@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K5_HUMAN: (2015-10-12 )
MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
Atome Classification :
(68 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710-.-.......720----........730.......740.......750.......760.....-------.-------.770.......780.......790....-...800.......810..--.....820.......830---.........840.......850--........860.......870.......880-........-890...----....900-..---.---.---------...-..910..---.....920.......930.......940.......950...-....960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTEADE
G
I
T
F
SVPPFAPSG
F
C
TIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGS
R
R
T
T
V
A
Y
V
INEASQG
Q
L
V
V
A
E
S
E
A
L
Q
S
L
R
E
A
C
E
T
V
G
A
T
L
E
T
L
H
FGKLDFG
E
T
T
V
L
D
R
FYNA
D
I
A
V
V
E
M
S
D
AFRQP
S
L
F
Y
H
LGV
R
E
S
FSMAN
N
I
I
L
Y
CDTN
S
D
S
L
Q
S
L
K
E
I
I
CQKNTMCTG
N
Y
T
F
V
P
Y
M
ITPH
N
K
V
Y
CC
D
S
S
F
M
K
G
L
T
E
L
MQPN
F
E
L
L
LG
P
I
C
L
P
L
V
D
R
F
I
Q
L
L
K
V
A
QAS
S
S
Q
Y
F
R
E
S
I
L
N
D
I
R
K
A
RNLYT
G
K
E
L
A
A
E
L
A
R
I
R
Q
R
VDN
I
E
V
L
T
A
D
I
V
I
N
L
L
L
S
Y
R
D
I
Q
D
Y
D
S
I
V
K
L
V
E
T
L
E
KLPTFDLASH
H
H
V
K
F
H
Y
A
F
A
LNRRNLPGDRA
K
A
L
D
I
M
I
P
MVQSEG
Q
V
A
S
D
M
Y
C
L
V
G
R
I
Y
K
D
M
FLDSNFTDTESRD
H
G
A
S
W
F
K
K
A
FESEP
T
L
Q
SGI
N
Y
A
V
L
L
L
AAGHQFESS
F
E
L
R
K
V
G
V
K
L
S
S
L
LGKKG
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
G
A
S
V
LAND
H
M
R
V
I
Q
AS
E
K
L
F
KLKT
P
A
W
Y
L
K
S
I
V
E
T
I
L
I
Y
K
H
F
V
K
LTTEQP
V
A
K
Q
E
L
V
D
F
W
M
D
F
L
V
E
ATKT
D
V
T
V
V
R
F
P
V
L
I
LEPTKIYQP
S
Y
L
SINNEVEE
K
T
I
S
I
W
H
VLPDDKKGIHEWNFSASSVRGV
S
I
S
K
F
EER
C
C
F
L
Y
V
L
HNSD
D
F
Q
I
Y
F
C
T
E
L
H
C
K
K
F
F
E
M
V
N
T
I
T
E
EKGRSTEEGD
C
E
S
D
L
L
E
YDYEYDENG
D
R
V
V
LGKG
T
Y
G
I
V
Y
AGRDLS
N
Q
V
R
I
A
I
K
EI--P-ERDSRYSQ
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
SFSEN
G
F
I
K
I
F
M
E
QVPG
G
S
L
S
A
L
L
R
-------S-------KWGPLKDNE
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
HD-N
Q
I
V
H
R
DIKG
D
N
V
L
I
N
TY--S
G
V
L
K
I
SDFGTSKRLA-----GINP
C
T
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I---DKGPRGYGKA
A
D
I
W
S
LG
C
T
I
I
EMATGKPPF--YELGEP
Q
A
-
A
M
F
K
V
G
----
M
F
K
VH---PE---I---
P
---------
E
SM-
S
A
E
A
K
A
F
---
I
L
K
CFEPDPD
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
SSKKKKTQPK
L
S
ALS-AG
S
N
E
Y
L
R
SISLPV
P
V
L
V
EDTSSSSEYGSVSPDT
E
L
KVDPFS
F
K
T
R
A
K
SCGE
R
D
V
K
G
I
R
T
L
F
LGIPDENFEDHSAPPSPEEKDS
G
F
F
M
L
RKDS
E
R
R
A
T
L
H
R
I
LTE
D
Q
D
K
I
V
R
N
L
M
E
S
L
A
QGAEEPK
L
K
W
E
H
I
T
T
L
I
A
S
L
R
E
F
V
R
STD
R
K
I
I
A
T
T
L
S
K
L
K
L
E
L
DFDSHG
I
S
Q
V
Q
V
V
L
FG
F
Q
D
A
V
N
K
V
L
R
NHNIK
P
H
W
M
F
A
L
D
S
I
I
R
K
A
V
Q
T
A
I
T
I
L
VPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVR
R
P
Q
A
V
I
E
D
A
V
ATS
G
V
S
T
L
S
S
T
VSHD
S
Q
S
AH
R
S
L
N
V
Q
LG
R
M
K
I
E
T
N
R
L
L
E
E
L
V
R
K
E
K
E
L
Q
A
L
L
H
R
A
I
E
E
K
D
Q
E
I
K
H
LKLKSQPIEIPEL
P
V
F
H
LNSSGTNT
E
D
S
E
L
T
D
W
LRVNGA
D
E
D
T
I
S
R
F
L
AED
Y
T
L
L
D
V
L
Y
Y
V
TRD
D
L
K
C
L
R
LRG
G
M
L
C
T
L
W
K
A
I
I
D
FRNKQT
3
PsiBlast_PDB
91.46
99%
-61
- C1 -
4BID
1
M3K5_HUMAN
A:
[11-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
-------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.70
99%
-59
- C1 -
4BIC
2
M3K5_HUMAN
A:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
-----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.67
99%
-61
- C1 -
4BIE
2
B:
[11-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
90.52
99%
-60
- C1 -
4BIC
2
B:
[11-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------------
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.27
99%
-60
- C1 -
4BID
1
B:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.99
99%
-61
- C1 -
4BIB
1
B:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
89.91
100%
-58
- C1 -
2CLQ
1
B:
[14-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
89.89
100%
-55
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[14-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
D
S
---
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.83
99%
-56
- C1 -
4BIE
2
M3K5_HUMAN
A:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
-------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
88.51
99%
-60
- C1 -
4BF2
1
B:
[28-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
--------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------------
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
88.31
99%
-58
- C1 -
4BHN
2
B:
[27-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
R
----
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.75
99%
-56
- C1 -
4BIB
3
M3K5_HUMAN
A:
[11-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
-------------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.25
99%
-56
- C1 -
4BF2
2
M3K5_HUMAN
A:
[28-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--
P
-
E
---------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
-------
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
E
L
G
E
P
Q
A
-
A
M
F
K
V
G
----
M
F
K
V
H
---
P
E
---
I
---
P
---------
E
S
M
-
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
57.05
35%
-45
- C1 -
4USF
1
?
B:
[24-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
--
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
--------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
E
---
P
P
---
T
LAQ
P
---------
S
R
W
-
S
S
N
F
K
D
F
---
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
56.50
35%
-48
- C1 -
4USF
1
?
A:
[24-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
--
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E----
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
E
---
P
P
---
T
LAQ
P
---------
S
R
W
-
S
S
N
F
K
D
F
---
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
55.43
33%
-52
- C1 -
4B6L
1
PLK3_HUMAN
A:
[16-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
--
P
-
Q
--
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
-------
A
-------
R
H
T
L
L
---
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
-
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
-
T
E
--
N
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
---
L
R
--
Q
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
---
E
T
A
D
L
K
E
-
T
Y
R
C
I
K
------
Q
V
H
---
Y
T
---
L
---
P
---------
A
S
L
-
S
L
P
A
R
Q
L
---
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
55.42
32%
-38
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[29-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
Q
-
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
55.32
34%
-51
- C1 -
4I6H
1
PLK2_HUMAN
A:
[35-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
--
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
-------
A
-------
R
K
---
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
---
N
K
--
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
ET
T
N
L
K
E
T
Y
R
-
S
I
R
E
A
R
----
Y
--------
T
---
M
---
P
---------
S
S
L
-
L
A
P
A
K
H
L
---
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
-
P
D
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.04
31%
-33
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[29-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
--
N
-
L
-----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
53.94
32%
-36
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[29-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
Q
-
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.71
34%
-47
- C1 -
4I5P
1
PLK2_HUMAN
A:
[35-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
--
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
-------
A
-------
R
K
---
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
---
N
K
--
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
ET
T
N
L
K
E
T
Y
R
-
S
I
R
E
A
R
----
Y
--------
T
---
M
---
P
---------
S
S
L
-
L
A
P
A
K
H
L
---
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
-
P
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.67
31%
-36
- C1 -
3FXZ
1
?
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.51
31%
-36
- C1 -
3FY0
1
PAK1_HUMAN
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
53.40
31%
-34
- C1 -
3Q53
1
PAK1_HUMAN
A:
[29-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
53.36
35%
-36
- C1 -
4O27
1
STK24_HUMAN
B:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
--
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
-------
P
---------
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
---
K
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
--
S
E
L
-
H
P
M
K
-
V
L
F
L
I
P
----
K
-
N
N
P
---
P
T
---
L
---
E
---------
G
N
Y
-
S
K
P
L
K
E
F
---
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
-
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
52.73
34%
-48
- C1 -
4I6B
1
PLK2_HUMAN
A:
[35-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
--
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
-------
A
-------
R
K
---
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
---
N
K
--
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
ET
T
N
L
K
E
T
Y
R
-
S
I
R
E
A
R
----
Y
--------
T
---
M
---
P
---------
S
S
L
-
L
A
P
A
K
H
L
---
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
-
P
D
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.52
32%
-37
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
52.37
31%
-33
- C1 -
4O0R
1
PAK1_HUMAN
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
52.30
31%
-37
- C1 -
4EQC
1
PAK1_HUMAN
A:
[32-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
52.28
32%
-36
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[29-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---------
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
52.25
32%
-38
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
-----
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
52.03
36%
-39
- C1 -
3GGF
1
STK26_HUMAN
A:
[31-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
--
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
-------
A
---------
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
D
F
G
V
A
--------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
D
M
-
H
P
M
R
-
V
L
F
L
I
P
----
K
-
N
N
P
---
P
T
---
L
---
V
---------
G
D
F
-
T
K
S
F
K
E
F
---
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
-
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
51.89
35%
-38
- C1 -
2J51
5
SLK_HUMAN
A:
[45-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
--
D
-
T
K
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
-----
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
E
---
P
P
---
T
LAQ
P
---------
S
R
W
-
S
S
N
F
K
D
F
---
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
51.49
32%
-39
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
-----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
51.28
35%
-37
- C1 -
4FZA
3
STK26_HUMAN
B:
[16-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
--
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
-------
A
---------
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
D
M
-
H
P
M
R
-
V
L
F
L
I
P
----
K
-
N
N
P
---
P
T
---
L
---
V
---------
G
D
F
-
T
K
S
F
K
E
F
---
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
-
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
51.12
34%
-48
- C1 -
4I5M
1
PLK2_HUMAN
A:
[35-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
--
P
-
H
--
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
-------
A
-------
R
K
---
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
---
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
----------------
T
P
N
Y
L
S
P
E
V
L
---
N
K
--
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
ET
T
N
L
K
E
T
Y
R
-
S
I
R
E
A
R
----
Y
--------
T
---
M
---
P
---------
S
S
L
-
L
A
P
A
K
H
L
---
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
-
P
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.08
32%
-35
- C1 -
4ZY5
1
PAK1_HUMAN
A:
[29-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
51.05
31%
-46
- C1 -
5AJQ
2
STK10_HUMAN
A:
[24-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
----
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCE
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
50.82
31%
-31
- C1 -
4O0T
1
PAK1_HUMAN
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
50.76
32%
-38
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
-----
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.53
32%
-35
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[29-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
50.36
35%
-40
- C1 -
4FZF
1
?
B:
[16-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
--
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
-------
A
---------
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
D
M
-
H
P
M
R
-
V
L
F
L
I
P
----
K
-
N
N
P
---
P
T
---
L
---
V
---------
G
D
F
-
T
K
S
F
K
E
F
---
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
-
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
50.33
36%
-39
- C1 -
3GGF
1
STK26_HUMAN
B:
[31-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
--
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
-------
A
---------
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
D
F
G
V
A
---------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
D
M
-
H
P
M
R
-
V
L
F
L
I
P
----
K
-
N
N
P
---
P
T
---
L
---
V
---------
G
D
F
-
T
K
S
F
K
E
F
---
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
-
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
50.06
35%
-44
- C1 -
4NZW
1
STK25_HUMAN
B:
[26-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
I
--
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
--
D
L
E
E
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
-------
P
---------
G
P
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
V
K
L
A
A
F
G
V
A
G
-------------------
T
P
F
W
M
A
P
E
V
I
---
K
Q
----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
D
L
-
H
P
M
R
-
V
L
F
L
I
P
----
K
-
N
S
P
---
P
T
---
L
---
E
---------
G
Q
H
-
S
K
P
F
K
E
F
---
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
-
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
49.23
33%
-40
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[16-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG---------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
------
P
P
M
K
V
L
----
M
L
T
L
Q
---
N
D
---
P
---
P
SLETGVQDK
E
M
L
-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
49.08
32%
-38
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[29-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
-------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
48.99
31%
-36
- C1 -
4AOT
1
STK10_HUMAN
A:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
------------------
G
T
P
Y
W
M
A
P
E
V
V
M--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
48.13
33%
-39
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[11-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD--------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
P
P
------
M
K
V
L
----
M
L
T
L
Q
---
N
D
---
P
---
P
SLETGVQDK
E
M
L
-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
47.38
33%
-37
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[11-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-----------
V
G
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
P
P
------
M
K
V
L
----
M
L
T
L
Q
---
N
D
---
P
---
P
SLETGVQDK
E
M
L
-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
46.89
33%
-39
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[16-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
-----
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD------------
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
------
P
P
M
K
V
L
----
M
L
T
L
Q
---
N
D
---
P
---
P
SLETG-----
M
L
-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
46.63
32%
-35
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
--
N
-
L
---
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
---------
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
46.59
33%
-37
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[11-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGDI
T
R
N
-----
F
V
G
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
P
P
------
M
K
V
L
----
M
L
T
L
Q
---
N
D
---
P
---
P
SLETGVQDK
E
M
L
-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
45.94
31%
-47
- C1 -
4USD
1
?
B:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
--------------------
G
T
P
Y
W
M
A
P
E
V
V
MC-------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
45.71
31%
-33
- C1 -
4AOT
1
STK10_HUMAN
B:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
45.55
33%
-36
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[11-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
-------
H
I
V
A
K
GEH
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD------------
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
P
P
------
M
K
V
L
----
M
L
T
L
Q
---
N
D
---
P
---
P
SLETGVQDK
E
M
L
-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
45.35
33%
-49
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[33-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
HL
E
-
I
K
P
A
I
R
N
Q
I
-----
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
---------------
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
---
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-------
I
------
F
V
G
T
R
S
Y
M
S
P
E
R
L
----
Q
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
G
--------
A
I
F
E
L
L
----
D
Y
I
V
N
E
P
P
P
K
---
L
---
P
---------
S
G
V
F
S
L
E
F
Q
D
F
---
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
-
I
G
L
N
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
44.50
31%
-45
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
-
K
S
------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
-------
E
-------
R
G
---
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
EE
N
S
K
I
M
I
T
D
F
G
L
S
K
--
M
-----
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
----
Y
Y
E
F
E
---
S
P
---
F
---
W
---------
D
D
I
-
S
E
S
A
K
D
F
---
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
-
I
Q
K
N
F
A
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
44.23
31%
-27
- C1 -
4USE
1
?
A:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
43.35
32%
-29
- C1 -
4ZJI
1
?
C:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
--
N
------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.18
31%
-36
- C1 -
4EQU
2
STK10_HUMAN
B:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-----
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
43.17
31%
-29
- C1 -
2J7T
1
STK10_HUMAN
A:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-----
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
42.76
31%
-43
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
-
K
S
------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
-------
E
-------
R
G
---
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
EE
N
S
K
I
M
I
T
D
F
G
L
S
K
--
M
-----
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
----
Y
Y
E
F
E
---
S
P
---
F
---
W
---------
D
D
I
-
S
E
S
A
K
D
F
---
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
-
I
Q
K
N
F
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
42.49
31%
-29
- C1 -
4BC6
2
STK10_HUMAN
A:
[19-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-
T
K
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
42.21
32%
-34
- C1 -
4ZJI
1
?
D:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
--------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
41.69
32%
-33
- C1 -
5D9H
1
?
A:
[25-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
GE
H
-------
K
N
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGDV
T
R
-------
V
G
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
P
P
M
K
V
-
L
M
L
T
L
Q
NDPP
T
L
E
T
G
---
V
--------
K
---------
E
M
M
-
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
40.74
32%
-34
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
--
N
-
L
Q
---
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-------
E
-------
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
--
D
G
S
V
K
L
T
D
F
G
------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
----
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
--
L
N
-
E
N
P
L
R
-
A
L
Y
L
I
A
----
T
N
G
T
----
P
E
---
L
QN-
P
---------
E
K
L
-
S
A
I
F
R
D
F
---
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
-
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
40.69
31%
-29
- C1 -
4USE
1
?
B:
[27-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-----
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
E
L
N
-
P
M
R
-
V
L
L
K
I
A
------
K
S
D
---
P
P
TLL
T
---
P
---------
S
K
W
-
S
V
E
F
R
D
F
---
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
-
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
38.75
32%
-36
- C1 -
5D9H
1
?
B:
[25-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
--
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
YIVNRGE
H
-------
K
N
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
---
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGDV
T
R
N
-------
G
T
P
C
W
M
A
P
E
V
M
---
E
Q
-
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
--
H
K
Y
P
P
M
K
V
-
L
M
L
T
L
Q
NDPP
T
L
E
T
G
---
V
E
---
D
---
K
---------
E
M
M
-
K
K
Y
G
K
S
F
RKL
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------