@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K5_HUMAN: (2015-10-13 )
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKNDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY
Atome Classification :
(92 SA)
.........10........20........30........40........50...--...-..60.-.......70-........80......------..90........100....--------...--110.......120.......130....-...140.......150.......160....----...170--........180.......190..--.......200.......210......---.220......--.230.......240--...---......250.......260.......270....--...280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEAPLR
P
A
A
D
I
L
RRNPQ
Q
D
Y
E
L
V
Q
R
VGSGTYGD
V
Y
K
ARNVHTG
E
L
A
A
V
K
I
I
K
LE--PGD-
D
F
S
L
I
-
Q
Q
E
I
F
M
V
K
E-CKHCN
I
V
A
Y
F
G
S
Y
L
S
R
------
E
K
L
W
I
C
M
EYCGGGSL
Q
D
I
Y
--------HVT--G
P
L
S
E
L
Q
I
A
Y
V
C
R
E
T
L
Q
G
L
A
Y
L
HTKGK-MHRDIKG
A
N
I
L
L
TDHG
D
V
K
L
ADFGV
A
A
K
I
T
----
A
T
I
A
K
---
R
K
S
FIGTPYWMAPE
V
A
A
V
E--KN--GG
Y
N
Q
L
C
D
I
W
A
V
G
I
T
A
I
ELGELQPPM---FD
L
H
P
M
R
A
L
F
--LMSKSNFQPPKL----KDK---T
K
W
S
S
T
F
H
N
F
V
K
I
A
LTKNPKKR
P
T
A
E
R
L
L
T
H
T
F--VAQPG
L
S
R
A
L
A
V
E
L
L
D
KVNNPDNHAHYTEADDDDFE
P
H
A
I
I
R
H
T
I
RSTNRNARAERTASEINFD
K
L
QFEPPLR
K
E
T
E
A
RDEMGLSSDP
N
F
M
L
Q
WNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFP
D
E
E
K
A
S
T
I
KHCPDSES
R
A
P
Q
I
L
R
RQSSPSCGPVAETSSIGN
G
D
G
I
S
K
L
M
SENTEGSAQAPQLPRKNDKRDFPKPAINGLPP
T
P
K
V
L
M
G
A
C
F
S
K
VFDGC
P
L
K
I
N
C
A
T
S
WIHPDTKD
Q
Y
I
I
F
GTED
G
I
Y
T
L
N
L
N
E
L
H
E
A
T
M
E
Q
LFPRK
C
T
W
L
Y
V
IN
N
T
L
M
SLSEG
K
T
F
Q
L
YS
H
N
L
I
A
L
F
E
HAKKPG
L
A
A
H
I
Q
THRF
P
D
R
ILPR
K
F
A
L
T
TKIPDTKGC
H
K
C
C
I
VRNPYT
G
H
K
Y
L
C
G
A
L
QS
G
I
V
L
L
Q
W
Y
E
P
M
Q
K
F
M
L
I
K
HFDFPLPS
P
L
N
V
F
E
M
L
VIPEQEY
P
M
V
C
V
A
ISKGTES
N
Q
V
V
Q
F
E
T
I
NLN
S
A
S
S
W
F
T
EIGAGSQQL
D
S
I
H
V
T
QLER
D
T
V
L
V
C
L
D
K
F
V
K
I
V
NL
Q
G
KL
K
S
S
K
K
L
A
S
EL
S
F
D
F
R
I
E
S
V
V
C
L
Q
D
S
V
L
A
F
W
KHGMQGKSFK
S
D
E
V
T
Q
E
ISD
E
T
R
V
F
R
L
LGS
D
R
V
V
V
L
ESRPTENPTAHS
N
L
Y
I
LAGHENSY
35
PsiBlast_CBE
85.74
45%
-91
- C2 -
5AJQ
2
STK10_HUMAN
A:
[13-285]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TM
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
84.76
43%
-86
- C2 -
4OBO
2
M4K4_HUMAN
A:
[20-311]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---------
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
84.51
43%
-88
- C2 -
4OBQ
2
M4K4_HUMAN
A:
[20-312]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
---------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
84.16
43%
-83
- C2 -
4U45
1
M4K4_HUMAN
A:
[20-312]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--
E
-
D
-
E
E
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPD--
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
84.00
43%
-85
- C2 -
4RVT
2
M4K4_HUMAN
A:
[22-312]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--------
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
83.60
43%
-82
- C2 -
4U44
2
M4K4_HUMAN
A:
[20-311]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--
E
-
D
-
E
E
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SHD---
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
83.48
43%
-83
- C2 -
4ZK5
2
?
A:
[20-312]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--
E
-
D
-
E
E
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
83.47
43%
-81
- C2 -
4U43
1
M4K4_HUMAN
A:
[20-312]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--
E
-
D
-
E
E
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
83.33
43%
-84
- C2 -
4OBP
2
M4K4_HUMAN
A:
[20-311]
-------------
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--
E
-
D
-
E
E
E
E
I
-
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
--------
K
N
T
KG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
-
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
--
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
---
C
D
M
H
P
M
R
A
L
F
--
L
I
P
R
N
--
P
P
P
R
L
----
K
S
K
---
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
--
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
--
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.09
45%
-81
- C2 -
3A7I
1
STK24_HUMAN
A:
[13-290]
--------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.30
45%
-82
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
---------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
81.91
44%
-89
- C2 -
4USF
1
?
A:
[13-276]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
-
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
--------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
--
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.69
48%
-73
- C2 -
2XIK
2
STK25_HUMAN
A:
[14-287]
------------
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
--
E
A
E
--
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
K
-
P
--
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
H
P
M
R
V
L
F
--
L
I
P
K
N
S
--
P
P
T
L
----
E
G
Q
---
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.40
45%
-76
- C2 -
3A7J
1
STK24_HUMAN
A:
[13-290]
--------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.53
48%
-76
- C2 -
4NZW
1
STK25_HUMAN
B:
[15-288]
------------
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
K
-
P
--
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
---------------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
L
H
P
M
R
V
L
F
--
L
I
P
K
N
S
--
P
P
T
L
----
E
G
Q
---
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
80.11
45%
-83
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--------------------
G
T
P
Y
W
M
A
P
E
V
V
M
----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.54
45%
-75
- C2 -
3A7H
1
STK24_HUMAN
A:
[11-290]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
79.31
44%
-86
- C2 -
4USF
1
?
B:
[13-276]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
-
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
----------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TS
K
D
--
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
--
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
78.99
39%
-79
- C2 -
4FIE
1
PAK4_HUMAN
B:
[158-408]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
78.86
40%
-78
- C2 -
4KS7
2
A:
[9-286]
-
K
A
A
L
R
M
V
V
D
--
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
------
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
--------
S
Q
V
--
R
-
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
----
K
D
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
S
D
S
P
V
Q
A
M
K
--
R
L
R
D
S
P
--
P
P
K
L
----
K
N
S
---
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
--
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
78.81
42%
-82
- C2 -
4O0R
1
PAK1_HUMAN
A:
[17-278]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
--
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
LK
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
78.67
46%
-75
- C2 -
4O27
1
STK24_HUMAN
B:
[3-274]
--------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
78.64
39%
-79
- C2 -
4FIE
1
PAK4_HUMAN
A:
[158-408]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
78.39
42%
-94
- C2 -
4ZJI
1
PAK1_HUMAN
A:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
--------
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.98
45%
-87
- C2 -
4USD
1
?
B:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
77.68
40%
-77
- C2 -
4KS8
1
A:
[9-286]
-
K
A
A
L
R
M
V
V
D
--
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
------
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
--------
S
Q
V
--
R
-
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
----
K
D
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
S
D
S
P
V
Q
A
M
K
--
R
L
R
D
S
P
--
P
P
K
L
----
K
N
S
---
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
--
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
76.66
45%
-83
- C2 -
4BC6
2
STK10_HUMAN
A:
[8-280]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
-----------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
76.49
42%
-91
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-------
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
76.44
45%
-76
- C2 -
4FZF
1
?
B:
[5-276]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
V
G
-----
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.44
44%
-76
- C2 -
3GGF
1
STK26_HUMAN
B:
[20-298]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
-----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
V
G
-----
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.34
44%
-76
- C2 -
3GGF
1
STK26_HUMAN
A:
[20-300]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
V
G
-----
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
76.02
42%
-84
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[18-279]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
--
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
------------
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
75.95
42%
-91
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
--------
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
75.85
45%
-75
- C2 -
4FZD
1
STK26_HUMAN
B:
[5-276]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
V
G
-----
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
75.67
42%
-84
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[18-279]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
--
Q
-
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
75.57
42%
-80
- C2 -
4O0T
1
PAK1_HUMAN
A:
[17-278]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
--
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
75.36
45%
-72
- C2 -
4FZA
3
STK26_HUMAN
B:
[5-276]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
R
-
A
--
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
V
G
-----
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.33
45%
-81
- C2 -
4USE
1
?
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
----------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
74.99
45%
-85
- C2 -
2J7T
1
STK10_HUMAN
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
K
-------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
74.65
42%
-92
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
--------
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
73.92
42%
-83
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[18-279]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
--
Q
-
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
73.66
42%
-78
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[18-279]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
73.08
42%
-83
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[18-279]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
Q
P
-
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
LK
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.47
45%
-79
- C2 -
4USE
1
?
B:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----
K
T
L
Q
K
---------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
72.45
44%
-76
- C2 -
2UV2
6
SLK_HUMAN
A:
[34-297]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
-
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
----
R
T
I
Q
R
---
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TS
K
D
--
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
--
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
72.11
44%
-78
- C2 -
2J51
5
SLK_HUMAN
A:
[34-297]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
E
E
-
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
--
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
-
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
----
R
T
I
Q
R
---
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TS
K
D
--
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
--
E
P
P
T
L
----
A
Q
P
---
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
--
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.71
45%
-82
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
-
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
71.01
45%
-80
- C2 -
4EQU
2
STK10_HUMAN
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
L
D
--
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
----
L
T
P
---
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
--
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
70.99
42%
-78
- C2 -
4P90
1
PAK1_HUMAN
B:
[17-278]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------------
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
---------------
S
K
---
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
70.82
40%
-82
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
--------
T
F
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.03
40%
-75
- C2 -
2F57
1
PAK7_HUMAN
A:
[52-302]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
---
F
N
E
P
P
L
Q
A
M
R
--
R
I
R
D
S
--
L
P
P
R
V
----
K
D
L
---
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
--
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
69.76
42%
-78
- C2 -
4ZJI
1
?
D:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
-------
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
LK
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.74
40%
-73
- C2 -
2F57
1
B:
[52-302]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
K
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
---
F
N
E
P
P
L
Q
A
M
R
--
R
I
R
D
S
--
L
P
P
R
V
----
K
D
L
---
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
--
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
Y
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
69.73
40%
-80
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
-----------
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
69.72
40%
-80
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
------------
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
69.55
40%
-81
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[9-285]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
I
T
R
N-----
F
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
69.50
36%
-87
- C2 -
5D9H
1
?
B:
[20-309]
-------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
KYIVNRGE
H
K
N
--
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
-
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGD
V
T
R
N
---------
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
T
L
ETGV
E
D
K
EMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
--
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
69.25
40%
-86
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[14-290]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
---------
T
F
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ETGV
Q
D
K
EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
K
A
K
N
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
68.86
36%
-86
- C2 -
5D9H
1
?
A:
[20-308]
-------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
GE
H
K
N
--
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
-
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGD
V
T
R
---------
V
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
T
L
ETGV--
K
EMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
--
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
68.53
39%
-79
- C2 -
2CDZ
1
A:
[38-288]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
67.38
39%
-80
- C2 -
4FIG
1
?
A:
[81-331]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
67.16
42%
-76
- C2 -
4ZJI
1
?
C:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
---------
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
67.01
39%
-77
- C2 -
4FIG
1
?
B:
[81-331]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
66.85
39%
-75
- C2 -
2X4Z
3
A:
[31-281]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
66.69
39%
-76
- C2 -
4FIF
1
PAK4_HUMAN
B:
[81-331]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
66.63
40%
-85
- C2 -
2VWI
1
OXSR1_HUMAN
C:
[14-290]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
I
T
R
NKV-----
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ET--------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
66.60
39%
-75
- C2 -
4JDI
1
PAK4_HUMAN
A:
[81-331]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
66.51
39%
-73
- C2 -
4FIF
1
PAK4_HUMAN
A:
[81-331]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
66.47
39%
-75
- C2 -
2J0I
4
A:
[38-288]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
66.40
42%
-83
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[19-280]
--------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
------
K
K
E
L
I
-
I
N
E
I
L
V
M
R
E
-
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
--------
T
E
T
--
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
-
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-----------
E
Q
S
K
---
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
---
L
N
E
N
P
L
R
A
L
Y
--
L
I
A
T
N
G
--
T
P
E
L
----
Q
N
P
---
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
65.79
39%
-75
- C2 -
4O0Y
1
A:
[28-278]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
65.77
40%
-85
- C2 -
2VWI
2
OXSR1_HUMAN
A:
[14-290]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
---
T
A
V
V
Q
A
A
Y
C
----
E
K
V
A
I
K
R
I
N
-------------------
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
-----------------
G
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ET-----EML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
65.63
39%
-71
- C2 -
2Q0N
7
A:
[36-286]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
65.24
39%
-76
- C2 -
4O0X
1
?
A:
[28-278]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.21
45%
-45
- C2 -
4QMN
1
STK24_HUMAN
A:
[22-297]
----------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
65.05
40%
-84
- C2 -
2VWI
1
OXSR1_HUMAN
B:
[14-290]
----------------
R
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
--
K
C
Q
T
S
M
D
E
L
-
L
K
E
I
Q
A
M
S
Q
-
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
K
S
--
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
-
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G--
G
D
------------
T
P
C
W
M
A
P
E
V
--
M
E
--
Q
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
---
H
K
Y
P
P
M
K
V
L
M
--
L
T
L
Q
N
D
--
P
P
S
L
ETG----ML-
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
--
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
65.04
39%
-74
- C2 -
4APP
2
A:
[31-281]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.70
45%
-47
- C2 -
4QMW
2
STK24_HUMAN
A:
[19-297]
-------
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
64.63
39%
-73
- C2 -
4O0V
1
A:
[28-278]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
64.61
33%
-88
- C2 -
3WIG
3
MP2K1_HUMAN
A:
[7-271]
------------------
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
-
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
----
D
S
M
A
-----
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
--
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP----
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
----
P
S
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
--
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.45
45%
-47
- C2 -
4QMU
2
STK24_HUMAN
A:
[19-297]
-------
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.22
45%
-43
- C2 -
4QMO
4
STK24_HUMAN
A:
[18-297]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.99
45%
-45
- C2 -
4QMT
2
STK24_HUMAN
A:
[22-297]
----------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
63.91
33%
-94
- C2 -
3OS3
2
MP2K1_HUMAN
A:
[7-271]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
-
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
-
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
--------
K
K
A
--
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
----
D
S
M
A
-----
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
--
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P--------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
----
P
-----
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
--
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.71
45%
-42
- C2 -
4QMQ
3
STK24_HUMAN
A:
[18-297]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
63.63
39%
-70
* C2 *
4NJD
1
A:
[31-281]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.33
45%
-41
- C2 -
4QMM
3
STK24_HUMAN
A:
[18-297]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.94
45%
-40
- C2 -
4QMP
2
STK24_HUMAN
A:
[18-297]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.90
45%
-39
- C2 -
4QML
2
STK24_HUMAN
A:
[25-297]
-------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.64
45%
-43
- C2 -
4QMV
3
STK24_HUMAN
A:
[18-297]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.99
45%
-44
- C2 -
4QMS
2
STK24_HUMAN
A:
[22-297]
----------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--------
E
-
P
--
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
----
E
G
-----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
--
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
54.77
39%
-57
- C2 -
5BMS
1
A:
[28-278]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
-
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
-
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
--------
T
H
T
--
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
---
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
----
K
N
L
---
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
--
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------