@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K7_HUMAN: (2015-10-12 )
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
Atome Classification :
(105 SA)
.........10........20......--..30........40........50..-----..-------.--------.-------.--.-----60....-----.----.-----.---------.----70----........80...-.-....90......--.---.--100.......110..-..--...-120.----.-.----..----....130.......140.......150.......160....----.----..170.....----..----180..---...-----.-----.--..190----..--.--......200-...--.---....210.......220..-.-..-..230.......240...-.....250----.-...------...260.......270.......280.......290.......300...----....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTASAASSSSSSSAG
E
M
I
EA
P
S
Q
VLN--FEEID
Y
K
E
I
E
V
E
E
V
VGRGA
F
G
V
V
C
KA-----KW-------R--------A-------K--D-----V
A
I
K
Q
I-----E----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
SRV-N-HP
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
EYAEGG
S
L
Y
N
-
V
L--HGA-E--P----L-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
CS
Q
G
V
A
Y
L
H
SM
Q
P
K
A
L
I
HRDLKPP
N
L
L
L
VA----G----
G
T
V
L
K
ICDFG----TA----
C
--
D
I
---
Q
T
H
-----M-----T--NNK------GS--A--AWMA
P
E
VF--EGS--N---YSEKCD
V
F
S
W
G
I
I
L
W
E
V
I
T-R-RK-
P
F
D
EIGG
P
A
F
R
I
M
-
W
A
VH-NGTRP
P
L
I
----
K
-NL
P
------
K
P
I
E
S
L
M
T
R
CWSKDPSQRP
S
M
E
E
I
V
K
I
M
T
H
L
M
R
YFPGADEPLQYPCQYS----DEGQSNSATSTG
S
F
M
D
I
ASTNTSNKSDTNMEQVPAT
N
D
T
I
K
R
L
E
S
K
L
L
K
N
Q
A
K
Q
QSESG
R
L
S
LGASRGSSVESLPPTSEGKRMSA
D
M
S
E
I
E
A
R
I
A
A
TTAYSKPKRGHRKTASFGNILDV
P
E
I
V
I
SGNGQPRR
R
S
I
Q
D
L
T
V
TGTEPGQVSSRSSSP
S
V
R
M
I
TTSGPTSEKPTRSHPWTPDDSTDTNGSDNSI
P
M
A
Y
L
T
LDHQLQPLAPCPNS
K
E
S
M
A
V
F
E
Q
H
C
K
M
A
Q
E
Y
M
K
V
Q
T
E
I
A
L
L
L
Q
R
K
Q
E
L
V
A
ELDQDE
K
D
Q
Q
N
T
S
R
L
V
Q
E
H
K
K
L
L
DENK
S
L
S
T
Y
Y
Q
Q
C
K
K
Q
L
E
V
I
R
S
Q
Q
Q
KRQGTS
5
PsiBlast_PDB
93.53
92%
-131
- C3 -
2YIY
1
M3K7_HUMAN
A:
[5-304]
--------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
--------------------------------------------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
PG
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.16
91%
-130
- C3 -
4O91
1
M3K7_HUMAN
A:
[5-306]
--------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
--------------------------------------------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
PG
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.99
91%
-128
- C3 -
4L3P
1
M3K7_HUMAN
A:
[6-308]
--------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
--------------------------------------------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
LPPG
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.92
92%
-131
- C3 -
4L52
1
M3K7_HUMAN
A:
[6-305]
--------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
----
T
---------------------------------------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.23
92%
-125
- C3 -
4L53
3
M3K7_HUMAN
A:
[6-305]
--------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
----
T
--------------------------------
K
------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
LPPG
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
91.67
98%
-133
- C3 -
2EVA
1
M3K7_HUMAN
A:
[2-280]
-----------------------------
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
----
T
---------------------------------------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
----
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
90.64
92%
-126
- C3 -
2EVA
1
M3K7_HUMAN
A:
[5-304]
--------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
-----
K
W
-------
R
--------
A
-------
K
--
D
-----
V
A
I
K
Q
I
-----
E
----
S
-----
E
---------
S
----
E
R
----
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
C
L
--
N
---
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
--
H
G
A
-
E
--
P
----
L
-
P
----
Y
Y
----
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
----
G
----
G
T
V
L
K
I
C
D
F
G
----
T
---------------------------------------
G
S
--
A
--
A
W
M
A
P
E
V
F
--
E
G
S
--
N
---
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
-
W
A
V
H
-
N
G
T
R
P
P
L
I
----
K
-
N
L
P
------
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
68.81
32%
-130
- C3 -
4G2F
1
A:
[28-297]
------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
S
RVL----------------------------------------PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
--
D
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
68.14
32%
-133
- C3 -
3DZQ
1
A:
[28-297]
------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
--------------------------------------------PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
--
D
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
L
K
I
I
T
N
L
L
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
67.91
31%
-135
- C3 -
2QO9
1
A:
[34-309]
------------------------
T
V
H
EF
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
S
RVL------------------------------------
K
--
I
PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
D
--
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
N
L
L
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
67.57
32%
-132
- C3 -
2QOC
2
A:
[11-280]
------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
S
RVLE
D
----------------------------------
K
--
I
PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
--
D
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
R
P
S
----
N
L
L
L
D
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
67.10
32%
-124
- C3 -
4C8B
2
RIPK2_HUMAN
A:
[28-316]
------------------------------
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
-----
R
H
-------
A
--------
D
WR-----
V
--
Q
-----
V
A
V
K
H
L
-----
H
----
I
HTPL
L
D
---------
S
----
E
R
----
K
D
V
L
R
E
A
E
I
L
H
K
A
-
R
-
F
S
Y
I
L
P
I
L
G
I
C
N
--
E
PE-
F
--
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
--
H
R
K
-
T
--
E
----
Y
-
P
----
D
V
----
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
----
E
----
F
H
-
V
K
I
A
D
F
---------------------------------------------
G
T
--
I
--
I
Y
M
P
P
E
N
Y
------------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
F
E
D
V
T
N
P
-
L
Q
I
M
-
Y
S
V
S
-
Q
G
H
R
P
V
I
N
----
E
E
S
L
P
YDIPH
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
----
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
66.79
32%
-133
- C3 -
4P4C
1
A:
[28-297]
------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
--------------------------------------------------PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
--
D
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
66.67
31%
-132
- C3 -
3FXX
1
A:
[30-307]
----------------------
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
S
RVLE
D
--
D
------------------------------
G
K
--
I
PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
D
--
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
A
A
R
P
S
N
L
----
L
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
66.61
31%
-122
- C3 -
4CLJ
1
A:
[23-304]
--------------------------
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-----
Q
V
-------
S
-----------------P
L
Q
-----
V
A
V
K
T
L
-----
P
EVC-
S
-----
E
---------
Q
----
D
E
----
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
SL-
P
--
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
-
F
L
--
R
E
T
-
R
--
P
----
R
-
P
SQPS
S
L
----
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
---
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
----
P
GP--
G
R
V
A
K
I
G
D
F
G
----
M
A
----
R
--
D
I
---
Y
R
-------------GG
C
A
M
------
L
P
--
V
--
K
W
M
P
P
E
A
F
--
M
E
G
--
I
---
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
-
Y
M
-
P
Y
P
S
K
S
--
N
Q
E
V
L
-
E
F
V
T
-
S
G
G
R
M
D
P
P
----
K
-
N
C
P
------
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.59
32%
-132
- C3 -
4TWO
1
A:
[28-297]
------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
S
RVL----------------------------------------PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
--
D
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
D
----
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
65.85
33%
-120
- C3 -
4MNF
1
B:
[44-313]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
--
E
-------------------------------
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
64.49
33%
-118
- C3 -
4EHG
1
BRAF_HUMAN
A:
[32-303]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PTPQ
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
--
E
------------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
64.49
33%
-117
- C3 -
4MNF
1
BRAF_HUMAN
A:
[44-313]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
--
E
-------------------------------
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
64.44
33%
-117
- C3 -
4WO5
1
B:
[28-298]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PT
P
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---------------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
R
M
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
64.41
34%
-115
- C3 -
1T46
1
?
A:
[19-307]
-------------------------------
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
-----
T
A
-------
Y
GLIKSD
A
-
A
-------
M
--
T
-----
V
A
V
K
M
L
-----
K
----
P
SAH--
L
---------
T
----
E
R
----
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
C
T
IG
G
---
P
--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
-
F
L
--
R
R
K
-
R
--
D
SF----
L
----
A
L
----
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
---
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
----
G
----
R
-
I
T
K
I
C
D
F
G
----
L
A
----
R
--
D
I
---
K
N
D
-----
S
N
Y
V
V
K
G
--
N
A
R
------
L
P
--
V
--
K
W
M
A
P
E
S
I
--
F
N
C
--
V
---
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
-
S
S
-
P
Y
P
G
M
P
V
D
S
-
K
F
Y
-
K
M
I
K
-
E
G
F
R
M
L
S
P
----
E
-
H
A
P
------
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
64.34
35%
-118
- C3 -
4CKJ
16
A:
[19-311]
-------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
-----
T
A
F
HLKGRA
G
--------
Y
-------
T
--
T
-----
V
A
V
K
M
L
-----
K
ENA-
S
-----
P
---------
S
----
E
L
----
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
QD
G
---
P
--
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
-
F
L
--
R
E
S
-
R
--
K
----
V
-
R
----
A
L
----
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
---
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
----
G
----
R
K
-
M
K
I
S
D
F
G
----
L
S
----
R
--
D
V
---
Y
E
E
-----
D
SYVKR
S
--
Q
G
R
------
I
P
--
V
--
K
W
M
A
I
E
S
L
--
F
D
H
--
I
---
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
-
G
N
-
P
Y
P
G
I
--
P
P
E
R
L
F
-
N
L
L
K
-
T
G
H
R
M
E
R
P
----
D
-
N
C
S
------
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.34
33%
-124
- C3 -
3PPZ
1
CTR1_ARATH
A:
[33-298]
-------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
-----
E
W
-------
H
--------
G
-------
S
--
D
-----
V
A
V
K
I
L
ME------------------------
A
----
E
R
V
---
N
E
F
L
R
E
V
A
I
M
K
R
L
-
R
-
H
P
N
I
V
L
F
M
G
A
V
T
--
Q
---
P
PN
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
-
L
L
--
H
K
S
-
G
--
A
----
R
-
E
----
Q
L
----
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
----
K
----
Y
T
V
-
K
V
C
D
F
G
----
L
S
----
R
--
L
K
---
A
S
T
-----
F
-----
L
--
S
S
K
SAA---
G
T
--
P
--
E
W
M
A
P
E
V
L
--
R
D
E
--
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
-
Q
Q
-
P
W
G
N
L
-
N
P
A
Q
V
V
A
-
A
V
G
F
-
K
C
K
R
L
E
I
P
----
R
-
N
L
N
------
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
64.08
33%
-119
- C3 -
3C4C
1
B:
[8-279]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
---------------------------------------S-----
G
S
--
I
--
L
W
M
A
P
E
V
I
RM
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
63.97
32%
-132
- C3 -
4TWN
1
A:
[28-297]
------------------------------
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-----
R
L
-------
K
--------
L
-------
P
--
S
K
K
E
I
S
V
A
I
K
T
L
-----
K
VGY-
T
-----
E
---------
K
----
Q
R
----
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
--
K
SK-
P
--
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
-
F
L
R
K
H
D
A
-
Q
---------------
F
----
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
---
G
Y
V
H
R
D
L
A
A
R
N
I
L
-
I
N
----
S
----
N
L
V
C
K
V
S
D
F
G
----
L
S
R--------------------------------------
K
--
I
PI
R
W
T
S
P
E
A
I
--
A
Y
R
--
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
-
P
Y
W
E
M
S
N
Q
--
D
V
I
-
K
A
V
D
-
E
G
Y
R
L
P
P
P
----
M
-
D
C
P
------
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
N
L
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
63.23
32%
-111
- C3 -
2XIR
1
A:
[23-311]
-------------------------------
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
-----
D
A
-------
F
--------
G
IDKTA
T
C
R
--
T
-----
V
A
V
K
M
L
-----
K
----
E
GAT--
H
---------
S
----
E
H
----
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
--
K
P
GG
P
--
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
-
Y
L
--
R
S
K
-
R
NE
F
----
V
-
P
YYKD
F
L
----
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
---
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
----
K
----
N
V
-
V
K
I
C
D
F
G
----
L
A
----
R
--
D
I
---
Y
K
D
PD
Y
V
R
K
-----
G
--
D
A
R
------
L
P
--
L
--
K
W
M
A
P
E
T
I
--
F
D
R
--
V
---
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
-
A
S
-
P
Y
P
G
V
K
I
D
E
-
E
F
C
-
R
R
L
K
-
E
G
T
R
M
R
A
P
----
D
-
Y
T
T
------
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.64
33%
-129
- C3 -
3P86
1
CTR1_ARATH
A:
[33-298]
-------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
-----
E
W
-------
H
--------
G
-------
S
--
D
-----
V
A
V
K
I
L
MEQ--
D
----
F
-----
H
---------
A
----
E
R
V
---
N
E
F
L
R
E
V
A
I
M
K
R
L
-
R
-
H
P
N
I
V
L
F
M
G
A
V
T
--
Q
---
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
-
L
L
--
H
K
S
-
G
--
A
----
R
-
E
----
Q
L
----
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
----
K
----
Y
T
V
-
K
V
C
D
F
---------------------------------------------
G
T
--
P
--
E
W
M
A
P
E
V
L
--
R
D
E
--
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
-
Q
Q
-
P
W
G
N
L
-
N
P
A
Q
V
V
A
-
A
V
G
F
-
K
C
K
R
L
E
I
P
----
R
-
N
L
N
------
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
62.57
33%
-122
- C3 -
3IDP
1
B:
[24-293]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PT
P
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
--------------------------------------LS----
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
62.54
33%
-125
- C3 -
4PP7
1
BRAF_HUMAN
A:
[32-302]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PTP
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---
V
---
K
S
R
-----
W
-----
S
-----LS----
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
62.51
33%
-124
- C3 -
4CQE
1
?
B:
[6-275]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
--------------------------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
R------
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
62.43
32%
-128
- C3 -
3ZBF
1
A:
[29-313]
-------------------------------
A
F
P
R
E
K
L
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
-----
T
A
-------
V
DILGVGSG
E
-------
I
--
K
-----
V
A
V
K
T
L
-----
K
----
K
GST--
D
---------
Q
----
E
K
----
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
LN
E
---
P
--
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
-
Y
L
--
R
K
A
-
R
--
M
ATFY
G
-
P
----
L
L
----
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
---
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
----
K
DYT
S
P
R
I
V
K
I
G
D
F
G
----
L
A
----
R
--
D
I
---
Y
-------------------------
L
P
--
V
--
R
W
M
A
P
E
S
L
--
M
D
G
--
I
---
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
-
H
Q
-
P
Y
P
A
H
--
S
N
L
D
V
L
-
N
Y
V
Q
-
T
G
G
R
L
E
P
P
----
R
-
N
C
P
------
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
62.39
33%
-122
- C3 -
4MBJ
1
B:
[32-303]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PTPQ
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---
V
---
K
S
R
-----
W
-----
S
--
G
S
H
Q
F
E
Q
L
S
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
62.26
33%
-119
- C3 -
3IDP
1
BRAF_HUMAN
A:
[24-293]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PT
P
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---------------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
---NP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
62.25
33%
-122
- C3 -
4CQE
1
?
A:
[6-275]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
--------------------------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
RM
Q
----
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
62.17
33%
-122
- C3 -
4PP7
1
B:
[32-302]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PTP
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---
V
---
K
S
R
-----
W
-----
S
--
G
S
H
Q
F
E
Q
L
S
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
62.00
33%
-120
- C3 -
4JVG
1
BRAF_HUMAN
C:
[12-283]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
----
L
A
---------------------------------------
S
--
I
--
L
W
M
A
P
E
V
I
R
M
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
61.99
33%
-125
- C3 -
4MBJ
1
BRAF_HUMAN
A:
[32-303]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PTPQ
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---
V
---
K
S
R
-----
W
-----
S
-----LS----
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
61.96
33%
-111
- C3 -
4G9R
1
B:
[32-302]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PT
P
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
--
E
K
-----------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.86
33%
-119
- C3 -
4JVG
1
BRAF_HUMAN
A:
[12-283]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---
V
---
K
S
-------------------------
S
--
I
--
L
W
M
A
P
E
V
I
R
M
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.73
33%
-117
- C3 -
4G9R
1
BRAF_HUMAN
A:
[32-302]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PT
P
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
--
E
K
---
S
-------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
61.72
33%
-123
- C3 -
5C9C
1
?
A:
[32-301]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
--------------------
A
PT
P
Q
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
----
L
A
----
T
----------------------------------
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
61.70
33%
-123
- C3 -
4JVG
1
D:
[12-283]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
----
L
A
----
T
---
V
---
K
S
-------------------------
S
--
I
--
L
W
M
A
P
E
V
I
RM
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
61.29
33%
-125
- C3 -
3OG7
1
BRAF_HUMAN
A:
[20-288]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
A
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-----------------
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
--------------------------------------------
G
S
--
I
--
L
W
M
A
P
E
V
I
R------
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.12
33%
-110
- C3 -
3C4C
1
BRAF_HUMAN
A:
[8-279]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
--------------------------------------S-----
G
S
--
I
--
L
W
M
A
P
E
V
I
R
M
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
61.09
33%
-121
- C3 -
4EHG
1
B:
[32-303]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
----
V
-----
T
---------
A
PTPQ
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
I
I
-
E
--
T
-----------
K
F
----
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
L
T
V
-
K
I
G
D
F
G
--------------------------------------LS----
G
S
--
I
--
L
W
M
A
P
E
V
I
--
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
F
M
V
G
-
R
G
Y
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.95
33%
-122
- C3 -
4JVG
1
BRAF_HUMAN
B:
[12-283]
-------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-----
K
W
-------
H
--------
G
----------
D
-----
V
A
V
K
M
L
-----
N
VTAP
T
-----
P
---------
Q
----
Q
L
----
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
S
T
--
K
---
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
--
H
A
S
-
E
--
T
-----------
K
F
----
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
----
D
----
N
T
V
-
K
I
G
D
F
G
----
L
A
----
T
----------------------------------
S
--
I
--
L
W
M
A
P
E
V
I
R
M
Q
D
S
--
N
P--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
R
D
-
Q
I
I
-
E
M
V
G
-
R
G
S
L
S
P
D
L
SKVR
S
-
N
C
P
------
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
60.92
32%
-117
- C3 -
2IVS
5
RET_HUMAN
A:
[14-310]
-------------------
E
D
P
K
W
-------
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
HL
K
G
-------
R
--------
A
G
Y
-----
T
--
T
-----
V
A
V
K
M
L
-----
K
ENA-
S
-----
P
---------
S
----
E
L
----
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
QD
G
---
P
--
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
-
F
L
--
R
E
S
-
R
--
K
----
V
G
P
----
G
Y
LRAL
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
---
L
V
H
R
D
L
A
A
R
N
-
I
L
V
A
----
E
----
G
R
K
M
K
I
S
D
F
G
----
L
S
----
R
--
D
V
YEE
D
S
Y
-----
V
-----
K
--
R
S
Q
------
G
R
IP
V
--
K
W
M
A
I
E
S
L
--
F
D
H
--
I
---
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
-
P
Y
P
G
I
--
P
P
E
R
L
F
-
N
L
L
K
-
T
G
H
R
M
E
R
P
----
D
-
N
C
S
------
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
60.82
33%
-108
- C3 -
4F0F
1
A:
[13-285]
-----------------------------
L
P
T
L
A
D
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
VK-----
D
--------
K
-------
S
--
V
-----
V
A
I
K
S
L
-----
I
----
L
-----
G
DSEGETEMI
E
----
K
F
----
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
F
V
P
C
G
D
L
Y
H
-
R
L
--
L
D
K
A
H
--
P
----
I
-
K
----
W
-------
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
G
----
L
S
----
Q
--
Q
S
---
V
H
S
-----
V
-----
S
--
G
L
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
--
G
A
E
EE
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
-
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
60.43
33%
-120
- C3 -
4KIO
3
ITK_HUMAN
C:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT------------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.39
33%
-118
- C3 -
4L7S
1
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.92
34%
-116
- C3 -
4YZN
1
A:
[20-287]
------------------------------------
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
----------------
V
-------
K
--
D
K
S
V
--
V
A
I
K
S
L
I
L--------------
E
---------
T
----
E
M
I
E
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
L
V
P
C
G
D
L
Y
H
R
L
L
--
D
K
A
-
H
--
P
----
I
-
K
----
W
S
----
V
K
L
R
L
M
---
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
L
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
G
----
L
S
----
Q
--
Q
S
---
V
H
S
-----
V
-----
S
--
G
L
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
GA
E
E
E
--
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
-
N
M
I
R
E
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
59.77
34%
-121
- C3 -
4YZM
1
B:
[20-287]
------------------------------------
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
----------------
V
-------
K
--
D
KS
V
--
V
A
I
K
S
L
I
LG-------------
E
---------
T
----
E
M
I
E
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
L
V
P
C
G
D
L
Y
H
R
L
L
--
D
K
A
-
H
--
P
----
I
-
K
----
W
S
----
V
K
L
R
L
M
---
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
L
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
G
----
L
S
----
Q
-------------------------
L
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
GA--
E
--
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
-
N
M
I
R
E
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.69
34%
-114
- C3 -
4F1O
1
A:
[20-287]
------------------------------------
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
----------------
V
-------
K
--
D
K
S
V
--
V
A
I
K
S
L
I
L
GDS
E
----
G
-----
E
---------
T
----
E
M
IEK
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
--
D
K
A
-
H
--
P
----
I
-
K
----
W
S
----
V
K
L
R
L
M
---
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
G
----
T
S
----
Q
--
Q
S
---
V
H
S
-----
V
-----
S
--
G
L
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
G
A
E
E
E
--
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
-
N
M
I
R
E
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.36
33%
-120
- C3 -
4PP9
1
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.26
33%
-118
- C3 -
4L7S
1
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K----
V
A
I
K
T
I
R----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.07
34%
-114
- C3 -
4F0F
1
A:
[20-287]
------------------------------------
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
----------------
V
-------
K
--
D
KS
V
--
V
A
I
K
S
L
I
LGDS
E
----
G
-----
E
---------
T
----
E
M
IE
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
--
D
K
A
-
H
--
P
----
I
-
K
----
W
S
----
V
K
L
R
L
M
---
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
G
----
L
S
----
Q
--
Q
S
---
V
H
S
-----
V
-----
S
--
G
L
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
GA
E
E
E
--
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
-
N
M
I
R
E
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.03
33%
-116
- C3 -
4CSV
1
?
A:
[7-264]
-------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-----
K
W
-------
R
--------
N
-------
Y
N
I
E
-----
V
A
V
K
T
L
K----
E
----
G
-----
T
---------
M
----
S
V
----
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
--
K
EP-
P
--
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
-
Y
L
--
R
D
C
----------------
V
-----
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
---
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
N
V
V
K
V
A
D
F
G
--------------------------------------------
F
P
--
I
--
K
W
T
A
P
E
A
I
--
S
Y
N
--
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
--
E
V
I
-
E
Q
V
E
-
R
G
Y
R
M
P
R
P
----
Q
-
G
C
P
------
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.52
34%
-120
- C3 -
4YZM
1
ROCO4_DICDI
A:
[20-287]
------------------------------------
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
----------------
V
-------
K
--
D
K
S
V
--
V
A
I
K
S
L
I
L------------------------
T
----
E
M
IEK
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
L
V
P
C
G
D
L
Y
H
R
L
L
--
D
K
A
-
H
--
P
----
I
-
K
----
W
S
----
V
K
L
R
L
M
---
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
L
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
G
----
L
S
----
Q
--
Q
-----------------------
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
GA
E
E
-------
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
-
N
M
I
R
E
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
57.49
33%
-126
- C3 -
4KIO
2
ITK_HUMAN
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
-------------------------------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.43
33%
-121
- C3 -
4KIO
2
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
--------------------------------
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
57.18
33%
-116
- C3 -
4MF1
1
B:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
----------------
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTR-----------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
56.90
33%
-115
- C3 -
4UEU
1
?
A:
[7-264]
-------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-----
K
W
-------
R
--------
N
-------
Y
N
I
E
-----
V
A
V
K
T
L
K----
E
----
G
-----
T
---------
M
----
S
V
----
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
--
K
EP-
P
--
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
-
Y
L
--
R
D
C
-
E
--
G
----
H
-
T
----
V
-----
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
---
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
N
V
V
K
V
A
D
F
G
----
L
A
----
R
LI-----------------------
A
K
------
F
P
--
I
--
K
W
T
A
P
E
A
I
--
S
Y
N
--
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
--
E
V
I
-
E
Q
V
E
-
R
G
Y
R
M
P
R
P
----
Q
-
G
C
P
------
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
56.55
33%
-120
- C3 -
4PP9
1
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
M--------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
56.51
33%
-105
- C3 -
3MJ2
1
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.46
33%
-117
- C3 -
3QGW
1
ITK_HUMAN
A:
[24-276]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
K
----
E
----
G
-----
S
---------
M
----
S
E
----
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
--------------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
56.38
33%
-115
- C3 -
3V5L
1
ITK_HUMAN
C:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT------------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.27
33%
-109
- C3 -
4F1M
2
A:
[20-287]
------------------------------------
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
-----
R
L
----------------
V
-------
K
--
D
K
S
V
--
V
A
I
K
S
L
I
LGDS
E
----
G
-----
E
---------
T
----
E
M
I
E
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
-
H
P
N
I
V
K
L
Y
G
L
M
H
--
N
---
P
--
P
R
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
--
D
K
A
-
H
--
P
----
I
-
K
----
W
S
----
V
K
L
R
L
M
---
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
-
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
LDEN
A
----
P
V
C
A
K
V
A
D
F
S
----
L
S
----
Q
--
Q
S
---
V
H
S
-----
V
-----
S
--
G
L
L
------
G
N
--
F
--
Q
W
M
A
P
E
T
I
GA
E
E
E
--
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
-
E
G
-
P
F
D
E
Y
S
Y
G
K
I
K
F
I
-
N
M
I
R
E
E
G
L
R
P
T
I
P
----
E
-
D
C
P
------
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
56.13
33%
-110
- C3 -
3QGY
1
ITK_HUMAN
A:
[24-276]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
K
----
E
----
G
-----
S
---------
M
----
S
E
----
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
55.87
33%
-114
- C3 -
1SM2
1
B:
[2-254]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
Q
A
-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
55.41
33%
-110
- C3 -
3T9T
3
A:
[5-257]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
55.33
33%
-113
- C3 -
1SNU
1
B:
[2-254]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
54.92
33%
-116
- C3 -
3V8W
1
B:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R-------------------------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
54.76
33%
-111
- C3 -
4PQN
2
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
--------------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
54.65
33%
-105
- C3 -
4HCU
1
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
54.65
33%
-107
- C3 -
3QGY
1
B:
[24-276]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
K
----
E
----
G
-----
S
---------
M
----
S
E
----
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
54.60
33%
-110
- C3 -
1SM2
1
ITK_HUMAN
A:
[2-254]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
54.55
33%
-116
- C3 -
3V8W
1
ITK_HUMAN
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R---------
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
-
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
54.36
33%
-114
- C3 -
3V8T
1
B:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
----------------
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
54.20
33%
-106
- C3 -
4M0Y
2
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
54.17
33%
-114
- C3 -
3V5L
1
ITK_HUMAN
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
--------------------------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
54.08
33%
-117
- C3 -
4RFM
1
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTR-----------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
54.06
33%
-105
- C3 -
4HCV
1
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
53.95
33%
-107
- C3 -
1SNU
1
ITK_HUMAN
A:
[2-254]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
53.84
33%
-107
- C3 -
4M15
2
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.77
33%
-116
- C3 -
3V8T
1
ITK_HUMAN
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
M--------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
--------
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
53.67
33%
-107
- C3 -
4HCT
1
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
53.64
33%
-109
- C3 -
4M14
2
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
53.62
33%
-111
- C3 -
4M13
1
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
53.57
33%
-109
- C3 -
4M0Z
2
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
53.57
33%
-113
- C3 -
4MF1
1
ITK_HUMAN
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
----------------
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
M--------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
53.41
33%
-107
- C3 -
3QGW
1
B:
[24-276]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
K
----
E
----
G
-----
S
---------
M
----
S
E
----
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
53.35
33%
-116
- C3 -
3V5J
1
B:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
--------------------------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
53.19
33%
-114
- C3 -
3V5L
1
D:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R---------------
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
M-------------------------------------------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.01
33%
-108
- C3 -
4M12
1
A:
[7-259]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
-----
A
---------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MTRF
V
L
----
D
--
D
Q
---
Y
T
S
-----
S
-----
T
--
G
T
K
------
F
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
52.70
33%
-119
- C3 -
3V5J
1
ITK_HUMAN
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
R
----
E
----
G
--------------------
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
-
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
-
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
51.55
33%
-116
- C3 -
3MJ1
1
A:
[4-256]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
-----------------------------------------
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
-
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
47.64
33%
-122
- C3 -
4QD6
2
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
--------------------------------
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
Q
A
-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
47.63
33%
-126
- C3 -
4PPA
2
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
-------------------------------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
47.08
33%
-119
- C3 -
4PPB
2
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
-------------------------------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
Q
A
-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
46.89
33%
-122
- C3 -
4PPC
2
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
----------------------------------------
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
46.28
33%
-124
- C3 -
4PPA
2
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K----
V
A
I
K
T
I
-------------------------------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
45.84
33%
-119
- C3 -
4PPB
2
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K----
V
A
I
K
T
I
-------------------------------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
---------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
45.79
33%
-121
- C3 -
4MF0
2
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
--------------------------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
45.27
33%
-120
- C3 -
4MF0
2
ITK_HUMAN
A:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
--------------------------
M
----
S
E
----
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
QA-
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
G
MT-------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
44.87
33%
-121
- C3 -
4PPC
2
B:
[4-261]
--------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-----
Y
W
-------
L
--------
N
-------
K
--
D
K
----
V
A
I
K
T
I
----------------------------------------
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
---A--
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
-
Y
L
--
R
T
Q
-
R
--
G
----
L
-------
F
----
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
---
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
-
V
G
----
E
----
N
Q
V
I
K
V
S
D
F
----------------------------------------------
P
--
V
--
K
W
A
S
P
E
V
F
--
S
F
S
--
R
---
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
-
G
K
I
P
Y
E
N
R
S
N
S
--
E
V
V
-
E
D
I
S
-
T
G
F
R
L
Y
K
P
----
R
-
L
A
S
------
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------