@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K8_HUMAN: (2015-10-12 )
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170...------.-----.--------..180...-----....190.......--200.......210...-....-220.--.......--230.......240.......250.......260......-.--.270.......280.......290.......--300----..-----......310.......320.......-330...-....340.......350........360.......370.......380......--.390.......400.......410.......420.......430.......440.......450.......460.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEYMSTGSD
N
K
E
E
I
D
L
L
I
K
HL
N
V
S
D
V
I
D
I
M
E
N
L
YASEEPAVYE
P
S
L
M
T
M
CQDSNQ
N
D
E
R
S
K
S
LLLSGQEVP
W
L
S
SVRYG
T
V
E
D
L
L
A
F
A
N
H
I
S
N
T
A
K
H
F
YGQRPQES
G
I
L
L
N
M
V
I
TPQNG
R
Y
Q
IDS
D
V
L
L
I
P
W
K
L
T
Y
R
NI
G
S
D
FIPRGAFG
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
KLIPVDQFK------P-----S--------D
V
E
I
Q
A
C
F-----RHE
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
EAGE
G
G
S
V
-
L
E
K
L
-
E
S-C--GPM
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
HHDIKPS
N
I
V
F
-
M
ST
K
A
V
-
L
--
V
DFGL
S
V
Q
M
TEDVYFPKDLRG
T
E
I
Y
MSP
E
V
I
--
L
C-----RG-----HSTK
A
D
I
Y
S
L
G
A
T
L
I
H
MQTGT
P
P
W
V
K
-RYPRSA-YP
S
Y
L
Y
I
I
HKQAP
P
L
E
-
D
I
A
DDC
S
P
G
M
R
E
L
I
E
A
S
L
ERNPNHR
P
R
A
A
D
L
L
K
H
EAL--NPPRED
Q
P
R
C
Q
S
L
D
S
A
L
L
E
R
K
R
L
L
S
R
K
ELELPENIADSSCTGS
T
E
E
S
E
M
L
K
R
Q
R
S
L
Y
I
D
L
G
A
L
A
G
Y
F
N
LVRGPPTLEYG
21
PsiBlast_CBE
99.55
100%
-106
- C1 -
4Y85
1
M3K8_HUMAN
C:
[10-327]
------------------------------------------------------------------------
L
S
S
V
R
Y
G
T
V
E
D
L
L
A
F
A
N
H
I
S
----------
P
Q
E
S
G
I
L
L
N
M
V
I
T
P
Q
N
G
R
Y
Q
I
D
S
D
V
L
L
I
P
W
K
L
T
Y
R
-----
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
K
------
P
-----
S
--------
D
V
E
I
Q
A
C
F
-----
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
-
E
S
-
C
--
G
P
M
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
T
K
A
V
-
L
--
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
C
-----
R
G
-----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
-
R
Y
P
R
S
A
-
Y
P
S
Y
L
Y
I
I
H
K
Q
A
P
P
L
E
-
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
--
N
P
-----------------------------------------------------------------------------
22
PsiBlast_CBE
98.57
100%
-105
- C1 -
4Y85
1
M3K8_HUMAN
B:
[10-327]
------------------------------------------------------------------------
L
S
S
V
R
Y
G
T
V
E
D
L
L
A
F
A
N
H
I
S
N
---------
P
Q
E
S
G
I
L
L
N
M
V
I
T
P
Q
N
G
R
Y
Q
I
D
S
D
V
L
L
I
P
W
K
L
T
Y
R
N
I
---
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
K
------
P
-----
S
--------
D
V
E
I
Q
A
C
F
-----
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
-
E
S
-
C
--
G
P
M
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
T
K
A
V
-
L
--
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
C
-----
R
G
-----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
-
R
Y
P
R
S
A
-
Y
P
S
Y
L
Y
I
I
H
K
Q
A
P
P
L
E
-
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
--
N
P
-----------------------------------------------------------------------------
2
PsiBlast_PDB
97.00
100%
-103
- C1 -
4Y85
1
M3K8_HUMAN
A:
[10-327]
------------------------------------------------------------------------
L
S
S
V
R
Y
G
T
V
E
D
L
L
A
F
A
N
H
I
S
N
T
--------
P
Q
E
S
G
I
L
L
N
M
V
I
T
P
Q
N
G
R
Y
Q
I
D
S
D
V
L
L
I
P
W
K
L
T
Y
R
N
I
---
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
K
------
P
-----
S
--------
D
V
E
I
Q
A
C
F
-----
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
-
E
S
-
C
--
G
P
M
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
T
K
A
V
-
L
--
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
C
-----
R
G
-----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
-
R
Y
P
R
S
A
-
Y
P
S
Y
L
Y
I
I
H
K
Q
A
P
P
L
E
-
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
--
N
P
-----------------------------------------------------------------------------
24
PsiBlast_CBE
95.34
100%
-108
- C1 -
4Y83
1
M3K8_HUMAN
B:
[10-327]
------------------------------------------------------------------------
L
S
S
V
R
Y
G
T
V
E
D
L
L
A
F
A
N
H
I
S
----------
P
Q
E
S
G
I
L
L
N
M
V
I
T
P
Q
N
G
R
Y
Q
I
D
S
D
V
L
L
I
P
W
K
L
T
Y
R
N
I
G
S
D
F
I
P
R
--
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
K
------
P
-----
S
--------
D
V
E
I
Q
A
C
F
-----
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
-
E
S
-
C
--
G
P
M
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
T
K
A
V
-
L
--
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
C
-----
R
G
-----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
-
R
Y
P
-----
P
S
Y
L
Y
I
I
H
K
Q
A
P
P
L
E
-
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
--
N
P
-----------------------------------------------------------------------------
23
PsiBlast_CBE
93.88
100%
-108
- C1 -
4Y83
1
M3K8_HUMAN
C:
[11-326]
-------------------------------------------------------------------------
S
S
V
R
Y
G
T
V
E
D
L
L
A
F
A
N
H
------------
P
Q
E
S
G
I
L
L
N
M
V
I
T
P
Q
N
G
R
Y
Q
I
D
S
D
V
L
-
I
P
W
K
L
T
Y
R
N
I
G
S
D
F
I
P
R
---
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
K
------
P
-----
S
--------
D
V
E
I
Q
A
C
F
-----
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
-
E
S
-
C
--
G
P
M
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
T
K
A
V
-
L
--
V
D
F
G
L
S
V
Q
M
-
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
C
-----
R
G
-----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
-
R
Y
P
----
Y
P
S
Y
L
Y
I
I
H
K
Q
A
P
P
L
E
-
D
I
---
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
--
N
------------------------------------------------------------------------------
1
PsiBlast_PDB
93.71
100%
-104
- C1 -
4Y83
1
M3K8_HUMAN
A:
[10-326]
------------------------------------------------------------------------
L
S
S
V
R
Y
G
T
V
E
D
L
L
A
F
A
N
H
-----------
R
P
Q
E
S
G
I
L
L
N
M
V
I
T
P
Q
N
G
R
Y
Q
I
D
S
D
V
L
L
I
P
W
K
L
T
Y
R
N
I
G
S
D
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
K
------
P
-----
S
--------
D
V
E
I
Q
A
C
F
-----
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
--
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
-
L
E
K
L
-
E
S
-
C
--
G
P
M
R
E
F
E
--
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
-
M
S
T
K
A
V
-
L
--
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
C
-----
R
G
-----
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
-
R
Y
--------
Y
L
Y
I
I
H
K
Q
A
P
P
L
E
-
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
R
A
A
D
L
L
K
H
E
A
L
--
N
------------------------------------------------------------------------------
110
HHSearch
56.74
30%
-76
- C1 -
4OBO
2
M4K4_HUMAN
A:
[29-311]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---E
I
----
K
-----
L
--------
E
I
N
M
L
K
K
Y
S
----
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
-
T
D
L
V
-
K
N
-
T
KG
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
--
V
D
F
G
-----------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
--
A
C
DENPD
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
-
M
H
P
M
R
A
-----
L
F
L
I
P
R
N
P
P
P
R
L
-
K
-
S
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
--
R
D
Q
----
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
------------------------------------------------------
53
PsiBlast_CBE
55.49
31%
-77
- C1 -
3K5U
1
AURKA_HUMAN
A:
[6-272]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
C
Q
--------------------------------------------------------------------
95
PsiBlast_CBE
55.15
31%
-79
- C1 -
1MQ4
1
AURKA_HUMAN
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
A
P
S
S
R
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
--------------------------------------------------------------------------
51
PsiBlast_CBE
54.70
31%
-77
- C1 -
4JBQ
1
AURKA_HUMAN
A:
[6-269]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
-----------------------------------------------------------------------
87
PsiBlast_CBE
54.67
31%
-84
- C1 -
3O50
1
AURKA_HUMAN
B:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
-------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
--------------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
-------------------------------------------------------------------------
52
PsiBlast_CBE
54.66
31%
-75
- C1 -
4JBO
1
AURKA_HUMAN
A:
[6-269]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
A
P
S
S
R
R
--
T
D
L
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
-----------------------------------------------------------------------
93
PsiBlast_CBE
53.91
31%
-90
- C1 -
2X81
1
AURKA_HUMAN
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
---
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
-------------------
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
--------------------------------------------------------------------------
88
PsiBlast_CBE
53.13
31%
-79
- C1 -
3O50
1
AURKA_HUMAN
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
----------------
T
L
D
Y
L
P
P
E
M
I
--
E
-------------
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
--------------------------------------------------------------------------
40
PsiBlast_CBE
52.42
31%
-79
- C1 -
2C6E
1
AURKA_HUMAN
B:
[10-270]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GVE
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
------------------
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
--------------------------------------------------------------------------
69
PsiBlast_CBE
52.33
31%
-71
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[32-284]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
D
S
--------------
Q
P
L
H
E
---
E
I
A
L
H
K
H
L
-----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
-
R
S
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
-
N
T
Y
S
G
V
-
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
-----
R
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
KV-------------------------------------------------------------------------------
68
PsiBlast_CBE
52.23
31%
-72
- C1 -
2CLQ
1
B:
[32-284]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
---------------
S
Q
P
L
H
E
---
E
I
A
L
H
K
H
L
-----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
-
R
S
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
-
N
T
Y
S
G
V
-
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
-----
R
G
-----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
KV-------------------------------------------------------------------------------
43
PsiBlast_CBE
52.16
31%
-79
- C1 -
4UYN
1
AURKA_HUMAN
A:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
------VEHQ
L
R
R
-
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
------------------
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
-----------------------------------------------------------------------
54
PsiBlast_CBE
51.97
31%
-73
- C1 -
3FDN
1
AURKA_HUMAN
A:
[6-272]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
A
----------
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
C
Q
--------------------------------------------------------------------
44
PsiBlast_CBE
51.86
31%
-79
- C1 -
3LAU
1
AURKA_HUMAN
A:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
-------------------
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
-----------------------------------------------------------------------
41
PsiBlast_CBE
51.82
31%
-77
- C1 -
2C6E
1
AURKA_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GVE
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
--------------
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
-------------------------------------------------------------------------
74
PsiBlast_CBE
50.99
31%
-81
- C1 -
3R21
1
AURKA_HUMAN
A:
[8-260]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
-----------
L
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
-------------------------------------------------------------------------
109
HHSearch
50.84
33%
-58
- C1 -
3A7I
1
STK24_HUMAN
A:
[23-299]
----------------------------------------------------------------------------------------------------------------------------------------
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
DE
I
E
D
I
Q
-----
Q
--------
E
I
T
V
L
S
Q
C
-----
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
-
E
--
P
--
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
--
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
--
K
Q
-----
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
-
L
H
P
M
K
V
-----
L
F
L
I
P
K
N
N
P
P
T
L
-
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
--
L
----
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
--------------------------------------------------
97
PsiBlast_CBE
50.58
31%
-77
- C1 -
3H10
1
AURKA_HUMAN
D:
[5-257]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GVEHQLRR
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
A
P
S
----------
T
L
D
Y
L
P
P
E
M
I
--
E
G
-----
R
M
-----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
-
N
T
Y
Q
E
T
-
Y
--------
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
--------------------------------------------------------------------------
34
PsiBlast_CBE
48.98
32%
-80
- C1 -
4ZJI
1
?
D:
[30-275]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----------
K
-----
K
--------
E
L
I
I
N
E
I
L
VMREN
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
-
C
----
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
-
L
--
T
D
F
G
F
-
A
Q
I
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
--
T
R
-----
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
-----
L
Y
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
--
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------
32
PsiBlast_CBE
48.97
32%
-81
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[30-275]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
----------------
K
--------
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
-
C
----
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
-
L
--
T
D
F
G
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
--
T
R
-----
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
-----
L
Y
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
--
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------
33
PsiBlast_CBE
48.37
32%
-79
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[30-275]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---------------
K
--------
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
-
C
----
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
-
L
--
T
D
F
G
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
--
T
R
-----
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
-----
L
Y
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
--
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------
64
PsiBlast_CBE
48.33
33%
-71
- C1 -
4USF
1
?
B:
[27-273]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
------
E
L
E
D
Y
M
V
--------
E
I
D
I
L
A
S
C
-----
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-
E
L
-
E
--
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
-
L
--
A
D
F
G
V
S
A
K
N
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
--
M
C
ETSKD
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
-
L
N
P
M
R
V
-----
L
L
K
I
A
K
S
E
P
P
T
L
-
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------
36
PsiBlast_CBE
48.14
32%
-79
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[30-275]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------------------------
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
-
C
----
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
-
L
--
T
D
F
G
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
--
T
R
-----
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
-----
L
Y
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
--
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
------------------------------------------------------------
117
HHSearch
47.77
33%
-71
- C1 -
4JDI
1
PAK4_HUMAN
A:
[79-330]
--------------------------------------------------------------------------------------------------------------------------------------------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
RREL
L
-
F
-----
N
--------
E
V
V
I
M
R
D
Y
-----
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
-
T
--
H
--
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
--
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
--
S
R
-----
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
-----
M
K
M
I
R
D
N
L
P
P
R
L
-
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
--
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--------------------------------------------------------------
35
PsiBlast_CBE
44.72
32%
-77
- C1 -
4ZJI
1
?
C:
[30-275]
-----------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
-----------
K
-----
K
--------
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
-
C
----
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
-
L
--
T
D
F
G
F
C
A
Q
-----
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
--
T
R
-----
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
-----
L
Y
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
--
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------
63
PsiBlast_CBE
41.09
33%
-68
- C1 -
2J51
5
SLK_HUMAN
A:
[48-294]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
------
E
LEDY
M
V
--------
E
I
D
I
L
A
S
C
-----
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-
E
L
-
E
--
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
-
L
--
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
--
M
C
ETSKD
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
-
L
N
P
M
R
V
-----
L
L
K
I
A
K
S
E
P
P
T
L
-
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------
77
PsiBlast_CBE
40.13
33%
-72
- C1 -
4EQU
2
STK10_HUMAN
B:
[30-276]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
------
E
L
E
D
Y
I
V
--------
E
I
E
I
L
A
T
C
-----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
-
D
--
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
-
L
--
A
D
F
G
V
S
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
--
M
C
-----
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
-
L
N
P
M
R
V
-----
L
L
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------
75
PsiBlast_CBE
37.04
33%
-69
- C1 -
4USE
1
?
B:
[30-276]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
------
E
L
E
D
Y
I
V
--------
E
I
E
I
L
A
T
C
-----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-
E
L
-
D
--
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
-
L
--
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
--
M
C
-----
E
T
M
K
DT
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
-
L
N
P
M
R
V
-----
L
L
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------
94
PsiBlast_CBE
29.54
31%
-77
- C1 -
2NP8
1
AURKA_HUMAN
A:
[9-166]
-----------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
------
K
-----
A
GV
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-----
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
-
Q
K
-
L
--
S
K
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
--
A
D
F
G
W
S
V
H
A
P
S
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------