@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K3_HUMAN: (2015-10-13 )
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
Atome Classification :
(91 SA)
.........-10.--.......20........30........40........50..-.....-.60........70........80..------......90........100.--------...--....110.......120.......130.......140.......150.......160----.....---..170.......180....--..--.190.........200.......210.......220.......230....------...---240........250.......260.......270.-......-280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNPGFDLSR-RN
P
--
Q
E
D
F
E
L
I
Q
R
IGSGTYG
D
V
Y
K
ARNVNTG
E
L
A
A
I
K
V
I
K
LEPGE-
D
F
A
V
V
-
Q
Q
E
I
I
M
M
KDCKHPN
I
V
A
Y
F
G
S
Y
L
R
R------D
K
L
W
I
C
M
EFCGGGSL
Q
D
I
-
Y
--------HVT--GPLS
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
LHSKGKMHRDIKG
A
N
I
L
L
TDNG
H
V
K
L
A
DFGVS
A
Q
I
T
----
A
T
I
A
K
---
R
K
S
FIGTPYWMAP
E
V
A
A
V
E--RK--G
G
--
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
LAELQPPMFDL
H
P
M
R
A
L
F
L
M
TKSNFQPP
K
L
------
K
D
K
---
M
-KWS
N
S
F
H
H
F
V
K
M
A
LTKNPKKR
P
T
A
E
K
L
L
QHP
F
V
-
T
Q
H
L
T
R
-
S
L
A
I
E
L
L
D
KVNNPDHSTYHDFDDDDPE
P
L
V
A
V
P
H
R
IHSTSR
N
V
R
E
E
KTRSE
I
T
F
G
Q
V
K
FDPPLRKETEPHHELPDSDGFLDSSE
E
I
Y
Y
T
ARS
N
L
D
L
Q
L
EYGQGHQG
G
Y
F
LGA
N
K
S
L
L
K
S
V
E
E
E
L
H
QRG
H
V
A
HLEDDEGDDDESKHS
T
L
K
AKIPPPLPPKPK
S
I
F
I
P
Q
E
MHSTEDENQGT
I
K
RCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGM
S
S
F
Q
LNGERD
G
S
L
C
Q
Q
Q
N
EHRGTNLS
R
K
E
KKDVPK
P
I
SNGLPPTP
K
V
H
M
G
A
C
F
S
K
V
FNGC
P
L
K
I
H
C
A
S
SWINPDTR
D
Q
Y
L
I
F
GAEE
G
I
Y
T
L
N
L
N
E
L
H
E
T
S
M
E
Q
L
F
P
RR
C
T
W
L
Y
VMNN
C
L
L
SISG
K
A
S
Q
L
YSHNL
P
G
L
F
D
Y
A
R
Q
M
Q
KLPVAIPAHKL
P
D
R
ILPRKFSVSAKIP
E
T
K
W
C
Q
K
C
CVVRNPYT
G
H
K
Y
L
C
G
A
L
Q
T
S
I
V
L
L
E
W
V
E
P
M
Q
K
F
M
L
I
KHIDFPIP
C
P
L
R
M
F
E
M
LVVPEQEY
P
L
V
C
V
GVSRGR
D
F
N
Q
V
V
R
F
E
TVNPNSTSSWFTESDTPQTNV
T
H
V
T
QLER
D
T
I
L
V
C
L
D
C
C
I
K
I
V
N
L
Q
G
R
LKSSRKLSSE
L
T
F
D
F
Q
I
E
S
I
V
C
L
Q
D
S
V
L
A
F
W
KHGMQGRSFRS
N
E
V
T
Q
E
ISD
S
T
R
I
F
R
LLGS
D
R
V
V
V
L
ESRPTDNPTANS
N
L
Y
I
L
AGHENSY
38
PsiBlast_CBE
84.95
47%
-81
- C1 -
4OBP
2
M4K4_HUMAN
A:
[14-308]
----
I
D
L
S
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
-
E
E
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.80
45%
-78
- C1 -
3A7I
1
STK24_HUMAN
A:
[13-299]
----
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.47
47%
-81
- C1 -
4U44
2
M4K4_HUMAN
A:
[14-308]
----
I
D
L
S
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
-
E
E
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SHD---
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
82.72
47%
-83
- C1 -
4OBO
2
M4K4_HUMAN
A:
[17-308]
-------
S
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
------
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
82.58
47%
-78
- C1 -
4U45
1
M4K4_HUMAN
A:
[14-308]
----
I
D
L
S
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
-
E
E
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPD--
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
82.32
46%
-87
- C1 -
5AJQ
2
STK10_HUMAN
A:
[13-277]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
--------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TM
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
82.14
47%
-78
- C1 -
4U43
1
M4K4_HUMAN
A:
[15-308]
-----
D
L
S
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
-
E
E
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
81.67
46%
-86
- C1 -
4USF
1
?
A:
[13-277]
-----------
N
P
--
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
-
M
L
-------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
--------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
--------RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
P
P
T
L
------
A
Q
P
---
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.52
45%
-73
- C1 -
3A7J
1
STK24_HUMAN
A:
[13-299]
----
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
81.35
47%
-80
- C1 -
4RVT
2
M4K4_HUMAN
A:
[20-310]
-------
S
L
-
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----
E
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.16
45%
-73
- C1 -
3A7H
1
STK24_HUMAN
A:
[11-298]
--
P
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
80.79
46%
-84
- C1 -
4USF
1
?
B:
[13-277]
-----------
N
P
--
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
-
M
L
-------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
----------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
--
T
S
--
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
P
P
T
L
------
A
Q
P
---
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
80.71
47%
-78
- C1 -
4ZK5
2
?
A:
[18-308]
--------
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
-
E
E
E
I
K
-
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.16
50%
-72
- C1 -
2XIK
2
STK25_HUMAN
A:
[13-287]
-------
S
R
-
V
D
P
--
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
--
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
K
-
P
--
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
--
P
P
T
L
------
E
G
Q
---
H
---
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
80.03
47%
-84
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[17-308]
-------
S
S
L
R
D
P
--
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
-
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
--
P
P
P
R
L
------
K
S
K
---
K
-
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
-
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
78.88
39%
-76
- C1 -
4FIE
1
PAK4_HUMAN
B:
[148-406]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
78.49
39%
-76
- C1 -
4FIE
1
PAK4_HUMAN
A:
[148-406]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.56
49%
-76
- C1 -
4NZW
1
STK25_HUMAN
B:
[14-288]
-------
S
R
-
V
D
P
--
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
K
-
P
--
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
---------------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
--
P
P
T
L
------
E
G
Q
---
H
---
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
76.79
43%
-83
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[14-274]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
76.24
46%
-79
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-291]
----------
A
D
P
--
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
-----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
V
G
------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
76.08
43%
-83
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[14-274]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
------------
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.82
46%
-76
- C1 -
4FZD
1
STK26_HUMAN
B:
[5-276]
-----------
D
P
--
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
V
G
------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
75.69
47%
-72
- C1 -
4O27
1
STK24_HUMAN
B:
[3-274]
-----------
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
75.65
46%
-80
- C1 -
3GGF
1
STK26_HUMAN
A:
[18-291]
--------
I
-
A
D
P
--
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
V
G
------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
75.43
43%
-82
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[14-274]
------
V
S
V
-
G
D
P
--
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
------
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
75.13
43%
-80
- C1 -
4O0R
1
PAK1_HUMAN
A:
[13-273]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.05
46%
-72
- C1 -
4FZA
3
STK26_HUMAN
B:
[5-276]
-----------
D
P
--
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
V
G
------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.56
46%
-74
- C1 -
4FZF
1
?
B:
[5-276]
-----------
D
P
--
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
V
G
------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.41
46%
-81
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--------------------
G
T
P
Y
W
M
A
P
E
V
V
M
------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
74.27
43%
-82
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[14-274]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.12
44%
-89
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
73.24
43%
-81
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[14-274]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
73.20
44%
-88
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.11
44%
-88
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.80
46%
-78
- C1 -
4AOT
1
STK10_HUMAN
B:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
---------
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.74
46%
-84
- C1 -
4USD
1
?
B:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.59
43%
-78
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[14-274]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
------
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
72.50
44%
-86
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
71.83
40%
-81
- C1 -
5D9H
1
?
B:
[10-307]
-------
A
V
-
G
W
P
IC
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
-
I
KYIVNRGE
H
K
N
--
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGD
V
T
R
N
---------
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
T
L
ETGVED
K
E
M
---
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
K
A
K
N
R
-
E
Y
L
I
E
K
L
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
71.82
40%
-80
- C1 -
5D9H
1
?
A:
[10-307]
-------
A
V
-
G
W
P
IC
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
-
I
K
Y
I
V
N
R
GE
H
K
N
--
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGD
V
T
R
---------
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
T
L
ETGV--
K
E
M
---
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
K
A
K
N
R
-
E
Y
L
I
E
K
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
71.75
43%
-77
- C1 -
4O0T
1
PAK1_HUMAN
A:
[13-273]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
70.68
42%
-82
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[9-285]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
I
T
R
N-----
F
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ETGV--
Q
D
K
EML
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
70.64
46%
-81
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
K
-------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.36
42%
-79
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[9-285]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
-----------
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ETGV--
Q
D
K
EML
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.98
46%
-78
- C1 -
4BC6
2
STK10_HUMAN
A:
[8-272]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
--------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
-----------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
69.63
46%
-78
- C1 -
4USE
1
?
A:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
----------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
69.61
43%
-78
- C1 -
4P90
1
PAK1_HUMAN
B:
[13-273]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
---------------
S
K
---
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
69.11
42%
-81
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[9-285]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
--------
T
F
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ETGV--
Q
D
K
EML
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
68.45
39%
-75
- C1 -
2CDZ
1
A:
[28-286]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
68.33
42%
-83
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[14-290]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
---------
T
F
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ETGV--
Q
D
K
EML
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
N
K
-
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
68.10
44%
-78
- C1 -
4ZJI
1
?
D:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
-------
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
67.84
39%
-70
- C1 -
2F57
1
B:
[42-298]
-----------
D
P
--
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
---
R
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
--
L
P
P
R
V
------
K
D
L
---
H
-
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
-
K
L
A
G
P
P
-
S
C
I
V
P
L
M
R
Q
Y
R
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.74
46%
-75
- C1 -
2J51
5
SLK_HUMAN
A:
[34-298]
-----------
N
P
--
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
--------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
----
R
T
I
Q
R
---
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
--
T
S
--
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
P
P
T
L
------
A
Q
P
---
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
67.39
39%
-73
- C1 -
2F57
1
PAK7_HUMAN
A:
[42-298]
-----------
D
P
--
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
---
R
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
--
L
P
P
R
V
------
K
D
L
---
H
-
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
-
K
L
A
G
P
P
-
S
C
I
V
P
L
M
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
67.20
39%
-74
- C1 -
4FIG
1
?
B:
[71-329]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
66.74
39%
-71
- C1 -
2X4Z
3
A:
[21-279]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
66.68
46%
-74
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-298]
-----------
N
P
--
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
--------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
----
R
T
I
Q
R
---
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
--
T
S
--
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
P
P
T
L
------
A
Q
P
---
S
-
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
66.64
42%
-78
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[9-285]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
------------
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ETGV--
Q
D
K
EML
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
66.41
39%
-77
- C1 -
4FIG
1
?
A:
[71-329]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
65.61
44%
-83
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-----------
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
-------
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.43
46%
-79
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.13
46%
-79
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
65.01
39%
-71
- C1 -
4FIF
1
PAK4_HUMAN
A:
[71-329]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
64.97
39%
-69
- C1 -
2Q0N
7
A:
[26-284]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
64.89
41%
-73
- C1 -
4KS8
1
A:
[30-278]
-----------------------
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
------
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
-
V
--------
S
Q
V
--
R
-
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
----
K
D
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
--
P
P
K
L
------
K
N
S
---
H
-
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
-
L
Q
T
G
L
P
-
E
C
L
V
P
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
64.88
39%
-71
- C1 -
2J0I
4
A:
[28-286]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
64.52
39%
-74
- C1 -
4FIF
1
PAK4_HUMAN
B:
[71-329]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
64.52
46%
-78
- C1 -
4USE
1
?
B:
[16-280]
-----------
D
P
--
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
-
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
K
---------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
--
P
P
T
L
------
L
T
P
---
S
-
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
64.42
42%
-82
- C1 -
2VWI
1
OXSR1_HUMAN
C:
[14-290]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
I
T
R
NKV-----
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ET----------
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
63.84
39%
-72
- C1 -
4APP
2
A:
[21-279]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
63.76
39%
-67
- C1 -
4NJD
1
A:
[21-279]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
63.29
42%
-81
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[14-290]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
------------
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ETG------ML-
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
62.85
39%
-71
- C1 -
4O0X
1
?
A:
[18-276]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
62.69
39%
-70
- C1 -
4JDI
1
PAK4_HUMAN
A:
[71-329]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.67
41%
-73
- C1 -
4KS7
2
A:
[30-278]
-----------------------
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
------
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
-
V
--------
S
Q
V
--
R
-
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
----
K
D
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
--
P
P
K
L
------
K
N
S
---
H
-
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
-
L
Q
T
G
L
P
-
E
C
L
V
P
L
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
62.56
39%
-68
* C1 *
4O0V
1
A:
[18-276]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
62.41
39%
-71
- C1 -
4O0Y
1
A:
[18-276]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
62.29
44%
-74
- C1 -
4ZJI
1
?
C:
[15-275]
------
V
S
V
-
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
-
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
---------
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
T
--
R
K
---
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
--
T
P
E
L
------
Q
N
P
---
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.81
42%
-81
- C1 -
2VWI
2
OXSR1_HUMAN
A:
[14-290]
---------------
R
D
D
Y
E
L
Q
E
V
I
G
---
T
A
V
V
Q
A
A
Y
C
----
E
K
V
A
I
K
R
I
N
-----------------
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
-
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
-----------------
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
--
P
P
S
L
ET-------EML
K
-
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.83
45%
-37
- C1 -
4QMN
1
STK24_HUMAN
A:
[22-305]
------
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.78
45%
-37
- C1 -
4QMQ
3
STK24_HUMAN
A:
[18-305]
--
P
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
56.03
45%
-38
- C1 -
4QMV
3
STK24_HUMAN
A:
[18-305]
--
P
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.93
45%
-36
- C1 -
4QMM
3
STK24_HUMAN
A:
[18-304]
--
P
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.88
45%
-38
- C1 -
4QMO
4
STK24_HUMAN
A:
[18-304]
--
P
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.79
45%
-40
- C1 -
4QMW
2
STK24_HUMAN
A:
[19-305]
---
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
54.98
45%
-39
- C1 -
4QMU
2
STK24_HUMAN
A:
[19-305]
---
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.06
45%
-36
- C1 -
4QMT
2
STK24_HUMAN
A:
[22-306]
------
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.98
45%
-34
- C1 -
4QMP
2
STK24_HUMAN
A:
[18-305]
--
P
G
M
Q
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.65
45%
-37
- C1 -
4QMS
2
STK24_HUMAN
A:
[22-305]
------
N
L
K
-
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
52.50
45%
-33
- C1 -
4QML
2
STK24_HUMAN
A:
[25-305]
----------
A
D
P
--
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
-
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
--
P
P
T
L
------
E
G
------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
48.63
39%
-56
- C1 -
5BMS
1
A:
[18-276]
-----------
D
P
--
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
-
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
-
K
M
I
R
D
N
L
-
P
P
R
L
------
K
N
L
---
H
-
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------