@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K2_HUMAN: (2015-10-12 )
MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
Atome Classification :
(86 SA)
.........10---.........20........30........40.......--.50..-..-...-.60......-..70........80.------.......90........100--------...--....----110.......120.......130.-......140..-.....150......------.160.......170.......180.....--..--.--190.........200.......210..---.....220..-.....230....----..--.---240.......250.......260.......270....-...-280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
L
L
RDVSLQ----
D
P
R
D
R
F
E
L
L
Q
R
VGAGTYG
D
V
Y
K
A
R
D
T
V
TSE
L
A
A
V
K
I
V
K
--LDPGD-
D
I
-
S
S
L
-
Q
Q
E
I
T
I
L
R
E-CRHP
N
V
V
A
Y
I
G
S
Y
LR------ND
R
L
W
I
C
M
EFCGGG
S
L
Q
E
I
Y
--------HAT--GP
L
E
----
E
R
Q
I
A
Y
V
C
R
E
A
L
K
G
L
H
H
L
H
SQG
K
I
-
H
RDIKG
A
N
L
L
L
-
T
LQG
D
V
K
L
A
DFGVS------
G
E
L
T
A
S
V
A
K
R
R
S
FIGTPYWMAP
E
-
V
A
A
V
E--RK--G--
G
--
Y
N
E
L
C
D
V
W
A
L
G
I
T
A
I
ELGELQPP
L
---
F
H
L
H
P
M
R
A
L
M
-
L
MSKSSFQPPKL----R
D
--
K
---
T
R
W
T
Q
N
F
H
H
F
L
K
L
A
LTKNPKKR
P
T
A
E
K
L
L
QHPF
T
T
Q
Q
-
L
P
R
-
A
L
L
T
Q
L
L
D
KASDPHLGTPSPEDCE
L
E
T
YDM
F
P
D
T
I
HSRGQHGPAERTPSE
I
Q
F
H
Q
V
KFGAPRRKETDPLNE
P
W
E
E
E
W
T
LL
G
K
E
E
L
S
G
S
L
L
Q
S
V
Q
E
A
L
E
ER
S
L
T
IR
S
A
S
E
F
Q
ELDSPDD
T
M
G
T
IKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLL
P
T
A
W
A
T
M
K
QREDPERSSCHGLPPTP
K
V
H
M
G
A
C
F
S
K
V
FNGC
P
L
R
I
H
A
A
V
T
W
I
HPVTRD
Q
F
L
V
V
GAEE
G
I
Y
T
L
N
L
H
E
L
H
E
D
T
L
E
K
L
I
S
HRC
S
W
L
Y
C
V
N
N
V
L
L
SLSGK
S
T
H
I
W
AHD
L
P
G
L
F
E
Q
R
R
L
Q
Q
QVPLSI
P
T
N
R
L
T
Q
R
I
I
P
R
R
FALSTKIPDTKG
C
L
Q
C
R
V
VRNPYT
G
A
T
F
L
L
A
A
L
P
T
S
L
L
L
L
Q
W
Y
E
P
L
Q
K
F
L
L
L
K
NFSSPLPSPAGMLEPLVLDGKEL
P
Q
V
C
VGAEGPEGPG
C
R
V
L
F
H
V
LPLEAGLTP
D
I
L
IPPEGIPG
S
A
Q
Q
V
I
Q
VDR
D
T
I
L
V
S
F
E
R
C
V
R
I
VNMQGEPTATLAP
E
L
T
FDFPI
E
T
V
V
C
L
Q
D
S
V
L
A
F
W
SHGMQGRSL
D
T
N
E
V
T
Q
E
IT
D
E
T
R
I
F
R
V
L
GAH
R
D
I
I
LESIPTDNPEAHS
N
L
Y
I
LTGHQSTY
40
PsiBlast_CBE
85.11
43%
-84
- C2 -
5AJQ
2
STK10_HUMAN
A:
[13-293]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
TM
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
84.58
44%
-86
- C2 -
4OBO
2
M4K4_HUMAN
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
-------
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-----------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
83.00
44%
-79
- C2 -
4OBP
2
M4K4_HUMAN
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
E
D
-
E
E
-
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
82.29
40%
-86
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[14-292]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
Q
Q
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
--------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
81.99
40%
-85
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[14-292]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
Q
-
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
81.05
44%
-79
- C2 -
4U45
1
M4K4_HUMAN
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
E
D
-
E
E
-
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
80.90
41%
-87
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
------
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
80.58
40%
-82
- C2 -
4O0R
1
PAK1_HUMAN
A:
[13-291]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
Q
Q
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
80.51
44%
-76
- C2 -
4U44
2
M4K4_HUMAN
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
E
D
-
E
E
-
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
----------
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
80.44
43%
-85
- C2 -
4USD
1
?
B:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
---------------------
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.43
44%
-78
- C2 -
4ZK5
2
?
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
E
D
-
E
E
-
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
80.32
44%
-79
- C2 -
4U43
1
M4K4_HUMAN
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
E
D
-
E
E
-
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
80.16
41%
-85
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
-----
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
80.09
44%
-86
- C2 -
4OBQ
2
M4K4_HUMAN
A:
[18-305]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
--------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
80.05
41%
-87
- C2 -
4ZJI
1
PAK1_HUMAN
A:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
------
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
80.01
44%
-83
- C2 -
4RVT
2
M4K4_HUMAN
A:
[20-307]
-------
S
L
R
----
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
--
V
-
T
------
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
-
V
I
A
C
D
--
E
N
PD
A
--
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
-
L
I
P
R
N
P
--
P
P
R
L
----
K
S
--
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
79.34
41%
-85
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
-------
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
79.33
40%
-82
- C2 -
3Q4Z
1
PAK1_HUMAN
A:
[14-292]
------
V
S
V
G
----
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
--
L
------
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.84
45%
-84
- C2 -
4USF
1
?
A:
[13-277]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
-------------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
----------RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
--
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
-
S
N
K
-
P
I
R
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.71
46%
-75
- C2 -
4FZF
1
?
B:
[3-276]
--------
M
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
A
---
G
P
F
D
----
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
----
V
G
--
D
-----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
78.65
43%
-77
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
-----------
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
-----------
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
78.58
40%
-83
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[14-292]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
Q
-
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.51
48%
-71
- C2 -
2XIK
2
STK25_HUMAN
A:
[4-287]
--
H
L
R
G
F
A
N
Q
H
SRV
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
--
L
E
E
A
E
--
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
K
P
---
G
P
L
E
----
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
H
P
M
R
V
L
F
-
L
I
P
K
N
S
--
P
P
T
L
----
E
G
--
Q
---
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
-
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
77.91
43%
-80
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
-------------
G
T
P
Y
W
M
A
P
E
-
V
V
M
--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
77.65
40%
-83
- C2 -
4P90
1
PAK1_HUMAN
B:
[13-291]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
------------
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
-----------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
77.59
40%
-79
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[14-292]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.38
47%
-76
- C2 -
4NZW
1
STK25_HUMAN
B:
[13-288]
----------HSRV
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
K
P
---
G
P
L
E
----
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
--------------
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
H
P
M
R
V
L
F
-
L
I
P
K
N
S
--
P
P
T
L
----
E
G
--
Q
---
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
-
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
77.07
40%
-77
- C2 -
4O0T
1
PAK1_HUMAN
A:
[13-291]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--
L
Q
Q
Q
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.07
45%
-80
- C2 -
4USF
1
?
B:
[13-277]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
N
---------
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
--
T
S
--
K
--
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
--
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
-
S
N
K
-
P
I
R
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.32
40%
-79
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[14-292]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
Q
P
-
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
---
C
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
76.11
46%
-78
- C2 -
3GGF
1
STK26_HUMAN
B:
[19-291]
---------
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
A
---
G
P
F
D
----
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
----
V
G
--
D
-----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
76.02
40%
-74
- C2 -
4KS7
2
A:
[10-286]
-
A
A
L
R
M
V
V
D
Q
G
---
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
--
L
R
K
Q
Q
-
R
R
-
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
--------
S
Q
V
---
R
L
N
----
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
-
T
L
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
-
V
I
S
-----
R
--
S
--
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
S
D
S
P
V
Q
A
M
K
-
R
L
R
D
S
P
--
P
P
K
L
----
K
N
--
S
---
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
-
C
L
V
P
L
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.93
46%
-80
- C2 -
3GGF
1
STK26_HUMAN
A:
[18-291]
--------
I
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
A
---
G
P
F
D
----
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
----
V
G
--
D
-----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.13
46%
-71
- C2 -
4FZA
3
STK26_HUMAN
B:
[3-276]
--------
M
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
A
---
G
P
F
D
----
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
----
V
G
--
D
-----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.50
45%
-72
- C2 -
4O27
1
STK24_HUMAN
B:
[1-274]
--------
M
A
----
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
74.13
40%
-75
- C2 -
2F57
1
PAK7_HUMAN
A:
[33-297]
-
A
L
Q
L
V
V
S
P
G
----
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
--
L
R
K
Q
Q
-
R
R
-
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
---
R
M
N
----
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
-
T
S
D
G
R
I
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
-
V
I
S
-----
R
--
L
--
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
---
F
N
E
P
P
L
Q
A
M
R
-
R
I
R
D
S
--
L
P
P
R
V
----
K
D
--
L
---
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
-
G
P
P
-
S
C
I
V
P
L
M
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
73.38
41%
-78
- C2 -
4ZJI
1
?
D:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
-------
A
Q
I
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.09
40%
-72
- C2 -
4KS8
1
A:
[10-286]
-
A
A
L
R
M
V
V
D
Q
G
---
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
--
L
R
K
Q
Q
-
R
R
-
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
--------
S
Q
V
---
R
L
N
----
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
-
T
L
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
-
V
I
S
-----
R
--
S
--
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
S
D
S
P
V
Q
A
M
K
-
R
L
R
D
S
P
--
P
P
K
L
----
K
N
--
S
---
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
-
C
L
V
P
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
73.07
43%
-73
- C2 -
4BC6
2
STK10_HUMAN
A:
[8-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
73.02
43%
-74
- C2 -
4USE
1
?
A:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
72.74
38%
-85
- C2 -
5D9H
1
?
B:
[17-307]
----------------
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
KYIVNRGE
H
K
N
--
G
V
L
E
----
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
AFLATG
G
D
V
T
R
N
--------
G
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
T
L
ETGV
E
D
--
K
EMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
-
K
N
R
-
E
Y
L
I
E
K
L
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.46
38%
-86
- C2 -
5D9H
1
?
A:
[17-307]
----------------
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
GE
H
K
N
--
G
V
L
E
----
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TG
G
D
V
T
R
--------
V
G
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
T
L
ETGV----
K
EMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
-
K
N
R
-
E
Y
L
I
E
K
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.15
41%
-83
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
--
L
Q
----
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
---------
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
72.14
40%
-71
- C2 -
2F57
1
B:
[33-297]
-
A
L
Q
L
V
V
S
P
G
----
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
--
L
R
K
Q
Q
-
R
R
-
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
---
R
M
N
----
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
-
T
S
D
G
R
I
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
-
V
I
S
-----
R
--
L
--
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
---
F
N
E
P
P
L
Q
A
M
R
-
R
I
R
D
S
--
L
P
P
R
V
----
K
D
--
L
---
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
-
G
P
P
-
S
C
I
V
P
L
M
R
Q
Y
R
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
71.47
43%
-74
- C2 -
2J7T
1
STK10_HUMAN
A:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
71.27
43%
-77
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
71.17
39%
-83
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
-------------
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
--
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
71.14
39%
-84
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
------------
V
G
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
--
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.10
39%
-86
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
---------
T
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
--
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
70.95
39%
-86
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
------
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
--
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
70.15
37%
-84
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[14-298]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
----------
T
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
--
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
-
K
N
K
-
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
69.66
37%
-85
- C2 -
2VWI
1
OXSR1_HUMAN
B:
[14-292]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
--
L
E
K
C
Q
T
S
M
-
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
-------------
T
P
C
W
M
A
P
E
-
V
--
M
E
--
Q
V
--
R
--
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
--
P
P
S
L
ETG------ML-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
69.23
43%
-76
- C2 -
4EQU
2
STK10_HUMAN
A:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.20
41%
-75
- C2 -
4ZJI
1
?
C:
[15-293]
------
V
S
V
G
----
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
-
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
----
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
-----
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
T
--
R
K
-----
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
--
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
67.92
43%
-72
- C2 -
4USE
1
?
B:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
-
E
L
-
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
--
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
D
--
P
P
T
L
----
L
T
--
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
67.92
45%
-72
- C2 -
2UV2
6
SLK_HUMAN
A:
[34-298]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
--
T
S
--
K
--
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
--
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
-
S
N
K
-
P
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.39
45%
-74
- C2 -
2J51
5
SLK_HUMAN
A:
[34-298]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
--
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
--
T
S
--
K
--
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
-
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
--
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
-
S
N
K
-
P
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
63.86
31%
-72
- C2 -
3WIG
3
MP2K1_HUMAN
A:
[6-271]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
N
--
S
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP---
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.64
31%
-72
- C2 -
3ORN
3
MP2K1_HUMAN
A:
[6-271]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
N
--
S
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP----
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
59.45
31%
-78
- C2 -
3OS3
2
MP2K1_HUMAN
A:
[6-271]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
N
--
S
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P-------
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
-------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
59.33
33%
-75
- C2 -
4BID
1
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
57.85
31%
-70
- C2 -
4AN2
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
N
E
--
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
57.76
33%
-72
- C2 -
4BIB
1
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.66
46%
-42
- C2 -
4QMP
2
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.52
46%
-42
- C2 -
4QMO
3
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
57.35
33%
-74
- C2 -
4BIE
2
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
---------
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
57.20
33%
-74
- C2 -
4BIE
2
M3K5_HUMAN
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
----------
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
57.10
33%
-73
- C2 -
4BIC
2
M3K5_HUMAN
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
------
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
56.62
31%
-71
- C2 -
4ANB
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
N
E
--
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
56.58
46%
-41
- C2 -
4QMQ
3
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
56.52
33%
-73
- C2 -
4BIC
2
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
56.49
33%
-70
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[30-281]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
D
S
-----
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
---
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.28
46%
-43
- C2 -
4QMN
1
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
55.98
33%
-72
- C2 -
4BIB
3
M3K5_HUMAN
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
----------
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
55.88
33%
-75
* C2 *
4BID
1
M3K5_HUMAN
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
----------
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
55.76
31%
-74
- C2 -
3SLS
2
MP2K1_HUMAN
A:
[25-284]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
---
G
------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
55.73
31%
-66
- C2 -
4AN3
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
N
E
----
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.63
46%
-45
- C2 -
4QMS
2
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
55.48
33%
-74
- C2 -
4BHN
2
B:
[43-294]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
-----
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
54.89
46%
-38
- C2 -
4QMM
3
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.76
46%
-38
- C2 -
4QML
2
STK24_HUMAN
A:
[26-297]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
--
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
P
---
G
P
L
D
----
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
--
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
-
L
I
P
K
N
N
--
P
P
T
L
--------
E
---
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
54.41
33%
-71
- C2 -
2CLQ
1
B:
[30-281]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
--
E
R
-----
S
-
Q
P
L
-
H
E
E
I
A
L
H
K
H
-
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
W-
G
P
L
K
DN--
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
--
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
G
E
P
Q
A
A
M
-
F
K
V
G
M
F
K
V
H
P
E
I
----
P
E
--
S
---
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
54.31
31%
-64
- C2 -
4AN9
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
--
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
N
E
---
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
--
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
P
P
M
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
----
L
P
--
S
---
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-
D
A
E
-
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
45.45
32%
-58
- C2 -
3ALN
1
MP2K4_HUMAN
B:
[18-297]
-----
D
F
T
A
E
----
D
L
K
D
----
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
-
Q
K
-
Q
L
L
-
M
D
L
D
V
V
M
R
S
-
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
------
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
--------
Y
V
Y
--
S
V
L
D
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
------
G
Q
L
--------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
---
P
-----------------
D
P
P
Q
L
----
S
N
SE
E
---
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
-
E
E
R
-
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
42.60
32%
-52
- C2 -
3ALN
1
MP2K4_HUMAN
A:
[18-297]
-----
D
F
T
A
E
----
D
L
K
D
----
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
-
Q
K
-
Q
L
L
-
M
D
L
D
V
V
M
R
S
-
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
------
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
--------
Y
V
Y
--
S
V
L
D
DVIP
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
------
G
Q
---------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
---
P
K
W
---------
T
Q
V
V
K
G
D
P
P
Q
L
----
S
N
SE
E
---
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
-
E
E
R
-
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
36.96
32%
-48
- C2 -
3ALO
1
MP2K4_HUMAN
A:
[18-297]
-----
D
F
T
A
E
----
D
L
K
D
----
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
ST
V
D
E
K
E
-
Q
K
-
Q
L
L
-
M
D
L
D
V
V
M
R
S
-
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
------
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
--------
Y
V
Y
--
S
V
L
D
DVIP
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
------
G
Q
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Y
-
M
A
P
E
R
I
D
P
--------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
---
P
K
W
N
S
V
F
D
-
Q
-
L
T
Q
V
V
K
G
D
P
P
Q
L
----
S
N
S
E
E
---
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
-
E
E
R
-
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------