@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3KL4_HUMAN: (2015-10-12 )
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAYPQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS
Atome Classification :
(93 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..----.....120.----......130.......140....--.---------..150.......160..-.....170.......180.......190...-....200.......210.....-..220.......230-........240.......250.......260.......270.......280.......290.......--300.--....---.--.310.......320.......330.......-340.......350.......360.-......370.......380.......390..------.....400-........410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAG
A
G
L
W
A
A
L
YDYEARGED
E
L
S
L
R
R
G
Q
L
V
E
V
L
S
QDAAVSGDEG
W
W
A
G
Q
V
Q
R
R
LGIFPANYVAPCRPAASPAPPPSRPS----S
P
V
H
V
A
F
E
R
----
L
E
L
K
E
L
IGAGGF
G
Q
V
Y
R
A
TWQG
Q
--
E
---------
V
A
V
K
A
ARQDP
E
Q
D
A
A
A
A
-
A
E
S
V
R
R
E
A
R
L
F
A
M
LRHP
N
I
I
E
L
R
G
V
C
LQQP
H
-
L
C
L
V
L
EFARGGA
L
N
R
A
L
AAANA-APDPRAPGPRRARR--IP
P
H
V
L
V
N
W
A
V
Q
I
A
R
G
M
L
Y
L
H
EE
A
F
V
P
I
L
H
R
DLKSS
N
I
L
L
L
E
KIEH
D
D
ICNK
T
L
K
IT
D
F
G
L
A
R
E
W
H
RT--TKMS--TAGT---
Y
--
A
WM
A
P
E
V
I
K
S
S
L
FSKGS
D
I
W
S
Y
G
V
L
L
W
E
L
L
T-GEVPYRGID
G
L
A
V
A
Y
G
V
A
V
N
K
L
TL-PIPST
C
P
E
P
F
A
K
L
M
K
E
C
WQQDPHIR
P
S
F
A
L
I
------
L
E
Q
L
T
A
I--E
G
A
V
M
TEM
P
Q
E
S
F
H
S
MQ
D
D
W
K
L
E
I
Q
Q
M
F
D
E
L
R
T
K
E
K
E
L
R
S
R
E
E
E
L
T
R
A
A
L
Q
Q
K
S
Q
E
E
L
L
K
R
R
E
Q
Q
L
A
E
R
E
I
D
V
L
E
R
EL
N
I
L
I
F
Q
LNQEKP
K
V
K
K
R
KGK
F
K
R
SRLKLKDGHRISLPSDF
Q
H
K
I
T
V
QASPN
L
D
K
RRSLNSSSSSPPSSPTM
M
P
R
L
R
A
I
Q
LTSDESNKTWGRNTVF
R
Q
E
E
F
E
D
V
K
R
N
F
K
KKGCTWGPNS
I
Q
MK
D
R
T
D
C
K
E
RIRPLSDGNSP
W
S
T
I
L
I
KNQKTM
P
L
A
S
L
FVDQPGSCEEPKLSPDGLEHRKPKQIKLPS
Q
A
Y
I
DLPLGKDAQRENPA
E
A
E
S
W
E
E
AASAN
A
A
T
V
S
I
E
MTPTNSLSRSPQRK
K
T
E
S
A
L
Y
G
C
T
V
L
L
A
S
V
A
LG
L
D
L
R
E
L
H
K
A
Q
AAEEPL
P
K
E
E
K
K
K
R
E
G
I
F
Q
R
A
S
KSRRSASPPTSLPSTCGEASSPPSL
P
L
S
S
ALGILSTPSFS
T
K
C
L
L
Q
MDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNL
P
S
S
F
L
Q
Q
T
CGNVPYCASSKHRP
S
H
HRRTMSDGNPTPT
G
A
T
I
I
SATGASALPLCPSPAPHSHLPREVSPKKH
S
T
V
H
I
V
PQRRPASLRSRSDLP
Q
A
Y
P
Q
T
A
V
S
Q
L
A
Q
T
A
CVVGRPGPH
P
T
Q
F
L
A
A
K
E
R
T
K
S
HV
P
S
L
L
DADVEGQSRDYT
V
P
L
C
R
MRSKTSRP
S
I
Y
E
L
E
K
E
FLS
81
PsiBlast_CBE
90.18
35%
-96
- C2 -
4QRC
1
A:
[35-320]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
--
D
PARPD
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
D
L
S
P
D
G
P
R
S
S
E
G
P-
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
DY
Y
K
K
T
--
S
N
G
R
---
L
PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.60
32%
-91
- C2 -
1OPK
3
ABL1_MOUSE
A:
[196-489]
---------------------------------------------------------------------------------------------------------
P
A
P
K
R
N
K
P
T
IYGV
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
N
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
88.44
35%
-97
- C2 -
4UXQ
1
A:
[21-306]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
--
D
PARPD
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
DY
Y
K
K
T
--
S
N
G
R
---
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
87.98
33%
-95
- C2 -
3K5V
2
ABL1_MOUSE
A:
[5-287]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
-
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
87.90
35%
-101
- C2 -
4R6V
1
A:
[35-320]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
--
D
Q
A
S
T
-----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
A
----------------------PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
87.88
35%
-104
- C2 -
4QQC
1
A:
[35-320]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
--
D
Q
A
S
T
-----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
----------------------
L
PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.55
32%
-90
- C2 -
2FO0
3
ABL1_HUMAN
A:
[193-488]
---------------------------------------------------------------------------------------------------------
P
A
P
K
R
N
K
P
T
VYGV
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
N
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--
S
D
E
V
E
K
E
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
87.47
35%
-99
- C2 -
4TYJ
2
A:
[23-311]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
--
D
PARPD
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P----------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
A
R
--------------------
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
S
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
87.15
33%
-99
- C2 -
1IEP
1
ABL1_MOUSE
B:
[5-276]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
86.97
35%
-95
- C2 -
4TYI
1
A:
[23-308]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
--
D
PARPD
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P--------------P-
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
A
R
G
-------------------
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.95
33%
-98
- C2 -
3K5V
2
ABL1_MOUSE
B:
[5-287]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
---
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
86.83
35%
-99
- C2 -
4QQ5
1
A:
[35-320]
-----------------------------------------------------------------------------------------------------------------------------
D
R
----
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
--
D
Q
A
S
T
-----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
--
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
---
H
R
D
L
A
A
R
N
V
L
V
T
E
--------
D
N
V
M
K
I
A
D
F
G
L
A
---------------------
L
PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
-
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
------
V
E
A
L
D
K
V
--
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
86.76
32%
-107
- C2 -
3DK3
1
ABL1_MOUSE
A:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
----
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
F
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
-
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
86.33
32%
-100
- C2 -
2G2H
1
ABL1_HUMAN
B:
[17-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.26
33%
-98
- C2 -
1OPJ
2
ABL1_MOUSE
B:
[5-287]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
86.17
32%
-104
- C2 -
3DK3
1
ABL1_MOUSE
B:
[13-276]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
----
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
F
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
-
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
86.16
32%
-101
- C2 -
3PYY
1
ABL1_HUMAN
A:
[28-286]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
----
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.03
38%
-92
- C2 -
3PPZ
1
CTR1_ARATH
A:
[39-293]
-----------------------------------------------------------------------------------------------------------------------------------
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
G
S
--
D
---------
V
A
V
K
I
L
M
---
E
----
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
G
A
-----
R
E
Q
L
D
E
R
R
R
---------
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
-
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
--------
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
T
--
F
L
S
S
KS
A
A
G
T
---
P
--
E
W
M
A
P
E
V
L
R
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
Q
V
V
A
A
V
G
F
K
C
K
R
L
-
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
------
M
D
L
L
R
P
L
--
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
86.01
34%
-98
- C2 -
3QRI
1
ABL1_HUMAN
A:
[5-267]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
K
F
P
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.80
32%
-88
- C2 -
1OPL
2
ABL1_HUMAN
A:
[235-531]
---------------------------------------------------------------------------------------------------------
P
A
P
K
R
N
K
P
T
VYGV
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
N
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--
S
D
E
V
E
K
E
L
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.75
33%
-103
- C2 -
3MS9
2
ABL1_MOUSE
B:
[5-276]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
---
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.64
33%
-95
- C2 -
1OPJ
2
ABL1_MOUSE
A:
[5-287]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.43
33%
-98
- C2 -
1IEP
1
ABL1_MOUSE
A:
[5-276]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
85.09
32%
-96
- C2 -
3OY3
1
ABL1_MOUSE
B:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.85
32%
-97
- C2 -
3OY3
1
ABL1_MOUSE
A:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
84.84
33%
-102
- C2 -
4CSV
1
?
A:
[13-269]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
N
I
E
---------
V
A
V
K
T
L
K
-----
E
G
T
M
S
-
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-------------------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
N
V
V
K
V
A
D
F
G
--------------------FP-
I
--
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
-
R
G
Y
R
M
-
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
---------
E
T
L
H
A
L
--
E
T
M
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
84.72
33%
-100
- C2 -
1FPU
1
ABL1_MOUSE
B:
[5-277]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
-------
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Fugue
84.60
34%
-110
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
----
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
N
--
K
---------
V
A
V
K
C
I
K
--------
N
D
-
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
-------------
R
S
V
--
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
---
H
R
D
L
A
A
R
N
V
L
V
S
E
--------
D
N
V
A
K
V
S
D
F
G
--------------------LLP
V
--
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
K
M
-
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
------
R
E
Q
L
E
H
I
--
K
T
H
---
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
84.53
32%
-101
- C2 -
2QOH
1
ABL1_MOUSE
A:
[15-274]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
---
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.47
33%
-99
- C2 -
1FPU
1
ABL1_MOUSE
A:
[5-277]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
84.42
32%
-102
- C2 -
2QOH
1
ABL1_MOUSE
B:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
---
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.36
33%
-98
- C2 -
1M52
3
ABL1_MOUSE
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
84.27
34%
-98
- C2 -
2HYY
1
ABL1_HUMAN
C:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
-
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-----
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
84.27
32%
-97
- C2 -
3KFA
1
ABL1_MOUSE
B:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
84.24
32%
-97
- C2 -
2G1T
1
ABL1_HUMAN
C:
[17-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
K
F
P
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
84.24
32%
-98
- C2 -
3UE4
1
ABL1_HUMAN
B:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
84.22
32%
-104
- C2 -
4WA9
1
ABL1_HUMAN
B:
[7-282]
--------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.11
38%
-98
- C2 -
3P86
1
CTR1_ARATH
A:
[39-293]
-----------------------------------------------------------------------------------------------------------------------------------
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
G
S
--
D
---------
V
A
V
K
I
L
M
---
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
G
A
-----
R
E
Q
L
D
E
R
R
R
---------
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
-
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
--------
T
V
K
V
C
D
F
-------------------
G
T
---
P
--
E
W
M
A
P
E
V
L
R
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
Q
V
V
A
A
V
G
F
K
C
K
R
L
-
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
------
M
D
L
L
R
P
L
--
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.08
33%
-99
- C2 -
1M52
1
ABL1_MOUSE
A:
[10-280]
-------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
83.96
32%
-99
- C2 -
2G1T
1
ABL1_HUMAN
B:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
K
F
P
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
83.94
32%
-97
- C2 -
2F4J
1
ABL1_HUMAN
A:
[16-283]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
83.90
34%
-101
- C2 -
3QRK
1
ABL1_HUMAN
A:
[5-267]
----------------------------------------------------------------------------------------------------------------
P
S
----
S
P
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
83.88
32%
-101
- C2 -
3KF4
1
ABL1_MOUSE
A:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
83.81
32%
-97
- C2 -
2HIW
1
ABL1_HUMAN
A:
[17-274]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
83.81
32%
-110
- C2 -
3PYY
3
ABL1_HUMAN
B:
[28-295]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
-------------------
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
83.76
32%
-97
- C2 -
3KFA
1
ABL1_MOUSE
A:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.54
32%
-99
- C2 -
4XEY
1
ABL1_HUMAN
A:
[116-388]
------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
83.43
32%
-101
- C2 -
2G1T
1
ABL1_HUMAN
A:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
K
F
P
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.43
32%
-98
- C2 -
3IK3
1
ABL1_MOUSE
B:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
83.41
32%
-95
- C2 -
2G2H
1
ABL1_HUMAN
A:
[17-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.27
32%
-101
- C2 -
2Z60
1
ABL1_MOUSE
A:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
---
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
83.26
34%
-98
- C2 -
2HYY
1
ABL1_HUMAN
D:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
--
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
83.02
32%
-94
- C2 -
3UE4
1
ABL1_HUMAN
A:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.96
34%
-98
- C2 -
4O91
1
M3K7_HUMAN
A:
[5-261]
--------------------------------------------------------------------------------------------------------------------------
I
D
Y
K
E
----
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
R
A
K
--
D
---------
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
-------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
------------
H
A
M
-
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
------------------
G
S
---
A
--
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
------
V
K
I
M
T
H
L
--
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.80
34%
-100
- C2 -
2YIY
1
M3K7_HUMAN
A:
[5-261]
--------------------------------------------------------------------------------------------------------------------------
I
D
Y
K
E
----
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
R
A
K
--
D
---------
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
-------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
------------
H
A
M
-
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
------------------
G
S
---
A
--
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
------
V
K
I
M
T
H
L
--
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
82.57
33%
-95
- C2 -
3HMI
1
A:
[34-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
E
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
------
H
Q
A
F
E
T
M
--
F
H
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
82.54
34%
-92
- C2 -
2HYY
1
ABL1_HUMAN
B:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
-
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
82.52
32%
-105
- C2 -
3IK3
1
ABL1_MOUSE
A:
[15-282]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
82.50
32%
-98
- C2 -
2G1T
1
ABL1_HUMAN
D:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
82.45
34%
-111
- C2 -
3CS9
1
ABL1_HUMAN
B:
[19-266]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
---
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
--------------------P--
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
82.40
32%
-101
- C2 -
2HIW
1
ABL1_HUMAN
B:
[17-274]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
82.32
34%
-92
- C2 -
2HYY
1
ABL1_HUMAN
A:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
-
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
82.32
32%
-98
- C2 -
2G2F
1
ABL1_HUMAN
B:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
81.95
34%
-95
- C2 -
2HZI
1
ABL1_HUMAN
A:
[19-266]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
81.95
32%
-102
- C2 -
3KF4
1
ABL1_MOUSE
B:
[15-274]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
---
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
81.88
34%
-101
- C2 -
3CS9
1
ABL1_HUMAN
A:
[19-266]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
81.63
32%
-93
- C2 -
2G2F
1
ABL1_HUMAN
A:
[17-281]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
81.24
31%
-113
- C2 -
4RFM
1
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
R
E
-----
G
A
M
S
-
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
-----------------FP-
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
A
I
--
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.23
34%
-95
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[11-267]
--------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
81.07
32%
-89
- C2 -
2G2I
1
ABL1_HUMAN
A:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.69
33%
-92
- C2 -
4UEU
1
?
A:
[13-268]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
N
I
E
---------
V
A
V
K
T
L
K
-----
E
G
T
M
S
-
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-------------
E
G
H
T
--
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
--------------
A
KFP
I
--
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
-
R
G
Y
R
M
-
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
---------
E
T
L
H
A
L
--
E
T
M
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
80.64
34%
-94
- C2 -
3CS9
1
ABL1_HUMAN
D:
[19-266]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------T--------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
80.64
32%
-90
- C2 -
4WA9
1
ABL1_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------
E
M
ERTD
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
--------------------------
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
80.37
33%
-93
- C2 -
2XYN
4
C:
[34-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
K
--
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
E
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
------
H
Q
A
F
E
T
M
--
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.29
34%
-102
- C2 -
4TWP
1
ABL1_HUMAN
B:
[10-257]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
80.24
31%
-101
- C2 -
3MJ2
1
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
R
E
-----
G
A
M
S
-
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
Y
T
S
--
S
T
G
T
KFP
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
80.05
33%
-92
- C2 -
2XYN
4
ABL2_HUMAN
B:
[34-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
--
S
LT-------
V
A
V
K
T
L
--
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
E
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
------
H
Q
A
F
E
T
M
--
F
H
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
79.98
34%
-98
- C2 -
2HZ4
1
ABL1_HUMAN
B:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
79.76
31%
-113
- C2 -
4MF1
1
ITK_HUMAN
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
--------
A
M
S
-
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
-------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
A
I
--
A
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
79.65
31%
-114
- C2 -
3MJ1
1
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
-----------------
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
---------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
79.54
34%
-91
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
79.50
31%
-108
* C2 *
4PQN
2
A:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
R
E
-----
G
A
M
S
-
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
--------------------FP-
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
79.40
34%
-102
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[15-262]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
----
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
-------------------P--
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
79.16
31%
-108
- C2 -
4MF1
1
B:
[9-261]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
--------
A
M
S
-
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
-----------------FP-
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
A
I
--
A
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
79.09
34%
-103
- C2 -
2HZI
1
ABL1_HUMAN
B:
[19-266]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
----
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
--
F
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
79.00
33%
-92
- C2 -
2XYN
2
ABL2_HUMAN
A:
[34-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
--
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
E
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
H
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
------
H
Q
A
F
E
T
M
--
F
H
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
78.78
32%
-92
- C2 -
2G2I
1
ABL1_HUMAN
B:
[17-275]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
Q
E
--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
--
P
A
G
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
-
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------
H
Q
A
F
E
T
M
FQ
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
78.25
33%
-94
- C2 -
3GVU
2
A:
[34-279]
-----------------------------------------------------------------------------------------------------------------------------------
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
--
S
L
T
-------
V
A
V
K
T
L
K
E
D
T
M
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-------------
E
E
--
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
---
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
--
T
Y
T
------
A
KFP
I
--
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
-
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
------
H
Q
A
F
E
T
M
--
F
H
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
75.17
31%
-123
- C2 -
4PPC
2
ITK_HUMAN
A:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
----------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
---------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
E
I
--
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
73.60
31%
-114
- C2 -
4PPC
2
B:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
----------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
---------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
E
I
--
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
73.07
31%
-115
- C2 -
4QD6
2
B:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
------------
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
E
I
--
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
72.98
31%
-114
- C2 -
4PPB
2
B:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
--
D
K--------
V
A
I
K
T
I
-------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
--------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
E
I
--
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
72.55
31%
-114
- C2 -
4PPB
2
ITK_HUMAN
A:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
--
D
K
--------
V
A
I
K
T
I
-------------
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
----------------
R
T
Q
R
GL
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
--------------------P--
V
--
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
-
F
R
L
-
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------
L
R
Q
L
A
E
I
--
A
E
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------