
K
L
A
D
F
G
V
S
A
K
N
--------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
SKDRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
E
P
P
-
T
--
L
A
Q
--
P
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
EKN
V
-
D
-
A
------
R
W
T
T
S
--
Q
L
L
Q
H
P
F
V
T
V
D
S
57
PsiBlast_CBE
70.66
36%
-68
- C1 -
4USF
1
?
A:
[18-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
-
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
-
F
Y
--
Y
-----
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-
E
--
R
----
P
L
--
T
E
-
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
-
D
---
I
K
L
A
D
F
G
V
S
A
K
------------------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
------RP---
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
E
P
P
-
T
--
L
A
Q
--
P
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
EKN
V
-
D
-
A
------
R
W
T
T
S
--
Q
L
L
Q
H
P
F
V
T
V
D
S
49
PsiBlast_CBE
69.07
37%
-70
- C1 -
4AOT
1
STK10_HUMAN
B:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
T
K
-
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
---------------P----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
69
PsiBlast_CBE
68.97
33%
-63
- C1 -
4B6L
1
PLK3_HUMAN
A:
[10-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
-
Q
R
E
K
I
L
N
---
E
I
E
L
H
R
D
L
-
Q
H
R
H
-
I
V
R
F
S
H
H
-
F
E
D
-------
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
-
I
W
K
A
-
R
--
H
----
T
L
--
L
E
-
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
-
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
-
N
---
M
-
E
---
L
K
V
G
D
F
G
L
A
-
A
R
L
E
P
---
P
E
Q
R
K
K
-
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
-----
R
--
Q
-----
G
-----
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
----
E
T
--
A
D
L
K
E
T
Y
-----------
R
C
I
-
K
--
Q
-
V
-
H
--
Y
T
L
--
P
A
-
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R--
A
-
S
-
P
------
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
94
PsiBlast_CBE
68.86
34%
-70
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[30-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-----------------
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
PPG
H
-
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
----------------N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPD
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
35
PsiBlast_CBE
68.80
36%
-79
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[23-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
-
T
-------
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
------------
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
33
PsiBlast_CBE
68.74
36%
-77
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-------
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
93
PsiBlast_CBE
68.67
34%
-72
- C1 -
4U43
1
M4K4_HUMAN
A:
[30-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-------
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
PPG
H
-
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
----------------N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPDA
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
36
PsiBlast_CBE
68.65
36%
-78
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[23-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
-
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
-
T
-------
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
50
PsiBlast_CBE
68.53
37%
-71
- C1 -
4AOT
1
STK10_HUMAN
A:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
T
K
-
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
39
PsiBlast_CBE
68.50
36%
-72
- C1 -
4O0R
1
PAK1_HUMAN
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
12
PsiBlast_PDB
68.47
36%
-76
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
-------
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
78
PsiBlast_CBE
68.46
32%
-75
- C1 -
3V5P
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
110
PsiBlast_CBE
68.44
32%
-74
- C1 -
3MA6
1
?
A:
[38-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
-----
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
40
PsiBlast_CBE
68.43
36%
-80
- C1 -
4P90
1
PAK1_HUMAN
B:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
-----------
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
---------------
S
K
R
S
-
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
77
PsiBlast_CBE
68.42
32%
-74
- C1 -
3V5T
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
95
PsiBlast_CBE
68.35
34%
-66
- C1 -
4OBP
2
M4K4_HUMAN
A:
[30-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-------
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
-----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
S
-
A
-------------N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPDA
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
79
PsiBlast_CBE
68.28
32%
-73
- C1 -
3V51
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
46
PsiBlast_CBE
68.08
37%
-74
- C1 -
4USD
1
?
B:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
T
K
-
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
--------------------
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
13
PsiBlast_PDB
67.99
36%
-74
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
------
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
80
PsiBlast_CBE
67.81
32%
-75
- C1 -
3UPZ
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
91
PsiBlast_CBE
67.78
34%
-67
- C1 -
4U45
1
M4K4_HUMAN
A:
[30-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-------
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
PP---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
S
-
A
-------------N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPD
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
85
PsiBlast_CBE
67.70
32%
-74
- C1 -
3SX9
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
103
PsiBlast_CBE
67.49
34%
-71
- C1 -
4RVT
2
M4K4_HUMAN
A:
[32-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-------
T
----
E
E
I
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
P
PG
H
-
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
----------------N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPD
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
31
PsiBlast_CBE
67.21
36%
-75
- C1 -
4ZJI
1
?
D:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
------
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
--
A
Q
---
I
T
---
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
76
PsiBlast_CBE
67.18
32%
-71
- C1 -
4JBV
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
92
PsiBlast_CBE
67.13
34%
-64
- C1 -
4U44
2
M4K4_HUMAN
A:
[30-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-------
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
H----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
S
-
A
--------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPDA
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
72
PsiBlast_CBE
67.03
32%
-72
- C1 -
4WG3
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
102
PsiBlast_CBE
67.01
32%
-78
- C1 -
3KU2
1
?
A:
[51-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
101
PsiBlast_CBE
66.86
32%
-72
- C1 -
4IFG
1
?
A:
[51-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
82
PsiBlast_CBE
66.79
32%
-72
- C1 -
3T3V
2
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
81
PsiBlast_CBE
66.50
32%
-71
- C1 -
3UPX
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
29
PsiBlast_CBE
66.48
36%
-77
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
-
N
L
Q
----
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
-------
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
-----------
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
--------------
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
75
PsiBlast_CBE
66.45
32%
-73
- C1 -
4M84
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
100
PsiBlast_CBE
66.42
32%
-75
- C1 -
4IHP
1
?
A:
[51-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
30
PsiBlast_CBE
66.38
36%
-74
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
-------
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
71
PsiBlast_CBE
66.34
32%
-72
- C1 -
4WG4
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
73
PsiBlast_CBE
66.30
32%
-73
- C1 -
4TZR
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
18
PsiBlast_PDB
66.20
36%
-71
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[23-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
-------
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
-
T
-------
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
89
PsiBlast_CBE
66.14
34%
-65
- C1 -
4ZK5
2
?
A:
[30-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
V
-------
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
-
F
I
K
K
S
P
PG
H
-
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
-
T
KG
N
----
T
L
--
K
E
-
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
-
E
---
V
K
L
V
D
F
G
V
S
-
A
-------------N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
-----
C
--
D
ENPDA
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
--
H
P
M
R
A
L
F
-----------
L
I
------
P
R
-
N
--
P
----
P
P
-
R
L
K
S
K
K
W
S
K
K
F
F
S
F
---
I
-
E
-
G
C
L
VKNY
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
70
PsiBlast_CBE
66.08
32%
-70
- C1 -
4WG5
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
87
PsiBlast_CBE
65.87
32%
-74
- C1 -
3I7B
4
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
37
PsiBlast_CBE
65.78
36%
-74
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[23-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
-
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
-
T
-------
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
28
PsiBlast_CBE
65.73
36%
-78
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
-
N
L
----
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
--
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
--------
P
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
19
PsiBlast_PDB
65.70
36%
-71
- C1 -
4EQC
1
PAK1_HUMAN
A:
[26-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
86
PsiBlast_CBE
65.69
32%
-73
- C1 -
3N51
3
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
74
PsiBlast_CBE
65.61
32%
-70
- C1 -
4ONA
1
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
83
PsiBlast_CBE
65.38
32%
-70
- C1 -
3T3U
5
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
54
PsiBlast_CBE
65.36
37%
-66
- C1 -
4O27
1
STK24_HUMAN
B:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--------
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
----
G
----
P
L
--
D
E
-
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
---
G
-
E
---
V
K
L
A
D
F
G
V
A
-
G
Q
L
T
D
---
T
Q
I
K
R
N
-
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
-----
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
--
H
P
M
K
V
L
F
-----------
L
I
------
P
K
-
N
NP
P
T
L
--
E
G
-
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N--
K
-
E
-
P
------
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
127
HHSearch
65.00
31%
-70
- C1 -
3C0I
1
CSKP_HUMAN
A:
[25-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-
D
V
A
K
F
T
S
S
-
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
-
I
V
E
L
L
E
T
-
Y
S
S
-------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
-
R
--
A
D
A
G
F
V
Y
--
S
E
-
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
---
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
---
S
G
L
V
A
G
-
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
-----
R
--
E
-----
P
-----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
---
Y
G
T
K
E
R
L
F
E
G
I
I
-----------
K
-
G
-
K
--
Y
K
M
-
N
--
P
R
Q
--
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
---
M
L
D
-
P
------
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
55
PsiBlast_CBE
64.91
37%
-74
- C1 -
4NZW
1
STK25_HUMAN
B:
[28-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
-
I
T
R
Y
F
G
S
-
Y
L
K
S
T
-----
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
K
P
----
G
----
P
L
--
E
E
-
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
---
G
-
D
---
V
K
L
A
A
F
G
V
A
-
G
------------------
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--------------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
--
H
P
M
R
V
L
F
-----------
L
I
------
P
K
-
N
--
S
P
---
P
T
-
L
E
G
Q
H
S
K
P
F
--
K
E
F
---
V
-
E
-
A
C
L
NKDP
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
51
PsiBlast_CBE
64.59
37%
-71
- C1 -
2J7T
1
STK10_HUMAN
A:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
----------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
----
Q
K
-----
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
38
PsiBlast_CBE
64.39
36%
-65
- C1 -
4O0T
1
PAK1_HUMAN
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
84
PsiBlast_CBE
64.35
32%
-70
- C1 -
3SXF
3
?
A:
[28-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
59
PsiBlast_CBE
63.86
36%
-66
- C1 -
2J51
5
SLK_HUMAN
A:
[39-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
-
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
-
F
Y
--
Y
-----
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-
E
--
R
----
P
L
--
T
E
-
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
-
D
---
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
----
Q
R
R
D
-
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
SKDRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
E
P
P
-
T
--
L
A
Q
--
P
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
EKN
V
-
D
-
A
------
R
W
T
T
S
--
Q
L
L
Q
H
P
F
V
T
V
D
S
32
PsiBlast_CBE
63.83
36%
-69
- C1 -
4ZJI
1
?
C:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
-
N
------
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
--------
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
136
HHSearch
63.70
33%
-62
- C1 -
4G3F
1
A:
[62-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
-
R
L
E
V
----------
F
R
-
V
E
E
L
V
A
C
A
G
L
-
S
S
P
R
-
I
V
P
L
Y
G
A
-
V
R
E
G
-------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
-
L
I
K
Q
-
M
--
G
----
C
L
--
P
E
-
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
-
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
---
G
S
R
---
A
A
L
C
D
F
G
H
A
-
L
C
L
----------
D
-
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
-----
G
--
K
-----
P
-----
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
Y
--
F
R
G
P
L
C
L
-----------
K
I
A
-
S
--
E
P
P
P
I
--
R
E
I
--
P
P
-
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R--
K
-
E
-
P
------
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
122
HHSearch
63.54
31%
-69
- C1 -
1ZY4
1
GCN2_YEAST
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
-
R
------
H
-
T
E
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
L
-
N
H
Q
Y
-
V
V
R
Y
Y
A
A
-
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
-
L
I
H
S
-
E
--
N
----
L
N
--
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
-
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
-
S
---
R
-
N
---
V
K
I
G
D
F
G
L
A
-
K
N
V
H
R
---------------
A
M
Y
V
A
T
E
V
L
D
-----
G
--
T
G----
H
-----
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
--
P
F
S
---
T
G
M
--
E
R
V
N
I
L
K
-----------
K
L
R
-
S
VS
I
E
F
-
P
--
P
D
F
--
D
D
-
N
K
M
K
V
E
K
K
I
I
R
L
L
I
---
D
H
D
-
P
------
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
53
PsiBlast_CBE
63.49
37%
-70
- C1 -
4BC6
2
STK10_HUMAN
A:
[13-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
T
K
-
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
----
Q
---------
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
44
PsiBlast_CBE
63.47
37%
-71
- C1 -
4USE
1
?
B:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
----------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
------------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
----
Q
K
-------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
M
K
DT
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
58
PsiBlast_CBE
63.34
36%
-66
- C1 -
2UV2
6
SLK_HUMAN
A:
[39-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
-
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
-
F
Y
--
Y
-----
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-
E
--
R
----
P
L
--
T
E
-
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
-
D
---
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
----
Q
R
R
D
-
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
SKDRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
E
P
P
-
T
--
L
A
Q
--
P
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
EKN
V
-
D
-
A
------
R
W
T
T
S
--
Q
L
L
Q
H
P
F
V
T
V
D
S
45
PsiBlast_CBE
63.06
37%
-67
- C1 -
4USE
1
?
A:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
-----
T
K
-
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
----
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
47
PsiBlast_CBE
62.96
37%
-67
- C1 -
4EQU
2
STK10_HUMAN
B:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
----------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
-------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
121
HHSearch
62.78
31%
-70
- C1 -
2W5A
5
NEK2_HUMAN
A:
[3-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
Y
G
S
M
----
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
-
I
V
R
Y
Y
D
R
-
I
I
D
R
T
-----
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
-
V
I
T
K
-
G
--
T
K
E
R
Q
Y
L
--
D
E
-
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
---
Q
-
N
---
V
K
L
G
D
F
G
L
A
-
R
I
L
------
T
S
F
A
K
-
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-----
R
--
M
-----------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
--
S
Q
K
E
L
A
G
-----------
K
I
R
-
E
--
G
-
K
-
F
--
R
R
I
--
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N--
L
-
K
-
D
------
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
98
PsiBlast_CBE
62.58
32%
-63
- C1 -
4MXA
1
?
A:
[29-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-----
Y
Y
Y
L
V
--
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
109
PsiBlast_CBE
62.55
32%
-71
- C1 -
3MA6
1
?
B:
[38-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
--
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
17
PsiBlast_PDB
62.34
36%
-70
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[23-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
-
T
-------
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
F
C
-
A
Q
---
I
T
P
E
Q
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
99
PsiBlast_CBE
61.98
32%
-63
- C1 -
4MX9
1
?
A:
[29-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
V
K
Q
K
-
T
D
K
E
--
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
-
I
M
K
L
Y
E
F
-
F
E
D
K
G
-----
Y
Y
Y
L
V
--
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
-
R
--
K
----
R
F
--
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
SKD
A
-
N
---
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
--
T
-----------
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
NGA
N
E
Y
--
D
I
L
K
K
V
E
-----------
K
G
K
-
Y
--
T
F
E
-
L
--
P
Q
W
--
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
---
T
-
Y
-
V
P-----
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
67
PsiBlast_CBE
61.94
35%
-73
- C1 -
4FZD
1
STK26_HUMAN
B:
[16-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
-
Y
L
K
G
S
-----
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
----
G
----
P
F
--
D
E
-
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
---
G
-
D
---
V
K
L
A
A
F
G
V
A
-
G
Q
L
T
---------
N
-
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
-----
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
--
H
P
M
R
V
L
F
-----------
L
I
P
-
K
--
N
---
N
--
P
----
P
T
-
L
V
G
D
F
T
K
S
F
--
K
E
F
---
I
-
D
-
A
C
L
NKDP
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
48
PsiBlast_CBE
61.63
37%
-67
- C1 -
4EQU
2
STK10_HUMAN
A:
[21-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
------------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
-
Y
Y
H
D
G
-----
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
--
R
----
G
L
--
T
E
-
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
---
G
-
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
--------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
-----
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
--
N
P
M
R
V
L
L
-----------
K
I
A
K
S
--
D
P
P
-
T
--
L
L
T
--
P
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
---
D
-
K
N
P
------
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
65
PsiBlast_CBE
60.82
35%
-69
- C1 -
3GGF
1
STK26_HUMAN
A:
[31-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
-
Y
L
K
G
S
-----
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
----
G
----
P
F
--
D
E
-
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
---
G
-
D
---
V
K
L
A
D
F
G
V
A
-------------
R
N
-
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
-----
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
--
H
P
M
R
V
L
F
-----------
L
I
P
-
K
--
N
---
N
--
P
----
P
T
-
L
V
G
D
F
T
K
S
F
--
K
E
F
---
I
-
D
-
A
C
L
NKDP
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
68
PsiBlast_CBE
60.65
35%
-66
- C1 -
4FZA
3
STK26_HUMAN
B:
[16-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
-
Y
L
K
G
S
-----
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
----
G
----
P
F
--
D
E
-
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
---
G
-
D
---
V
K
L
A
A
F
G
V
A
-
G
Q
L
T
D
T
Q
I
K
---
R
N
-
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
-----
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
--
H
P
M
R
V
L
F
-----------
L
I
P
-
K
--
N
---
N
--
P
----
P
T
-
L
V
G
D
F
T
K
S
F
--
K
E
F
---
I
-
D
-
A
C
L
NKDP
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
64
PsiBlast_CBE
60.65
35%
-69
- C1 -
3GGF
1
STK26_HUMAN
B:
[31-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
-
Y
L
K
G
S
-----
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
----
G
----
P
F
--
D
E
-
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
---
G
-
D
---
V
K
L
A
D
F
G
V
A
--------------
N
-
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
-----
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
--
H
P
M
R
V
L
F
-----------
L
I
P
-
K
--
N
---
N
--
P
----
P
T
-
L
V
G
D
F
T
K
S
F
--
K
E
F
---
I
-
D
-
A
C
L
NKDP
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
66
PsiBlast_CBE
60.18
35%
-65
- C1 -
4FZF
1
?
B:
[16-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
-----
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
-
Y
L
K
G
S
-----
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
----
G
----
P
F
--
D
E
-
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
---
G
-
D
---
V
K
L
A
A
F
G
V
A
-
G
Q
L
T
D
T
Q
I
K
---
R
N
-
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
-----
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
--
H
P
M
R
V
L
F
-----------
L
I
P
-
K
--
N
---
N
--
P
----
P
T
-
L
V
G
D
F
T
K
S
F
--
K
E
F
---
I
-
D
-
A
C
L
NKDP
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
14
PsiBlast_PDB
47.79
36%
-32
- C1 -
4ZLO
2
?
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
------
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
-
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
----
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
-
S
---
V
K
L
T
D
F
G
-------------
S
K
R
S
-
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
-----
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
--
N
P
L
R
A
L
Y
-----------
L
I
A
-
T
--
N
G
T
----
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E--
M
-
D
-
V
------
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K