@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K1_HUMAN: (2015-10-12 )
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
Atome Classification :
(81 SA)
.........10.........20........30........40........50.-....-...-60........70........80...------.....90........100.-.--------.--------.--...--110.......120.......130..-.....140.....-..150.......160--......-.170.......180.......--190-........200.......210...---....220...-....230.......240-------........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDVVDPDIFN-RDP
R
D
H
Y
D
L
L
Q
R
LGGGT
Y
G
E
V
F
K
A
R
DKVSG
D
L
V
A
L
K
M
V
KMEP-DD
D
V
-
S
T
L
-
Q
K
E
I
L
I
LKTCRHA
N
I
V
A
YHG
S
Y
L
W
L
------
Q
K
L
W
I
C
M
E
F
CGAG
S
L
Q
D
I
Y
-
Q
--------
V
--------T--G
S
L
--
S
E
L
Q
I
S
Y
V
C
R
E
V
L
Q
G
L
A
Y
L
H
S
Q
K
K
I
-
H
R
DIKG
A
N
I
L
IND-AG
E
V
R
L
A
DFGI
S
A
Q
I
--
G
A
T
L
A
R
-
R
L
S
FIGTPYWMA
P
E
V
A
A
V
ALK--G
G
--
Y
N
E
L
C
D
I
W
S
L
G
I
T
A
I
E
L
A
ELQPPL---FDVHP
L
R
V
L
F
-
L
M
TKSGYQPPRLKEKG--------
K
W
S
A
A
F
H
N
F
I
K
V
T
LTKSPKKRP
S
A
T
K
M
L
S
H
Q
L
VSQPGLNR
G
L
I
L
D
L
L
D
K
LKNPGKGPSIGDIEDEEPELP
P
A
I
P
R
R
I
R
S
THRSSSLGIP
D
A
D
C
C
R
R
H
M
E
F
R
K
LRGMETRPPANTARLQP
P
R
D
LRSSS
P
R
K
Q
LSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSP
G
V
L
V
R
CASGPPPNSPRPGPPPSTSSP
H
L
TAHSEPSLWNPPSRELDKPPLLPP
K
K
E
K
M
K
R
K
G
C
A
L
L
V
K
L
FNGC
P
L
R
I
HS
T
A
AWTHPSTKD
Q
H
L
L
L
GAEE
G
I
F
I
L
NRNDQ
E
A
T
L
E
M
LFPSR
T
T
W
V
Y
S
I
N
N
V
L
M
SLSGKTPH
L
Y
S
H
S
I
L
G
L
L
E
R
K
ETRAGNPIAHI
S
P
H
R
L
L
A
R
K
NMVSTKIQDTKGC
R
A
C
C
VAEGASSGG
P
F
L
CG
A
L
E
T
S
V
V
L
L
Q
W
Y
Q
P
M
N
K
F
L
L
V
R
Q
V
L
FPLPT
P
L
S
V
F
A
L
LTGPGSEL
P
A
V
C
I
GVSPGRPG
K
S
V
L
F
H
T
V
R
F
G
A
L
S
C
W
L
G
EMSTEHRGP
V
Q
V
T
QVEE
D
M
V
M
V
L
MDG
S
V
K
L
VTPEGSPVRGLRTPEI
P
M
T
E
A
V
E
A
V
A
M
VG
G
Q
L
Q
A
F
W
KHG
V
Q
V
W
AL
G
S
D
Q
L
L
Q
E
LRDP
T
L
T
F
R
LLGSPR
L
E
CSGTISPHC
N
L
L
L
PGSSNSPASASRVAGITGL
48
PsiBlast_CBE
87.42
41%
-91
- C1 -
4RVT
2
M4K4_HUMAN
A:
[17-312]
------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----
E
-
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
86.96
41%
-85
- C1 -
4U43
1
M4K4_HUMAN
A:
[15-312]
------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
-
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
86.80
41%
-92
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[17-312]
--------
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
-------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
86.01
41%
-89
- C1 -
4OBO
2
M4K4_HUMAN
A:
[17-311]
--------
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-------
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
--------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
85.88
41%
-82
- C1 -
4U45
1
M4K4_HUMAN
A:
[13-312]
----
D
I
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
-
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPD--
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
85.86
41%
-81
- C1 -
4U44
2
M4K4_HUMAN
A:
[13-311]
----
D
I
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
-
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SHD---
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
-------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
85.57
41%
-81
- C1 -
4OBP
2
M4K4_HUMAN
A:
[14-311]
-----
I
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
-
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
85.20
41%
-84
- C1 -
4ZK5
2
?
A:
[18-312]
---------
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
-
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
-
K
--------
N
--------
T
KG
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
--
P
P
P
R
L
K
S
K
K
--------
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.26
43%
-100
- C1 -
5AJQ
2
STK10_HUMAN
A:
[13-285]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
K
T
-------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
81.16
43%
-93
- C1 -
4AOT
1
STK10_HUMAN
B:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
--------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
--------P-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
80.85
43%
-97
- C1 -
4USD
1
?
B:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
80.32
40%
-102
- C1 -
4USF
1
?
A:
[13-277]
------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
--------
L
--------
E
--
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K
----------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
------RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
P
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.26
43%
-89
- C1 -
4O27
1
STK24_HUMAN
B:
[3-276]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
79.57
41%
-94
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[18-274]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
----------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.27
43%
-93
- C1 -
4FZD
1
STK26_HUMAN
B:
[5-278]
------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-----------------
A
--
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
--
T
-------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
V
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.23
43%
-93
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
----------------
G
T
P
Y
W
M
A
P
E
V
V
M
----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
78.71
41%
-94
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-------
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
78.50
41%
-96
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
78.14
41%
-95
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
77.98
41%
-93
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[18-274]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
77.89
40%
-96
- C1 -
4USF
1
?
B:
[13-277]
------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
--------
L
--------
E
--
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
--
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
P
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
77.78
43%
-89
- C1 -
4NZW
1
STK25_HUMAN
B:
[17-290]
------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
-----------------
P
--
G
P
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----------------
T
P
F
W
M
A
P
E
V
I
K
---
Q
------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
H
P
M
R
V
L
F
-
L
I
P
K
N
S
--
P
P
T
L
--
E
G
--------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.89
43%
-96
- C1 -
3GGF
1
STK26_HUMAN
A:
[20-293]
------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-----------------
A
--
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
V
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
76.86
41%
-96
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.47
41%
-87
- C1 -
4O0R
1
PAK1_HUMAN
A:
[17-273]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.35
43%
-94
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
K
T
L
Q
K
-----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.39
43%
-90
- C1 -
4FZF
1
?
B:
[5-278]
------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-----------------
A
--
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
V
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.13
43%
-92
- C1 -
3GGF
1
STK26_HUMAN
B:
[20-293]
------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-----------------
A
--
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
V
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
74.76
41%
-90
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[18-274]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.76
43%
-94
- C1 -
4BC6
2
STK10_HUMAN
A:
[8-280]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
K
T
L
Q
---------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
74.70
41%
-92
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[18-274]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
-
Q
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
74.45
41%
-84
- C1 -
4O0T
1
PAK1_HUMAN
A:
[17-273]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.36
43%
-87
- C1 -
4FZA
3
STK26_HUMAN
B:
[5-278]
------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-----------------
A
--
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
V
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.17
41%
-89
- C1 -
4P90
1
PAK1_HUMAN
B:
[17-273]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------------
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
-------------
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.32
43%
-94
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.51
41%
-85
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[18-274]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
P
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
--
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.71
43%
-92
- C1 -
4USE
1
?
A:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
K
T
L
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.57
43%
-92
- C1 -
4USE
1
?
B:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
K
T
L
Q
K
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.48
43%
-94
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-288]
------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--------
L
--------
D
--
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
--
L
----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
--
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
D
P
P
T
L
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
71.27
41%
-93
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
---------
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-------
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.17
40%
-90
- C1 -
2J51
5
SLK_HUMAN
A:
[34-298]
------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
--------
L
--------
E
--
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
--
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
--
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
P
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
70.96
41%
-88
- C1 -
4ZJI
1
?
D:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
--
T
---
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.30
31%
-88
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[6-271]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
---
S
F
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP-----
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
69.82
36%
-95
- C1 -
5D9H
1
?
B:
[17-307]
--------------
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
-
K
--------
Y
IVNRGEHK
N
--
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
AT
G
G
D
V
T
R
N-----
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
----
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
T
L
-
E
T
G
VEDKEMMK
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.44
36%
-89
- C1 -
5D9H
1
?
A:
[17-307]
--------------
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
-
K
--------
Y
I
V
N
R
GEHK
N
--
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
-----
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
----
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
T
L
-
E
T
G
VKEMMK--
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
69.34
40%
-89
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-298]
------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
--------
L
--------
E
--
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
--
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
--
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
P
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
68.95
37%
-91
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[14-293]
--------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
-
K
H
I
V
A
K
GEH
K
--------
S
--
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
----
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
S
L
-
E
T
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
68.86
37%
-86
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[9-288]
--------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
-
K
H
I
V
A
K
GEH
K
--------
S
--
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
---------
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
----
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
S
L
-
E
T
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.86
41%
-85
- C1 -
4ZJI
1
?
C:
[19-275]
------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
--------
E
--------
T
---
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
-------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
--
K
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
67.88
37%
-86
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[9-288]
--------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
-
K
H
I
V
A
K
GEH
K
--------
S
--
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N---
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
----
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
S
L
-
E
T
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
67.54
37%
-89
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[9-288]
--------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
-
K
H
I
V
A
K
GEH
K
--------
S
--
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
----
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
S
L
-
E
T
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
67.30
37%
-85
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[9-288]
--------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
-
K
H
I
V
A
K
GEH
K
--------
S
--
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
----------
T
P
C
W
M
A
P
E
V
M
E
Q
V
----
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
S
L
-
E
T
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
66.39
31%
-88
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[6-271]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
---
S
F
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP----
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
65.00
33%
-84
- C1 -
4BHN
2
B:
[43-295]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
64.83
33%
-90
- C1 -
4BID
1
M3K5_HUMAN
A:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
64.61
31%
-85
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[9-264]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
-
E
--
F
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
------
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
64.50
33%
-85
- C1 -
4BIE
2
B:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
---------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
64.39
31%
-89
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[9-264]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
-
E
--
F
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
------
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
64.05
33%
-86
- C1 -
4BIC
2
M3K5_HUMAN
A:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
------
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
63.83
33%
-88
- C1 -
4BIE
2
M3K5_HUMAN
A:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
63.79
31%
-91
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[6-271]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
---
S
F
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P--------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
----------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
63.77
31%
-86
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[9-264]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
-
E
----
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
------
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.75
33%
-87
- C1 -
4BIB
3
M3K5_HUMAN
A:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
63.55
37%
-88
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[14-292]
--------------
R
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
-
K
H
I
V
A
K
GEH
K
--------
S
--
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
----------
T
P
C
W
M
A
P
E
V
M
E
Q
V
----
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
--
D
P
P
S
L
-
E
T
G
MLK-----
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
63.30
31%
-91
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[25-284]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
---------
F
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
---
G
------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
63.07
33%
-86
- C1 -
4BID
1
B:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
63.04
33%
-83
- C1 -
4BIB
1
B:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
62.66
33%
-84
- C1 -
4BF2
1
B:
[43-295]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
----------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
62.10
33%
-89
* C1 *
4BF2
2
M3K5_HUMAN
A:
[43-295]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
-------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
-------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
61.51
31%
-84
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[9-264]
---------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-
K
P
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
--------
K
--------
A
--
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
-
E
---
V
G
T
R
S
Y
M
S
P
E
----
R
L
Q
--
G
T
H-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
------
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.22
33%
-87
- C1 -
2CLQ
1
B:
[30-282]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.10
33%
-83
- C1 -
4BIC
2
B:
[27-279]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
----------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.68
33%
-88
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[30-282]
-----------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
D
-
S
----
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
--------
S
--------
K
W-
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--
A
G
------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
----------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.62
43%
-57
- C1 -
4QMS
2
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.24
43%
-54
- C1 -
4QMO
3
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.14
43%
-54
- C1 -
4QMT
2
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.96
43%
-49
- C1 -
4QML
2
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.79
43%
-51
- C1 -
4QMM
3
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.99
43%
-55
- C1 -
4QMN
1
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.12
43%
-53
- C1 -
4QMQ
3
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.57
43%
-52
- C1 -
4QMP
2
STK24_HUMAN
A:
[26-299]
------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-----------------
P
--
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
--
N
P
P
T
L
--
E
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------