@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K4_HUMAN: (2015-10-12 )
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
Atome Classification :
(54 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350.......1360......1370.-.....1380.....-.---1390......1400......1410......1420.....----.1430--.-----.--.-..---...1440......1450......1460......1470.......1480......1490...--...1500-.......1510..--....1520......1530......1540..---....1550......----------------1560....--...1570....----------..1580......1590......1600.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MREAAAALVPPPA
F
A
VTP
A
A
AMEEPPPPPPPPPPPPEPETESE
P
E
C
C
L
A
ARQEGTLGDSACKSP
E
S
D
L
E
DFSDETNTENLYGTSPPS
T
P
R
Q
M
K
R
M
S
T
K
H
QRNNVGRPA
S
R
S
N
L
K
E
K
MNAPNQPPHKDTG
K
T
V
E
N
V
E
E
Y
S
Y
K
Q
E
K
K
I
R
A
A
L
RT
T
E
R
D
R
KKN
V
Q
C
S
F
M
L
D
SVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDC
P
A
D
R
L
K
F
F
E
T
L
R
L
L
L
K
L
T
SVS
K
K
K
D
R
E
QRGQENT
S
G
F
W
LNRSN
E
L
I
W
L
E
L
Q
AWHAGRTINDQ
D
F
F
L
Y
T
A
R
Q
A
I
P
D
I
I
N
E
I
L
T
F
K
VDYG
S
F
A
F
V
RDRAGFNGTSVE
G
Q
C
KATPG
T
K
I
V
G
YS
T
H
H
E
H
L
Q
R
QRV
S
F
E
Q
V
K
R
I
M
E
L
L
E
Y
I
E
A
L
Y
P
S
L
Q
A
L
Q
K
D
Y
E
K
Y
A
A
K
D
F
Q
D
R
V
Q
A
L
C
L
W
L
N
I
T
K
D
L
N
Q
K
L
R
I
M
G
T
VLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTE
G
E
L
K
E
L
ESSTDE
S
E
E
EQISDPRV
P
E
I
RQPIDNSFDIQ
S
R
D
C
I
S
K
K
L
E
R
L
ESEDDSLGWGAPDWSTEAGF
S
R
H
C
L
T
S
I
Y
R
P
F
V
D
K
A
L
K
Q
M
G
L
R
K
L
I
L
R
L
H
K
LMDGSL
Q
R
A
R
I
A
L
V
KNDRPVEFSEFPDPMWGSD
Y
V
Q
L
SRTPPSSEEKCSAV
S
W
E
E
L
KAMDLPSFE
P
A
F
L
V
L
C
R
V
L
L
N
V
I
H
E
C
L
K
L
R
L
EQRPAGE
P
S
L
L
S
I
K
Q
L
V
R
E
C
K
E
V
L
KG
G
L
L
M
K
Q
Y
Y
Q
F
M
L
Q
E
V
L
E
D
L
EKPDCN
I
D
A
F
E
E
D
L
H
K
M
L
M
V
Y
F
D
Y
M
R
S
W
I
Q
M
L
Q
Q
L
P
Q
A
S
H
S
L
K
N
L
L
E
E
EW
N
F
T
K
E
I
T
H
Y
I
RGGEAQ
A
G
K
L
F
C
D
I
A
G
M
L
L
K
ST
G
S
F
L
E
F
G
L
Q
E
S
C
A
E
F
W
TSADDSS
A
S
D
E
I
R
R
S
V
I
E
I
S
R
A
L
K
E
L
F
H
E
A
R
E
R
A
S
K
A
L
G
F
A
K
M
L
R
K
D
L
E
I
A
A
E
FRLSA
P
V
R
D
L
L
D
V
LKSK
Q
Y
V
K
V
QIPGLE
N
L
Q
M
FVPD
T
L
A
E
E
K
S
I
I
L
Q
L
L
N
A
AAGKDCSKDSD
D
V
L
I
D
A
Y
L
L
L
TKHGDRARDSEDSWGTWEAQ
P
V
K
V
V
PQ
V
E
T
V
D
T
L
R
S
M
Q
V
D
N
L
L
L
V
V
M
QSAHL
T
I
Q
R
K
A
F
Q
Q
S
I
E
G
L
M
T
L
C
Q
EQTSSQ
P
V
I
A
K
A
L
Q
Q
L
K
N
D
A
L
E
L
C
N
R
I
S
N
A
I
D
R
V
D
H
M
F
TSEFDAEVDESES
V
T
L
Q
Q
Y
Y
R
E
A
M
I
Q
GYNF
G
F
E
Y
H
K
E
V
V
R
L
M
S
G
E
F
R
Q
K
I
G
D
K
Y
I
S
F
A
R
K
W
M
N
Y
V
L
T
KCESGRGTRPRWATQ
G
F
D
F
L
Q
A
I
E
P
A
F
I
S
ALPE
D
D
F
L
S
L
Q
A
L
M
N
E
C
I
G
H
V
IGKPHSPV
T
G
L
Y
L
A
I
HRNSPRPMKVPRCHSDPPN
P
H
L
I
I
PTPEGFSTRSMPS
D
A
RSHGS
P
A
A
A
A
A
A
A
A
A
A
V
AASRPSPSGGDSVL
P
K
S
I
S
SAHDTRGSSVPEN
D
R
L
A
S
I
A
A
E
L
Q
F
R
S
LSRHSSPTEERDEPAYPRGDSSGST
R
R
S
W
E
L
R
T
L
I
SQSKD
T
A
SKLG
P
I
E
A
I
Q
K
S
V
R
L
F
E
E
K
R
Y
R
E
M
R
R
K
N
I
I
G
QVCDTPKS
Y
D
N
V
M
H
VG
L
R
K
V
T
F
K
WQRGNKIGE-GQY
G
K
V
Y
T
C
I
SVDT
G
E
L
M
A
M
K
E
I-RFQPNDH
K
T
I
K
E
T
A
-
D
---
E
L
K
I
F
EGIKHP
N
L
V
R
Y
FG
V
E
L
H
R
E
E
M
Y
I
F
M
E
YCDEG
T
L
E
----
E
V
-
S
---R-----L--
G
-
L
Q
---
E
H
V
I
R
L
YSK
Q
I
T
I
A
I
N
V
L
H
EHGI
V
H
R
DIKG
A
N
I
F
L
-TSSG
L
I
K
LGDF
G
C
S
V
K
LKNNAQTMP--GEVNST--LG
T
A
A
Y
M
A
P
E
V
I
T
--RAKGEGHGR
A
A
D
I
W
S
L
G
C
V
V
I
E
MVTGKR
P
W
---
H
E
YEH
N
F
Q
I
M
Y
K
VG----------------MGH-KPPI--PERLSPE
G
K
D
F
----------
L
S
H
C
L
ESDPK
M
R
W
T
A
S
Q
L
L
D
H
S
F
V
K
VCTDEE
36
PsiBlast_CBE
74.20
35%
-61
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
Q
-
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
6
PsiBlast_PDB
74.16
36%
-66
- C2 -
4USF
1
?
A:
[18-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
S
E
E
E
L
E
-
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
-
M
L
E
L
E
-----
R
--
P
-
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
---------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E----
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
E
-
P
P
T
L
AQ
P
S
R
W
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
13
PsiBlast_PDB
73.82
35%
-60
- C2 -
3FXZ
1
?
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
--
E
Q
S
K
R
S
TM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
8
PsiBlast_PDB
73.45
35%
-61
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
----
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
-------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
7
PsiBlast_PDB
72.08
35%
-61
- C2 -
4ZJI
1
PAK1_HUMAN
A:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
-----
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
50
PsiBlast_CBE
71.86
34%
-67
- C2 -
5AJQ
2
STK10_HUMAN
A:
[18-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
---
E
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
K
T
---------
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
37
PsiBlast_CBE
71.50
35%
-62
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
Q
-
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
11
PsiBlast_PDB
70.62
35%
-59
- C2 -
4EQC
1
PAK1_HUMAN
A:
[25-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
--
E
Q
S
K
R
S
TM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
1
PsiBlast_PDB
70.46
40%
-66
- C2 -
4BF2
2
M3K5_HUMAN
A:
[43-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
-----------
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
--------
E
E
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------
31
PsiBlast_CBE
70.20
35%
-62
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
-----
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
-------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
34
PsiBlast_CBE
70.15
35%
-61
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-----
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
25
PsiBlast_CBE
70.10
40%
-65
- C2 -
4BIC
2
B:
[27-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
----
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
-----------
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----
47
PsiBlast_CBE
70.02
34%
-64
- C2 -
4AOT
1
STK10_HUMAN
B:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
E
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
-------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
23
PsiBlast_CBE
69.67
40%
-61
- C2 -
4BIE
2
B:
[27-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
-------
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
----------
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----
14
PsiBlast_PDB
69.59
35%
-59
- C2 -
3FY0
1
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
--
E
Q
S
K
R
S
TM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
18
PsiBlast_PDB
69.27
35%
-58
- C2 -
4O0R
1
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
--
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
57
PsiBlast_CBE
68.98
32%
-71
* C2 *
4NZW
1
STK25_HUMAN
B:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
I
G
K
-
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
-
D
L
E
-
E
A
E
D
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
-
L
---
K
-----
P
--
G
P
L
E
---
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
----------------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
-
H
P
M
R
V
L
F
L
I
P
----------------
K
N
S
-
P
P
T
L
--
E
G
Q
H
S
K
P
F
K
E
F
----------
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
22
PsiBlast_CBE
68.81
40%
-64
- C2 -
4BF2
1
B:
[43-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
----------
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
-----------
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
48
PsiBlast_CBE
68.48
34%
-64
- C2 -
4AOT
1
STK10_HUMAN
A:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
E
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
---------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
3
PsiBlast_PDB
68.34
40%
-63
- C2 -
4BIC
2
M3K5_HUMAN
A:
[27-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
-----
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
S
KWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
G
--------
E
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
17
PsiBlast_PDB
68.25
35%
-56
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
28
PsiBlast_CBE
68.03
36%
-57
- C2 -
4USF
1
?
B:
[18-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
S
E
E
E
L
E
-
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
-
M
L
E
L
E
-----
R
--
P
-
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
---
N
------------
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
E
-
P
P
T
L
AQ
P
S
R
W
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
4
PsiBlast_PDB
67.80
40%
-59
- C2 -
4BID
1
M3K5_HUMAN
A:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
--------
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------
5
PsiBlast_PDB
67.64
40%
-63
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[30-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
D
S
---
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
G
-------
E
T
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
35
PsiBlast_CBE
67.58
35%
-60
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
--------------
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
26
PsiBlast_CBE
67.38
40%
-60
- C2 -
4BIB
1
B:
[27-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
----
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
S
KWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
56
PsiBlast_CBE
67.21
31%
-53
- C2 -
4AGU
1
CDKL1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
K
I
G
K
I
G
E
-
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
--
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
---
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
----
E
L
-
D
---
R
-----
Y
Q
R
G
-
V
P
---
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
-
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
--------------------
R
W
Y
R
S
P
E
L
L
----
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
PGK
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
DLI
P
R
H
Q
Q
V
F
S
T
NQYF
S
G
V
-
K
I
P
D
--
P
E
D
M
E
P
L
E
L
K
F
PNIS
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
---
21
PsiBlast_CBE
67.05
40%
-58
- C2 -
4BHN
2
B:
[43-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
----
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
----------
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-------
24
PsiBlast_CBE
66.91
40%
-57
- C2 -
4BID
1
B:
[27-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
----
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
16
PsiBlast_PDB
66.40
35%
-59
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
------
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
55
PsiBlast_CBE
66.02
31%
-55
- C2 -
4AGU
1
CDKL1_HUMAN
B:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
K
I
G
K
I
G
E
-
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
--
L
E
S
--
D
P
V
I
K
K
I
A
L
R
---
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
----
E
L
-
D
---
R
-----
Y
Q
R
G
-
V
P
---
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
-
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
--------------------
R
W
Y
R
S
P
E
L
L
----
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
PGK
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
DLI
P
R
H
Q
Q
V
F
S
T
NQYF
S
G
V
-
K
I
P
D
--
P
E
D
M
E
P
L
E
L
K
F
PNIS
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
--
27
PsiBlast_CBE
65.64
40%
-64
- C2 -
2CLQ
1
B:
[30-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
R
----
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
SKWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---
A
----------
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
44
PsiBlast_CBE
65.48
34%
-66
- C2 -
4USD
1
?
B:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
E
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
-----------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C-------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
58
PsiBlast_CBE
65.46
31%
-53
- C2 -
4O27
1
STK24_HUMAN
B:
[13-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
-
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
A
E
D
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
-
L
---
E
-----
P
--
G
P
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
------
K
R
N
E
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
----
H
S
E
L
H
P
M
K
V
L
F
L
I
P
----------------
K
N
N
-
P
P
T
L
--
E
G
N
Y
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
54
PsiBlast_CBE
65.19
31%
-53
- C2 -
4AGU
1
CDKL1_HUMAN
C:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
K
I
G
K
I
G
E
-
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
--
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
---
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
----
E
L
-
D
---
R
-----
Y
Q
R
G
-
V
P
---
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
-
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
--------------------
R
W
Y
R
S
P
E
L
L
----
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
PGK
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
DLI
P
R
H
Q
Q
V
F
S
T
NQYF
S
G
V
-
K
I
P
D
--
P
E
D
M
E
P
L
E
L
K
F
PNIS
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
---
2
PsiBlast_PDB
65.06
40%
-60
- C2 -
4BIB
3
M3K5_HUMAN
A:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
-
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
---
P
E
--------
L
H
-
E
---
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
----
A
L
-
L
---
R
S
KWGP
L
--
K
-
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
----------------
M
F
K
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------
19
PsiBlast_PDB
64.93
35%
-54
- C2 -
4O0T
1
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
Q
Q
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
--
E
Q
S
K
R
S
EM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
40
PsiBlast_CBE
64.40
34%
-62
- C2 -
4P90
1
PAK1_HUMAN
B:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
-----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
-----------
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
-------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
30
PsiBlast_CBE
63.92
35%
-59
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
-
N
L
Q
---
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-------------EQ
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
-------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
32
PsiBlast_CBE
63.06
35%
-57
- C2 -
4ZJI
1
?
D:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-----
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
-------
A
Q
I
T
---
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
29
PsiBlast_CBE
59.78
35%
-62
- C2 -
4ZJJ
1
PAK1_HUMAN
D:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
-
N
L
---
P
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
----------
P
E
Q
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
59
PsiBlast_CBE
59.75
31%
-57
- C2 -
3COK
1
PLK4_HUMAN
A:
[13-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
V
G
N
L
L
G
K
-
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
-
N
---
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
----
R
Y
-
L
---
K
-----
N
--
R
-
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
-
T
R
N
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
-----------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
D
T
D
T
V
K
-----
V
V
----------------
L
A
--
D
Y
E
M
--
P
S
F
L
S
I
E
A
K
D
L
----------
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
------
33
PsiBlast_CBE
58.70
35%
-53
- C2 -
4ZJI
1
?
C:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
-
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-----
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
-----
S
K
R
S
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
46
PsiBlast_CBE
57.84
34%
-58
- C2 -
4EQU
2
STK10_HUMAN
A:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
------
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
------
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
--------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
49
PsiBlast_CBE
57.69
34%
-59
- C2 -
2J7T
1
STK10_HUMAN
A:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
----
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
K
T
L
Q
--
K
-------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
45
PsiBlast_CBE
57.49
34%
-58
- C2 -
4EQU
2
STK10_HUMAN
B:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
----
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
-----------
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
9
PsiBlast_PDB
53.23
36%
-51
- C2 -
2J51
5
SLK_HUMAN
A:
[39-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
S
E
E
E
L
E
-
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
-
M
L
E
L
E
-----
R
--
P
-
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
---
N
T
R
T
I
Q
--
R
R
-
D
S
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
E
-
P
P
T
L
AQ
P
S
R
W
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
20
PsiBlast_PDB
53.12
37%
-49
- C2 -
2UV2
6
SLK_HUMAN
A:
[42-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
L
G
D
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
------
D
T
K
S
E
E
E
L
E
-
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
-
M
L
E
L
E
-----
R
--
P
-
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
---
N
T
R
T
-
I
--
Q
R
R
D
S
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
E
-
P
P
T
L
AQ
P
S
R
W
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
60
PsiBlast_CBE
52.85
31%
-54
- C2 -
4YUR
1
PLK4_HUMAN
A:
[15-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
V
G
N
L
L
G
K
-
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
-
N
---
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
----
R
Y
-
L
---
K
-----
N
--
R
-
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
-
T
R
N
M
N
I
K
I
A
D
F
----------------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-------
T
V
K
N
T
L
N
K
V
V
----------------
L
A
--
D
Y
E
M
--
P
S
F
L
S
I
E
A
K
D
L
----------
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
------
61
PsiBlast_CBE
52.62
31%
-57
- C2 -
4JXF
2
PLK4_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
V
G
N
L
L
G
K
-
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
-
N
---
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
----
R
Y
-
L
---
K
-----
N
--
R
-
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
-
T
R
N
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
-----
M
P
--
H
E
-------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
--------
V
K
N
T
L
N
K
V
V
----------------
L
A
--
D
Y
E
M
--
P
S
F
L
S
I
E
A
K
D
L
----------
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
-----
43
PsiBlast_CBE
52.28
34%
-50
- C2 -
4USE
1
?
A:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
E
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
K
T
L
Q
------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
42
PsiBlast_CBE
50.54
34%
-52
- C2 -
4USE
1
?
B:
[21-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
----
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
K
T
L
Q
--
K
---------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
51
PsiBlast_CBE
49.73
34%
-53
- C2 -
4BC6
2
STK10_HUMAN
A:
[13-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
-
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
---
E
T
K
S
E
E
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-
D
---
R
--------
G
-
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
---
N
L
K
T
L
Q
-------------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
L
K
I
A
----------------
K
S
D
-
P
P
T
L
LT
P
S
K
W
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
10
PsiBlast_PDB
37.86
35%
-23
- C2 -
4ZLO
2
?
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
R
F
E
K
I
G
Q
---
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-----
K
K
E
L
--
I
I
-
N
---
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
----
D
V
V
T
---
E
-----
T
--
C
-
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-----------------
S
K
R
S
TM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
----------------
T
N
G
-
T
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S